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Saved by @Mollyycolllinss

The focal S:N501 build is now updated with data from 13 Jan!

There are a total of 247 non-UK & non-South African sequences in 501Y.V1 (B.1.1.7 #b117) & 501Y.V2.

I'll do an additional thread later on, covering S:E484 & the 'Ohio variants'.

1/18

https://t.co/3bdttjKVl4

 There are 244 new sequences in 501Y.V1 (B.1.1.7) from Australia, Belgium, Denmark, Germany, India, Israel, Italy, Netherlands, New Zealand, Norway, Portugal, Singapore, Spain & USA, as well sequences as from Ecuador and Greece for the first time.

2/18
Greece has 3 new sequences in 501Y.V1 for the first time. They indicate 2 separate introductions.

Ecuador has 2 sequences for the first time. They also indicate 2 separate introductions.

3/18
The USA has 61 new sequences (orange), from Florida, Minnesota, California, Pennsylvania, & New York.

A few of these represent separate introductions. Others form distinct clusters that may indicate ongoing local transmission.

4/18
Israel has 35 new sequences (orange). Some of these show separate introductions, but many link with older sequences, indicating ongoing local transmission.

5/18
The Netherlands has 34 new sequences (orange). A few of these represent separate introductions, but most form a large cluster with older sequences from the Netherlands, indicating ongoing local transmission.

6/18
Portugal has 31 new sequences (orange). Though hard to see in the zoomed-out view, most of these represent separate introductions. There is one case where 2 new seqs are identical to an older one, but this could be a common exposure source.

7/18
Denmark has 20 new sequences (orange). A few of these indicate separate introductions, but must cluster with older sequences in smaller groups or in the very large Danish group previously identified, indicating local transmission.

8/18
Norway has 14 new sequences (orange). Most indicate separate introductions, but a few are identical to or related to an older sequence, which may indicate local transmission.

9/18
Spain has 11 new sequences (orange). All of these indicate separate introductions, though some new sequences link together to form tight clusters. This could indicate local transmission or a common source.

10/18
New Zealand has 10 new sequences (orange). All represent separate introductions, though some new sequences are linked together.

11/18
Singapore has 6 new sequences (orange). Though hard to see in zoomed-out view, most of these indicate separate introductions.

12/18
Italy has 6 new sequences (orange). It's a bit hard to see in the zoomed-out view, but none of these link directly with older samples, indicating separate introductions - though 2 new seqs link together.

13/18
Germany has 4 new sequences (orange). Though hard to see in the zoomed-out view, these all represent separate introductions.

14/18
Australia also has 4 new sequences (orange), including the first from Western Australia. These indicate separate introductions, though 2 of the new sequences are identical (marked in red).

15/18
India has 2 new sequences (orange, one hidden behind the green - pic 1). One is a separate introduction, the other links with a previous sequence (pic 2).

Belgium has 1 new sequence, which links 1 mutation away from a previous sequence (pic 3).

16/18
There are 3 new non-South African sequences in 501Y.V2, from Germany for the first time. They are identical, which may indicate a common exposure.

17/18
The updated country plots will go up soon, and I'll add another thread later on S:E484 & the 'Ohio variants'.

18/18
The updated country plots are now up. As always, be careful interpreting plots as many countries are selectively sequencing S:N501 & S-drop outs (which often increases S:N439), so frequencies are often not representative!

19/18

https://t.co/c7wlQOufTQ

More from Dr Emma Hodcroft

Dr Emma Hodcroft
Dr Emma Hodcroft
@firefoxx66
To add to the excitement of your Saturday evening, the focal S:N501 build is now updated with data from 8th Jan, including 48 new seqs in 501Y.V1 (B.1.1.7 #b117) & 501Y.V2.

1/12

https://t.co/AbdhO1rqpw


There are 46 new non-UK sequences in 501Y.V1, from the Netherlands, Italy, Israel, Ireland, Norway, Sweden, the USA, and Luxembourg.
And 2 new non-South African sequences in 501Y.V2, from Australia for the first time.

2/12


In 501Y.V1:

Ireland has 4 new sequences (orange). 2 sit separately but are identical, indicating an additional introduction. 2 link to a previous sequence (green), 1 mutation away each. This could indicate location transmission, unsampled diversity, or a common exposure.

3/12


The Netherlands has 10 new seqs (orange). Many sit apart on the tree, indicating additional introductions. 3 cluster together separated by a few mutations. 2 are identical to an older seq. 1 falls in a cluster of older seqs. Some of these could indicate local transmission.

4/12


Israel has 22 new sequences (orange). 1 links to an older sequence, but is separated by 3 mutations, so may be separate introductions. Another is identical to an older sequence. But most new sequences cluster together (blue), clearly indicating local transmission.

5/12
FOR LATER READ
Dr Emma Hodcroft
Dr Emma Hodcroft
@firefoxx66
The S:N501 build is now updated with data from 25th Jan.

Remember, you can always check on any country by just typing that country name in the 'Filter' box on the left menu!

1/18

https://t.co/FTjvV7T7wL


In the 501Y.V1 (B.1.1.7) variant, here are a few of the non-UK countries with new sequences in this variant, including Denmark, Italy, Spain, France, Portugal, Norway, Germany, the USA, South Kora, & Switzerland, & the UAE, Austria, & Czech Republic for the 1st time

2/18


Denmark has 52 new samples (some yellow), showing both separate introductions and further spread of existing local clusters.

3/18


Spain has 62 new sequences (orange & yellow). Many of these are separate introductions, and a few new sequences form distinct clusters. Some new sequences also cluster closely with older sequences (green).

4/18


France has 72 new sequences (orange & yellow). These show both separate introductions and clustering with older sequences.

5/18
FOR LATER READ
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Dr Emma Hodcroft
Dr Emma Hodcroft
@firefoxx66
The latest S:N501 focal build is now up, with data from 28th Dec:

We can see new sequences from Italy, Israel, Spain, France, & Ireland in the SE England variant (501Y.V1) & Switzerland in the South African variant (501Y.V2).

1/8

https://t.co/PEU7dhptO6


In 501Y.V1 (SE England variant), we can see 1 new sequence from France & Spain, each. The French sample has a travel history to the UK.

3 new sequences are from Israel (marked 1 & 2). Zooming in on '2' (divergence view) shows they are identical, indicating 1 introduction.

2/8


There are 7 new sequences from Ireland, found roughly in 5 places on the tree (4 are singletons, 3 cluster together - 2nd 'group' from the top).

These indicate at least 5 introductions, but we need to zoom in on the 3 that cluster to see more clearly.

3/8


Zooming in to the 3 that cluster together (divergence view), shows it can be difficult to distinguish introductions sometimes, especially as we expect strong travel links between the UK & Ireland, & may only be sampling the total diversity present in Ireland.

4/8


14 new sequences from Italy are scattered across the tree - some alone & some clustering.

Zooming in on a few clusters shows some seem to be linked, while others are harder to determine.
4 seem to be clearly linked as 1 introduction.

5/8
WORLD
Dr Emma Hodcroft
Dr Emma Hodcroft
@firefoxx66
Happy Tuesday! The latest focal S:N501 build is now updated with sequences from 11 Jan.
There are 101 new sequences in the 501Y.V1 (B.1.1.7 #b117) & 501Y.V2 variants.

Additionally, I'll include some updates on S:E484K in this thread.

1/20

https://t.co/dXx6nk6Llz


There are 97 new non-UK sequences in 501Y.V1, including the first sequences in the cluster from Slovakia, Mexico, & Belgium, plus additional sequences from the Netherlands, Denmark, Australia, Spain, Ireland, & Sweden.

2/20


Slovakia has 10 sequences that fall in 501Y.V1 for the first time. These are closely linked, & likely indicate a single introduction and ongoing transmission (remember: vertical distance is not meaningful on the same branch - position of the 2 English samples is arbitrary).

3/20


Belgium has 5 sequences in 501Y.V1 for the 1st time, indicating 3 separate intros. 3 seqs cluster together (zoomed, divergence), indicating a single introduction. The connection to Netherlands might indicate transmission, or 2 transmissions from same diversity in the UK.

4/20


Mexico also has a sequence that falls into 501Y.V1 for the first time.

5/20
FOR LATER READ
Dr Emma Hodcroft
Dr Emma Hodcroft
@firefoxx66
A brief update to the focal S:N501 builds to start your Friday off right! This one includes data from 7 Jan 21.

We have about 20 new sequences each in 501Y.V1 (B.1.1.7 #b117) & 501Y.V2.

Let's take a look at the new sequences, starting with 501Y.V1

1/14

https://t.co/kT1gFsSZn0


There are 22 new non-UK sequences in 501Y.V1, including for the first time from Luxembourg (3), & additional seqs from Singapore (1), Australia (4), France (12), & Switzerland (2).

2/14


First, Luxembourg has 3 sequences in 501Y.V1 for the first time. Each represents a separate introduction.

3/14


France has 12 new sequences (orange). Many of these represent independent introductions.

Zooming in (divergence view), we can see 2 new sequences are identical (possible local transmission), & 2 differ by 2 mutations (1 each).

4/14


Australia has 4 new sequences (red and orange) which are spread across the tree, representing separate additional introductions.

5/14
FOR LATER READ

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@TorontoIDDoc
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It is true, there are people who haven't been following guidelines (by definition that happened a LOT at Christmas/NYE in my region), but even before, we know transmission in private gatherings happens. 2/

These private gatherings are pictured to be big raucous parties, but in reality, even before lockdown, this is just people having dinner, watching TV, doing things we did before on a daily basis. These little ripples when added across the country make a big wave.. 3/

...and little can be done about this apart from positive messaging. You can't very well have police patrolling neighbourhoods across the country. 4/

Next thing is we keep hearing over and over and over, stay home. There are diminishing returns with this advice, but also, most people who can stay home ARE. So what's the issue? There are a HUGE # of people who can't stay home because they work in essential jobs 5/
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XVIII Airborne Corps🐉...
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1 of 16: WE ARE ALL JEWS HERE: THE STORY OF RODDIE EDMONDS

One of the most moving and relevant stories of the Battle of the Bulge, or any American Soldier in any war, is that of Master Sergeant Roddie Edmonds, a Knoxville, Tennessee native, who served with the 106th Infantry.


2 of 16:

Roddie was captured early on in the Battle of the Bulge, on December 19th, when Panzer forces plowed through his unit.

He, along with almost his entire regiment, was forced to surrender.


3 of 16:

The men were transported to the Stalag IX-A POW camp in Ziegenhain, Germany.

Roddie was the senior enlisted American Soldier at the site. As such, he was the conduit between all American Soldiers and their German captors.


4 of 16:

In late January, the camp’s commandant, Major Siegmann [pictured here], ordered Roddie, a Christian, to identify all Jewish Soldiers and order them to stand in formation by themselves the next day.

[Jewish Soldiers were a minority within American units]


5 of 16:

Throughout WWII, captured Jewish Soldiers were often tortured and then killed by their German captors.

In fact, Jewish Soldiers had been told to bury their dog tags before capture. The dog tag identified Jews with the letter “H” for Hebrew.
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Twitter Data
@TwitterData
r u abbreving less rn?

Since the switch to 280 characters a year ago, we've seen an increase in people writing out full words and phrases.


All about the please and thank you.

With 280 characters, people are saying 'please' (+54%) and ‘thank you’ (+22%) more.

THANKS!!!!

💬💬💬

280 characters later, there are more ? and replies to Tweets. More room, more conversations!
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Derik Chica
Derik Chica
@DerikChica
Yesterday I refused unsafe work. This is how it went.

#onted #onpoli #osstf

1st, to the haters. Since when is it "normal" to go to work scared for your health, your life, and your family's lives? It is our right not be scared at work and our employer (in my case, the gov) needs to put measures in place so we aren't afraid. That is law, not just words.

There were 2 steps to the refusal. Refusing to work to my employer, and refusing to work to the Ministry. If my concerns were addressed in Step 1 - to my employer, there is not need to go to the Ministry. We went to the Ministry.

Involved in my refusal were my administration team, a Health and Safety Inspector from my employer, a Health and Safety Inspector from my union, and later in Step 2, a Ministry of Labour Inspector.

I first stated my specific concerns to my adm. They were so supportive in doing everything in their power to address my concerns. I want to thank them for that. They took my concerns seriously. My concerns were all tied to the increased contagiousness of the new variants:
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Ezra Klein
Ezra Klein
@ezraklein
This is a piece I've been thinking about for a long time. One of the most dominant policy ideas in Washington is that policy should, always and everywhere, move parents into paid labor. But what if that's wrong?

My reporting here convinced me that there's no large effect in either direction on labor force participation from child allowances. Canada has a bigger one than either Romney or Biden are considering, and more labor force participation among women.

But what if that wasn't true?

Forcing parents into low-wage, often exploitative, jobs by threatening them and their children with poverty may be counted as a success by some policymakers, but it’s a sign of a society that doesn’t value the most essential forms of labor.

The problem is in the very language we use. If I left my job as a New York Times columnist to care for my 2-year-old son, I’d be described as leaving the labor force. But as much as I adore him, there is no doubt I’d be working harder. I wouldn't have stopped working!

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The 2020s will be known as the Remote Work decade

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Guruvayur Sri Krishna & Coconut with Horns.
#Krishnaleela
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We’ve all grown up listening to stories of Shri Krishna. This one is a famous story of Shri Krishna in Guruvayur Temple, also called Dakshina Dwaraka.


There lived a villager who planted coconut saplings and had promised that he would offer the 'first coconut' from each of his coconut trees to "Guruvayurappan". When the trees started to yield coconuts, he collected the first coconut from all the trees in a sack 👇


and set forth to Guruvayur.

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@SriramKannan77 @Jayalko1


The robber with anger asked the villager "Is Guruvaurappan's coconut any different? Does it have horns ?".
Saying so the robber pulled the sack forcefully out of the villager's hand, and coconuts came out..👇


To their astonishment each and every coconut in the sack had horns! Even today, the coconut with horns are displayed in the temple for devotees to see.

Below Picture is not original, as we cannot take photos inside temple.
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ब्राह्मणों का इतिहास👁️...
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1)King Porus was a famous Indian king, his real name was #Purushotama. He belonged to PURU tribe mentioned in #RIG_VEDA, the Ancient books of India.


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3)Word of Mouth Oral tradition in #Mohyal_Brahmin families since ancient times has kept the Great Saga of their Great Elder known to them as Maharaja “ #Puru” alive.

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Butt plugs were originally sold as a miracle cure for headaches, acne, and insanity

Thread, article here and h/t: @qikipedia :
https://t.co/Ts84xnmWKJ


For a long time, medicine was pre-occupied with the question "can this be solved by putting something in the butt?"

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