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Lots of tweets about this today!
Let's see what we can see in the focal S:E484 build!
Phylogenetics (what I do - making 'family trees' from virus genetics) can be very informative to see how different variants are spreading, and how cases
There are two variants circulating predominantly in Brazil:
- 20B/S.484K seems to be older & more widespread. It has (among others) a mutation at position 484
- 20J/501Y.V3 is smaller & detected recently. It has mutations at 501 *and* 484.
2/10
https://t.co/Cw5u2kuATa
The variant predominantly in the UK (501Y.V1 / B.1.1.7) and the variant predominantly in South Africa (501Y.V2) also both have 501. 501Y.V2 *also* has the 484K mutation.
Why are there concerns about these mutations? You can read more at https://t.co/wVE7ubYBoy!
3/10
The view below is from an analysis focusing on sequences with a mutation at 484. It shows all the samples in the 2 variants (20B/S.484K & 20J/501Y.V3) & how they're related. More closely related = closer together (very, very roughly).
4/10
We can colour these samples by region to see where they're from. As we expect - most are in Brazil! A few are in Argentina (also red).
5/10
https://t.co/Cw5u2kuATa
Let's see what we can see in the focal S:E484 build!
Phylogenetics (what I do - making 'family trees' from virus genetics) can be very informative to see how different variants are spreading, and how cases
There are two variants circulating predominantly in Brazil:
- 20B/S.484K seems to be older & more widespread. It has (among others) a mutation at position 484
- 20J/501Y.V3 is smaller & detected recently. It has mutations at 501 *and* 484.
2/10
https://t.co/Cw5u2kuATa

The variant predominantly in the UK (501Y.V1 / B.1.1.7) and the variant predominantly in South Africa (501Y.V2) also both have 501. 501Y.V2 *also* has the 484K mutation.
Why are there concerns about these mutations? You can read more at https://t.co/wVE7ubYBoy!
3/10

The view below is from an analysis focusing on sequences with a mutation at 484. It shows all the samples in the 2 variants (20B/S.484K & 20J/501Y.V3) & how they're related. More closely related = closer together (very, very roughly).
4/10

We can colour these samples by region to see where they're from. As we expect - most are in Brazil! A few are in Argentina (also red).
5/10
https://t.co/Cw5u2kuATa

Our top 15 tweets
A #prodmgmt thread 👇
https://t.co/Yv854Sd3P3
https://t.co/sXaMH1bZ9m
https://t.co/5X7bOTsS7m
https://t.co/w1y6LTtPS2
A #prodmgmt thread 👇
https://t.co/Yv854Sd3P3
Sum up Product Management in 4 words or less. \U0001f609
— Product School (@productschool) April 10, 2020
https://t.co/sXaMH1bZ9m
\u201cWithout data, you\u2019re just another person with an opinion.\u201d
— Product School (@productschool) July 22, 2020
-W. Edwards Deming
https://t.co/5X7bOTsS7m
MVP (Minimum Viable Product) or MLP (Minimum Lovable Product)? \u2764\ufe0f
— Product School (@productschool) July 6, 2020
https://t.co/w1y6LTtPS2
UI/UX are not just add-ons for a product. They\u2019re critical elements that need care, research, and a Product Manager\u2019s full attention.
— Product School (@productschool) July 12, 2020
So, here’s a way of reframing this question: which societies enabled coexistence and collaboration between people with divergent social styles, rather than imposing a dominant social style? Such social pluralism is very important indeed.
I suspect that the vast majority of the answers to the original question will fall foul of the tendency to project ideal social arrangements that reflect our own style of social understanding and engagement, and that this will lead them to talk past one another.
Consider the perspective of someone far away from you on in the neurological map, who doesn’t overlap with your socially calibrated genetic resources for social intelligence: the social heaven of an autist introvert may be the social hell of a bipolar extrovert, and vice versa.
I’ve had many good conversations about this with people in different parts of the map who overlap with me in different ways (h/t @tjohnlinward, @dynamic_proxy, @maradydd, @mojozozoe, @UnclePhobic) whose personal heavens I would like to visit, but maybe not live in full time.
We get to see glimpses of these heavens not merely in the past, but in the present, and abstract their geometries, both in spatial/architectural terms (https://t.co/aTcRgtJOVJ) and in temporal/dynamic terms (). The physical/computational platforms around us configure our agency.
Which human societies, past or present, come closest to your ideal of how we should live together?
— Keith Frankish (@keithfrankish) January 15, 2021
I suspect that the vast majority of the answers to the original question will fall foul of the tendency to project ideal social arrangements that reflect our own style of social understanding and engagement, and that this will lead them to talk past one another.
Consider the perspective of someone far away from you on in the neurological map, who doesn’t overlap with your socially calibrated genetic resources for social intelligence: the social heaven of an autist introvert may be the social hell of a bipolar extrovert, and vice versa.
I’ve had many good conversations about this with people in different parts of the map who overlap with me in different ways (h/t @tjohnlinward, @dynamic_proxy, @maradydd, @mojozozoe, @UnclePhobic) whose personal heavens I would like to visit, but maybe not live in full time.
We get to see glimpses of these heavens not merely in the past, but in the present, and abstract their geometries, both in spatial/architectural terms (https://t.co/aTcRgtJOVJ) and in temporal/dynamic terms (). The physical/computational platforms around us configure our agency.
I’m still not over the fact that only one black bar applicant who was a first time bar taker and a graduate of an ABA accredited school passed the CA bar exam in February 2020 🥺
It costs on average $15k to study for the bar exam and pay expenses. Because of the racial wealth gap most Black bar applicants have to work while studying in order to pay their fees and living costs. This dramatically decreases their chances of passing the exam.
Here are a few
https://t.co/EXDaCreVrO
https://t.co/LMUFMEWuI8
It costs on average $15k to study for the bar exam and pay expenses. Because of the racial wealth gap most Black bar applicants have to work while studying in order to pay their fees and living costs. This dramatically decreases their chances of passing the exam.
Here are a few
https://t.co/EXDaCreVrO
https://t.co/LMUFMEWuI8