"Three modes of evolution have thus been brought before us: evolution by fortuitous variation, evolution by mechanical necessity, and evolution by creative love." - C.S. Peirce 1893
More from Carlos E. Perez
Nice to discover Judea Pearl ask a fundamental question. What's an 'inductive bias'?
I crucial step on the road towards AGI is a richer vocabulary for reasoning about inductive biases.
explores the apparent impedance mismatch between inductive biases and causal reasoning. But isn't the logical thinking required for good causal reasoning also not an inductive bias?
An inductive bias is what C.S. Peirce would call a habit. It is a habit of reasoning. Logical thinking is like a Platonic solid of the many kinds of heuristics that are discovered.
The kind of black and white logic that is found in digital computers is critical to the emergence of today's information economy. This of course is not the same logic that drives the general intelligence that lives in the same economy.
Help! What precisely is "inductive bias"? Some ML researchers are in the opinion that the machine learning category of \u2018inductive biases\u2019 can allow us to build a causal understanding of the world. My Ladder of Causation says: "This is mathematically impossible". Who is right? 1/
— Judea Pearl (@yudapearl) February 14, 2021
I crucial step on the road towards AGI is a richer vocabulary for reasoning about inductive biases.
explores the apparent impedance mismatch between inductive biases and causal reasoning. But isn't the logical thinking required for good causal reasoning also not an inductive bias?
An inductive bias is what C.S. Peirce would call a habit. It is a habit of reasoning. Logical thinking is like a Platonic solid of the many kinds of heuristics that are discovered.
The kind of black and white logic that is found in digital computers is critical to the emergence of today's information economy. This of course is not the same logic that drives the general intelligence that lives in the same economy.
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Keep dwelling on this:
Further Examination of the Motif near PRRA Reveals Close Structural Similarity to the SEB Superantigen as well as Sequence Similarities to Neurotoxins and a Viral SAg.
The insertion PRRA together with 7 sequentially preceding residues & succeeding R685 (conserved in β-CoVs) form a motif, Y674QTQTNSPRRAR685, homologous to those of neurotoxins from Ophiophagus (cobra) and Bungarus genera, as well as neurotoxin-like regions from three RABV strains
(20) (Fig. 2D). We further noticed that the same segment bears close similarity to the HIV-1 glycoprotein gp120 SAg motif F164 to V174.
https://t.co/EwwJOSa8RK
In (B), the segment S680PPRAR685 including the PRRA insert and highly conserved cleavage site *R685* is shown in van der Waals representation (black labels) and nearby CDR residues of the TCRVβ domain are labeled in blue/white
https://t.co/BsY8BAIzDa
Sequence Identity %
https://t.co/BsY8BAIzDa
Y674 - QTQTNSPRRA - R685
Similar to neurotoxins from Ophiophagus (cobra) & Bungarus genera & neurotoxin-like regions from three RABV strains
T678 - NSPRRA- R685
Superantigenic core, consistently aligned against bacterial or viral SAgs
Further Examination of the Motif near PRRA Reveals Close Structural Similarity to the SEB Superantigen as well as Sequence Similarities to Neurotoxins and a Viral SAg.
The insertion PRRA together with 7 sequentially preceding residues & succeeding R685 (conserved in β-CoVs) form a motif, Y674QTQTNSPRRAR685, homologous to those of neurotoxins from Ophiophagus (cobra) and Bungarus genera, as well as neurotoxin-like regions from three RABV strains
(20) (Fig. 2D). We further noticed that the same segment bears close similarity to the HIV-1 glycoprotein gp120 SAg motif F164 to V174.
https://t.co/EwwJOSa8RK
In (B), the segment S680PPRAR685 including the PRRA insert and highly conserved cleavage site *R685* is shown in van der Waals representation (black labels) and nearby CDR residues of the TCRVβ domain are labeled in blue/white
https://t.co/BsY8BAIzDa
Sequence Identity %
https://t.co/BsY8BAIzDa
Y674 - QTQTNSPRRA - R685
Similar to neurotoxins from Ophiophagus (cobra) & Bungarus genera & neurotoxin-like regions from three RABV strains
T678 - NSPRRA- R685
Superantigenic core, consistently aligned against bacterial or viral SAgs