More from For later read
https://t.co/w7koHyMJjL
The article mentions a “10 nucleotide linker” (GCAUAUGACU) in the poly-A tail. This is described in the patent link below (Modification of RNA, producing an increased transcript stability and translation
Here is a link to the full mRNA code if you wish to download it, blast it or make up a batch in your garage
The mRNA sequences used for Moderna mRNA-1273 & Pfizer BNT162b2 mRNA vaccines for COVID-19 (Direct link in Word Format). WHO International Nonproprietary Name Program # 11889 "Messenger RNA encoding the full-length SARS-CoV-2 spike glycoprotein"https://t.co/zTb7B0Apic pic.twitter.com/8tZxAZWI5S
— Roland Baker (@RolandBakerIII) December 24, 2020
An overview of the encoded spike
Moderna's mRNA-1273 & Pfizer's BNT162b2 consist of mRNA 3821 nucleotides long encoding *all* 1273 amino acids of the Spike including a 2 Proline-stabilized RBD and this includes the NTD (blue in monomer, dark gray in trimer attached to antibodies). AA 64, 66, 187, 213, 214 red. pic.twitter.com/4MX1ByAsrR
— Roland Baker (@RolandBakerIII) December 19, 2020
Initial mouse
News: NIH-Moderna investigational COVID-19 vaccine shows promise in mouse studies https://t.co/7JYuUyZT45
— NIH (@NIH) August 5, 2020
@KevinCoates correct me if I'm wrong, but basic point seems to be that banning targeted ads will lower platform profits, but will mostly be beneficial for consumers.
Some counterpoints 👇
That targeted ads allow for "free" products for consumers is a common talking point and we're going to see more of it in the coming months.: https://t.co/Xty3My3f0u (1/14)
— Kevin Coates (@KevinCoates) February 16, 2021
1) This assumes that consumers prefer contextual ads to targeted ones.
This does not seem self-evident to me
Great post by @Sherman1890 got me thinking about the future of targeted ads.
— Dirk Auer (@AuerDirk) February 12, 2021
More and more tools (privacy labels, ad blockers, GDPR) enable consumers to opt-out from targeted ads - can limit the data platforms receive or block ads altogether.
The end of targeted ads? \U0001f9f5\U0001f447 https://t.co/MA6A3BrUWq
Research also finds that firms choose between ad. targeting vs. obtrusiveness 👇
If true, the right question is not whether consumers prefer contextual ads to targeted ones. But whether they prefer *more* contextual ads vs *fewer* targeted
2) True, many inframarginal platforms might simply shift to contextual ads.
But some might already be almost indifferent between direct & indirect monetization.
Hard to imagine that *none* of them will respond to reduced ad revenue with actual fees.
3) Policy debate seems to be moving from:
"Consumers are insufficiently informed to decide how they share their data."
To
"No one in their right mind would agree to highly targeted ads (e.g., those that mix data from multiple sources)."
IMO the latter statement is incorrect.