1/ Happy to announce that we have submitted our #paper ‘Bayes Lines Tool (BLT) - A SQL-script for analyzing diagnostic test results with an application to SARS-CoV-2-testing’.
In this ⬇️thread⬇️, I will explain why our tool is that powerful for decision makers. #UnbiasedScience
More from Dr. Simon ツ
1/: Avicenna was a Persian scientist, who lived 1000 years ago. He put two lambs in separate cages, which had the same health conditions. But only one lamb could see a wolf that was put in a third cage. The observations were astounding. (h/t @farmer_student) ⬇️a thread⬇️
2/: Both lambs were provided with the same feed. Also, the weight was exactly the same when the experiment started. Several months later, the lamb with sight on the wolf became cranky, restless, weak, and showed a significant weight loss and signs of poor development.
3/: The lamb that was under chronic stress as it was placed in a situation of constant apparent danger died eventually. 🐑🪦 In fact, the wolf did not pose a danger at all, but this was beyond the lamb's perception.
4/: This experiment showed that increased levels of the stress hormone cortisol have a bad impact on the metabolism of mammals. And 1000 years after this experiment, we are facing a similar situation again but with the difference that we are aware of the impact of stress.
5/: Currently, we are overwhelmed with medial and governmental propaganda with respect to a common cold virus (that might hypothetically be more lethal though) that doesn't do harm to the majority of the people. Extreme global measures are taken.
2/: Both lambs were provided with the same feed. Also, the weight was exactly the same when the experiment started. Several months later, the lamb with sight on the wolf became cranky, restless, weak, and showed a significant weight loss and signs of poor development.
3/: The lamb that was under chronic stress as it was placed in a situation of constant apparent danger died eventually. 🐑🪦 In fact, the wolf did not pose a danger at all, but this was beyond the lamb's perception.
4/: This experiment showed that increased levels of the stress hormone cortisol have a bad impact on the metabolism of mammals. And 1000 years after this experiment, we are facing a similar situation again but with the difference that we are aware of the impact of stress.
5/: Currently, we are overwhelmed with medial and governmental propaganda with respect to a common cold virus (that might hypothetically be more lethal though) that doesn't do harm to the majority of the people. Extreme global measures are taken.
Cortisol is known as the 'stress hormone' and is a silent killer. Cortisol levels are increased by:
— Dr. Simon \u30c4 (@goddeketal) February 17, 2021
\U0001f449\U0001f3fc Fear & anxiety
\U0001f449\U0001f3fc Constant stress
\U0001f449\U0001f3fc Social isolation
The media propagated fear and political measures are counterproductive. They shorten our lives. https://t.co/6BZ34pVBjw
1/ One year of destroyed economies, social isolation & deep social splits calls for an anniversary ⬇️thread ⬇️ to celebrate the RT-qPCR manuscript by Christian Drosten (@c_drosten) & Victor Corman (@vmcorman), submitted on 21st Jan 2020 to @Eurosurveillanc. #UnbiasedScience
2/ Before this very publication, virologists were neither treated like superstars, nor were they considered icons or half-gods. In 2009, Drosten almost succeeded in installing the false premise virology could supersede holistic medical sciences as discussed in this thread.
3/ Drosten is a virologist. He neither has any background in epidemiology, nor has he ever worked in the civil service. He also doesn’t have a background in public health. Yet he and his colleagues affect our daily lives to the level of whom to meet up or how to flush the toilet.
4/ Before January 2020, Drosten and Corman were common virologists at Charité Berlin, whenever they were not involved in economic implications (https://t.co/UTDwG8U7Du). Other than that, they looked at coronaviruses in dromedary calves in the Middle East or Africa. 😍 #cute
5/ Finally in Jan 2020, the published paper laid the theoretical grounds for the current pandemic, the RT-qPCR mass testing-religion, for which he was awarded his second German Federal Cross of Merit (he received the first one in 2005 for developing the SARS-CoV PCR test).
2/ Before this very publication, virologists were neither treated like superstars, nor were they considered icons or half-gods. In 2009, Drosten almost succeeded in installing the false premise virology could supersede holistic medical sciences as discussed in this thread.
3/ Drosten is a virologist. He neither has any background in epidemiology, nor has he ever worked in the civil service. He also doesn’t have a background in public health. Yet he and his colleagues affect our daily lives to the level of whom to meet up or how to flush the toilet.
4/ Before January 2020, Drosten and Corman were common virologists at Charité Berlin, whenever they were not involved in economic implications (https://t.co/UTDwG8U7Du). Other than that, they looked at coronaviruses in dromedary calves in the Middle East or Africa. 😍 #cute
5/ Finally in Jan 2020, the published paper laid the theoretical grounds for the current pandemic, the RT-qPCR mass testing-religion, for which he was awarded his second German Federal Cross of Merit (he received the first one in 2005 for developing the SARS-CoV PCR test).
Substantial analysis of @BenMarten regarding the mortality in Germany. Particularly noticeable is the "excess mortality" in December. Ben states that "lockdown deaths" could play an important role here. I would like to elaborate my thoughts on that. ⬇️Mini-Thread⬇️
Factor 1: Vitamin D deficiency.
Many people (especially elderly) have been locked in during the summer. Also the majority of holiday trips have been cancelled, leading to a lower 25(OH)D blood serum level as usual. The body can store vitamin D up to several months.
As vitamin D is a hormon that modulates the immune responses, we can assume that the lockdown measures had some adverse effect on our immune system. Especially elderly people in retirement homes must have been severely affected.
Factor 2: Loneliness
"Loneliness, it seems, can lead to long-term "fight-or-flight" stress signaling, which negatively affects immune system functioning. Simply put, people who feel lonely have less immunity and more inflammation than people who
Factor 3: Hyper Hygiene
Constant disinfections and high hygienic standards weaken the immune system. It gets literally "out of
Im Dezember gibt es tats\xe4chlich, eine signifikante \xdcbersterblichkeit, die es allerdings so in den letzten 50 Jahren auch schon gab.
— Ben Marten \U0001f642 (@BenMarten) January 22, 2021
Wir wissen, dass #Lockdowns keinen/kaum nutzen bringen. Daher k\xf6nnte man vermuten, dass hier zus\xe4tzlich auch noch die Lockdowntoten dabei sind... pic.twitter.com/nYjviDs51T
Factor 1: Vitamin D deficiency.
Many people (especially elderly) have been locked in during the summer. Also the majority of holiday trips have been cancelled, leading to a lower 25(OH)D blood serum level as usual. The body can store vitamin D up to several months.
As vitamin D is a hormon that modulates the immune responses, we can assume that the lockdown measures had some adverse effect on our immune system. Especially elderly people in retirement homes must have been severely affected.
Factor 2: Loneliness
"Loneliness, it seems, can lead to long-term "fight-or-flight" stress signaling, which negatively affects immune system functioning. Simply put, people who feel lonely have less immunity and more inflammation than people who
Factor 3: Hyper Hygiene
Constant disinfections and high hygienic standards weaken the immune system. It gets literally "out of
1/: The Nuremberg Code is a set of research ethics principles for human experimentation created as a result of the Nuremberg trials at the end of the Second World War. In light of the current events, they are more actual than ever before. ⬇️an important thread⬇️
2/: These so-called ‘Doctors’ Trial’ focused on physicians who conducted #inhumane and #unethical human experiments in German concentration camps, in addition to those who were involved in over 3,500,000 sterilizations of German citizens. (the picture shows doctors/criminals)
3/: Ten points of the code were given in the section of the verdict entitled "Permissible Medical Experiments". They can be found in detail on the following website:
4/: Point #1 means that the person involved should have legal capacity to give consent; should be so situated as to be able to exercise free power of choice, without the intervention of any element of force, fraud, or deceit.
5/: Using an insufficiently-tested vaccine on humans is unethical. However, as long as people voluntarily consent to receive the vaccine, being informed about all risks, everything is OK. Doing this with force, however, is against the Nuremberg Code.
2/: These so-called ‘Doctors’ Trial’ focused on physicians who conducted #inhumane and #unethical human experiments in German concentration camps, in addition to those who were involved in over 3,500,000 sterilizations of German citizens. (the picture shows doctors/criminals)
3/: Ten points of the code were given in the section of the verdict entitled "Permissible Medical Experiments". They can be found in detail on the following website:
4/: Point #1 means that the person involved should have legal capacity to give consent; should be so situated as to be able to exercise free power of choice, without the intervention of any element of force, fraud, or deceit.
5/: Using an insufficiently-tested vaccine on humans is unethical. However, as long as people voluntarily consent to receive the vaccine, being informed about all risks, everything is OK. Doing this with force, however, is against the Nuremberg Code.
Important - share: Camera footage out of care homes (USA, corrected), provided by @RobertKennedyJr's team. You can clearly see: Collateral Damages, Army assisting, force, death.
— Bobby Rajesh Malhotra \u30c4 (@Bobby_Network) February 17, 2021
Worldwide phenomen, also in Germany:https://t.co/GV7gqiPl1u
21st Century Nuremberg Trials-material pic.twitter.com/wPekgPYHIR
More from Tech
1/ 👋 Excited to share what we’ve been building at https://t.co/GOQJ7LjQ2t + we are going to tweetstorm our progress every week!
Week 1 highlights: getting shortlisted for YC W2019🤞, acquiring a premium domain💰, meeting Substack's @hamishmckenzie and Stripe CEO @patrickc 🤩
2/ So what is Brew?
brew / bru : / to make (beer, coffee etc.) / verb: begin to develop 🌱
A place for you to enjoy premium content while supporting your favorite creators. Sort of like a ‘Consumer-facing Patreon’ cc @jackconte
(we’re still working on the pitch)
3/ So, why be so transparent? Two words: launch strategy.
jk 😅 a) I loooove doing something consistently for a long period of time b) limited downside and infinite upside (feedback, accountability, reach).
cc @altimor, @pmarca
4/ https://t.co/GOQJ7LjQ2t domain 🍻
It started with a cold email. Guess what? He was using BuyMeACoffee on his blog, and was excited to hear about what we're building next. Within 2w, we signed the deal at @Escrowcom's SF office. You’re a pleasure to work with @MichaelCyger!
5/ @ycombinator's invite for the in-person interview arrived that evening. Quite a day!
Thanks @patio11 for the thoughtful feedback on our YC application, and @gabhubert for your directions on positioning the product — set the tone for our pitch!
Week 1 highlights: getting shortlisted for YC W2019🤞, acquiring a premium domain💰, meeting Substack's @hamishmckenzie and Stripe CEO @patrickc 🤩
2/ So what is Brew?
brew / bru : / to make (beer, coffee etc.) / verb: begin to develop 🌱
A place for you to enjoy premium content while supporting your favorite creators. Sort of like a ‘Consumer-facing Patreon’ cc @jackconte
(we’re still working on the pitch)
3/ So, why be so transparent? Two words: launch strategy.
jk 😅 a) I loooove doing something consistently for a long period of time b) limited downside and infinite upside (feedback, accountability, reach).
cc @altimor, @pmarca
4/ https://t.co/GOQJ7LjQ2t domain 🍻
It started with a cold email. Guess what? He was using BuyMeACoffee on his blog, and was excited to hear about what we're building next. Within 2w, we signed the deal at @Escrowcom's SF office. You’re a pleasure to work with @MichaelCyger!
5/ @ycombinator's invite for the in-person interview arrived that evening. Quite a day!
Thanks @patio11 for the thoughtful feedback on our YC application, and @gabhubert for your directions on positioning the product — set the tone for our pitch!
