The pre CISION tech is simply an attempt to improve the safety profile... 2/10
AVA6000 approved by MHRA. Superb news. First dosing 'around mid-year'; first data to come within 3-4 months after that.
A summary thread on the significance of AVA6000 - and #AVCT's pre CISION platform as a whole - to both the oncology industry and to AVCT itself. 1/10
The pre CISION tech is simply an attempt to improve the safety profile... 2/10
Most therapeutics going through clinical trials look for an improvement of at least 20% over the existing industry-standard drug. A 50% increase in efficacy would usually be considered an astonishing result.
In pre-clinical mouse models for #AVCT's AVA6000 3/10
What this means is that the pre CISION tech could be used to enable the giving of doses to patients that are multiple times more potent... 4/10
For example, in #AVCT's pre-clinical trials, pro-dox (AVA6000) doses were 6x more potent than the standard dox doses.
The results? The...5/10
#AVCT isn't looking to improve chemotherapies by 25-30%, like most drugs in clinical trials.
Its pre CISION has the potential to improve the safety profile - and thus the... 6/10
https://t.co/XOEE45CBtZ
AVCT holds the global exclusive licence over...8/10
TMAC will produce Affimer Drug Conjugates - a potentially more powerful class of oncology treatment than Antibody Drug Conjugates. 9/10
First though, success for AVA6000 please!
Then hopefully @avacta's first TMAC drug to enter Phase I next year 10/10
More from Society
A thread exploring the Nashville bombing in the context of the 2020 Digital War (via SolarWinds) against the United States perpetrated by our enemies, likely China, Iran and/or Russia.
SolarWinds Hack
A digital "Pearl Harbor" moment for the United States, whoever was responsible had access to the keys to the kingdom for months during 2020, including sensitive military infrastructure. This is war!
SunGard + SolarWinds
SolarWinds software company is owned by same company that owns SunGard, which essentially provides data center services. A secure place to host internet servers with redundant power and "big pipe" data connections.
https://t.co/U3P3SrrkM1
SunGard Data Center
In Nashville, around the corner from their "big pipe" connection, AT&T. Like any data center, highly secure. Only authorized personnel can enter, and even fewer can access the actual server rooms. Backup generators are available in case of power failure.
If the SunGard hardware was being used to "host" critical command and control software related to SolarWinds, the US powers would be very interested in gaining special access keys that are stored on the hard-drives of specific servers.
I've heard a lot of scientists claim these three - including most recently the chief advisor to the CDC, where the claim that most transmission doesn't happen within the walls of schools. There is strong evidence to rebut this claim. Let's look at
The science shows us that most disease transmission does not happen in the walls of the school, but it comes in from the community. So, CDC is advocating to get our K-5 students back in school at least in a hybrid mode with universal mask wearing and 6 ft of distancing. https://t.co/dfvJ2nl2s4
— Rochelle Walensky, MD, MPH (@CDCDirector) February 14, 2021
Let's look at the trends of infection in different age groups in England first- as reported by the ONS. Being a random survey of infection in the community, this doesn't suffer from the biases of symptom-based testing, particularly important in children who are often asymptomatic
A few things to note:
1. The infection rates among primary & secondary school children closely follow school openings, closures & levels of attendance. E.g. We see a dip in infections following Oct half-term, followed by a rise after school reopening.
We see steep drops in both primary & secondary school groups after end of term (18th December), but these drops plateau out in primary school children, where attendance has been >20% after re-opening in January (by contrast with 2ndary schools where this is ~5%).
My first observations in the main thread are here, but this offshoot is needed because there's been so many wise & witty things I've
37.90/ Limbaugh was a cruel hate-machine who made a fortune off hurting people. To say "don't speak ill of the dead" is the attitude of abuse enablers.
— Joshua Cypess (@JoshuaCypess) February 18, 2021
If you can't condemn a ghoul who dedicated his life to destroying society, you're part of the problem! https://t.co/ijvG2zDACH
2/ First, re: those who in their wayward moral obtuseness feel we "can't speak ill of the dead." I've said that this is what abuse enablers say, but I hear that some religious traditions preach this. Oy.
So there's this: https://t.co/7Ky4RA3nkZ &
This is how Rush's death should be honored. Let's not speak ill of the dead, let's quote Rush speaking ill of the dead.
— Sane English (@SaneEnglish) February 17, 2021
3/ Drucker is another great wit, and this carries the proper mood
It's easy to make fun of Rush Limbaugh right now, but it's important to remember that he also brought a lot of people a lot of joy by dying
— Mike Drucker (@MikeDrucker) February 17, 2021
4/ There's definitely a Jewish Tradition angle for how to treat evil people who die: the only respect is to justice, right & wrong, and above all compassion's existence necessitates condemning cruelty
It\u2019s ok\u2014essential, even\u2014to speak the truth about people who caused great harm.
— Rabbi Danya Ruttenberg (@TheRaDR) February 17, 2021
Even after their death.
5/ We're coming up on #Purim, and that's all about how to remember evil. There may be a reason, then, that I share the attitude of many other people committed to righting
today i said Jewish culture requires dancing on the graves of those who have wronged us and i picked up like 300 followers LMAO
— Erin Biba (@erinbiba) February 18, 2021
people love Jewish vengeance \U0001f923\U0001f923
wait till they hear about Purim