The latest focal S:N501 build is now up! It includes data from 4 Jan 2021.

We have new sequences in 501Y.V1/B.1.1.7 from Denmark, Singapore, Australia, Italy, Spain, France, Portugal, Germany, Brazil, Jamaica, Luxembourg, Pakistan & the USA.

1/12

https://t.co/FTjvV7T7wL

The focal S:N501 build has been updated with data from 15 Jan, & includes 164 non-UK, non-South African sequences in 501Y.V1 (B.1.1.7 #b117) & 501Y.V2.

The S:E484 build has also been updated. Includes 501Y.V3 & 20B/S.484K (predominantly in Brazil).

1/16

https://t.co/3bdttjKVl4

There are 161 new, non-UK sequences in 501Y.V1 (B.1.1.7) from the Netherlands, Denmark, Australia, Spain, Norway, Germany, the USA, & Switzerland, and from Turkey and Ecuador for the first time.

2/16

Turkey has 19 sequences in 501Y.V1 for the first time. These indicate many independent introductions, though a few clusters may indicate local transmission, and pairs with common exposure.

3/16

Ecuador has 4 sequences in 501Y.V1 for the first time, which represent 2 separate introductions (pic 2). 3 are identical, and may represent exposure to a common source (pic 3). The connection to the Spanish sequence may be a common source, or onward transmission.

4/16

Denmark has 66 new sequences (orange). A few are independent introductions, though many link with older sequences, showing continuing local transmission.

5/16

To add to the excitement of your Saturday evening, the focal S:N501 build is now updated with data from 8th Jan, including 48 new seqs in 501Y.V1 (B.1.1.7 #b117) & 501Y.V2.

1/12

https://t.co/AbdhO1rqpw

There are 46 new non-UK sequences in 501Y.V1, from the Netherlands, Italy, Israel, Ireland, Norway, Sweden, the USA, and Luxembourg.
And 2 new non-South African sequences in 501Y.V2, from Australia for the first time.

2/12

In 501Y.V1:

Ireland has 4 new sequences (orange). 2 sit separately but are identical, indicating an additional introduction. 2 link to a previous sequence (green), 1 mutation away each. This could indicate location transmission, unsampled diversity, or a common exposure.

3/12

The Netherlands has 10 new seqs (orange). Many sit apart on the tree, indicating additional introductions. 3 cluster together separated by a few mutations. 2 are identical to an older seq. 1 falls in a cluster of older seqs. Some of these could indicate local transmission.

4/12

Israel has 22 new sequences (orange). 1 links to an older sequence, but is separated by 3 mutations, so may be separate introductions. Another is identical to an older sequence. But most new sequences cluster together (blue), clearly indicating local transmission.

5/12

The latest S:N501 focal build is now up, with data from 28th Dec:

We can see new sequences from Italy, Israel, Spain, France, & Ireland in the SE England variant (501Y.V1) & Switzerland in the South African variant (501Y.V2).

1/8

https://t.co/PEU7dhptO6

In 501Y.V1 (SE England variant), we can see 1 new sequence from France & Spain, each. The French sample has a travel history to the UK.

3 new sequences are from Israel (marked 1 & 2). Zooming in on '2' (divergence view) shows they are identical, indicating 1 introduction.

2/8

There are 7 new sequences from Ireland, found roughly in 5 places on the tree (4 are singletons, 3 cluster together - 2nd 'group' from the top).

These indicate at least 5 introductions, but we need to zoom in on the 3 that cluster to see more clearly.

3/8

Zooming in to the 3 that cluster together (divergence view), shows it can be difficult to distinguish introductions sometimes, especially as we expect strong travel links between the UK & Ireland, & may only be sampling the total diversity present in Ireland.

4/8

14 new sequences from Italy are scattered across the tree - some alone & some clustering.

Zooming in on a few clusters shows some seem to be linked, while others are harder to determine.
4 seem to be clearly linked as 1 introduction.

5/8

Happy Tuesday! The latest focal S:N501 build is now updated with sequences from 11 Jan.
There are 101 new sequences in the 501Y.V1 (B.1.1.7 #b117) & 501Y.V2 variants.

Additionally, I'll include some updates on S:E484K in this thread.

1/20

https://t.co/dXx6nk6Llz

There are 97 new non-UK sequences in 501Y.V1, including the first sequences in the cluster from Slovakia, Mexico, & Belgium, plus additional sequences from the Netherlands, Denmark, Australia, Spain, Ireland, & Sweden.

2/20

Slovakia has 10 sequences that fall in 501Y.V1 for the first time. These are closely linked, & likely indicate a single introduction and ongoing transmission (remember: vertical distance is not meaningful on the same branch - position of the 2 English samples is arbitrary).

3/20

Belgium has 5 sequences in 501Y.V1 for the 1st time, indicating 3 separate intros. 3 seqs cluster together (zoomed, divergence), indicating a single introduction. The connection to Netherlands might indicate transmission, or 2 transmissions from same diversity in the UK.

4/20

Mexico also has a sequence that falls into 501Y.V1 for the first time.

5/20

There is a recent new word in Chinese that I think deserves introducing into the Western neoreactionary canon.

The word is 内卷 (nei-juan) which has been translated as "involution". Originally a Chinese phenomenon it increasingly applies anywhere there is modernity.

To capture the essence of what "involution" means it helps to picture a spiral in your mind. Our modern narrative says that as we progress technologically we should progress OUT of the spiral and have more free time to be capable of ever more amazing things...

But what if the progression of technology and society actually sends us WITHIN the spiral in an infinite number of ever-decreasing circles? What if we are walking DOWN the spiral staircase of progress rather than UP?

"Involution" in its original meaning has been used to describe agrarian societies and how their development actually leads to self-perpetuating processes that prevent change and progress rather than encourage it.

Increased food production has limited many civilisations and sent them into stagnancy rather than allowed them to grow. This stagnancy can continue for millennia in safe environments till threatened, other times it drives the civilisation into extinction from external threats.

12 January 2020 #MAGAanalysis #EO13959

Did We Declare War Against China In November?

I was tagged on a video that's going round this morning. It's got our new, very strange friend Simon Parks, Charlie Ward, and a gal, don't know her last name, named Danielle.

1 So, today we turn to early Islamic Beirut. what do we know of the earliest times of #Beirut under early Islamic rule, starting with the #conquest. How and when did Beirut enter the emerging Muslim empire? -rm

2 Let’s start with traditional sources for the early Islamic period. Of those, only al-Balādhurī (d. ca. 892), the Abbasid scholar, is informative. Other Muslim and non-Muslim sources including al-Ṭabarī's Tārīkh are silent on the matter.-rm

3 In his small tome, Futūḥ al-Buldān, al-Balādhurī tells his readers: “After the conquest of Damascus, Yazīd came to Sidon, ʿArqa, Byblos, and Beirut which lie on the sea coast with his brother Muʿāwiya leading the van of the army.”-rm

4 Hence, the men who conquered Beirut were Yazīd b. Abī Sufyān (d. 639) and his half-brother and future caliph Mu‘āwiya (r. 661-680). The date of the conquest of the coast falls between 636 and 639 at the latest, the date of the death of Yazīd in the plague of Emmaus. -rm

5 Yazīd and the Muslim army likely took the coastal road to Beirut, a path taken by numerous armies before. They would have either swung from Damascus to Baalbek through the Hims gap to ‘Arqa, then Byblos, crossed the Dog River, and arrived at the eastern side of Beirut.

Welcome to a new Legislative Day in the Senate of the Federal Republic of Nigeria!

Senate President, @DrAhmadLawan leads the Principal Officers into the Chambers, takes the official prayers and begin the day's proceedings at 10:40am.

#TodayInSenatePlenary

Senator Ibrahim Oloriegbe moves for the adoption of Votes and Proceedings for Tuesday, 15th February, 2021.

Senator Ezenwa Onyewuchi seconds.

#TodayInSenatePlenary

Senator Ayo Akinyelure presents18 petitions from the Office of the President of the Senate to the floor of the Senate.

Petitions are laid and referred to the Committee on Ethics, Privileges and Public Petitions and to report back in six weeks.

#TodayInSenatePlenary

Senator Solomon Adeola {@YAYIAdeola} cites Order 43 to inform the Senate on the demise of Alhaji Lateef Kayode Jakande, the first civilian Governor of Lagos State.