Lots of tweets about this today!
Let's see what we can see in the focal S:E484 build!

Phylogenetics (what I do - making 'family trees' from virus genetics) can be very informative to see how different variants are spreading, and how cases

The focal S:N501 build has been updated with data from 15 Jan, & includes 164 non-UK, non-South African sequences in 501Y.V1 (B.1.1.7 #b117) & 501Y.V2.

The S:E484 build has also been updated. Includes 501Y.V3 & 20B/S.484K (predominantly in Brazil).

1/16

https://t.co/3bdttjKVl4

There are 161 new, non-UK sequences in 501Y.V1 (B.1.1.7) from the Netherlands, Denmark, Australia, Spain, Norway, Germany, the USA, & Switzerland, and from Turkey and Ecuador for the first time.

2/16

Turkey has 19 sequences in 501Y.V1 for the first time. These indicate many independent introductions, though a few clusters may indicate local transmission, and pairs with common exposure.

3/16

Ecuador has 4 sequences in 501Y.V1 for the first time, which represent 2 separate introductions (pic 2). 3 are identical, and may represent exposure to a common source (pic 3). The connection to the Spanish sequence may be a common source, or onward transmission.

4/16

Denmark has 66 new sequences (orange). A few are independent introductions, though many link with older sequences, showing continuing local transmission.

5/16

The latest focal S:N501 build is now up! It includes data from 4 Jan 2021.

We have new sequences in 501Y.V1/B.1.1.7 from Denmark, Singapore, Australia, Italy, Spain, France, Portugal, Germany, Brazil, Jamaica, Luxembourg, Pakistan & the USA.

1/12

https://t.co/FTjvV7T7wL

Denmark has 43 new sequences (in orange). These indicate additional introductions, as well as further expansion of the existing large local transmission cluster we saw previously (shown in zoomed divergence view).

2/12

10 new sequences from Portugal (orange) indicate additional, separate introductions.

3/12

Singapore has 5 new sequences (yellow). These indicate at least 5 separate introductions for the total of 6 sequences, with two identical sequences likely being 1 introduction.

4/12

5 new sequences from the US, from Florida & California (older sequences crossed through).

Zooming in (divergence view) on the California cluster, the relationship between these samples is difficult to infer from phylogenies alone.

5/12

A brief update to the focal S:N501 builds to start your Friday off right! This one includes data from 7 Jan 21.

We have about 20 new sequences each in 501Y.V1 (B.1.1.7 #b117) & 501Y.V2.

Let's take a look at the new sequences, starting with 501Y.V1

1/14

https://t.co/kT1gFsSZn0

There are 22 new non-UK sequences in 501Y.V1, including for the first time from Luxembourg (3), & additional seqs from Singapore (1), Australia (4), France (12), & Switzerland (2).

2/14

First, Luxembourg has 3 sequences in 501Y.V1 for the first time. Each represents a separate introduction.

3/14

France has 12 new sequences (orange). Many of these represent independent introductions.

Zooming in (divergence view), we can see 2 new sequences are identical (possible local transmission), & 2 differ by 2 mutations (1 each).

4/14

Australia has 4 new sequences (red and orange) which are spread across the tree, representing separate additional introductions.

5/14

Real talk.

The right as spent years trying to paint @NancyPelosi & @HillaryClinton as extreme leftists who will take your guns, sterilize your sons, outlaw Christianity, and tax you at 80%.

Meanwhile...

The far left has tried to insist that they were both Republican-lite.

1/

Some on the far left call them war mongering neoliberal corporate owned whores.

That's on a good day, for both.

None of these charges, by either side, are remotely true of course. Not that this matters to the people putting this shit out there.

2/

The facts are these.

@HillaryClinton and @NancyPelosi have been fighting people, usually white men, for tnings their entire lives.

With little respite.

At times they have had to make impossible choices and compromises just to beo let in the door. Most women have.

3/

It must be easy to be some 26 yo white dude who has never had anyone tell him no his whole life to sit in judgement of women like them.

"How dare she..."

...do what was necessary to get a place at the table.

...do exactly what men have been doing w/o your disapproval.

4/

Let's face it, most men suck when it comes to issues that don't pertain directly to their own self interests. White men are even worse. We just are.

Most men especially suck when it comes to women's issues and I mean really suck.

How many left leaning men fell to #MeToo?

5/

My wonderful @jainfamilyinst colleagues @laura_bmw & @Edi_Nilaj have released their new report "Student Debt and Young America," which pretty comprehensively demolishes many of the myths about who does and doesn't have student debt.
https://t.co/y02KFosRQ3
Highlights to follow
/1

@laura_bmw @Edi_Nilaj First of all, look at this one chart that tells you why the student debt crisis is happening: rising debt; stagnant income, and the gap has opened widest for minority borrowers.
/2

You look at that chart and you see the total failure of the human capital model to explain labor market outcomes, insofar as it even is a falsifiable social science hypothesis.
/3

Second, while it's true that total loan balances are increasing in income, student debt has increased most over time among the lowest-income groups. This tells you that student debt is becoming a marker of the disadvantaged rather than the advantaged.
/4

Third, balances on outstanding loans are rising over time, not declining. As I said in my last report, the student debt crisis is a crisis of non-repayment. This is why it's foolish to think the student debt is ever going to be paid back, whether it's cancelled now or not.
/5