BC CATEGORY C19
Saved by @vliscony

1/: Scientific integrity is a valuable commodity. What happens when external funders take influence on both scientific™ findings and media coverage can be seen in the current global crisis. It is time to return to the fundamental principles of science: ⬇️A thread⬇️

 2/: In this thread, I will roughly explain why #empiricism and #repeatability are important factors for science and why model approaches should be interpreted with caution (and that is what I am saying as a modeller).
3/: I am aware that the principle of science is far more profound than explained in this thread, but this thread is written for laymen on @twitter and not for the lecture room. Also, within the scientific community, there is no clear consensus about this topic either.
4/: In recent years, I have been working on complex food production systems that increase food production and show high nutrient and water use efficiencies. I have thus been involved in plant growth experiments and holistic system modelling activities (@MATLAB, @AnyLogicCo).
5/: The plant growth experiments included environmental factors, #metagenomics (i.e. microbial genome sequencing), flow regulations etc. and the modelling covered the prediction on non-existing systems based on experimental and literature data.
6/: The IMHO most important principle of science is #empiricism. Empirical evidence is information that verifies the truth (which accurately corresponds to reality) or falsity (inaccuracy) of a claim. However, experiments and observations usually do not represent the "truth".
7/: There can be many intervening factors that have an impact on the observations. The less the conditions are controlled, the higher the deviations. So in order to “find the truth”, one wants to conduct an experiment in an environment with as few as possible inference factors.
8/: I will explain this through the example of my plant growth experiments. One can conduct the experiment in a greenhouse; solar radiation, humidity, temperature etc., are no stable factors. However, in a “climate chamber”, all of these factors can be standardized.
9/: This allows us to compare experiments with one another much easier. But there are also other factors that are not easy to control. These are (often) the genetic diversity of plant species, microbiological characteristics of the process water etc.
10/: This brings us to the point to talk about #repeatability. First of all, it’s essential that an experiment should contain several replications (or, if not possible repetitions) and control groups to ensure a high statistical relevance with respect to the made observations.
11/: However, the results are fundamentally dependent on the many factors, which have a decisive influence on the experiment’s outcome. I will give you two examples to explain what I mean: (a) my experiences with plant growth experiments; (b) vitamin D #COVID trials.
12/: In one experiment, we observed that lettuce grew much faster (40%) when being grown in aquaculture-derived water that contained many bacteria (i.e. which was not sterile such as it is the case for hydroponics systems). https://t.co/WBMyfb5v8k
13/: I repeated this experiment in different locations repeatedly, and the results seem to differ (still, we always see a growth advantage). This has to do with environmental conditions, different microbial strains in the process water, different seed material/quality etc.
14/: So what’s the truth? I don’t know. Why don’t I know? Because it depends. What does it depend on? Well, many factors.

And plant growth experiment cannot be considered complex compared to the field of epidemiology or alike, where it’s even harder to control conditions.
15/: I was able to make similar observations regarding vitamin D studies. Many studies have been conducted in this field, and they are everything but uniform, also due to different hypotheses. An overview of conducted vitamin D studies can be found here: https://t.co/zhzTWwF9br
16/: In general, we can see that vitamin D has a high impact on the severity of the course of COVID, the death rate etc. And yet, meta-analyses generally compare apples and oranges (which is often unavoidable, so there is nobody to blame). https://t.co/YgJJNwMfzE
17/: The approach of every study differs in the following approaches: (1) amount IU of vitamin D administered; (2) time of administration; (3) physical characteristics of the patients; (4) selection of individuals; (5) dietary co-factors; etc. just to name some.
18/: There are, for example, studies out there that claim that vitamin D doesn't have an impact on COVID. Those studies, however, assume that a sufficient vitamin D blood serum level lays around 20 ng/mL, which is a completely faulty assumption. Still made it through peer review.
19/: Such drawn conclusions can cause confusions, and it’s the scientific community’s job to analyse, verify, and discuss findings. Such open discussions (which should include transparent peer-review processes) would help us to reduce biases. https://t.co/c1ONzsVMWC
20/: After having given you a brief insight into #empiricism and #repeatability, I want to talk about the field of modelling. During this 'pandemic', the outcome of models, again and again, justify political restrictions. But how does modelling work?
21/: The objective of a prediction model is to predict the future on the basis of available or predicted data. Often, complex situations have to be simplified for a model to work.
22/: In the last couple of months, we came across many modelled predictions: almost all of them were completely wrong (remark: don’t let physicists work in the field of epidemiology). Issues such as #seasonality have been purposely neglected, which is a methodological failure.
23/: Comparing the model prediction with the actual observations is called “model validation”. Every serious scientist should validate their models and publicly discuss why the model failed or was able to predict the future. This is somehow not the case anymore.
24/: It would be exciting to get to know why @ViolaPriesemann, @EricTopiol, @CorneliusRoemer, @neil_ferguson, or @VSPTUBerlin (who are traffic planners lol) do not validate their COVID-models but instead keep on publishing doomsday scenarios with their faulty work.
25/: It is also useful to illustrate complex relationships in so-called causal-loop diagrams prior to blindly modelling a situation. That is at least what I do (see graphic for Kombucha).
26/: A holistic causal loop diagram demonstrating the complexity of the pandemic environmental–health–socio–economic system can be found in this publication: https://t.co/CpCL4wMq2b. This could for example be a solid basis for a holistic model (consisting of several submodels).
27/: Every serious scientist should keep on questioning the “reality” and his/her own work. I can only recommend the mentioned “scientists” and many other modellers to read the following article. https://t.co/UBoPEliLiL
28/: I also have another shout-out to the media: why do you keep on giving scientists a platform that have been wrong several times.
29/: … are openly lying... https://t.co/nPKyuGTr63
30/: … committed scientific fraud… (hello @Eurosurveillanc & @StephenABustin)
https://t.co/1m7rpVqYFQ
31/: … let their bachelor students do the modelling job…
https://t.co/5hLDktlvf8
32/: … lack of a scientific degrees…
https://t.co/pMIGbbKrLU
33/: … make false statements… (plus get funded by #Soros, @wef and @WHO; i.e. conflict of interests)
https://t.co/nElSOLHMUd
34/: … defame genuine colleagues…
https://t.co/h78oX9Ah3a
35/: … have conflicts of interests… (best wishes to the @gatesfoundation). etc.
https://t.co/2AzbGs4KDT
36: Also, the #TeamScience that the media talks about is much bigger than assumed. Critical voices are disregarded or discredited. Instead, those who are in line with the agenda (no matter how unscientific their approach is) are presented as “THE SCIENCE™” we should listen to.
37/: Last but not least, John Ioannidis wrote one of the most important publications of the last decades about this topic: “Why Most Published Research Findings Are False”. Give it a go because he is part of the real #TeamScience. https://t.co/LeGCfIMHFf

More from Dr. Simon ツ

Dr. Simon \u30c4
Dr. Simon ツ
@goddeketal
1/: The Nuremberg Code is a set of research ethics principles for human experimentation created as a result of the Nuremberg trials at the end of the Second World War. In light of the current events, they are more actual than ever before. ⬇️an important thread⬇️


2/: These so-called ‘Doctors’ Trial’ focused on physicians who conducted #inhumane and #unethical human experiments in German concentration camps, in addition to those who were involved in over 3,500,000 sterilizations of German citizens. (the picture shows doctors/criminals)


3/: Ten points of the code were given in the section of the verdict entitled "Permissible Medical Experiments". They can be found in detail on the following website:

4/: Point #1 means that the person involved should have legal capacity to give consent; should be so situated as to be able to exercise free power of choice, without the intervention of any element of force, fraud, or deceit.


5/: Using an insufficiently-tested vaccine on humans is unethical. However, as long as people voluntarily consent to receive the vaccine, being informed about all risks, everything is OK. Doing this with force, however, is against the Nuremberg Code.
CATEGORY C19
Dr. Simon \u30c4
Dr. Simon ツ
@goddeketal
1/ Happy to announce that we have submitted our #paper ‘Bayes Lines Tool (BLT) - A SQL-script for analyzing diagnostic test results with an application to SARS-CoV-2-testing’.

In this ⬇️thread⬇️, I will explain why our tool is that powerful for decision makers. #UnbiasedScience


2/ In the meantime, the submitted paper is available on the preprint platform @zenodo_org. Factual criticism is highly desired and encouraged. The publication itself presents a seminal Bayesian calculator, the Bayes Lines Tool (BLT). (Petje af, @waukema!)

3/ The Bayes Line Tool (available on https://t.co/jIomSIxOd9) is able to back-solve disease #prevalence, test #sensitivity, test #specificity, and therefore, true positive, false positive, true negative and false negative numbers from official governmental test outcome reports.

4/ This is done by creating confusion matrices with four variables. Namely: TP, FP, TN, FN. In order to calculate the matrices, we need prevalence, specificity, and sensitivity as well as the number of people that got tested (within a given period) and the number of positives.


5/ The number of positives and the number of tests are given by the government. Prevalence, specificity, and sensitivity are unknown. So we assume any combination of them ranging from 0-99%. These three combinations can amount up to #millions of #combinations.
TECH
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Dr. Simon \u30c4
Dr. Simon ツ
@goddeketal
Substantial analysis of @BenMarten regarding the mortality in Germany. Particularly noticeable is the "excess mortality" in December. Ben states that "lockdown deaths" could play an important role here. I would like to elaborate my thoughts on that. ⬇️Mini-Thread⬇️


Factor 1: Vitamin D deficiency.

Many people (especially elderly) have been locked in during the summer. Also the majority of holiday trips have been cancelled, leading to a lower 25(OH)D blood serum level as usual. The body can store vitamin D up to several months.


As vitamin D is a hormon that modulates the immune responses, we can assume that the lockdown measures had some adverse effect on our immune system. Especially elderly people in retirement homes must have been severely affected.

Factor 2: Loneliness

"Loneliness, it seems, can lead to long-term "fight-or-flight" stress signaling, which negatively affects immune system functioning. Simply put, people who feel lonely have less immunity and more inflammation than people who

Factor 3: Hyper Hygiene

Constant disinfections and high hygienic standards weaken the immune system. It gets literally "out of
WORLD
Dr. Simon \u30c4
Dr. Simon ツ
@goddeketal
1/ One year of destroyed economies, social isolation & deep social splits calls for an anniversary ⬇️thread ⬇️ to celebrate the RT-qPCR manuscript by Christian Drosten (@c_drosten) & Victor Corman (@vmcorman), submitted on 21st Jan 2020 to @Eurosurveillanc. #UnbiasedScience


2/ Before this very publication, virologists were neither treated like superstars, nor were they considered icons or half-gods. In 2009, Drosten almost succeeded in installing the false premise virology could supersede holistic medical sciences as discussed in this thread.

3/ Drosten is a virologist. He neither has any background in epidemiology, nor has he ever worked in the civil service. He also doesn’t have a background in public health. Yet he and his colleagues affect our daily lives to the level of whom to meet up or how to flush the toilet.


4/ Before January 2020, Drosten and Corman were common virologists at Charité Berlin, whenever they were not involved in economic implications (https://t.co/UTDwG8U7Du). Other than that, they looked at coronaviruses in dromedary calves in the Middle East or Africa. 😍 #cute


5/ Finally in Jan 2020, the published paper laid the theoretical grounds for the current pandemic, the RT-qPCR mass testing-religion, for which he was awarded his second German Federal Cross of Merit (he received the first one in 2005 for developing the SARS-CoV PCR test).
SOCIETY
Dr. Simon \u30c4
Dr. Simon ツ
@goddeketal
1/: Avicenna was a Persian scientist, who lived 1000 years ago. He put two lambs in separate cages, which had the same health conditions. But only one lamb could see a wolf that was put in a third cage. The observations were astounding. (h/t @farmer_student) ⬇️a thread⬇️


2/: Both lambs were provided with the same feed. Also, the weight was exactly the same when the experiment started. Several months later, the lamb with sight on the wolf became cranky, restless, weak, and showed a significant weight loss and signs of poor development.

3/: The lamb that was under chronic stress as it was placed in a situation of constant apparent danger died eventually. 🐑🪦 In fact, the wolf did not pose a danger at all, but this was beyond the lamb's perception.

4/: This experiment showed that increased levels of the stress hormone cortisol have a bad impact on the metabolism of mammals. And 1000 years after this experiment, we are facing a similar situation again but with the difference that we are aware of the impact of stress.

5/: Currently, we are overwhelmed with medial and governmental propaganda with respect to a common cold virus (that might hypothetically be more lethal though) that doesn't do harm to the majority of the people. Extreme global measures are taken.
CATEGORY C19

More from Category c19

Brumby
Brumby
@the_brumby
This will be my first and possibly last tweet (thread) as I am mostly here to learn. It is prompted by a recent study questioning lockdown efficacy that is getting a lot of attention. It appears people believe it to be the first of its kind, but I have been collecting similar

studies since March 2020. Below are 30 published papers finding that lockdowns had little or no efficacy (despite unconscionable harms) along with a key quote or two from each:

1.https://t.co/VseXe862AX

“there is no evidence that more restrictive nonpharmaceutical interventions (“lockdowns”) contributed substantially to bending the curve of new cases in England, France, Germany, Iran, Italy, the Netherlands, Spain, or the United States in early 2020”

2.https://t.co/EzTSzeZyue

“Inferences on effects of NPIs are non-robust and highly sensitive to model specification. Claimed benefits of lockdown appear grossly exaggerated.”

3.https://t.co/4c4LqeQ5bz

“government actions such as border closures, full lockdowns, and a high rate of COVID-19 testing were not associated with statistically significant reductions in the number of critical cases or overall mortality”
CATEGORY C19
Robin Monotti FRSA \u2b50
Robin Monotti FRSA ⭐...
@robinmonotti
PROBIOTICS & VIT D: "The vitamin D receptor is highly expressed in the gastrointestinal tract where it transacts gene expression..These results support the underlying hypothesis that the human gut microbiome and vitamin D metabolism are integrally related"
https://t.co/15rVFa1fkk


"Men with higher levels of 1,25(OH)2D and higher activation ratios, but not 25(OH)D itself, are more likely to possess butyrate producing bacteria that are associated with better gut microbial health."

"Several studies suggest that gut microbiota alter intestinal vitamin D metabolism (VDM), and probiotic supplements can affect circulating vitamin D levels."

"Because the serum 25(OH)D correlates with overall vitamin D storage, it is the preferred clinical measure to assess vitamin D sufficiency."

"Clinically, serum 25(OH)D levels ≥20 ng/ml are considered adequate while 25(OH)D levels <20 ng/ml are defined as vitamin D deficiency."
CATEGORY C19
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Alex Berenson
Alex Berenson
@AlexBerenson
1/ Let’s talk about vaccine misinformation, @cdcgov style. On Friday the CDC ran a report titled “Reduction in COVID-19 Patients Requiring Mechanical Ventilation Following Implementation of a National COVID-19 Vaccination Program.”

The headline is a lie. No other word will do...


2/ How do I know? From the data in the report itself.

The report, written by three Israeli scientists, intentionally tries to obscure the facts it presents (I’m not entirely sure why it was written at all), but they come out anyway to anyone paying attention...

3/ Your first clue the authors have no interest in presenting the facts honestly comes when they refuse simply to divulge how many people were on ventilators before and after the start of vaccinations on Dec. 19. Instead they focus on the ratio of patients in two age groups...
CATEGORY C19
Howard Steen
Howard Steen
@HowardSteen4
1/n Presenting Part One of my second trilogy (following the 2020 Lockdown Trilogy) in my Cartoon series:

“The War of the Worlds & Age of Extinction Cometh – The Transformers of MolBiol”

A comprehensive guide of the imagery found in this canvas is contained in this thread:


2/n Starting at the upper RH part of the image and moving from right to left, one first sees the “Three Witches of Molbiol” riding on a Trojan Horse. The three witches (ref: Macbeth) are depicted as enablers of the crisis via their mischief = misuse of molecular biology.


3/n Let us start with the arguably fake Prof. Drosten who heads the Charité Institute in Berlin. Drosten led work to develop a first PCR test protocol for SARS-CoV-2 published by @Eurosurveillanc in record time and promoted by WHO as a ‘gold standard’.


4/n Had Drosten done his work honestly and produced a test capable of detecting the SARS-CoV-2 entity, all might be well today, but he did not. His manifest scientific failings and problems with conflicts of interest are fully documented in here:

5/n Of course Drosten could not have carried off this piece of MolBiol sleight of hand all on his own. He needed accomplices & global support. A key European ‘witch’ was Dutch based @MarionKoopmans , a co-author of the Corman-Drosten scientific paper.
CATEGORY C19
Robin Monotti FRSA
Robin Monotti FRSA
@robinmonotti
I have studied the pandemic response of many countries. One of them got a key element right, which resulted in very few deaths: Japan. Their response was to keep people OUT of hospitals. A policy of early home treatment works best, hospitals only for severe cases & NO INTUBATIONS

JAPAN: "No restrictions were placed on residents’ movements, and businesses from restaurants to hairdressers stayed open. No high-tech apps that tracked people’s movements were deployed." RESULT: Among the lowest deaths in the

Saving the NHS simply means providing early treatment kits in pharmacies & avoiding hospitals for Covid19 patients. For Covid19 infections during a pandemic, hospitals are the problem, not the solution.

I have read accounts of people with high fever literally turned away from hospitals, yet being told by phone what treatment protocol to follow. That was the best pandemic response by far, NOT lockdowns.

JAPAN had some of the lowest Covid19 mortality in the world:
-NO LOCKDOWN
-NO TEST AND TRACE
-NO BUSINESS CLOSURES
-NO HOSPITAL FOR NON CRITICAL CASES
-HOME TREATMENT
-HEALTHY DIET
-LOW OBESITY
CATEGORY C19

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@franciscodeasis https://t.co/OuQaBRFPu7
Unfortunately the "This work includes the identification of viral sequences in bat samples, and has resulted in the isolation of three bat SARS-related coronaviruses that are now used as reagents to test therapeutics and vaccines." were BEFORE the


chimeric infectious clone grants were there.https://t.co/DAArwFkz6v is in 2017, Rs4231.
https://t.co/UgXygDjYbW is in 2016, RsSHC014 and RsWIV16.
https://t.co/krO69CsJ94 is in 2013, RsWIV1. notice that this is before the beginning of the project

starting in 2016. Also remember that they told about only 3 isolates/live viruses. RsSHC014 is a live infectious clone that is just as alive as those other "Isolates".

P.D. somehow is able to use funds that he have yet recieved yet, and send results and sequences from late 2019 back in time into 2015,2013 and 2016!

https://t.co/4wC7k1Lh54 Ref 3: Why ALL your pangolin samples were PCR negative? to avoid deep sequencing and accidentally reveal Paguma Larvata and Oryctolagus Cuniculus?
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IT WAS RISHI KANADA WHO GAVE THE ATOMIC THEORY & TALKED ABOUT THE GRAVITY OF EARTH, 2600 YEARS BEFORE AN APPLE FELL IN FRONT OF NEWTON'S EYES:

Scientists of the modern world credit an English scientist John Dalton (1766 CE -1844 CE) for the Atomic Theory.


And this is because, most of us are not even aware of an ancient Indian Sage named Kanada, who was the first to formulate the theory of atoms, almost 2600 yrs before Dalton and talk about earth's gravity.


Rishi Kanada was born around 600 BCE in Dwarka, Gujarat and he was the son of a philosopher named Ulka. He was fascinated with the minute detailing of the things right from his childhood. Once, when he was very young, he accompanied his father on a journey to Prayaga.


He saw plentiful grains scattered along the path leading to the shore of river Ganga. It's a tradition in Hindu families to scatter the grains for the ants and birds to feed on them. Suddenly, an ant caught his attention, who was feeding on a rice grain.


He was mesmerised by this very fact that how a small grain of rice becomes food for the ant but to satisfy the hunger of a person so many grains are needed together. This incidence made him realize the importance of a single grain of rice.
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LING PURANA: IMPORTANCE AND CHARACTERISTICS

Reading Ling Purana provides bhog and moksha to the reader and listeners. It is about Shiva's sermon to Brahma when Shiva entered the Agni Ling and preached about Dharma sidhhi through the stories of Agni Kalp.


Vyasji divided this into two parts. This book is different from others and has eleven thousand shlokas which depict the glory of Shiva. This Puran is the summary about importance of Tridev.
It starts first with a questions. Then it describes the Shrishti in brief.

Then there is description of Yog and Kalp. Next is the evolution of Ling and its puja Vidhi. It consists of dialogue between Sanat Kumar and Shail etc. It also mentions the character of Dadhichi, the dharma representation of that yug, Bhuvan kosh description,

Chandravansh and Surya vansh. Next there is elaborate description of Shrishti, story of Tripur, Ling and Pashu Paash vimoksha, Vrats for Shiva, Discipline, Repentance, Arisht, description of Shri Shail. Next is the story of Andhakasur, Varah, Narsingh,

k¡lling of Jalandhar, Shiv sahastra naam, story of Daksha's yagya and its destruction, killing of Madan and marriage of Parvati.

Next is Vinayak katha, Shiv tandav, Ambrish katha and Upmanyu .
RELIGION
Priyanka (Astrology Guidance)
Priyanka (Astrology Gu...
@AstroAmigo
1

From today, we will memorize the names of 27 Nakshatras in Vedic Jyotish to never forget in life.

I will write 4 names. Repeat them in SAME sequence twice in morning, noon, evening. Each day, revise new names + recall all previously learnt names.

Pls RT if you are in.

2

Today's Nakshatras are:-

1. Ashwini - अश्विनी

2. Bharani - भरणी

3. Krittika - कृत्तिका

4. Rohini - रोहिणी

Ashwini - अश्विनी is the FIRST Nakshatra.

Repeat these names TWICE now, tomorrow morning, noon and evening. Like this tweet if you have revised 8 times as told.

3

Today's Nakshatras are:-

5. Mrigashira - मृगशिरा

6. Ardra - आर्द्रा

7. Punarvasu - पुनर्वसु

8. Pushya - पुष्य

First recall previously learnt Nakshatras twice. Then recite these TWICE now, tomorrow morning, noon & evening in SAME order. Like this tweet only after doing so.

4

Today's Nakshatras are:-

9. Ashlesha - अश्लेषा

10. Magha - मघा

11. Purvaphalguni - पूर्वाफाल्गुनी

12. Uttaraphalguni - उत्तराफाल्गुनी

Purva means that comes before (P se Purva, P se pehele), and Uttara comes later.

Read next tweet too.

5

Purva, Uttara prefixes come in other Nakshatras too. Purva= pehele wala. Remember.

First recall previously learnt 8 Nakshatras twice. Then recite those in Tweet #4 TWICE now, tomorrow morning, noon & evening in SAME order. Like this tweet if you have read Tweets #4 & 5, both.
VEDICNAKSHATRA
Anu Satheesh \U0001f1ee\U0001f1f3
Anu Satheesh 🇮🇳...
@AnuSatheesh5
Magudeswarar Temple, Kodumudi
#Erode
#Tamilnadutemples 🚩

Situated on the banks of the river Kaveri, Magudeswarar Temple is one among Paadal Petra Shiva Sthalam. Kshetram is famous Parihara Sthala for Naga Dosham and for performing Tarpanam to the departed souls.


There are 3 sannidhi here for Paramashiva, Mahavishnu and Brahma Deva.

Sthala Puranam says that once Adisesha and Vayu Deva placed Meru parvat at the centre to decide who is stronger among them. Parvatam was held tightly by Adisesha and Vayu blew the wind to push Parvatham.


In this struggle, peak of meru  parvatham broke into 7 pieces and fell in different places as precious gems. Diamond fell at  Kodumudi as Magudeswarar. Panchamirtham abhishekam is very famous here. Vanni tree situated here is very old which contains medicinal values.


It is believed that Agasthiya Muni did Prathishta of Shiva Lingam here. As Adisesha is one of the reason for creation of the temple, this is famous Parihara Sthalam for Naga Dosham. It is believed that those who


who take a bath in the river Kaveri and worship paramashiva and mahavishnu, will be cured of diseases and will get relief from all illness.

Om Namah Shivaye
Om Namo Narayanaya
🙏🕉🙏
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