Transduction is the process by which foreign DNA is introduced into a cell by a virus or viral vector.

Viral vectors are tools commonly used by molecular biologists to deliver genetic material into cells.
Viruses have evolved?

specialized molecular mechanisms

to efficiently

transport their genomes

inside the cells they infect.
Delivery of genes, or other genetic material, by a vector is termed transduction and the infected cells are described as transduced.
A transducer is a device that converts energy from one form to another. Usually a transducer converts a signal in one form of energy to a signal in another.
Transducers are often employed at the boundaries of automation, measurement, and control systems, where electrical signals are converted to and from other physical quantities (energy, force, torque, light, motion, position, etc.).
The process of converting one form of energy to another is known as transduction.
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active sensors, in contrast, generate an electric current in response to an external stimulus which serves as the output signal without the need of an additional energy source. Such examples are a photodiode, and a piezoelectric sensor, thermocouple.
Piezoelectric crystals – converts deformations of solid-state crystals (vibrations) to and from electrical signals
Piezoelectricity is the electric charge that accumulates in certain solid materials (such as crystals, certain ceramics, and biological matter such as bone, DNA and various proteins) in response to applied mechanical stress.

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Pott found an association between exposure to soot and a high incidence of scrotal skin cancer in chimney sweeps. This cancer is now known as Pott's or chimney sweep cancer.

Coal contains trace amounts of naturally-occurring radioactive elements. The process of burning coal at coal-fired power plants, called combustion, creates wastes that contain small amounts of naturally-occurring radioactive material (NORM).

Fly ash particles (a major component of coal ash) can become lodged in the deepest part of your lungs, where they trigger asthma, inflammation and immunological reactions.
Localized Surface Plasmon Resonance - an overview | ScienceDirect Topics

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In some cases, almost 100% of the light energy can be converted to the second harmonic frequency. These cases typically involve intense pulsed laser beams passing through large crystals, and careful alignment to obtain phase matching.

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Why can cefepime cause neurological toxicity?

And why is renal failure the main risk factor for this complication?

The answer requires us to learn about cefepime's structure and why it unexpectedly binds to a certain CNS receptor.

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Let's establish a few facts about cefepime:

🔺4th generation cephalosporin antibiotic
🔺Excretion = exclusively in the urine (mostly as unchanged drug)
🔺Readily crosses the blood-brain barrier (so it easily accesses the brain)

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The first report of cefepime neurotoxicity was in 1999.

A patient w/ renal failure received high doses of cefepime and then developed encephalopathy, tremors, myoclonic jerks, and tonic-clonic seizures.

✅All symptoms resolved after hemodialysis.

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Cefepime neurotoxicity is surprisingly common, occurring in up to 15% of treated critically ill patients (w/ symptoms varying from encephalopathy to seizures).

💡The main risk factors = renal failure and lack of dose adjustment for renal function.

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What about cefepime induces neurotoxicity?

One clue is that it's not the only antibiotic that causes neurotoxicity, particularly seizures.

This actually is a class effect w/ other beta-lactam antibiotics (including penicillins and carbapenems).

https://t.co/Lf4BhON9IY

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