An interesting thing about carp is that they can go into anoxic hibernation and switch to an anaerobic metabolism based on converting glycogen to ethanol.

The waste ethanol is diffused out the gills

https://t.co/V3D1umHf04

Carp can switch over to an anaerobic metabolism and quietly exhale booze until the situation gets better.
They basically evolved the same metabolic pathway as yeast, independently.

In theory, if you spent a few thousand years breeding carp for it, you could use them to make booze.

They'd be enormous, almost entirely glycogen deposits with a fish added as an afterthought.
The really interesting thing about anaerobic carp, is that they can go 4-5 months without oxygen by relying on liver glycogen.

You, a human, have only about 100 grams of glycogen in your liver, about 400 more grams in your skeletal muscles. Call it 500 grams total.
In humans, glycogen is also burned for energy. This is where the marathon runner's bonk comes from: you only have about 2,000 calories worth, and running a marathon burns those 2,000 calories.
You have far, far too little glycogen in you to go anaerobic like the friendly carp.

Carp can be 12% glycogen by weight.

A 75kg human would need to have 9kg of glycogen to match their carp friend.

https://t.co/Bt29kS7pO5
Even if you did have 18x more glycogen than other humans, and the necessary pyruvate decarboxylase pathways to use it, you'd still have problems.
For one, that 9kg of glycogen would provide about 36,000 calories of anaerobic respiration.

Call it 18 days worth. You'd need a lot more if you wanted to beat your carp friend at holding your breaths.
For another, you'd *also* have to get rid of the lactic acid and ethanol.

You currently do this in the liver, by further metabolizing ethanol into acetaldehyde.

You do this completely differently depending on whether you're a fetus or not.
You'd not only need a vastly, vastly larger amount of glycogen, but a way of excreting the waste products more efficient than liver processing and the citric acid cycle and such.
In humans, of all ages, ethanol is itself metabolized into waste products like acetic acid and acetyl-CoA, this is the citric acid cycle. You already rely on this to survive.

https://t.co/gsnliVwr3G
However, to be more like a carp, this is simply not good enough. Far, far too much ethanol, far too few places it's metabolized.

You're gonna need a bigger liver or a better way
The simplest solution is to engineer a symbiotic relationship with acetic acid bacteria, perhaps reforming the liver into an enormous swollen mass of bacteria-riddled flesh.
But then you've got an acetic acid disposal problem.

You're gonna scare your carp friends by pissing vinegar at them.
The inelegant solution is that you're gonna need to be hooked up to a waterproof combined liver and kidney dialysis machine, to basically bypass both those organs with the power of modern technology.
So, there you are, with a 75kg mass of glycogen stores on an otherwise stick-thin fragile body, wearing a whirring dialysis machine hooked straight into you. At intervals it shits out vinegar pellets that drop down to the ocean floor below you.

Now you can hang out with a carp.

More from Anosognosiogenesis

Look at some historical examples of mass psychogenic illnesses: dancing plagues, laughing plagues, meowing nuns,

Here's a video on them:

They are interesting, but what is more interesting to me is Culture Bound Syndrome.
https://t.co/hMKaApUMZn

Basically: mass psychogenic illness, and presentation of various mental illnesses, do not occur in a vacuum. Cultures shape them.

For instance, Koro.

There have been several mass outbreaks of men completely convinced their penises are shrinking, anchoring them with string at night so they don't get sucked back inside.

Almost all in Southeast

Here's a description of one outbreak in Hainan in 1984:
So you want to generate interesting melodies.

1. Make a file called 1235.txt containing, one per line, all 24 unique permutations of the elements 1 2 3 5.


2. Cp 1235.txt to D.txt

3. Use sed to convert the numbers in D.txt to notes. Now you have 24 permutations of the major tetrachord in D.

4. Play them each. If it sounds like it increases tension, mark the beginning of that cell in 1235.txt with a +. If it sounds like it decreases tension, mark with a -.

Now those 24 melodic cells are divided into two groups: tension increasers and resolvers.

5. Rinse and repeat for all 12 keys.

You now have 13 plaintext files, filled with stuff like + 1 2 5 3 and - D E F# A

6. Figuratively roll dice to decide, given a +/- cell, what the next cell should be.

33% chance a + follows a +, etc.

Now you're outputting a stream of dynamic tensions: ++-+++-+-+---+ etc
So I've mentioned the sharpie test and the tueller drill.

Another reason you are dead within 1.5 seconds of encountering your first fast zombie, is adrenaline.


Most people who get attacked with a knife and survive to talk about it, say they never even knew a knife was there.

Or that they'd been stabbed, until after the fact.

In many cases, they think they'd just been punched, and are completely surprised

One reason the adage is "the winner is the one who dies in the ambulance, not the gutter," is because it's entirely possible to receive a fatal wound, not realize it, and then inflict a fatal wound on the other guy without *him* realizing it.

A dozen times within 30 seconds.

The marker drill teaches how you *will* get cut, fatally, without realizing it.

In full adrenaline freakout, this is even more pronounced.
The US immigration act of 1907 signed by Teddy Roosevelt: ableist as hell. https://t.co/ficeXOImo5


One theory for why the Spanish flu was so unusually lethal for young people:

They hadn't lived through the previous flu pandemic of 1889-1890 (https://t.co/OiDZYtdbWx) that killed about 1 million people. And thus had no carryover immunity.

It's suspected that the 1889 pandemic was not influenza, but a coronavirus.

The 1889 virus spread rapidly, killing mostly the elderly.

The 1889 virus was the first truly modern pandemic: people knew about germs, it spread via trains, it spread at the speed of modern transportation and commerce

More from Science

https://t.co/a6yrWK5dqg


https://t.co/Xe5xFdtDfO


https://t.co/e3RBxj0ly3


https://t.co/cJlCMqyP2v


https://t.co/5n5TK67iKB

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https://t.co/6cRR2B3jBE
Viruses and other pathogens are often studied as stand-alone entities, despite that, in nature, they mostly live in multispecies associations called biofilms—both externally and within the host.

https://t.co/FBfXhUrH5d


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