PROBIOTICS & VIT D: "The vitamin D receptor is highly expressed in the gastrointestinal tract where it transacts gene expression..These results support the underlying hypothesis that the human gut microbiome and vitamin D metabolism are integrally related"
https://t.co/15rVFa1fkk

"Men with higher levels of 1,25(OH)2D and higher activation ratios, but not 25(OH)D itself, are more likely to possess butyrate producing bacteria that are associated with better gut microbial health."
"Several studies suggest that gut microbiota alter intestinal vitamin D metabolism (VDM), and probiotic supplements can affect circulating vitamin D levels."
"Because the serum 25(OH)D correlates with overall vitamin D storage, it is the preferred clinical measure to assess vitamin D sufficiency."
"Clinically, serum 25(OH)D levels ≥20 ng/ml are considered adequate while 25(OH)D levels <20 ng/ml are defined as vitamin D deficiency."
"However, it is the active form of vitamin D, 1,25(OH)2D, that interacts specifically with the vitamin D receptor (VDR) and transacts gene expression."
"Those men with the highest compared to lowest 1,25(OH)2D and activation ratios are more likely to possess butyrate-producing bacteria that are associated with favorable gut microbial health."
"25(OH)D levels vary with site and sun exposure, but 1,25(OH)2D levels do not follow this association."
"the serum 1,25(OH)2D was the factor that explained the highest proportion of the variance in α-diversity (e.g., bacterial species diversity within an individual) at just over 5%"
"Greater α-diversity [gut bacterial species diversity] is associated with higher 1,25(OH)2D levels and larger vitamin D activation and catabolism ratios."
"Overall, apart from known correlates such as race and geographic locations, measures of vitamin D metabolic flux were remarkably associated with microbial β-diversity"
"We report robust correlations between the vitamin D metabolites, 1,25(OH)2D and 24,25(OH)2D, and the gut microbiome in 567 older men representing six geographic sites across the United States"
"Those men with higher levels of 1,25(OH)2D had greater α-diversity, even after adjusting for previously characterized determinants of microbial diversity including age, geographical origin, race, PPI, and antibiotic use."
"Serum 25(OH)D is the preferred clinical measure because it is representative of overall body stores of vit D; however, our results suggest it is the regulation of VDM, reflected by active hormone & metabolic ratios rather than body stores that have the most health implications."
"The positive association between diversity metrics and vitamin D activation and catabolism ratios suggests that physiologically normal vitamin D flux is more likely to occur in individuals with healthy microbiomes."
"In summary, we provide strong evidence of important interactions between host vitamin D signaling and the health of the gut microbiome in older men."

More from Robin Monotti FRSA ⭐

More from Category c19

@welt published an article today on the “panic paper”-scandal in Germany.

Title is "Maximum collaboration”, showing @BMI_Bund / Horst Seehofer had a secret paper drafted in the 1st COVID-19 wave that dramatically depicted the threat.

A scandal of gigantic proportions. Thread⬇️


2/: @welt released 2 versions: long version as print, short-edit, online.

This thread focuses on the long version. It's of crucial importance-people around the globe understand this earthshaking scandal. Share.

English:
https://t.co/qAbU6D8c0P

German: https://t.co/W2i1FtVrCg


3/: Mid-March 2020: Federal Minister of the Interior-Horst Seehofer (@BMI_Bund, @cducsubt) was on the edge: Christian Drosten (@c_drosten) & Lothar Wieler (@RKI) urgently warned: Germany was threatened w/ dramatic consequences if the country returned to everyday life too quickly.


4/: Horst Seehofer sent his Secretary of State Markus Kerber into the lane. The plan was to bring together leading scientists: they should produce a paper that would then serve as legitimation for further tough political measures, beyond Easter - now known as the “panic paper”.


5/: Markus Kerber launched a corresponding call to researchers via e-mail, 4 days later, the request was fulfilled: A classified paper, which presented the danger posed by the virus as dramatically as possible, and which quickly spread through the media.
1/: The inventor of the corona PCR-Test @c_drosten is one of the #protagonists of the current crisis. He is known for involving himself in contradictions. In 2014, he gave a legendary #interview to @wiwo (https://t.co/jzTRh5Suhc) that I will address in this ⬇️short thread⬇️.


2/: The interview is significant because @c_drosten made totally sane statements back then that follow the principle of common sense. Considering his involvement in the "genesis of the current pandemic", his assertions appear in an entirely different


3/: In 2014, for instance, washing the hands was sufficient against being infected by coronaviruses. Several years he demands measures that destroy national economies and social life worldwide.


4/: Young @c_drosten also severely criticized the fact that Saudi Arabia used the PCR method to detect potential infections. From his point of view, that specific method could lead to many irrelevant cases. Nowadays, his view shifted his opinion towards 'collective punishment'.


5/: Whereas he demands "testing, testing, testing" nowadays and spreads panic and fear via (social) media, he heavily condemned that behaviour of Saudi media in 2014. On top of that, he expressed his concern that medial panic could increase the number of lab tests significantly.

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