The latest S:N501 focal build is now up, with data from 28th Dec:

We can see new sequences from Italy, Israel, Spain, France, & Ireland in the SE England variant (501Y.V1) & Switzerland in the South African variant (501Y.V2).

1/8

https://t.co/PEU7dhptO6

The S:N501 build is now updated with data from 25th Jan.

Remember, you can always check on any country by just typing that country name in the 'Filter' box on the left menu!

1/18

https://t.co/FTjvV7T7wL

In the 501Y.V1 (B.1.1.7) variant, here are a few of the non-UK countries with new sequences in this variant, including Denmark, Italy, Spain, France, Portugal, Norway, Germany, the USA, South Kora, & Switzerland, & the UAE, Austria, & Czech Republic for the 1st time

2/18

Denmark has 52 new samples (some yellow), showing both separate introductions and further spread of existing local clusters.

3/18

Spain has 62 new sequences (orange & yellow). Many of these are separate introductions, and a few new sequences form distinct clusters. Some new sequences also cluster closely with older sequences (green).

4/18

France has 72 new sequences (orange & yellow). These show both separate introductions and clustering with older sequences.

5/18

The latest focal S:N501 build is now up! It includes data from 4 Jan 2021.

We have new sequences in 501Y.V1/B.1.1.7 from Denmark, Singapore, Australia, Italy, Spain, France, Portugal, Germany, Brazil, Jamaica, Luxembourg, Pakistan & the USA.

1/12

https://t.co/FTjvV7T7wL

Denmark has 43 new sequences (in orange). These indicate additional introductions, as well as further expansion of the existing large local transmission cluster we saw previously (shown in zoomed divergence view).

2/12

10 new sequences from Portugal (orange) indicate additional, separate introductions.

3/12

Singapore has 5 new sequences (yellow). These indicate at least 5 separate introductions for the total of 6 sequences, with two identical sequences likely being 1 introduction.

4/12

5 new sequences from the US, from Florida & California (older sequences crossed through).

Zooming in (divergence view) on the California cluster, the relationship between these samples is difficult to infer from phylogenies alone.

5/12

A brief update to the focal S:N501 builds to start your Friday off right! This one includes data from 7 Jan 21.

We have about 20 new sequences each in 501Y.V1 (B.1.1.7 #b117) & 501Y.V2.

Let's take a look at the new sequences, starting with 501Y.V1

1/14

https://t.co/kT1gFsSZn0

There are 22 new non-UK sequences in 501Y.V1, including for the first time from Luxembourg (3), & additional seqs from Singapore (1), Australia (4), France (12), & Switzerland (2).

2/14

First, Luxembourg has 3 sequences in 501Y.V1 for the first time. Each represents a separate introduction.

3/14

France has 12 new sequences (orange). Many of these represent independent introductions.

Zooming in (divergence view), we can see 2 new sequences are identical (possible local transmission), & 2 differ by 2 mutations (1 each).

4/14

Australia has 4 new sequences (red and orange) which are spread across the tree, representing separate additional introductions.

5/14

The focal S:N501 build is now updated with data from 13 Jan!

There are a total of 247 non-UK & non-South African sequences in 501Y.V1 (B.1.1.7 #b117) & 501Y.V2.

I'll do an additional thread later on, covering S:E484 & the 'Ohio variants'.

1/18

https://t.co/3bdttjKVl4

There are 244 new sequences in 501Y.V1 (B.1.1.7) from Australia, Belgium, Denmark, Germany, India, Israel, Italy, Netherlands, New Zealand, Norway, Portugal, Singapore, Spain & USA, as well sequences as from Ecuador and Greece for the first time.

2/18

Greece has 3 new sequences in 501Y.V1 for the first time. They indicate 2 separate introductions.

Ecuador has 2 sequences for the first time. They also indicate 2 separate introductions.

3/18

The USA has 61 new sequences (orange), from Florida, Minnesota, California, Pennsylvania, & New York.

A few of these represent separate introductions. Others form distinct clusters that may indicate ongoing local transmission.

4/18

Israel has 35 new sequences (orange). Some of these show separate introductions, but many link with older sequences, indicating ongoing local transmission.

5/18

The focal S:N501 build has been updated with data from 15 Jan, & includes 164 non-UK, non-South African sequences in 501Y.V1 (B.1.1.7 #b117) & 501Y.V2.

The S:E484 build has also been updated. Includes 501Y.V3 & 20B/S.484K (predominantly in Brazil).

1/16

https://t.co/3bdttjKVl4

There are 161 new, non-UK sequences in 501Y.V1 (B.1.1.7) from the Netherlands, Denmark, Australia, Spain, Norway, Germany, the USA, & Switzerland, and from Turkey and Ecuador for the first time.

2/16

Turkey has 19 sequences in 501Y.V1 for the first time. These indicate many independent introductions, though a few clusters may indicate local transmission, and pairs with common exposure.

3/16

Ecuador has 4 sequences in 501Y.V1 for the first time, which represent 2 separate introductions (pic 2). 3 are identical, and may represent exposure to a common source (pic 3). The connection to the Spanish sequence may be a common source, or onward transmission.

4/16

Denmark has 66 new sequences (orange). A few are independent introductions, though many link with older sequences, showing continuing local transmission.

5/16

How PM Imran Khan was humiliated during OIC conference.

Pakistani Prime Minister Imran Khan has condemned the construction of the Ayodhya Ram Temple in India at the Conference of Islamic Countries (OIC).

UAE,which chaired the confernce asked Imran,What is the problem for the Islamic world with India building a temple in their country?
What is the problem for the Muslims of the world with the AyodhyaRama Temple? We hv no interest in interfering in the intrnal affairs of India.

In addition, we have provided 13 acres of land in our country for temple construction and 13.5 acres of land for parking and other facilities for Hindus.

Nowhere in the world have Hindus, who live and study attempt or incite riots or carry out suicide attacks in the name of

religion. They are peaceful and live according to the laws of the land.

Temple construction in India is an internal matter of India.  That is not the issue to be discussed here now.  India will look after India.

When will Pakistan repay the money it

borrowed from OlC? All Islamic countries except Pakistan contributed to this fund. Pakistan only borrows but failed to pay up.

Then the President of the Maldives stood up and began to say "The separatist and coup attempts instigated by Pakistan have created many internal

Portugal is famous for its mild climate and sunny beaches, but each year hundreds of people freeze to death and millions struggle to survive frigid winter weather.

Here's a quick thread based on my @POLITICOEurope story on Portuguese energy poverty

When I lived in Lisbon my friends and I joked that although the Portuguese were famous for melancholia, uncharacteristic (and unrealistic) optimism defined their approach to thermal insulation: homes seemed to be built as if the weather was expected to be perfect year-round.

While the weather is, indeed, really great for most of the year, it can also be really awful sometimes. In the Summer temperatures can shoot up to truly unbearable levels for weeks on end, and in the Winter the icy humidity can easily make you feel like you're freezing 24/7.

This reality is a huge problem precisely because so many Portuguese people live in homes that don't have the capacity to shelter them from the heat when temperatures rise and the cold when they drop. And that means that every year that means people die because of the weather.

This issue can be traced back to the rural exodus that took place during the second half of the XX century, when millions fled the interior to seek better futures either outside the country — immigrating to France, Germany and Luxembourg — or in cities like Lisbon and Porto.