Keep dwelling on this:
Further Examination of the Motif near PRRA Reveals Close Structural Similarity to the SEB Superantigen as well as Sequence Similarities to Neurotoxins and a Viral SAg.
https://t.co/EwwJOSa8RK
https://t.co/BsY8BAIzDa
https://t.co/BsY8BAIzDa
Y674 - QTQTNSPRRA - R685
Similar to neurotoxins from Ophiophagus (cobra) & Bungarus genera & neurotoxin-like regions from three RABV strains
T678 - NSPRRA- R685
Superantigenic core, consistently aligned against bacterial or viral SAgs
Keep on Puffing, Ignore the Guys in White Coats!
https://t.co/EWmVWI5jYr
Anyway, this is where Cheng et al (2020) got the neurotoxin motifs from
Superantigenic character of insert unique to SARS-CoV-2
https://t.co/EwwJOSa8RK
Bracci L., Ballas S. K., Spreafico A., Neri P., Molecular mimicry between the rabies virus glycoprotein and human immunodeficiency virus-1 GP120: cross-reacting antibodies induced by rabies vaccination.
https://t.co/UZbe658OGR
(apart from being good news for smokers...)
Maybe someone else can unravel the implications?
@Parsifaler @w_mccairn @Rossana38510044
"For binding experiments, cells were harvested mechanically with a rubber policeman & centrifuged"
Binding of HIV-1 gp120 to the nicotinic receptor (1992)
https://t.co/6veoEkVbVp
Referenced in Bracci et al (1997)
https://t.co/UZbe658OGR
Sequence homology between HIV gp120, rabies virus glycoprotein, and snake venom neurotoxins - Is the nicotinic acetylcholine receptor an HIV receptor?
https://t.co/XGVUNyORP3
(Sönnerborg & Johansson, 1993)
The neurotoxin-like sequence of human immunodeficiency virus GP120: A comparison of sequence data from patients with and without neurological symptoms
https://t.co/s8DIeMNMmD
1. Molecular mimicry of HIV gp120 (2005) https://t.co/KzfEpbjbvk
2. McCoy cell line as a possible model containing CD4+ receptors for the study of HIV-1 replication
https://t.co/iG8NSrGrlI
3. Snake envenomation https://t.co/uJy1bi7NEU
4. Modified venom and venom components as anti-retroviral agents (PATENT)
https://t.co/VRH0gJlbqM
5. Recombinant Newcastle disease virus (NDV) strain rL-RVG expressing the rabies virus glycoprotein
https://t.co/31SNcPXNYJ
6. Structure, Function, and Antigenicity of the SARS-CoV-2 Spike Glycoprotein
https://t.co/Ce9cAEOCQH
Role of HIV gp120 in crossing blood brain barrier
Interactions of SARS-CoV-2 with the Blood–Brain Barrier
https://t.co/oZWRqn5cGr
HIV-1 protein gp120 crosses the blood-brain barrier role of adsorptive endocytosis
https://t.co/9pdkqSt0xz
Final Thesis Jack Sim
In-vitro Characterisation of Targeting Ligands for
Enhanced Delivery Across the Blood-Brain Barrier
https://t.co/GAURhTA376
https://t.co/XQ71CTh93k
Simulations support the interaction of the SARS-CoV-2 spike protein with nicotinic acetylcholine receptors and suggest subtype specificity
https://t.co/umDn3S549X
Simulations support the interaction of the SARS-CoV-2 spike protein with nicotinic acetylcholine receptors
https://t.co/1Qg0tKg3YI
Media Review:
https://t.co/2yyYJw3zVv
2. SARS-CoV-2 spike may act as a superantigen to trigger the development of MIS-C as well as cytokine storm in adult COVID-19 patients
https://t.co/sXQyd7kMx5
COVID-19–associated multisystem inflammatory syndrome in children (MIS-C): A novel disease that mimics toxic shock syndrome—the superantigen hypothesis
https://t.co/NxmPM719VB
https://t.co/b8PssOG6my
SEB confirmed again
1. What is Happening with Smokers and COVID-19?
https://t.co/wXGYU9EjAp
2. Cytokine Release Syndrome (CRS) and Nicotine in COVID-19 Patients
https://t.co/3oA9sWOTaU
and
https://t.co/4yGz47igy2
3. Involvement of nicotine receptors in COVID-19
https://t.co/0GtJwhu9tU
Who put the Benzedrine in Mrs Murphy's Ovaltine?
Who put SAg & SEB in SARS COV-2's Spike Protein?
Note:
A monoclonal antibody against staphylococcal enterotoxin B superantigen inhibits SARS-CoV-2 entry
https://t.co/x7iAVt4Zvm
But a solution is proposed...
A monoclonal antibody against staphylococcal enterotoxin B superantigen inhibits SARS-CoV-2 entry in vitro
https://t.co/x7iAVt4Zvm
and
https://t.co/NgZ7aNd2KS
Molecular mimicry between rabies virus glycoprotein & HIV-1 GP120
https://t.co/Ahp5mE27uI
A Novel Vaccine Employing Non-Replicating Rabies Virus Expressing Chimeric SARS-CoV-2 Spike Protein Domains: Functional Inhibition of Viral/Nicotinic Acetylcholine Receptor Complexes
https://t.co/Zp6gHLPE1x
Persistent SARS-2 infections contribute to long COVID-19
https://t.co/R5UI7pOynJ
For the Curious:
Dampened Bat Immune System Interferon Response?
Why COVID-19 Transmission Is More Efficient and Aggressive Than Viral Transmission in Previous Coronavirus Epidemics?
https://t.co/yNTOP9Lf37
Good Luck with finding the answers!
https://t.co/9iQQBiUjaS
References 145, 146 & 147 for the curious:
https://t.co/yNTOP9Lf37
Host resistance influences patterns of experimental viral adaptation
https://t.co/gnLm32z0G6
More from Billy Bostickson 🏴👁&👁 🆓
1/x Fort Detrick History
Mr. Patrick, one of the chief scientists at the Army Biological Warfare Laboratories at Fort Detrick in Frederick, Md., held five classified US patents for the process of weaponizing anthrax.
2/x
Under Mr. Patrick’s direction, scientists at Fort Detrick developed a tularemia agent that, if disseminated by airplane, could cause casualties & sickness over 1000s mi². In a 10,000 mi² range, it had 90% casualty rate & 50% fatality rate
3/x His team explored Q fever, plague, & Venezuelan equine encephalitis, testing more than 20 anthrax strains to discern most lethal variety. Fort Detrick scientists used aerosol spray systems inside fountain pens, walking sticks, light bulbs, & even in 1953 Mercury exhaust pipes
4/x After retiring in 1986, Mr. Patrick remained one of the world’s foremost specialists on biological warfare & was a consultant to the CIA, FBI, & US military. He debriefed Soviet defector Ken Alibek, the deputy chief of the Soviet biowarfare program
https://t.co/sHqSaTSqtB
5/x Back in Time
In 1949 the Army created a small team of chemists at "Camp Detrick" called Special Operations Division. Its assignment was to find military uses for toxic bacteria. The coercive use of toxins was a new field, which fascinated Allen Dulles, later head of the CIA
Mr. Patrick, one of the chief scientists at the Army Biological Warfare Laboratories at Fort Detrick in Frederick, Md., held five classified US patents for the process of weaponizing anthrax.
2/x
Under Mr. Patrick’s direction, scientists at Fort Detrick developed a tularemia agent that, if disseminated by airplane, could cause casualties & sickness over 1000s mi². In a 10,000 mi² range, it had 90% casualty rate & 50% fatality rate
3/x His team explored Q fever, plague, & Venezuelan equine encephalitis, testing more than 20 anthrax strains to discern most lethal variety. Fort Detrick scientists used aerosol spray systems inside fountain pens, walking sticks, light bulbs, & even in 1953 Mercury exhaust pipes
4/x After retiring in 1986, Mr. Patrick remained one of the world’s foremost specialists on biological warfare & was a consultant to the CIA, FBI, & US military. He debriefed Soviet defector Ken Alibek, the deputy chief of the Soviet biowarfare program
https://t.co/sHqSaTSqtB
5/x Back in Time
In 1949 the Army created a small team of chemists at "Camp Detrick" called Special Operations Division. Its assignment was to find military uses for toxic bacteria. The coercive use of toxins was a new field, which fascinated Allen Dulles, later head of the CIA
1. Strange goings on down at Uncle Sam's Farm in Ukraine?
h/t @DrKevinWMcCair1 video:
https://t.co/1lrFeWcakB
From Daily Expose:
U.S. DoD awarded a contract for ‘COVID-19 Research’ in Ukraine 3 months before Covid was known to even
2. The findings seem to be kosher and can "currently" be confirmed by:
1. checking the DOD Award to Black & Veatch
CONT_IDV_HDTRA108D0007_9700, here:
https://t.co/G5ZEUhPm5U
2. click the tab for sub-awards
3. 7th down from top
4. 19-6192 is the sub-award ID
5. Note Date
3. Download the CSV file by clicking top right:
Again Data is confirmed (with more detail in Column 32 in the csv file)
4. CSV Details (Column 32)
Note Kiev, Ukraine Mentioned and Date 2019
5. CSV Details (2)
Mentions Labyrinth's HQ in Saint Petersburg, Florida, not Russia ;)
URL in CSV directs to original URL
https://t.co/G5ZEUhPm5U
Copy & Paste URL, not click.
Last column with date does not refute finding, it is:
"subaward_fsrs_report_last_modified_date"
h/t @DrKevinWMcCair1 video:
https://t.co/1lrFeWcakB
From Daily Expose:
U.S. DoD awarded a contract for ‘COVID-19 Research’ in Ukraine 3 months before Covid was known to even
2. The findings seem to be kosher and can "currently" be confirmed by:
1. checking the DOD Award to Black & Veatch
CONT_IDV_HDTRA108D0007_9700, here:
https://t.co/G5ZEUhPm5U
2. click the tab for sub-awards
3. 7th down from top
4. 19-6192 is the sub-award ID
5. Note Date
3. Download the CSV file by clicking top right:
Again Data is confirmed (with more detail in Column 32 in the csv file)
4. CSV Details (Column 32)
Note Kiev, Ukraine Mentioned and Date 2019
5. CSV Details (2)
Mentions Labyrinth's HQ in Saint Petersburg, Florida, not Russia ;)
URL in CSV directs to original URL
https://t.co/G5ZEUhPm5U
Copy & Paste URL, not click.
Last column with date does not refute finding, it is:
"subaward_fsrs_report_last_modified_date"
British instructors train Ukrainian military to operate NLAW tank killers (Jan 25th 2022)
"The studies began on Jan. 25 at the Ukrainian Armed Forces’ 184th Training Center in Lviv Oblast, under guidance of British personnel, part of Operation ORBITAL"
https://t.co/SjIg8lpmzR https://t.co/UpKreBEMvJ
2015- 2021: JMTG-U in Yavoriv:
“The training here improves the Armed Forces of Ukraine’s capability, readiness & lethality”
“Together, this training group is helping to forge a new kind of NATO-compatible professional fighting force in
Early Days (2015)
"US has taken over costs of joint operations
It is important for them that soldiers who fought in Eastern Ukraine participate in the exercises
80 % of the soldiers now here at Yavoriv have served on the front lines in Donetsk & Luhansk"
https://t.co/pVOZR4xaAD
Centuria-Azov -Lyiv Presence
Far-Right Group Made Its Home in Ukraine’s Major Western Military Training Hub (September 21, 2021)
https://t.co/o4KWOPH2Kb
PDF (93 Pages of Photographic
2021 - Yavoriv Training
"Oleksii Reznikov, Minister of Defense of Ukraine, visited Yavoriv training fields, the Centre for Simulation of Combat Operations, and talked to servicemen of the partner countries.. in particular, foreign military instructors"
https://t.co/WHUgCggLjj
"The studies began on Jan. 25 at the Ukrainian Armed Forces’ 184th Training Center in Lviv Oblast, under guidance of British personnel, part of Operation ORBITAL"
https://t.co/SjIg8lpmzR https://t.co/UpKreBEMvJ
2015- 2021: JMTG-U in Yavoriv:
“The training here improves the Armed Forces of Ukraine’s capability, readiness & lethality”
“Together, this training group is helping to forge a new kind of NATO-compatible professional fighting force in
Early Days (2015)
"US has taken over costs of joint operations
It is important for them that soldiers who fought in Eastern Ukraine participate in the exercises
80 % of the soldiers now here at Yavoriv have served on the front lines in Donetsk & Luhansk"
https://t.co/pVOZR4xaAD
Centuria-Azov -Lyiv Presence
Far-Right Group Made Its Home in Ukraine’s Major Western Military Training Hub (September 21, 2021)
https://t.co/o4KWOPH2Kb
PDF (93 Pages of Photographic
2021 - Yavoriv Training
"Oleksii Reznikov, Minister of Defense of Ukraine, visited Yavoriv training fields, the Centre for Simulation of Combat Operations, and talked to servicemen of the partner countries.. in particular, foreign military instructors"
https://t.co/WHUgCggLjj
