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Saved by @BillyBostickson

Zhengli Shi and Deyin Guo in 2015
Coronavirus nsp10/nsp16 Methyltransferase Can Be Targeted by nsp10-Derived Peptide In Vitro and In Vivo To Increase or Decrease Replication and Pathogenesis
https://t.co/YMlsqFOvZp

 Deyin Guo 2016:
Molecular mechanisms of coronavirus RNA capping and methylation
https://t.co/xdEU5goLB6
Deyin Guo 2012
Short peptides derived from the interaction domain of SARS coronavirus nonstructural protein nsp10 can suppress the 2′-O-methyltransferase activity of nsp10/nsp16 complex
https://t.co/x30jPYFDTa
Deyin Guo 2013
Structure-function Analysis of SARS Coronavirus RNA Cap Guanine-N7 Methyltransferase.
https://t.co/NG57b85hcs
Deyin Guo 2016
Identification and Characterization of a Ribose 2’-O-Methyltransferase Encoded by the Ronivirus Branch of Nidovirales
https://t.co/zZ5V7erseD
Yu Chen's Lab
Lab head
Yu Chen
Lab members (6)
Top co-authors
Deyin Guo
Wuhan University
Ke Lan
Wuhan University
Andong Wu
Nanchang University
Chen Shuliang
Wuhan University
Ke Xu
Wuhan U
https://t.co/Ny5TPjNBHh
Deyin Guo 2009
Functional screen reveals SARS coronavirus nonstructural protein nsp14 as a novel cap N7 methyltransferase
https://t.co/9xN1Y8cSV5
Deyin Guo 2011
Biochemical and Structural Insights into the Mechanisms of SARS Coronavirus RNA Ribose 2′-O-Methylation by nsp16/nsp10 Protein Complex
https://t.co/N2iMtjkZ0c
Figure 7. (Lower Right) Structural mechanisms of nsp10 in stimulating the binding of capped RNA to nsp16.
Deyin Guo's 2017 "Archived" HIV Project...or was it?
Cellular factors regulating HIV-1 replication
https://t.co/SOieGZtvLI
Deyin Guo and Researchers from the State Key Laboratory of Virology, College of Life Sciences, Wuhan University, 2015
The nucleocapsid protein of coronaviruses acts as a viral suppressor of RNA silencing in mammalian cells
https://t.co/mp5MJH9Aho
Back to Deyin Guo's "archived" HIV Project
1. Paper 1:
Inhibition of HIV-1 Transcription and Replication by a Newly Identified Cyclin T1 Splice Variant (April 2013)
Back to Deyin Guo's "archived" HIV Project
2. Paper 2:
Regulation of the Alternative Splicing and Function of Cyclin T1 by the Serine-Arginine-Rich Protein ASF/SF2
https://t.co/7dEiHnJ1jb
Back to Deyin Guo's "archived" HIV Project
3. Paper 3:
M2 pyruvate kinase enhances HIV-1 transcription from its long terminal repeat
https://t.co/GfnHDPOTAR
From Coronavirus to HIV and back to Coronavirus with Deyin Guo and friends:
https://t.co/a2kjcwVBkM
https://t.co/zVzx0CgLTm
Deyin Guo's Tsinghua University Project Associates 2018
Cryo-EM structure of the SARS coronavirus spike glycoprotein in complex with its host cell receptor ACE2
https://t.co/zVzx0CgLTm
More from the Coronavirus Project
https://t.co/16HCDJg7Vc
2017 Deyin Guo
Electron microscopy studies of the coronavirus ribonucleoprotein complex
https://t.co/etEBKfeunu
Coronaviruses: genome structure, replication, and pathogenesis (Deyin Guo 2020)
https://t.co/LANkA4X3WJ
Deyin Guo and his Lab (October 2019)
P200 family protein IFI204 negatively regulates type I interferon responses by targeting IRF7 in nucleus
https://t.co/f0Tyzfqjx8
This research has to be considered in the light of other research by Deyin Guo (& allegations)
See here:
Serial passage in Wuhan with Deyin Guo!
https://t.co/r3qTaJdivw
CCR5 editing by SA Cas9 in human primary CD4+ T cells promotes HIV-1 resistance
https://t.co/PA26YQ7qIx
Tweets 35 - 55 on Deyin Guo here:
https://t.co/2WctrvmLp3
The End?
Unroll @threadreaderapp

More from Billy Bostickson 🏴👁&👁 🆓

Billy Bostickson \U0001f3f4\U0001f441&\U0001f441 \U0001f193
Billy Bostickson 🏴👁&👁 ...
@BillyBostickson
1. WIV Research groups (archived pages) for Reference
dsRNA viruses molecular biology

https://t.co/lwrQoo6ygG


2. Emerging Viruses Group

https://t.co/ND56gVGOAn


3. Structural Biology of Viral Genome Replication
https://t.co/wUqc0YIP3X


4. Molecular Biology of hepatitis Viruses & Gene Therapy
https://t.co/snBbxkhNsC


5. Insect Virus Genetic Engineering Lab
https://t.co/S68mVOA2Ob
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Billy Bostickson \U0001f3f4\U0001f441&\U0001f441 \U0001f193
Billy Bostickson 🏴👁&👁 ...
@BillyBostickson
1. Messy Thread exploring connections between
@DARPA @doddtra PREDICT & @EcoHealthNYC
What happened to FLIRT?
https://t.co/wgttFlgcP1
EcoHealth Alliance analyzed all airports in the US by assessing how often passengers trickle in from areas with confirmed cases of Zika virus.

2. “I believe this is something that people should know,” said Andrew Huff, vice-president of group, who oversees efforts to forecast the spread of infectious diseases. “If you know where an infectious disease is, you can take precautions.”
Andrew Huff used to run their database


3. Andrew Huff
https://t.co/yqP8NbiN5X
Data papers:
https://t.co/mCdcAMTHNW
FLIRT (Zika)
https://t.co/MyUM3mt6c3
MANTLE https://t.co/dBsFAixRXv
MANTLE

4. GRITS and EcoHealth Alliance and DTRA
Global Disease Warning Software - May 28, 2015
EcoHealth Alliance and its Partners Create Biosurveillance Application with $2.2 million grant from the DTRA to continue the development of disease warning software

Global Rapid Identification Tool System (GRITS) software developed with ProMED, International Society for Infectious Disease, & Kitware
Biosurveillance app that enables infectious disease analysts to monitor textual data sources for infectious disease threats in near real time.
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Billy Bostickson \U0001f3f4\U0001f441&\U0001f441 \U0001f193
Billy Bostickson 🏴👁&👁 ...
@BillyBostickson
Worth taking a break to watch this interview
Liu Xin's exclusive interview with China's 'Batwoman' https://t.co/Tsno7CRVys via @YouTube
1. Shi Claims ther never have been any lab leaks at P4 or the 2 P3s
2. Shi claims her lab records are transparent & available for inspection

3. Shi says all experimental work has been published
4. Shi claims her database is open for inspection!


Screenshots (1)


Screenshots (2)


Screenshots (3)
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Billy Bostickson \U0001f3f4\U0001f441&\U0001f441 \U0001f193
Billy Bostickson 🏴👁&👁 ...
@BillyBostickson
1/ BIO TERROR! History, Present and Future....
Human experimentation, modern nightmares and lone madmen in the twentieth

2/ BIO TERROR! History, Present and Future....
The History of Biological Weapons Use:
What We Know and What We Don't. W. Seth

3/ BIO TERROR! History, Present and Future....
Biological Warfare in the 17th Century
W. Seth Carus
https://t.co/GEnU8fUC3m
and
Biological Warfare Plan in the 17th Century—the Siege of Candia,

4/ BIO TERROR! History, Present and Future....
Biological Warfare at the 1346 Siege of Caffa
https://t.co/BQZ8riLq1o
The 'Hittite Plague', an Epidemic of Tularemia and the First Record of Biological

5/ BIO TERROR! History, Present and Future....
The Plague of Athens: An Ancient Act of Bioterrorism?
https://t.co/YjiG4PspCA
Applying Modern Immunology to the Plague of
Ancient
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Billy Bostickson \U0001f3f4\U0001f441&\U0001f441 \U0001f193
Billy Bostickson 🏴👁&👁 ...
@BillyBostickson
French Connection (should be 22 Tweets):
https://t.co/7i37TNmEI6
back up:
https://t.co/c2ddnImYIo


French Connection Part 2
1. Thread on Jean-Robert Bonami
(the ignored French virologist)
https://t.co/R0Ia2z4wuH
who was the doctoral supervisor for Zhengli Shi's thesis on white spot syndrome virus in
ALL

More from All

Vibhu Vashisth
Vibhu Vashisth
@VIBHU_Tweet
MAHARAANI TARARANI: THE QUEEN OF MARATHAS

Rani Tarabai was the brave daughter-in-law of Chhatrapati Shivaji and one of the greatest medieval Monarchs India ever had.
She was born in 1675 to one of the bravest commander-in-chiefs of Shivaji's Army named Hambir Rao Mohite.


Tarabai was just 8yrs old when she was married to Shivaji's younger son, Rajaram. Mughals and Marathas were constantly at war with each other. Shivaji was crowned the ruler of the Independent Maratha Swarajya in 1674 which was established by him.


However,the great leader died in 1680&the Maratha Samrajya went into a complete&total chaos.Marathas saw some very tough times ahead. In 1689,when Raigad Fort fell to the Mughal Army of over 15000,Shivaji's first wife Saibai and his elder son Sambhaji were captured&put to death.


Sambhaji's wife and son Shahu were taken prisoners to the Mughal court. During the same battle, Shivaji's second son Rajaram(Tarabai's husband) , who was the heir to the throne now, managed to escape using a disguise. He made his way to the Gingee Fort in Tamil Nadu.


Mughal General Zulfikar Khan, however, followed them to Gingee laying siege to the Gingee Fort. From 1690-1698,This was the longest siege by a Mughal Army of any Fort which stands testimony to the military and diplomatic credentials of Rani Tarabai.
ALL
\U0001d54d\U0001d560\U0001d56a\U0001d552\U0001d558\U0001d556\U0001d563
𝕍𝕠𝕪𝕒𝕘𝕖𝕣...
@V0YAGERTWEETS
Ｇａｕ Ｍａｔａ Ｉｎ Ｖｅｄｉｃ
Ｃｕｌｔｕｒｅ

It is said that the one who bears the dust thrown from the hoof of Gaumata on his head, as if taking a bath in the water of the teerth sthalam and getting rid of all sins.


Ved and all other Hindu scriptures venerate the cow. The Vedic dictionary, Nighantu, gives amongst other synonyms of 'Gau' [ or cow] the words 'Aghnya', 'Ahi', and 'Aditi'.

Yaska the vedic decoder and commentator on Nighantu, defines these as-

Aghnya —— the one that ought not to be killed
Ahi —— the one that must not be slaughtered.
Aditi —— the one that ought not to be cut into pieces.

These three names of cow signify that this is an animal which should not to be put to tortures. These words appear frequently throughout the Veda in context of the cow.

But in due course the falsehood of killing cows spread far and wide and they became even more deep rooted when western scholars with their half baked knowledge of Sanskrit transliterated these interpretations of commentaries of Sayanacharya ,
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Vibhu Vashisth
Vibhu Vashisth
@VIBHU_Tweet
Did you know?

When Saudi Arabia's King visited India in 1955, PM Nehru ordered all the Hindu Temples and Idols of Hindu Deities that came in Saudi King's way to be covered up.
Our temples are the architectural marvels in their own league.


Each of our temples tells the story of our rich history and cultural heritage. Was Nehru that ashamed of his own nation's heritage that he had to cover them up or there was some other reason? The answer would be best known to him only.

PM Nehru invited the then Saudi King Saud bin Abdul Aziz to India who accepted the invitation and planned a 17 day long official visit to India in 1955. Saudi King had brought a large delegation with him and he had to visit various Indian cities like Mumbai, Hyderabad, Agra,


Aligarh, Shimla, Mysore and Varanasi. However, when Saudi King reached Varanasi, Nehru ordered to cover all the temples and Idols with curtains that came in the way of the Royal Convoy. During his stay in Varanasi, Govt buildings were painted with the words "Kalma Tayyiba".


'Kalma Tayyiba' means 'There is not God but only Allah and Mohammed is his messenger'. In addition to it, Pooja and Aartis were also stopped at temples. I can call it the appeasement politics of the highest order and Nehru was indeed the greatest appeaser of all times.
ALL
Angela Jamison
Angela Jamison
@AnJamison
@LancPAExaminer @buzz\_chronicles @buzz\\\_chronicles @buzz_chronicles save as category @pdfmakerapp grab @pdfmakerapp grab this @readwiseio save @readwiseio save thread @threader compile summarize @Threadreaderapp unroll please @ttttreads unroll @unrollthread.com @SaveToBookmarks
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Aditya Shah
Aditya Shah
@AdityaD_Shah
How will next 10-15 years be different for India?
In the next 10 years,India will undertake massive infrastructure projects which will propel India to a $5 Trillion economy

A thread🧵on how India is spending big on Infrastructure upgradation like never before

Lets go👇

(1/17)


How big is India's Infra push?

India spent $14 Trillion on infrastructure in the 75 years since its independence.

$7 trillion was in the last 9 years.

Another $7 Trillion will be spent in the next 9 years!

Big Big Spending is coming in!

(2/17)


So where is this money being spent?

1. Roads
There has been an increase in the construction of National Highways (NHs)/roads over
time, with 10,457 km of roads constructed in FY22 as compared to 6,061 km in FY16.

(3/17)


In FY23(until October 2022), 4,060 km of NHs/roads were constructed, which was around 91 per cent of the achievement in the corresponding period of the previous financial year

(4/17)


The ambition is to take the rate of daily highway construction in India to 100km per day

Dubbed India’s ‘highway revolution’,
Rapid highway construction is central to the country’s push to transform itself into a staggering US$5 trillion economy by 2025.

(5/17)
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Emperor\U0001f451
Emperor👑
@EmperorBTC
Technical Analysis Masterclass- Part 2

'Entering the trade'

Entering a trade without ascertaining a certain things is gambling.

In this masterclass we will learn the pre-requisites to enter a trade.

DON'T ENTER A TRADE WITHOUT DETERMINNG THE FOLLOWING.

Please share.

We understand what reward to risk (popularly called risk to reward) is.
It will be denoted by R:R.

We will also try to bust a few myths about R:R and how to avoid losing trades.

Before entering a trade, you need to determine 3 things.

1. Entry trigger
2. Stop loss
3. Target

1. Entry trigger = Reasons for entering a trade. There could be multiple reasons or a single reason for entry.

Generally a set of reasons AKA confluence is a higher probability trade and a generally a safer entry.

Example of an entry trigger.


2. Stop Loss.

The price in the opposite direction of the trade where the trade is exited, at a loss.

At this level, the reason for the entry becomes invalidated according to TA and the price can then move in the opposite direction, probabilistically.


3. Target is the possible price level that the asset might touch based on previous trends or confluence AND where a possible reversal could occur.

Target is the next path of least resistance from where the price might reverse.

We will always ONLY use TA to determine all 3.
TRADING
Suhas S. Hardutt
Suhas S. Hardutt
@HarduttSuhas
THE BATTLE OF TALIKOTA and the destruction of Vijaynagar (Hampi)
26 January 1565

A tale of valor, deception and decimation.

A grim reminder that if we fail to protect our heritage, it will eventually crumble under the onslaught of "forces of anarchy".
(Elaborate thread)


This decisive battle was fought between the Vijayanagara empire and the Deccan sultanates resulting in a rout of Vijayanagara and ending the last major medieval era Hindu kingdom in south India.(1)

The seeds of 1565 encounter were sown more than 250 years earlier when the forces of the Delhi Sultanate, during the time of Alauddin Khilji and later Md Bin Tughlaq swept through southern India in an expansion spree.(2)

By middle of the 14th century, facing rebellions, Tughlaq withdrew to Delhi, leaving behind 2 empires, Bahmani, which ruled the Deccan from Kalaburagi, and Vijayanagara, which ruled most south India with its capital at Vijayanagar.(3)

The Raichur Doab, between the Krishna and Tungabhadra rivers, existed as a natural boundary between these two kingdoms, with wars often breaking out over control of this territory.(4)
HISTORY
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Brittany Packnett
Brittany Packnett
@MsPackyetti
We should stop confusing what someone was doing when we became aware of them with all they are capable of, interested in, or ever hope to be

Let folks have their many talents, interests and gifts. Life is far more fun with variety, loves.

A lot of folks have come to know me as an activist & I’m grateful that folks care to know me at all.

But I wasn’t born in 2014. I was a whole teacher, executive, policy person, speaker, arts and culture lover, reader, writer, woman of faith, fashion and more before 4 yrs ago 🤷🏾‍♀️

We rightfully complain that marginalized people are not allowed to be fully human.

But we internalize and transfer our oppression daily. It’s a smog. We all breathe it in & act it out.

And then tell WoC “girl ain’t you supposed to be a _______? Why you doing ____?”

Can I live?

And don’t go reading anything personal into this-this isn’t about me necessarily and it’s no subtweet (I try hard not to do that.)

I’ve just been observing that behavior more and more lately. Especially when it comes to marginalized folks.

Evolution should be our aspiration.

“Can’t knock the hustle” should be our anthem.

As long as someone isn’t bringing active and continual harm, why can’t they explore their many sides?
SOCIETY
Vigilant AFA
Vigilant AFA
@AfaVigilant
One fascist to watch in 2021 is Joseph Charles "Oakman" Golinske of SE MI. He's been a Proud Boy for a couple years, but took a break recently from the group and promotes himself through the "Oak Nation" channel on Telegram.


Most people may be familiar with him as the tall guy in the Proud Boys bridge shot, from their August 17, 2019 attack on Portland, which featured an American Guard bus trying (and failing) to bludgeon antifascists with hammers.


He was also with his g/f at the time (Dominique Tota, left of Tarrio), and that's definitely a twitter account folks will want to block/report because he posts on it.


He's been plenty active at the pro-Covid/anti-mask/ReOpen protests in Lansing MI, seen here with Jerry Wayne and an effigy of Gretchen Whitmer, who his militia friends tried to kidnap and publicly execute.


Outside of the Proud Boys, his solo "career" with Oak Nation features the same misogyny, classism and gateway to far-right domestic terrorism the Proud Boys themselves feature. Here's him peddling oxychlorinque and bragging about harassing service workers.
FOR LATER READ
Yoruba History - by NNP
Yoruba History - by NN...
@YorubaHistory
The Ife Primary Education Research Project (1970-1983).

aka

The Ife 6-Year Primary Project.


In 1970, as the Director of the Institute of Education of the then University of Ife (now Obafemi Awolowo University, Ile-Ife), later Dean Faculty of Education, Prof. Babs Fafunwa & his team embarked on one of the most groundbreaking research projects in education for Yorubaland.


The aim of the project was to test the hypothesis that the best instructional medium for good concept formation at a very tender age is the mother tongue.

This was bolstered by the observation that “of all the continents and peoples of the world, it is only in Africa…

…that formal education is offered in a language that is foreign to the child.”

So, Yoruba was to be used & tested as an exclusive medium of passing information or instructions to a set of pupils.

The project was based on the premise that:

(a). the child will benefit culturally, socially, linguistically & cognitively.

(b). the child’s command of English will be improved if he is taught English as an entirely separate subject by a specialist teacher through the 6 years.
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