BC SCIENCE
Saved by @Alex1Powell

All Biological life on earth is possible because of a discrete digital mechanism of preservation and replication.

 The mechanism of signaling between the superorganism we know of as bacteria and its ongoing war against viruses is through a digital mechanism.
The source of innovation in biology is in this milieu of microbiome and viromes that are ubiquitous in every complex multicellular organism on earth. Humans are walking ecologies and cannot survive stripped of these ecologies.
We can picture this as a cloud of digital interaction that surrounds all of us.
The cells of multicellular creatures however do not communicate in the same way as bacteria. The DNA of mammals are sequestered from daily activity so as to prevent wear and tear.
The lifespan of mammals are related to their metabolism. The faster a mammal's heart beats the less time it has to live. A multicellular creature degrades like an analog system with each iteration error is accumulated.
Death is inevitable for multicellular creatures because our bodies have similar dynamics as non-linear systems found in chaos theory. The attractors that lead to our existence can lead to chaos and thus death.
Fortunately, evolution has gifted us with some of the digital mechanisms that bacteria have. The immune system is digital in nature. The same system that protects us from bacteria and viruses is also the same system that corrects for errors in our bodies.
At higher scales, evolution creates species that are more analog. But there is a constant tension between the drive to become analog and the need for preservation and replication.
All biological creatures balance these opposing forces by leveraging what is known as code duality. Every system has both an analog part that meets with the world and a digital part that preserves itself against the world.
In biology, the stuff that interprets the digital code of RNA are analog devices. More specifically, mechanical and electrical nano-machines.
The molecular machinery that converts energy into motion and energy into sensing are a consequence of biological innovation happening at bacteria and viral level.
But what meets the reality of physics and chemistry are analog machines. Living things require analog machinery to interpret and act within the world. The language of reality at higher scales is an analog language.
But to scale in size any organism requires digital mechanisms. Therefore this code duality must exist at many scales in a complex organism.
A common idea about the brain is that it is a dynamical system. A dynamical system is unlike a digital system like a computer. Brains have evolved to make sense of and move within their environments. They can only do so if they meet with the analog environment.
This idea however is an incomplete picture in the framing of code duality. The brain should have a digital component as predicted by this hypothesis of code duality. That digital component shares the same origin as our immune system.
Our immune system has the fascinating capability of recalling all the pathogens that have attempted to infect the body. What is the mechanism of this incredible memory system?
I've mentioned earlier that the human cognitive system consists of 3 'brains'. The nervous system, the endocrine system and the immune system. It's a very different triune brain that people conventionally think of.
The difference with biology and things that we design is that the latter has a designer that organizes things. So in a computer, the common currency is electrons. In biology, there is no common currency but a bureaucracy of transactions between different incompatible coins.
RNA has a surprisingly common currency (i.e. nucleotides). It is universal across earth originating living things. The power of digital systems come from a multitude of possible combinations. This only comes from standardization that leads to compatibility.
So evolution despite not having a designer with a mind, it has arrived at a strategy that acts like it has a mind!
@threadreaderapp unroll

More from Carlos E. Perez

Carlos E. Perez
Carlos E. Perez
@IntuitMachine
It is astonishing that most of cognitive science ignores an obvious reality. That there are two kinds of humans.

Tomasello has a very credible hypothesis that what distinguishes humans from the great apes is the inclination towards shared intentional behavior. What is innate is the disposition and like personalities, it is what defines our cognition as we grow.

If cognitive preference is so critical in cognitive development then why is it that we seem to have completely ignored the difference in cognitive preferences between men and women?

Humans are that species of primates that wandered out into the savannah. The savannah is different enough from a dense jungle to exert the evolutionary pressures that encourage the development of planning and forecasting skills.

Furthermore, human infants required a disproportional amount of effort to rear. This meant the specialization of roles between women who were responsible for rearing offspring and men who were responsible for bringing home the bacon. Failure in either implied death.
SCIENCE
Carlos E. Perez
Carlos E. Perez
@IntuitMachine
The Nature versus Nurture is a debate about scientific doctrine. It is a debate about the correct way of explanation for cognition.

The Representation versus Non-Representation shares the same debate. It is also about the correct way of explanation for cognition.

It is also the difference between thinking in nouns versus thinking in verbs. Nature and Representation have deep roots in Western thinking. It is a functionalist and reductionist way of thinking that meets its limits when analyzing complex adaptive systems.

It is perhaps due to this Western bias that concepts from the study of complex systems have had little traction in modern society. It is of course, more than a Western bias, but a human bias to seek out simple causal explanations of this world.

But the world is complex and messy. Spiral dynamics which is an evolutionary model of individuals and society explains how models of the world shape ourselves and our civilization.
SCIENCE
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Carlos E. Perez
Carlos E. Perez
@IntuitMachine
It's a very different perspective when we realize that our bodies consist of an entire ecology of bacteria and viruses that are also passed to our ancestors. Mammals rear their young and as a consequence transfer the microbiome and virome to their offspring.


What does it mean to treat our individuality as ecologies? We are all ecologies existing in other ecologies. Nature is constantly performing a balancing act across multiple scales of existence.

There are bacteria and viruses that are unique to your ancestry as that of your own DNA. They have lived in symbiosis with your ancestor and will do so for your descendants.

It is an empirical fact that the microbiome in our stomach can influence not only our own moods but also our metabolism and thus our weight and health.

It is also intriguing to know that brains evolved out of stomachs and that our stomachs contain hundreds of millions of neurons. Humans can literally think with their gut.
HEALTH
Carlos E. Perez
Carlos E. Perez
@IntuitMachine
Chess may be a good analogy for explaining the difference between a descriptive model of reality and a generative model of reality.

A descriptive model of chess will describe the rules (i.e. initial setup, allowed moves, points per piece, objectives). This tells you how a chessboard might evolve and also narrows the combinations of realistic chess positions.

In contrast, a generative model involves the actual gameplay between competing players that follow the rules. It generates new styles and patterns. It establishes new strategies and tactics. It generates new openings, middle gameplay, and end game tactics.

A generative model is an evolutionary model that leads to emergent behavior. As a consequence, a master of chess is able to recall the layout of chess positions in a real game in an instant, yet is unable to remember pieces placed in random positions.

That is because causality is present in the movements of pieces in a chessboard. An intuitive system like the human mind is able to capture that causality as a means to understanding and recall.
INTERNET
Carlos E. Perez
Carlos E. Perez
@IntuitMachine
Programming in abstractions is very different from a system that is capable of its own 'abstracting'. But what does abstracting mean? We only know of its inputs and outputs, but we fail to describe its inner workings.

I like this short video about living in space. This is because it makes you realize the gaps in your knowledge when you turn off something (i.e. gravity) that you have always assumed to be present.


Perhaps we can understand 'abstracting' better if we turn of many assumptions that we unconsciously carry around. Perhaps we need to get rid of the excess baggage that is confusing our thinking about abstraction.

Turning off gravity and living in space is a perfect analogy. We somehow have to turn off a cognitive process to understand the meaning of abstraction.

The first step to divorce ourselves from our habitual cognitive processes is to realize the pervasiveness of 'noun-thinking' .
INTERNET

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Jason Hickel
Jason Hickel
@jasonhickel
Here's more on the new mitigation scenario for 1.5C. How does it work? What would society look like? Are we willing to do what's required to stop climate breakdown? See thread.


1. Most models assume we need to keep growing the economy indefinitely. The problem is this makes it impossible to transition to zero emissions quickly enough; so they speculate on geoengineering and negative-emissions technologies to save us. Scientists reject this as too risky.

2. By contrast, this scenario proposes that high-income countries don't *need* more growth, and can scale down unnecessary production and consumption. This reduces energy demand (from 140 EJ in 2020 to 40 EJ in 2050), and enables a rapid transition to renewable energy.

3. What does it require? In the global North (Annex 1 countries)
•a shift from private cars to public transportation
•reduction in flights
•smaller average house size

Meanwhile, consumption in the global South (non-Annex 1 countries) rises to converge.


4. Significant reduction of aggregate material use. How? Longer product lifespans; regionalization of production and consumption; ban on advertising; a shift in taxes from labour to resources. All of this allows us to reduce ground freight, which cuts energy use.
SCIENCE
Yardley Yeadon
Yardley Yeadon
@MichaelYeadon3
In a number of Sunday papers:
Scientific advisers said it was “hard to see” when the restrictions would end as new variants continued to emerge, delivering a potentially devastating blow to the travel industry. The prime minister said that after progress with vaccinations...

...”what we don’t want to see is all that work undone by the arrival of a new variant that is vaccine-busting”.
The idea is planted in people’s mind that this virus is mutating in such a way as to evade prior immunity. This is completely unfounded, certainly as regards immunity..

...gained naturally, after repelling the virus (which well around 99.9% of the population do, fewer, obviously in the very elderly & already ill, more in those younger & well). It’s important to appreciate that upon infection, the human immune system cuts up an infectious...

...agent into short pieces. Each of these short pieces of protein are presented to other cells in the immune system, like an identity parade. Our cells have a truly astonishing range of abilities to recognise different protein structures, and there will be some which recognise...

...each of the pieces of the invader. The cells which recognise a piece are instructed to multiply selectively so that, after a few days to a couple of weeks, our bodies contain large numbers of virus piece specific cells. These have a range of functions. Some make antibodies...
SCIENCE
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10-K Diver
10-K Diver
@10kdiver
1/

Get a cup of coffee.

In this thread, I'll help you understand the basics of Binomial Thinking.

The future is always uncertain. There are many different ways it can unfold -- some more likely than others. Binomial thinking helps us embrace this view.


2/

The S&P 500 index is at ~3768 today.

Suppose we want to predict where it will be 10 years from now.

Historically, we know that this index has returned ~10% per year.

If we simply extrapolate this, we get an estimate of ~9773 for the index 10 years from now:


3/

What we just did is called a "point estimate" -- a prediction about the future that's a single number (9773).

But of course, we know the future is uncertain. It's impossible to predict it so precisely.

So, there's a sense of *false precision* in point estimates like this.

4/

To emphasize the uncertainty inherent in such predictions, a better approach is to predict a *range* of values rather than a single number.

For example, we may say the index will return somewhere in the *range* of 8% to 12% (instead of a fixed 10%) per year.

5/

10 years from now, this implies an index value in the *range* [8135, 11703]:
SCIENCE
James Mitchell \u24cb\U0001f42c
James Mitchell Ⓥ🐬...
@MesMitch
The endangered whales must contend with up to 1,000 boats moving daily through an important feeding area in the eastern South Pacific, according to research published in the scientific journal Nature.@WeDontHaveTime
#ForNature @JohnKerry
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The Tycoon Mindset
The Tycoon Mindset
@tycoonmindset05
Solara Active Pharma Science con call was today at 3:30 PM.

@Gautam__Baid @unseenvalue @drprashantmish6 @rdkriplani

Here are the key takeaways of the call. 👇🧵

Business Updates:

• Speed of filing products has been increased. Filed 5 new DMFs – 3 in US and 2 in EU
• Currently ramping up the facility in VIZAG with strong customer attraction, and will be commercialized as planned in Q3
• VIZAG EBIDTA growth guidance changed to 40%+ YoY

• Growth Driver: Broad based growth in other products and Vizag.

• PLI: Company has filed Mysore for PLI scheme for 1 molecule.

• Technology: Company is about to complete its 2 out of 3 technology, which will enhance efficiency for Solara.

Demand in some of sectors is moderated:
• Mgmt expected moderation in demand, hence company has taken necessary steps for those products.

Gross Margins:
• It was down a bit due to product mix however.

Fiscal 2022:
• Solara has grown in regulated market space.
• Vizag will kick in. CRAMS will support tailwind.
• Most of the CRAMS is commercial API.

• Most of the product is expected to be stable both in term of demand and price in the coming few quarter
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Tip from the Monkey
Pangolins, September 2019 and PLA are the key to this mystery
Stay Tuned!


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2. A jacobin capuchin dangling a flagellin pangolin on a javelin while playing a mandolin and strangling a mannequin on a paladin's palanquin, said Saladin
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Here is my Thread on 'Ketu (South Node) Through Nakshatras' The 27 Constellations 🙏❣.

Do check your “Past life Mastery” which KETU Represents🤞🏻.


1. Ketu in Ashwini Nakshatra:

Here native is Great at Financial Planning, Face reading, understanding other’s mind and intention, Driving Fast they don’t like but they are wayyy smooth over driving Fast. This is also great position which can make native Great Surgeon,

Neurologist, Psychologist.
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They are good at Flirting, Attracting opposite sex, studing ancient subjects. They are also Great at Creativity and Artistic activities. The are lazy but they are really open minded who handles situations really well.

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Jaya_Upadhyaya
Jaya_Upadhyaya
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SRI SWETHA VINAYAGAR, THIRUVALANCHUZHI, KUMBAKONAM
(TN)
#bharatmandir

While main deity is Shiva as Kapartheeswarar, the kshetram is famous for Ganesha, known as Swetha/Vellai Vinayagar (white Vinayak)

During samudra manthan, Vasuki snake (used as rope) started spewing venom.


Unable to bear the intense heat, Devas rushed to Siva. He told them that this was because the task was started without getting Ganesha’s approval.
So the Devas created a Ganesha murti from white sea foam and worshipped it.
It was later taken by Indra to Indralok.
@GunduHuDuGa


But once Indra had to come to Earth to pray to Shiva to seek relief from a curse inflicted on him. So he brought the murti of Ganesha with him. When he came here, he wanted to take bath before puja. So he gave the murti to a boy to hold for sometime. The boy was actually Shiva.


He kept the murti down and vanished. Indra could not lift it again and a divine voice told him to let Vinayagar stay there and visit every Ganesh Chaturthi to pray.
Since Vinayagar is made of foam, no abhishekam is done here. Only punugu is applied n camphor powder is sprinkled
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Anu Satheesh
Anu Satheesh
@AnuSatheesh5
Puthucode Annapoorneshwari Temple,
Palakkad, Kerala 🚩
#keralatemples
अन्नपूर्णे सदापूर्णे शङ्करप्राणवल्लभे 
ज्ञानवैराग्यसिद्ध्यर्थं भिक्षां देहि च पार्वति 

Temple is also called Puthukode Bhaghavathy Kshetram
Parasurama did Prathishta of Devi here. Temple is one amoung 👇


108 Durga temples
Navarathri festival is celebrated in a grant manner here. Annadanam is done daily on these days. The Idichu pizhinja payasam/ Chathachatayam is the main nivedyam in Annapoorneswari temple during Navarathri.
In the mornings, Devi Mahatmyam and Sundarakandam are


recited here daily.
Sri Godavarma Raja gifted lots of rice fields for the maintenance of the temple.
Annapoorneshwari holds Shanku and Chakra in her hands. Puthucode Annapoorneswari Temple is managed by the Naduvil Madom Devaswom.
🙏🕉🙏
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George Mack
George Mack
@george__mack
THREAD: 15 of the most useful razors and rules I've found.

Rules of thumb that simplify decisions.

Bezos' Razors:

• If unsure what action to take, let your 80-year-old self make it.

• If unsure who to work with, pick the person that has the best chances of breaking you out of a 3rd world prison.

Skinner's Law:

• If procrastinating on an item, you only have 2 options:

1. Make the pain of not doing it greater than the pain of doing it.

2. Make the pleasure of doing it greater than the pleasure of not doing it.

Luck Razor:

• If stuck with 2 equal options, pick the one that feels like it will produce the most luck later down the line.

I used this razor to go for drinks with a stranger rather than watch Netflix.

In hindsight, it was the highest ROI decision I've ever made.

Bragging Razor:

• If someone brags about their success or happiness, assume it’s half what they claim.

• If someone downplays their success or happiness, assume it’s double what they claim.

The map is not the terrain.
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