Chuan Qin, a party member of CCP, Director of the Institute of Laboratory Animal Sciences, CAMS; 1st person on finding and establishing the 1st animal model of SARS infection & also awarded the Advanced Individual Award of the United Front Work System due to the finding in 2003
https://t.co/7VE46nGYf2
A suspected contractor of Chuan QIN team - Cyagen, a biotechnological CRO founded in Guangzhou and established several branches globally, including Santa Clara, California. Cyagen is the world's largest provider of custom-engineered mouse and rat models
Not easy to find evidence on Qin's involvement in the serial passage experiments. But quite easy to find sth from their contractor. Obviously this company contracts their program of humanised rats regarding to #SARS_CoV_2 and passage experiments on rats
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APIs in general are so powerful.
Best 5 public APIs you can use to build your next project:
1. Number Verification API
A RESTful JSON API for national and international phone number validation.
🔗 https://t.co/fzBmCMFdIj
2. OpenAI API
ChatGPT is an outstanding tool. Build your own API applications with OpenAI API.
🔗 https://t.co/TVnTciMpML
3. Currency Data API
Currency Data API provides a simple REST API with real-time and historical exchange rates for 168 world currencies
🔗 https://t.co/TRj35IUUec
4. Weather API
Real-Time & historical world weather data API.
Retrieve instant, accurate weather information for
any location in the world in lightweight JSON format.
🔗 https://t.co/DCY8kXqVIK
Best 5 public APIs you can use to build your next project:
1. Number Verification API
A RESTful JSON API for national and international phone number validation.
🔗 https://t.co/fzBmCMFdIj
2. OpenAI API
ChatGPT is an outstanding tool. Build your own API applications with OpenAI API.
🔗 https://t.co/TVnTciMpML
3. Currency Data API
Currency Data API provides a simple REST API with real-time and historical exchange rates for 168 world currencies
🔗 https://t.co/TRj35IUUec
4. Weather API
Real-Time & historical world weather data API.
Retrieve instant, accurate weather information for
any location in the world in lightweight JSON format.
🔗 https://t.co/DCY8kXqVIK
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Keep dwelling on this:
Further Examination of the Motif near PRRA Reveals Close Structural Similarity to the SEB Superantigen as well as Sequence Similarities to Neurotoxins and a Viral SAg.
The insertion PRRA together with 7 sequentially preceding residues & succeeding R685 (conserved in β-CoVs) form a motif, Y674QTQTNSPRRAR685, homologous to those of neurotoxins from Ophiophagus (cobra) and Bungarus genera, as well as neurotoxin-like regions from three RABV strains
(20) (Fig. 2D). We further noticed that the same segment bears close similarity to the HIV-1 glycoprotein gp120 SAg motif F164 to V174.
https://t.co/EwwJOSa8RK
In (B), the segment S680PPRAR685 including the PRRA insert and highly conserved cleavage site *R685* is shown in van der Waals representation (black labels) and nearby CDR residues of the TCRVβ domain are labeled in blue/white
https://t.co/BsY8BAIzDa
Sequence Identity %
https://t.co/BsY8BAIzDa
Y674 - QTQTNSPRRA - R685
Similar to neurotoxins from Ophiophagus (cobra) & Bungarus genera & neurotoxin-like regions from three RABV strains
T678 - NSPRRA- R685
Superantigenic core, consistently aligned against bacterial or viral SAgs
Further Examination of the Motif near PRRA Reveals Close Structural Similarity to the SEB Superantigen as well as Sequence Similarities to Neurotoxins and a Viral SAg.
The insertion PRRA together with 7 sequentially preceding residues & succeeding R685 (conserved in β-CoVs) form a motif, Y674QTQTNSPRRAR685, homologous to those of neurotoxins from Ophiophagus (cobra) and Bungarus genera, as well as neurotoxin-like regions from three RABV strains
(20) (Fig. 2D). We further noticed that the same segment bears close similarity to the HIV-1 glycoprotein gp120 SAg motif F164 to V174.
https://t.co/EwwJOSa8RK
In (B), the segment S680PPRAR685 including the PRRA insert and highly conserved cleavage site *R685* is shown in van der Waals representation (black labels) and nearby CDR residues of the TCRVβ domain are labeled in blue/white
https://t.co/BsY8BAIzDa
Sequence Identity %
https://t.co/BsY8BAIzDa
Y674 - QTQTNSPRRA - R685
Similar to neurotoxins from Ophiophagus (cobra) & Bungarus genera & neurotoxin-like regions from three RABV strains
T678 - NSPRRA- R685
Superantigenic core, consistently aligned against bacterial or viral SAgs