The latest focal S:N501 build is now up! It includes data from 4 Jan 2021.

We have new sequences in 501Y.V1/B.1.1.7 from Denmark, Singapore, Australia, Italy, Spain, France, Portugal, Germany, Brazil, Jamaica, Luxembourg, Pakistan & the USA.

1/12

https://t.co/FTjvV7T7wL

Happy Tuesday! The latest focal S:N501 build is now updated with sequences from 11 Jan.
There are 101 new sequences in the 501Y.V1 (B.1.1.7 #b117) & 501Y.V2 variants.

Additionally, I'll include some updates on S:E484K in this thread.

1/20

https://t.co/dXx6nk6Llz

There are 97 new non-UK sequences in 501Y.V1, including the first sequences in the cluster from Slovakia, Mexico, & Belgium, plus additional sequences from the Netherlands, Denmark, Australia, Spain, Ireland, & Sweden.

2/20

Slovakia has 10 sequences that fall in 501Y.V1 for the first time. These are closely linked, & likely indicate a single introduction and ongoing transmission (remember: vertical distance is not meaningful on the same branch - position of the 2 English samples is arbitrary).

3/20

Belgium has 5 sequences in 501Y.V1 for the 1st time, indicating 3 separate intros. 3 seqs cluster together (zoomed, divergence), indicating a single introduction. The connection to Netherlands might indicate transmission, or 2 transmissions from same diversity in the UK.

4/20

Mexico also has a sequence that falls into 501Y.V1 for the first time.

5/20

The latest S:N501 focal build is now up, with data from 28th Dec:

We can see new sequences from Italy, Israel, Spain, France, & Ireland in the SE England variant (501Y.V1) & Switzerland in the South African variant (501Y.V2).

1/8

https://t.co/PEU7dhptO6

In 501Y.V1 (SE England variant), we can see 1 new sequence from France & Spain, each. The French sample has a travel history to the UK.

3 new sequences are from Israel (marked 1 & 2). Zooming in on '2' (divergence view) shows they are identical, indicating 1 introduction.

2/8

There are 7 new sequences from Ireland, found roughly in 5 places on the tree (4 are singletons, 3 cluster together - 2nd 'group' from the top).

These indicate at least 5 introductions, but we need to zoom in on the 3 that cluster to see more clearly.

3/8

Zooming in to the 3 that cluster together (divergence view), shows it can be difficult to distinguish introductions sometimes, especially as we expect strong travel links between the UK & Ireland, & may only be sampling the total diversity present in Ireland.

4/8

14 new sequences from Italy are scattered across the tree - some alone & some clustering.

Zooming in on a few clusters shows some seem to be linked, while others are harder to determine.
4 seem to be clearly linked as 1 introduction.

5/8

To add to the excitement of your Saturday evening, the focal S:N501 build is now updated with data from 8th Jan, including 48 new seqs in 501Y.V1 (B.1.1.7 #b117) & 501Y.V2.

1/12

https://t.co/AbdhO1rqpw

There are 46 new non-UK sequences in 501Y.V1, from the Netherlands, Italy, Israel, Ireland, Norway, Sweden, the USA, and Luxembourg.
And 2 new non-South African sequences in 501Y.V2, from Australia for the first time.

2/12

In 501Y.V1:

Ireland has 4 new sequences (orange). 2 sit separately but are identical, indicating an additional introduction. 2 link to a previous sequence (green), 1 mutation away each. This could indicate location transmission, unsampled diversity, or a common exposure.

3/12

The Netherlands has 10 new seqs (orange). Many sit apart on the tree, indicating additional introductions. 3 cluster together separated by a few mutations. 2 are identical to an older seq. 1 falls in a cluster of older seqs. Some of these could indicate local transmission.

4/12

Israel has 22 new sequences (orange). 1 links to an older sequence, but is separated by 3 mutations, so may be separate introductions. Another is identical to an older sequence. But most new sequences cluster together (blue), clearly indicating local transmission.

5/12

The S:N501 build is now updated with data from 25th Jan.

Remember, you can always check on any country by just typing that country name in the 'Filter' box on the left menu!

1/18

https://t.co/FTjvV7T7wL

In the 501Y.V1 (B.1.1.7) variant, here are a few of the non-UK countries with new sequences in this variant, including Denmark, Italy, Spain, France, Portugal, Norway, Germany, the USA, South Kora, & Switzerland, & the UAE, Austria, & Czech Republic for the 1st time

2/18

Denmark has 52 new samples (some yellow), showing both separate introductions and further spread of existing local clusters.

3/18

Spain has 62 new sequences (orange & yellow). Many of these are separate introductions, and a few new sequences form distinct clusters. Some new sequences also cluster closely with older sequences (green).

4/18

France has 72 new sequences (orange & yellow). These show both separate introductions and clustering with older sequences.

5/18

President Muhammadu Buhari’s romance with Niger Republic has become an affront to the national interest of Nigeria. When he was sworn-in as an elected president in 2015 he went to Mamadou Issoufou’s presidential palace in Niamey, Niger Republic, to celebrate.

They gave him the reception of a conquering Fulani warlord: a white horse and sword.
I found that curious. How can a Nigerian leader celebrate his electoral victory in a foreign country and not Daura, his supposed hometown in Nigeria?

Answer has since been provided through Buhari’s policy actions in the past 5+ years. We have since learnt that Buhari is a first-generation Nigerian whose father, Ardo Adamu Buhari, a duck seller, had migrated from Niger, settled in Nigeria and married a Nigerian woman, Zulaihat.

The borders defined by the European colonial masters mean nothing to typical Northerners. When you hear that Nigerian borders are porous, what it really means is that there is no intention in the minds of Northern Nigerians and their elite to create an effective barrier between..

them and their kith and kin in the neighbouring countries of Niger, Chad and Northern Cameroun. Meanwhile, the Southern borders are strictly monitored (within the limits permitted by the selfish interests of corrupt Customs and Immigration officials).

So just saw a clip with CNN pundits claiming Nigeria investing in rail transport with Chinese funding is nothing but a white elephant project. It would have been better spent to build schools. Since when did the media decide what Nigeria should and shouldn't do with its money?

Ive seen a Focus on Kenya Exclusive on CNN. They spent 4 minutes talking about Kenya's mobile banking system, which is the most sophisticated in the world, and spent an hour on Kenya's Kibera slums. When terrorist struck Nairobi mall CNN was unabash in showing images of blood

and gore of dead victims repeatedly all through the day. This will never happen in a similar style terror attack anywhere in the West. It’s time to take a hard look at the role of the liberal media in perpetuating a horribly simplistic and stereotypical portrayal of Africa

At what point do we stop being dormant?. At what point do we fight back to salvage our self esteem and integrity as Africans? They did not condemn the U.S invasion of Iraq that has forever changed the middle east.

THREAD

1)
#Iran’s regime has a network of apologists/lobbyists in the US influencing foreign policymakers.

Kaveh Afrasiabi was recently arrested for acting as an agent of #Iran's regime.
https://t.co/fJq6jRtBha

There are more.

cc: @TheJusticeDept