A brief update to the focal S:N501 builds to start your Friday off right! This one includes data from 7 Jan 21.

We have about 20 new sequences each in 501Y.V1 (B.1.1.7 #b117) & 501Y.V2.

Let's take a look at the new sequences, starting with 501Y.V1

1/14

https://t.co/kT1gFsSZn0

There are 22 new non-UK sequences in 501Y.V1, including for the first time from Luxembourg (3), & additional seqs from Singapore (1), Australia (4), France (12), & Switzerland (2).

2/14
First, Luxembourg has 3 sequences in 501Y.V1 for the first time. Each represents a separate introduction.

3/14
France has 12 new sequences (orange). Many of these represent independent introductions.

Zooming in (divergence view), we can see 2 new sequences are identical (possible local transmission), & 2 differ by 2 mutations (1 each).

4/14
Australia has 4 new sequences (red and orange) which are spread across the tree, representing separate additional introductions.

5/14
Switzerland has 2 new sequences. One (marked 1st pic) is a clear separate introduction. The other (marked 2nd pic, zoomed, divergence) is from Bern & identical to an earlier sequence from Zurich ('ZH'). This could be local transmission or a common exposure.

6/14
There is 1 new sequence from Singapore (orange).

Zooming in (divergence view), we can see it is identical to 2 older sequences, which may indicate local transmission or a common exposure.

7/14
There are ~19 new non-South African sequences in 501Y.V2, including for the first time from Botswana (6), South Korea (1), & France (1), as well as additional sequences from the UK (~9).

(UK data may be affected by subsampling due to large sequence numbers.)

8/14
At least 9 new sequences from the UK are now in 501Y.V2 (UK data may be impacted by subsampling).

These are a mix of separate introductions & local transmission.

Connections to French sequences are in the next tweet...

9/14
France has 2 sequences in 501Y.V2. They cluster together, which may indicate local transmission or a common source.
They are related to seqs from England, but whether this is European transmission or exposure to common diversity in S Africa can't be distinguished clearly.

10/14
Botswana has 6 sequences in 501Y.V2. One sits apart from the others, indicating at least 2 introductions.

The other 5 cluster together, but are separated by a 1-3 mutations. This could indicate local transmission or transmission from unsampled South African diversity.

11/14
Lastly, South Korea has a sequence in 501Y.V2 for the first time.

12/14
As previously, the country plots are also updated. Lithuania is now added!

Remember: many countries are currently focusing sequencing efforts on S:N501 variants, so frequencies are often not true representations of the 501Y variants.

13/14

https://t.co/c7wlQOLRiq
Finally, we've added a new label to help identify a cluster of sequences with a S:N501*T* mutation currently circulating in Australia.

This is another independent appearance of a S:N501 (again, to T, not Y) mutation, & is not related to 20C/501Y.V2 or 20B/501Y.V1.

14/14

More from Dr Emma Hodcroft

More from For later read

The common understanding of propaganda is that it is intended to brainwash the masses. Supposedly, people get exposed to the same message repeatedly and over time come to believe in whatever nonsense authoritarians want them to believe /1

And yet authoritarians often broadcast silly, unpersuasive propaganda.

Political scientist Haifeng Huang writes that the purpose of propaganda is not to brainwash people, but to instill fear in them /2


When people are bombarded with propaganda everywhere they look, they are reminded of the strength of the regime.

The vast amount of resources authoritarians spend to display their message in every corner of the public square is a costly demonstration of their power /3

In fact, the overt silliness of authoritarian propaganda is part of the point. Propaganda is designed to be silly so that people can instantly recognize it when they see it


Propaganda is intended to instill fear in people, not brainwash them.

The message is: You might not believe in pro-regime values or attitudes. But we will make sure you are too frightened to do anything about it.
Excited we finally have a draft of this paper, which attempts to provide a 'unifying theory' of the long economic divergence between the Middle East & Western Europe

As we see it, there are 3 recent theories that hit on important aspects of the divergence...

1/


One set of theories focus on the legitimating power of Islam (Rubin, @prof_ahmetkuru, Platteau). This gave religious clerics greater power, which pulled political resources away form those encouraging economic development

But these theories leave some questions unanswered...
2/

Religious legitimacy is only effective if people
care what religious authorities dictate. Given the economic consequences, why do people remain religious, and thereby render religious legitimacy effective? Is religiosity a cause or a consequence of institutional arrangements?

3/

Another set of theories focus on the religious proscriptions of Islam, particular those associated with Islamic law (@timurkuran). These laws were appropriate for the setting they formed but had unforeseeable consequences and failed to change as economic circumstances changed

4/

There are unaddressed questions here, too

Muslim rulers must have understood that Islamic law carried proscriptions that hampered economic development. Why, then, did they continue to use Islamic institutions (like courts) that promoted inefficiencies?

5/

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