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@KaylaAncrum 1) This reminds me of junior high back in the Chicago suburbs when some classmates pretended my name was ‘too hard’ & relentlessly teased me as ‘Shoehead,’ ‘Shitvo,’ & ‘Shamu’ for almost 2 years until my social studies teacher Mr. C decided to absolutely GO OFF on them:

2) In class one day, to everyone’s utter astonishment, he stopped his lecture & said ‘I think some of you are having trouble pronouncing Shuvo’s name. It’s easy to say shoo-VOH, but your behaviour inspires me to give you new names now. Let’s point out a few examples.’

3) Mr. C turned to a red-haired jerk who often led the bullying and said ‘If you don’t shape up, you’ll be known as Carrot Head in my class, since you’re uglier than Carrot Top and you’re certainly bigheaded and arrogant.’

His face turned redder than his hair.

4) He then then turned to a classmate named Edie & said to her ‘I won’t call you Edie anymore, I’ll call you Dedie, as in DD, since that’s the grade you get in my class & it’s short for Dum-Dum, which is what you proved to be.’

I actually felt bad for her she was so mortified.

5) Then he turned to another kid whose last name was McCracken & said ‘You will be known as McChicken, since you’re a coward, & based on your performance it seems the most you can ever aspire to be is a fast food server, so wipe that smug grin off your face, cluck cluck.’

!!
1. Why haven't Dr. Alice Latinne @nycbat @peterdaszak
@EpsteinJon @HumeField @CarlosTorrelio @linfa_wang
of @EcoHealthNYC released the first draft of:
https://t.co/nbZPxmEdja
Why haven't US authorities forced them to?
@USAIDGH @OneHealthUCD @NIHDirector
@dylanbgeorge @cmyeaton

Dr. Alice Latinne Alice Latinne sampling a rodent in SE Sulawesi @PREDICTproject in 2017 and 2018 in Indonesia, before her work on bats with Zhengli Shi:
Origin & cross-species transmission of bat coronaviruses in China
Earliest Version: 2. May 31, 2020
https://t.co/vF0tGWDFjv


3.


4. @franciscodeasis


5. @MonaRahalkar
1/15
Why can cefepime cause neurological toxicity?

And why is renal failure the main risk factor for this complication?

The answer requires us to learn about cefepime's structure and why it unexpectedly binds to a certain CNS receptor.

#MedTwitter #Tweetorial


2/
Let's establish a few facts about cefepime:

đŸ”ș4th generation cephalosporin antibiotic
đŸ”șExcretion = exclusively in the urine (mostly as unchanged drug)
đŸ”șReadily crosses the blood-brain barrier (so it easily accesses the brain)

https://t.co/rjYG1BfGPR


3/
The first report of cefepime neurotoxicity was in 1999.

A patient w/ renal failure received high doses of cefepime and then developed encephalopathy, tremors, myoclonic jerks, and tonic-clonic seizures.

✅All symptoms resolved after hemodialysis.

https://t.co/u7JLVitQpp


4/
Cefepime neurotoxicity is surprisingly common, occurring in up to 15% of treated critically ill patients (w/ symptoms varying from encephalopathy to seizures).

💡The main risk factors = renal failure and lack of dose adjustment for renal function.

https://t.co/nxbnzSq8AR


5/
What about cefepime induces neurotoxicity?

One clue is that it's not the only antibiotic that causes neurotoxicity, particularly seizures.

This actually is a class effect w/ other beta-lactam antibiotics (including penicillins and carbapenems).

https://t.co/Lf4BhON9IY
This is trash, @AP. Utter garbage. Shame on the “journalists” who wrote this (really? You needed 2 people to report out this garbage?) Also, you don’t even make clear that this lady is wrong. You treat it as a legitimate position. What the fuck is wrong with you?


Look at this. This treats both views as legitimate. Fucking garbage.


Have you learned nothing?! This is such bullshit. Why the fuck do I even bother trying to push back on bad journalism? No one in positions of power ever listen.

I used to think that bad journalism was mostly the result of honest mistakes, but the past few years have really hammered home for me how much it is intentional trash. Shame on @AP for that bullshit. Shame on @ABC for letting Rand Paul rant about his election conspiracy theories.

Seriously, @AP @ClaireGalofaro @JulietLinderman? You didn’t even bother to note that this lady’s delusions are false.
Feels like a good time to share my path from random person on the internet to @Coinbase to @1confirmation

Nothing special just curiosity and hustle which everyone has, it just needs to be unlocked

Coinbase is now a giant that's easy to hate on but started as an underdog just like every other startup. @brian_armstrong launched it by himself in June 2012

I got curious after reading his Hacker News post (
https://t.co/t69Tz5E2Eb) and became one of the first users


Months earlier a @fredwilson post (https://t.co/wmu3WRuYCy) about BTC intrigued me and I made my first purchase by taking out cash from an ATM then going to a CVS to Moneygram it to Mt. Gox

Buying on https://t.co/lvwtxPqm8B was a huge improvement from that initial experience

Bitcoin wasn’t in high demand then so Brian sent "bitcents" to users 😂

Down the rabbit hole I went


July 2013: Cold emails ftw (this was one of many)