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ATROCIOUS big pharma price gouging of insulin:

This crying mother can’t afford the $1000 for her son’s insulin.

📌yet, it only costs pharma $5 to produce.

📌Insulin was invented 100 years ago by Fred Banting—who donated patent for $1 to make it free for all.

Let that sink in.

 2) Insulin is one of the most disgusting cases of price gouging ever.

America has long taken a free market approach to pharmaceuticals.
Drug companies haggle separately over drug prices with a variety of private insurers across the country...

https://t.co/1I9JlE5Ysa
3) “Meanwhile, Medicare, the government health program for those over age 65 — it’s also the nation’s largest buyer of drugs—is barred from negotiating drug prices. That gives pharma more leverage, and it leads to the kind of price surges of EpiPens, opioid antidotes, & insulin.”
4) In 2018:
Johnson & Johnson CEO made $30M
Pfizer CEO made $28M
Merck CEO made $18M
Eli Lilly CEO made $16M
Gilead CEO made $16M

Meanwhile:

📌Americans spent $535B on Rx drugs

📌1/4 of diabetics rationed insulin to survive

📌500K Americans went bankrupt from medical bills.
5) What’s the right price patients should pay for medications? ZERO dollars, because no copay ==> more patients get their medicine ==> saves lives and saves money. Copays decrease adherence, and copays hurt patients who actually need them.
6) Yet, America has the highest rate of skipping drugs -- 1 in 6 patients!!! It’s shameful how much Americans have to skip their prescription medicine compared to other countries that pay much less and have zero copays.
https://t.co/vhhfXwrsTE
7) Not just insulin, parents of kids with allergies are forced to shell out $600 for EpiPen because it is a matter of life and death. Here is a dark story about Mylan, the EpiPen maker who pharma jacked up the price from a few $ to $600.
8) First, Mylan didn’t even invent epinephrine, which is simply our human hormone, better known as *adrenaline*, packaged into an 💉 injector (not some wild invention), invented by scientists paid by taxpayers. But big pharma gets to hold parents of kids with allergies hostage.
9) Even worse, Mylan was also recently ***criminally charged*** by Department of Justice for outright fraudulent EpiPen billing, and fined $465 million for its corruption.

https://t.co/KE90EdsQCf

More from Eric Feigl-Ding

Eric Feigl-Ding
Eric Feigl-Ding
@DrEricDing
📍DOUBLE REINFECTIONS—wow, both PM Justin Trudeau and Biden’s HHS Secretary Becerra got *reinfected* with #COVID19–from same conference—➡️when did Becerra last get infected? May 18th 2022—not even a full month ago! Trudeau in Jan 2022. I worry it’s reinfections due to #BA5/#BA4.


2) #BA5 and #BA4 are worrisome. They are surging and they have high reinfection potential. Your past BA1/BA2 doesn’t substantially protect you from #Ba5/4


3) Excess deaths—the new #BA4 & #BA5 variants of the coronavirus are currently the **fastest growing** strains in the US & UK. ➡️They are exponentially replacing all other past strains. Learn from South Africa’s early warning signs and their excess deaths. #CovidIsNotOver #COVID


4) Is it a Paxlovid rebound for Becerra, as some are asking? Unclear—Paxlovid rebound usually only happens at day 10-14 that we know of and have data. The FDA says it’s 1-2% rebound but I counted 12% from this Pfizer graph submitted to FDA.


5) and yes, #ba5 / #BA4 are very problematic. they are 2x more resistant than even BA2 for neutralizing the virus compared to those who had breakthrough reinfections from older Omicron.
CATEGORY PDFMAKERAPP GRAB THIS READWISEIO SAVE READWISEIO SAVE THREAD THREADER COMPILE SUMMARIZE
Eric Feigl-Ding
Eric Feigl-Ding
@DrEricDing
JUST ONE PERSON—UK 🇬🇧 scientists think one immunocompromised person who cleared virus slowly & only partially wiped out an infection, leaving behind genetically-hardier viruses that rebound & learn how to survive better. That’s likely how #B117 started. 🧵 https://t.co/bMMjM8Hiuz


2) The leading hypothesis is that the new variant evolved within just one person, chronically infected with the virus for so long it was able to evolve into a new, more infectious form.

same thing happened in Boston in another immunocompromised person that was sick for 155 days.

3) What happened in Boston with one 45 year old man who was highly infectious for 155 days straight before he died... is exactly what scientists think happened in Kent, England that gave rise to #B117.


4) Doctors were shocked to find virus has evolved many different forms inside of this one immunocompromised man. 20 new mutations in one virus, akin to the #B117. This is possibly how #B1351 in South Africa 🇿🇦 and #P1 in Brazil 🇧🇷 also evolved.


5) “On its own, the appearance of a new variant in genomic databases doesn’t tell us much. “That’s just one genome amongst thousands every week. It wouldn’t necessarily stick out,” says Oliver Pybus, a professor of evolution and infectious disease at Oxford.
SCIENCE
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Eric Feigl-Ding
Eric Feigl-Ding
@DrEricDing
JUST IN — "Camp Auschwitz" insurrectionist of the Capitol siege was just arrested this morning in Newport News, VIrginia.

2) this guy was just arrested.


3) We cannot have a repeat of the fascism from WW2. This is @Schwarzenegger’s speech was so powerful.


4) My wife @andreafeigl1’s 🇦🇹 great grandfather secretly fought Hilter’s Nazi regime & smuggled many Jews to safety as an aircraft engineer. He was thrown into a concentration camp, and escaped.

She knows a few things about Nazi history—Jan 6th was downright fascist. Read 👇


5) So this cover is from a semi-tabloid magazine in Germany, according to @andreafeigl1. But even so, how did such a magazine still get it so damn right?! Maybe Germany 🇩🇪 has seen this kinda fascism before...
LEGAL
Eric Feigl-Ding
Eric Feigl-Ding
@DrEricDing
Wow. 1 in 3 hospitalized with #COVID19 gets readmitted to the hospital within a few months after discharge. ~48,000 UK patients.

Great animated lecture on #LongCovid by @Dr2NisreenAlwan, animated by @VickiGSP using info from UK @IndependentSage experts.


2) Furthermore, 1 in 8 of those who were discharged subsequently die. And many suffer long term ailments like heart disease, liver, kidney, diabetes, and more. This doesn’t even include less clinical critical cognitive effects. #LongCovid is real.


3) How common is #LongCovid overall? UK estimates 1 in 5 at 5 weeks and 1 in 10 have symptoms have even 12 weeks after initial #COVID19 diagnosis.

Lecture again by @Dr2NisreenAlwan


4) Let these numbers sink in... 1 in 10 at 12 weeks still have symptoms!


5) Here is the original study of the above lecture from few weeks ago. We need to prepare our healthcare system long term for the impact of millions with #LongCovid. This is gonna be larger than Gulf War Syndrome or long term health of 9/11 first responders.
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Eric Feigl-Ding
Eric Feigl-Ding
@DrEricDing
NEW—CDC was truly suffocated by Trump WH at every turn. Kyle McGowan, a former chief of staff at CDC, and his deputy, Amanda Campbell, witnessed WH dismissal of science, WH’s slow suffocation of CDC’s voice, meddling in messages & siphoning of CDC budget.
https://t.co/HeuNbUggiw


2) ““Everyone wants to describe the day that the light switch flipped—It didn’t happen that way—more of like a hand grasping something, and it slowly closes, closes, closes, closes until you realize that, middle of the summer, it has a complete grasp on everything at the CDC”

3) “Mr. McGowan and Ms. Campbell, both 34, say they tried to protect their colleagues against political meddling from WH and HHS but was largely stifled by the Trump administration.

4) “The White House insisted on reviewing — and often softening — the C.D.C.’s closely guarded coronavirus guidance documents, the most prominent public expression of its latest research and scientific consensus on the spread of the virus.”

5) “The documents were vetted not only by the White House’s coronavirus task force but by what felt to the agency’s employees like an endless loop of political appointees across Washington.
Mr. McGowan recalled a White House fixated on the economic implications of public health.
HEALTH

More from Finance

Neil Bananas Bharadwa \U0001f44a\U0001f3fd
Neil Bananas Bharadwa ...
@MrNeilB
Having made over 1000 boxes for vulnerable families in Cambridge via @RedHenCambridge (thanks to our customers 🙏🏽) My thoughts on the £30 box thing. Lots of factors at play here. 1/

If the pics in this @BootstrapCook thread are true and correct then the Govt/taxpayers & families in need are getting absolutely SHAFTED 👇🏽 2/


There are some mitigating circumstances. A £30 box won’t ever contain £30 (retail) worth of food - people aren’t factoring in
-the cost of the box
-paying someone to fill it
-rent & rates
-& most expensive the *transport/distribution*

3/

If you’re doing the above at scale. Delivering *across the UK* it’s not cheap BUT IMHO there should be at LEAST £20 worth of groceries in a £30 box. To get more value they need more fresh produce. Just carrots & apples is terrible. 4/

I’m gonna put my rep on the line here & say something about these big national catering companies whose names I’ve seen mentioned. They are an ASSHOLE to deal with & completely shaft small businesses like mine with their terms which is why I won’t deal with them. 5/
FINANCE
Brian Feroldi
Brian Feroldi
@BrianFeroldi
1/ My Mission: To Spread Financial Wellness (thread)

Here’s what "financial wellness" means to me

⬇️⬇️⬇️⬇️⬇️⬇️⬇️⬇️⬇️⬇️

2/ Mindset

Humans are programmed to think short-term

Evolutionary, thinking short-term makes sense. It helps with survival.

Financial wellness is all about training yourself to develop a long-term mindset

Not easy -- it takes practice


3/ Mindset

If you join the right tribes, you can’t help but improve

My favs:
@AffordAnything
@ChooseFiFI
FinTwit
@MicroCapClub
@themotleyfoolFool
@visualizevalue

Twitter / Podcasts / Blogs / YouTube -- when used correctly -- are amazing


4/ Mindset

Educate yourself - constantly!

Especially about:

1⃣Money
2⃣Relationships
3⃣Health

These 3 categories have an outsized influence on all areas of your life

Books


5/ Career

In the beginning, focus on growing your income

Do more than what is expected

Become a lynchpin

Find a career that you ENJOY (<- important!) that also has high-income potential

Start a side hustle (<- important!)

Build your talent
FINANCE
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10-K Diver
10-K Diver
@10kdiver
Get a cup of coffee.

Let's kickstart 2022!

To that end, here are 22 key concepts to help you appreciate and achieve Financial Independence.

Concept #1.

What is Financial Independence?

It's a state of *self-sufficiency*. It's when you have enough money, and enough income-producing assets, that you and your family can live comfortably for the rest of your lives -- WITHOUT needing a job.

Concept #2.

Financial Independence is not really about spending MONEY how we like -- although, to an extent, that becomes possible.

It's about being FREE to spend our TIME how we like.


Concept #3.

Financial Independence is not really about quitting our jobs and retiring from work -- although that's possible.

It's about being FREE to pursue *whatever* kind of work we find most fulfilling. Things we love to do. Things the world benefits from. Etc.


Concept #4.

For most of us, the path to Financial Independence consists of:

- Starting Early,
- Saving Diligently, and
- Investing Responsibly.

Here's an inspiring story of a janitor who amassed an $8M fortune by following this very playbook:
FINANCE
Vitor Const\xe2ncio
Vitor Constâncio
@VMRConstancio
A potential problem is looming, and the media are pursuing a new story that builds on the following chain of reasoning: 1) higher inflation is coming;2) if CBs increase interest rates debts will explode and recession may ensue; 3) CBs are caught in an impossible dilemma 1/12

It´s perhaps too complex for some tweets, but.. Registered inflation this year is bound to be higher than present forecasts, resulting from one-off price spikes and base effects That will not start a sustained high inflation process, but temporary higher inflation is possible 2/

For example, Euro Area inflation increased suddenly from several months at -0.3% to +0.9% in Jan. This jump resulted mostly from several base effects, especially the change to German VAT. Inflation expectations increasing but higher in the US than in the EA 3/


The major one-off base effect will come from oil prices that decreased abysmally in March 2020 and have recovered. Some estimates put US inflation in April reaching 4%! After vaccinations, later in the year, pent-up consumer demand will also increase prices.4/


Despite the increased spending of accumulated savings, the savings rate will remain higher than before Covid for precautionary reasons (Fig 1). No permanent spending spree will materialise. Wages will remain subdued for a while (Fig2). Higher but not high inflation is coming.5/
FINANCE
Maureen Fitzsimmons
Maureen Fitzsimmons
@mojos55
@BylineTimes
1. The £22 billion Test and Trace system had a ‘relatively small’ effect on the R-number, a new evaluation from the Department of Health and Social Care has found.
2. EXCLUSIVE Firm Chaired by Government Procurement Advisor Awarded £38 Million Contract –
FINANCE

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Vibhu Vashisth
Vibhu Vashisth
@VIBHU_Tweet
🌺श्री गरुड़ पुराण - संक्षिप्त वर्णन🌺

हिन्दु धर्म के 18 पुराणों में से एक गरुड़ पुराण का हिन्दु धर्म में बड़ा महत्व है। गरुड़ पुराण में मृत्यु के बाद सद्गती की व्याख्या मिलती है। इस पुराण के अधिष्ठातृ देव भगवान विष्णु हैं, इसलिए ये वैष्णव पुराण है।


गरुड़ पुराण के अनुसार हमारे कर्मों का फल हमें हमारे जीवन-काल में तो मिलता ही है परंतु मृत्यु के बाद भी अच्छे बुरे कार्यों का उनके अनुसार फल मिलता है। इस कारण इस पुराण में निहित ज्ञान को प्राप्त करने के लिए घर के किसी सदस्य की मृत्यु के बाद का समय निर्धारित किया गया है...

..ताकि उस समय हम जीवन-मरण से जुड़े सभी सत्य जान सकें और मृत्यु के कारण बिछडने वाले सदस्य का दुख कम हो सके।
गरुड़ पुराण में विष्णु की भक्ति व अवतारों का विस्तार से उसी प्रकार वर्णन मिलता है जिस प्रकार भगवत पुराण में।आरम्भ में मनु से सृष्टि की उत्पत्ति,ध्रुव चरित्र की कथा मिलती है।


तदुपरांत सुर्य व चंद्र ग्रहों के मंत्र, शिव-पार्वती मंत्र,इन्द्र सम्बंधित मंत्र,सरस्वती मंत्र और नौ शक्तियों के बारे में विस्तार से बताया गया है।
इस पुराण में उन्नीस हज़ार श्लोक बताए जाते हैं और इसे दो भागों में कहा जाता है।
प्रथम भाग में विष्णुभक्ति और पूजा विधियों का उल्लेख है।

मृत्यु के उपरांत गरुड़ पुराण के श्रवण का प्रावधान है ।
पुराण के द्वितीय भाग में 'प्रेतकल्प' का विस्तार से वर्णन और नरकों में जीव के पड़ने का वृत्तांत मिलता है। मरने के बाद मनुष्य की क्या गति होती है, उसका किस प्रकार की योनियों में जन्म होता है, प्रेत योनि से मुक्ति के उपाय...
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Kestrel \u2664 lwj kin
Kestrel ♤ lwj kin
@slutxian
MDZS is laden with buddhist references. As a South Asian person, and history buff, it is so interesting to see how Buddhism, which originated from India, migrated, flourished & changed in the context of China. Here's some research (🙏🏼 @starkjeon for CN insight + citations)

1. LWJ’s sword Bichen ‘is likely an abbreviation for the term 躲避红尘 (duǒ bì hóng chén), which can be translated as such: 躲避: shunning or hiding away from 红尘 (worldly affairs; which is a buddhist teaching.) (https://t.co/zF65W3roJe) (abbrev. TWX)

2. Sandu (三 毒), Jiang Cheng’s sword, refers to the three poisons (triviṣa) in Buddhism; desire (kāma-taṇhā), delusion (bhava-taṇhā) and hatred (vibhava-taṇhā).

These 3 poisons represent the roots of craving (tanha) and are the cause of Dukkha (suffering, pain) and thus result in rebirth.

Interesting that MXTX used this name for one of the characters who suffers, arguably, the worst of these three emotions.

3. The Qian kun purse “乾坤袋 (qián kūn dài) – can be called “Heaven and Earth” Pouch. In Buddhism, Maitreya (मैत्रेय) owns this to store items. It was believed that there was a mythical space inside the bag that could absorb the world.” (TWX)
RELIGION
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Anu Satheesh \U0001f1ee\U0001f1f3
Anu Satheesh 🇮🇳...
@AnuSatheesh5
Cherthala Karthyayani Kshetram
#Alappuzha, Kerala
#KeralaTemples 🚩

Cherthala Karthyayani Temple Prathishta was done by Vilwamangalam Swamy. Chertala Pooram is very famous. Devi is Mangalya Dayini here removes obstacles relating to marriages. Sthala Puranam says that, once 👇


Vilwamangalam Swamiyar was passing this area after Prathista of Padmananbhaswamy Temple, he felt Devi chaitanyam and recognized as Karthyayani Devi. But Devi seeing Vilwamangalam went inside the pond. Swamy searched for Devi continously for 6 days and on 7th day Vilwamangalam


got hold of Devi's hair. Thus only Devi's head is Prathishta here. Devotees do Kozhi parathal ( offering cock) here as an offering to Karthyayani Devi.

Karthyayaniamme Sharanam
🙏🕉🙏
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Andrew Chen
Andrew Chen
@andrewchen
👇Thread.

Published a new essay: The red flags and magic numbers that investors look for in your startup’s metrics – 80 slide deck included!


This was a deck that I created on my (longish) interview process with @a16z. It was a long path, starting with meeting folks at the firm 10 years ago. But the purpose of the deck was to explain how I would use my superpower in an investing context

Here's what I explain in the deck. As investors (whether angel or VC) we're often confronted with an up-and-to-the-right graph. Is it going to go up? Or down?


One solution to forecast these growth curves is the Growth Accounting Framework, where you add up New+Reactivated and subtract churned users. In each time period that gives you the difference in monthly actives.


The problem with this is that it's a lagging metric, not a leading one. We need to go one level deeper and look at the underlying loops that drive these numbers, to understand the quality.
STARTUPS
SK
SK
@sk_diary1
#sculpture #story -

Chandesha-Anugraha Murti - One of the Sculpture in Brihadeshwara Temple at Gangaikonda Cholapuram - built by Raja Rajendra Chola I

This Sculpture depicts Bhagwan Shiva along with Devi Paravathi blessing Chandeshwara - one of the 63 Nayanmars.

#Thread


Chandeshwara/Chandikeshwara is regarded as custodian of Shiva Temple's wealth&most of Shiva temples in South India has separate sannathi for him.

His bhakti for Bhagwan Shiva elevated him as one of foremost among Nayanmars.
He gave importance to Shiva Pooja&protection of cows.


There are series of paintings, illustrating the #story of Chandikeshwar in the premises of
Sri Sathiyagireeswarar #Temple at Seinganur,near Kumbakonam,TN

Chandikeshwara's birth name
is Vichara sarman.He was born in the village of Senganur on the banks of River Manni.


His Parent names were Yajnathatan and Pavithrai.
Vichara Sarman was a gifted child and he learnt Vedas and Agamas at a very young age.
He was very devout and would always think about Bhagwan Shiva.

One day he saw a cowherd man brutally assaulting a cow,Vichara Sarman could not tolerate this. He spoke to cowherd: ‘Do you not know that the cow is worshipful & divine? All gods & Devas reside in https://t.co/ElLcI5ppsK it is our duty to protect cows &we should not to harm them.
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