NEW—CDC was truly suffocated by Trump WH at every turn. Kyle McGowan, a former chief of staff at CDC, and his deputy, Amanda Campbell, witnessed WH dismissal of science, WH’s slow suffocation of CDC’s voice, meddling in messages & siphoning of CDC budget.
https://t.co/HeuNbUggiw
Mr. McGowan recalled a White House fixated on the economic implications of public health.
They compromised anyway, recommending social distancing without a reference to the typical six-foot measurement.
“What’s not legitimate is to overrule science,” he said.
(Sidebar: Dr Messonier is my hero)
“They need to be allowed to lead.”
➡️ all this is incredible painful to me cuz of what I also went thru in Jan trying to warn:
https://t.co/I5G7PL6boG
More from Eric Feigl-Ding
Breaking—UK scientists just reported a case-control study that the mutated UK 🇬🇧B.1.1.7 variant is not associated w/ more severe #COVID19— “found no significant differences in hospital admissions and case fatality at 28 days, & occurrence of reinfections”, says @mvankerkhove
2) That said, the new UK mutated strain is a more transmissible (contagious) variant. Keep transmissibility and illness severity separate. They are two different things. Don’t get them confused.
3) The new UK variant severity study is included in today’s WHO report, to be released soon this afternoon according to WHO sources. Waiting for it to drop. I’ll keep folks posted on the details.
4) Update: here is UK Technical report on #SARSCoV2 variant of concern (B.1.1.7) in 🇬🇧 with prelim findings from their case-control study of no increased severity for the new variant that I reported yesterday.
5) Also keep in a mind that a virus that spreads faster (more contagious) yields much worse total outcomes than a virus that is just merely more severe.
All things equal, a new mutated variant that is more contagious & no more severe is worse. And that is what we now have.
2) That said, the new UK mutated strain is a more transmissible (contagious) variant. Keep transmissibility and illness severity separate. They are two different things. Don’t get them confused.
3) The new UK variant severity study is included in today’s WHO report, to be released soon this afternoon according to WHO sources. Waiting for it to drop. I’ll keep folks posted on the details.
4) Update: here is UK Technical report on #SARSCoV2 variant of concern (B.1.1.7) in 🇬🇧 with prelim findings from their case-control study of no increased severity for the new variant that I reported yesterday.
5) Also keep in a mind that a virus that spreads faster (more contagious) yields much worse total outcomes than a virus that is just merely more severe.
All things equal, a new mutated variant that is more contagious & no more severe is worse. And that is what we now have.
Why a SARS-CoV-2 variant that's 50% more transmissible would in general be a much bigger problem than a variant that's 50% more deadly. A short thread... 1/
— Adam Kucharski (@AdamJKucharski) December 28, 2020
JUST ONE PERSON—UK 🇬🇧 scientists think one immunocompromised person who cleared virus slowly & only partially wiped out an infection, leaving behind genetically-hardier viruses that rebound & learn how to survive better. That’s likely how #B117 started. 🧵 https://t.co/bMMjM8Hiuz
2) The leading hypothesis is that the new variant evolved within just one person, chronically infected with the virus for so long it was able to evolve into a new, more infectious form.
same thing happened in Boston in another immunocompromised person that was sick for 155 days.
3) What happened in Boston with one 45 year old man who was highly infectious for 155 days straight before he died... is exactly what scientists think happened in Kent, England that gave rise to #B117.
4) Doctors were shocked to find virus has evolved many different forms inside of this one immunocompromised man. 20 new mutations in one virus, akin to the #B117. This is possibly how #B1351 in South Africa 🇿🇦 and #P1 in Brazil 🇧🇷 also evolved.
5) “On its own, the appearance of a new variant in genomic databases doesn’t tell us much. “That’s just one genome amongst thousands every week. It wouldn’t necessarily stick out,” says Oliver Pybus, a professor of evolution and infectious disease at Oxford.
2) The leading hypothesis is that the new variant evolved within just one person, chronically infected with the virus for so long it was able to evolve into a new, more infectious form.
same thing happened in Boston in another immunocompromised person that was sick for 155 days.
3) What happened in Boston with one 45 year old man who was highly infectious for 155 days straight before he died... is exactly what scientists think happened in Kent, England that gave rise to #B117.
Immunocompromised 45 year old suffered from #COVID19 for 155 days before he died. The virus was changing very quickly inside the man's body\u2014it acquired a big cluster of >20 mutations\u2014resembled the same ones seen in #B117 & #B1351. (NPR audio Part 1 of 2)\U0001f9f5https://t.co/7kWiBZ1xGk pic.twitter.com/ZJ7AExB78Y
— Eric Feigl-Ding (@DrEricDing) February 8, 2021
4) Doctors were shocked to find virus has evolved many different forms inside of this one immunocompromised man. 20 new mutations in one virus, akin to the #B117. This is possibly how #B1351 in South Africa 🇿🇦 and #P1 in Brazil 🇧🇷 also evolved.
2) NPR report audio part 2 of 2:
— Eric Feigl-Ding (@DrEricDing) February 8, 2021
Dr. Li couldn't believe what they found. "I was shocked," he says. "When I saw the virus sequences, I knew that we were dealing with something completely different and potentially very important." pic.twitter.com/HT3Yt6djFd
5) “On its own, the appearance of a new variant in genomic databases doesn’t tell us much. “That’s just one genome amongst thousands every week. It wouldn’t necessarily stick out,” says Oliver Pybus, a professor of evolution and infectious disease at Oxford.
JUST IN — "Camp Auschwitz" insurrectionist of the Capitol siege was just arrested this morning in Newport News, VIrginia.
2) this guy was just arrested.
3) We cannot have a repeat of the fascism from WW2. This is @Schwarzenegger’s speech was so powerful.
4) My wife @andreafeigl1’s 🇦🇹 great grandfather secretly fought Hilter’s Nazi regime & smuggled many Jews to safety as an aircraft engineer. He was thrown into a concentration camp, and escaped.
She knows a few things about Nazi history—Jan 6th was downright fascist. Read 👇
5) So this cover is from a semi-tabloid magazine in Germany, according to @andreafeigl1. But even so, how did such a magazine still get it so damn right?! Maybe Germany 🇩🇪 has seen this kinda fascism before...
2) this guy was just arrested.
3) We cannot have a repeat of the fascism from WW2. This is @Schwarzenegger’s speech was so powerful.
This speech will go down as one of the greatest speeches. @Schwarzenegger is right\u2014Jan 6th 2021 was our Kristallnacht. Austria \U0001f1e6\U0001f1f9 tried to resist Hilter takeover for years but succumbed because Hitler\u2019s lies went unchallenged. We must #impeach now. pic.twitter.com/gOChiGLuHK
— Eric Feigl-Ding (@DrEricDing) January 10, 2021
4) My wife @andreafeigl1’s 🇦🇹 great grandfather secretly fought Hilter’s Nazi regime & smuggled many Jews to safety as an aircraft engineer. He was thrown into a concentration camp, and escaped.
She knows a few things about Nazi history—Jan 6th was downright fascist. Read 👇
Some saw clearly what MAGAism is - pure fascism - in 2016.
— Dr. Andrea Feigl (@andreafeigl1) January 6, 2021
More see it 2day
Some saw this playbook b4: WW2
Americans r too unaware of history since it didn't happen on home soil
But we MUST heed these lessons, lest it b 2 late 4 democracy & consequences are unfathomable
\U0001f9f5 pic.twitter.com/QdoVG3LsrB
5) So this cover is from a semi-tabloid magazine in Germany, according to @andreafeigl1. But even so, how did such a magazine still get it so damn right?! Maybe Germany 🇩🇪 has seen this kinda fascism before...
⚠️TWO DIFFERENT #COVID19 PANDEMICS—Many think with cases dropping that pandemic is nearly over. But truth is, there are now 2 different #SARSCoV2 pandemics diverging—old strain is waning, while the more contagious #B117 strain is dominating. We will be soon slammed very hard. 🧵
2) Here is what is really going to happen... most countries are having a gentle case decline with R(e) currently around 0.9. But this is deceiving. The #B117 is still relatively rare so far, so the R is being influenced mostly by the old common variant. But not for long...
3) Here is what is going to happen... currently R is ~0.9 in many places, but with the more infectious #B117, the R will jump 50% approximately. And it is inevitable (all CDC and Danish models say this) that B117 will take over as the reigning dominant variant soon...
4) and when that happens, what worked before to keep the pandemic contained at R of 0.9 will no longer work. Here is the model for Alberta, 🇨🇦 by @GosiaGasperoPhD. The B117 dotted red line will soon dominate and drive a new surge in latter half of March and April.
5) And Denmark 🇩🇰 CDC has found the same thing. I GQR works now for keeping R around 0.9 or even 0.8, will absolutely not work anymore once #B117 variant takes over. Forget about it. We will be hit hard. But there is a way—if we suppress R to 0.7 or less.
https://t.co/gOq0put4H5
2) Here is what is really going to happen... most countries are having a gentle case decline with R(e) currently around 0.9. But this is deceiving. The #B117 is still relatively rare so far, so the R is being influenced mostly by the old common variant. But not for long...
3) Here is what is going to happen... currently R is ~0.9 in many places, but with the more infectious #B117, the R will jump 50% approximately. And it is inevitable (all CDC and Danish models say this) that B117 will take over as the reigning dominant variant soon...
4) and when that happens, what worked before to keep the pandemic contained at R of 0.9 will no longer work. Here is the model for Alberta, 🇨🇦 by @GosiaGasperoPhD. The B117 dotted red line will soon dominate and drive a new surge in latter half of March and April.
5) And Denmark 🇩🇰 CDC has found the same thing. I GQR works now for keeping R around 0.9 or even 0.8, will absolutely not work anymore once #B117 variant takes over. Forget about it. We will be hit hard. But there is a way—if we suppress R to 0.7 or less.
https://t.co/gOq0put4H5
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🌿𝑻𝒉𝒆 𝒔𝒕𝒐𝒓𝒚 𝒐𝒇 𝒂 𝑺𝒕𝒂𝒓 : 𝑫𝒉𝒓𝒖𝒗𝒂 & 𝑽𝒊𝒔𝒉𝒏𝒖
Once upon a time there was a Raja named Uttānapāda born of Svayambhuva Manu,1st man on earth.He had 2 beautiful wives - Suniti & Suruchi & two sons were born of them Dhruva & Uttama respectively.
#talesofkrishna https://t.co/E85MTPkF9W
Now Suniti was the daughter of a tribal chief while Suruchi was the daughter of a rich king. Hence Suruchi was always favored the most by Raja while Suniti was ignored. But while Suniti was gentle & kind hearted by nature Suruchi was venomous inside.
#KrishnaLeela
The story is of a time when ideally the eldest son of the king becomes the heir to the throne. Hence the sinhasan of the Raja belonged to Dhruva.This is why Suruchi who was the 2nd wife nourished poison in her heart for Dhruva as she knew her son will never get the throne.
One day when Dhruva was just 5 years old he went on to sit on his father's lap. Suruchi, the jealous queen, got enraged and shoved him away from Raja as she never wanted Raja to shower Dhruva with his fatherly affection.
Dhruva protested questioning his step mother "why can't i sit on my own father's lap?" A furious Suruchi berated him saying "only God can allow him that privilege. Go ask him"
Once upon a time there was a Raja named Uttānapāda born of Svayambhuva Manu,1st man on earth.He had 2 beautiful wives - Suniti & Suruchi & two sons were born of them Dhruva & Uttama respectively.
#talesofkrishna https://t.co/E85MTPkF9W
Prabhu says i reside in the heart of my bhakt.
— Right Singh (@rightwingchora) December 21, 2020
Guess the event. pic.twitter.com/yFUmbfe5KL
Now Suniti was the daughter of a tribal chief while Suruchi was the daughter of a rich king. Hence Suruchi was always favored the most by Raja while Suniti was ignored. But while Suniti was gentle & kind hearted by nature Suruchi was venomous inside.
#KrishnaLeela
The story is of a time when ideally the eldest son of the king becomes the heir to the throne. Hence the sinhasan of the Raja belonged to Dhruva.This is why Suruchi who was the 2nd wife nourished poison in her heart for Dhruva as she knew her son will never get the throne.
One day when Dhruva was just 5 years old he went on to sit on his father's lap. Suruchi, the jealous queen, got enraged and shoved him away from Raja as she never wanted Raja to shower Dhruva with his fatherly affection.
Dhruva protested questioning his step mother "why can't i sit on my own father's lap?" A furious Suruchi berated him saying "only God can allow him that privilege. Go ask him"
https://t.co/6cRR2B3jBE
Viruses and other pathogens are often studied as stand-alone entities, despite that, in nature, they mostly live in multispecies associations called biofilms—both externally and within the host.
https://t.co/FBfXhUrH5d
Microorganisms in biofilms are enclosed by an extracellular matrix that confers protection and improves survival. Previous studies have shown that viruses can secondarily colonize preexisting biofilms, and viral biofilms have also been described.
...we raise the perspective that CoVs can persistently infect bats due to their association with biofilm structures. This phenomenon potentially provides an optimal environment for nonpathogenic & well-adapted viruses to interact with the host, as well as for viral recombination.
Biofilms can also enhance virion viability in extracellular environments, such as on fomites and in aquatic sediments, allowing viral persistence and dissemination.
Viruses and other pathogens are often studied as stand-alone entities, despite that, in nature, they mostly live in multispecies associations called biofilms—both externally and within the host.
https://t.co/FBfXhUrH5d
Microorganisms in biofilms are enclosed by an extracellular matrix that confers protection and improves survival. Previous studies have shown that viruses can secondarily colonize preexisting biofilms, and viral biofilms have also been described.
...we raise the perspective that CoVs can persistently infect bats due to their association with biofilm structures. This phenomenon potentially provides an optimal environment for nonpathogenic & well-adapted viruses to interact with the host, as well as for viral recombination.
Biofilms can also enhance virion viability in extracellular environments, such as on fomites and in aquatic sediments, allowing viral persistence and dissemination.
