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Saved by @Alex1Powell

An interesting thing about carp is that they can go into anoxic hibernation and switch to an anaerobic metabolism based on converting glycogen to ethanol.

The waste ethanol is diffused out the gills

 https://t.co/V3D1umHf04

Carp can switch over to an anaerobic metabolism and quietly exhale booze until the situation gets better.
They basically evolved the same metabolic pathway as yeast, independently.

In theory, if you spent a few thousand years breeding carp for it, you could use them to make booze.

They'd be enormous, almost entirely glycogen deposits with a fish added as an afterthought.
The really interesting thing about anaerobic carp, is that they can go 4-5 months without oxygen by relying on liver glycogen.

You, a human, have only about 100 grams of glycogen in your liver, about 400 more grams in your skeletal muscles. Call it 500 grams total.
In humans, glycogen is also burned for energy. This is where the marathon runner's bonk comes from: you only have about 2,000 calories worth, and running a marathon burns those 2,000 calories.
You have far, far too little glycogen in you to go anaerobic like the friendly carp.

Carp can be 12% glycogen by weight.

A 75kg human would need to have 9kg of glycogen to match their carp friend.

https://t.co/Bt29kS7pO5
Even if you did have 18x more glycogen than other humans, and the necessary pyruvate decarboxylase pathways to use it, you'd still have problems.
For one, that 9kg of glycogen would provide about 36,000 calories of anaerobic respiration.

Call it 18 days worth. You'd need a lot more if you wanted to beat your carp friend at holding your breaths.
For another, you'd *also* have to get rid of the lactic acid and ethanol.

You currently do this in the liver, by further metabolizing ethanol into acetaldehyde.

You do this completely differently depending on whether you're a fetus or not.
You'd not only need a vastly, vastly larger amount of glycogen, but a way of excreting the waste products more efficient than liver processing and the citric acid cycle and such.
In humans, of all ages, ethanol is itself metabolized into waste products like acetic acid and acetyl-CoA, this is the citric acid cycle. You already rely on this to survive.

https://t.co/gsnliVwr3G
However, to be more like a carp, this is simply not good enough. Far, far too much ethanol, far too few places it's metabolized.

You're gonna need a bigger liver or a better way
The simplest solution is to engineer a symbiotic relationship with acetic acid bacteria, perhaps reforming the liver into an enormous swollen mass of bacteria-riddled flesh.
But then you've got an acetic acid disposal problem.

You're gonna scare your carp friends by pissing vinegar at them.
The inelegant solution is that you're gonna need to be hooked up to a waterproof combined liver and kidney dialysis machine, to basically bypass both those organs with the power of modern technology.
So, there you are, with a 75kg mass of glycogen stores on an otherwise stick-thin fragile body, wearing a whirring dialysis machine hooked straight into you. At intervals it shits out vinegar pellets that drop down to the ocean floor below you.

Now you can hang out with a carp.

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@pookleblinky
You know all those mysterious disappearances youtubers?

If I were a serial killer, it would be an irresistible temptation to get in on that action.

It'd be simple.

Capture a hiker. Immediately freeze their body.

Wait 5 years, 10 years.

Place their body 15km away in an inaccessible location.

Wait 5 years to make a video about it.

"search and rescue parties scoured the area for weeks, with no result. 5 years later, a troop of boy scouts discovered his body over 30 miles away, in a tree. Forensics indicate he'd only been dead less than a week."

Imagine publicly describing, with millions of views, the circumstances of one of your victims and *no one* having a clue.

5.6 million views where you describe exactly where and when that hiker disappeared, and how mysteriously they were found.

"Park rangers say the only way to get there is to climb down a 2,000 foot cliff using climbing equipment. It's not a straight fall. How did he get there?"
YOUTUBE
Anosognosiogenesis
Anosognosiogenesis
@pookleblinky
So you want to generate interesting melodies.

1. Make a file called 1235.txt containing, one per line, all 24 unique permutations of the elements 1 2 3 5.


2. Cp 1235.txt to D.txt

3. Use sed to convert the numbers in D.txt to notes. Now you have 24 permutations of the major tetrachord in D.

4. Play them each. If it sounds like it increases tension, mark the beginning of that cell in 1235.txt with a +. If it sounds like it decreases tension, mark with a -.

Now those 24 melodic cells are divided into two groups: tension increasers and resolvers.

5. Rinse and repeat for all 12 keys.

You now have 13 plaintext files, filled with stuff like + 1 2 5 3 and - D E F# A

6. Figuratively roll dice to decide, given a +/- cell, what the next cell should be.

33% chance a + follows a +, etc.

Now you're outputting a stream of dynamic tensions: ++-+++-+-+---+ etc
CULTURE
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@pookleblinky
An interesting take on zombies would be a virally mediated analgesia.

This kind of zombie plague has already happened before. Leprosy-induced neuropathy has been a thing for all of human history.

You'd just need to improve upon it.

Imagine getting a terrible flu, and after a high fever, discovering you can no longer perceive pain.

Imagine 30% of a population acquiring analgesia.

There's a reason people born with congenital analgesia don't often survive childhood, and why leprosy is so lethal.

Such an analgesia plague would hit poor people the hardest.

Restaurant workers scalding their forearms down to the muscle, warehouse workers not noticing they've crushed toes, etc

Hospitals would fill with people who'd suffered minor injuries of all kinds that'd gotten infected.

Or people who'd let illnesses go ignored until far too late.
SOCIETY
Anosognosiogenesis
Anosognosiogenesis
@pookleblinky
Look at some historical examples of mass psychogenic illnesses: dancing plagues, laughing plagues, meowing nuns,

Here's a video on them:

They are interesting, but what is more interesting to me is Culture Bound Syndrome. https://t.co/hMKaApUMZn

Basically: mass psychogenic illness, and presentation of various mental illnesses, do not occur in a vacuum. Cultures shape them.

For instance, Koro.

There have been several mass outbreaks of men completely convinced their penises are shrinking, anchoring them with string at night so they don't get sucked back inside.

Almost all in Southeast

Here's a description of one outbreak in Hainan in 1984:
HISTORY
Anosognosiogenesis
Anosognosiogenesis
@pookleblinky
Vormithrax is basically the Lobos of Cataclysm. He plays the game with challenges that'd make it impossible for other people to survive even for a few minutes.

While his challenge runs are stunning, it is annoying that there *is* a meta.

In each, "normally I'd ___ but I can't do it so easily now, so ___"

What usually happens is someone watches a Cataclysm video, gets it, and then dies.

Then dies and dies and dies, having tons of fun in the process.

And then they learn the meta.

Grind slings to level crafting, search bushes to level survival. Make a knife spear. Stop making a knife spear, they nerfed it.

And before you know it, every game starts the same way. Like a video game, not an apocalypse simulator, or a story generator.
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Robbie Andrew
Robbie Andrew
@robbie_andrew
"NO LONGER BEST IN THE WORLD"
UNEP's new Human Development Index includes a new (separate) index: Planetary pressures-adjusted HDI (PHDI). News in Norway is that its position drops from #1 to #16 because of this, while Ireland rises from #2 to #1.
Why?

https://t.co/aVraIEzRfh


Check out Norway's 'Domestic Material Consumption'. Fossil fuels are no different here to Ireland's. What's different is this huge 'non-metallic minerals' category.
(Note also the jump in 1998, suggesting data problems.)
https://t.co/5QvzONbqmN


In Norway's case, it looks like the apparent consumption equation (production+imports-exports) for non-metal minerals is dominated by production: extraction of material in Norway.
https://t.co/5QvzONbqmN


And here we see that this production of non-metallic minerals is sand, gravel and crushed rock for construction. So it's about Norway's geology.
https://t.co/y6rqWmFVWc


Norway drops 15 places on the PHDI list not because of its CO₂ emissions (fairly high at 41st highest in the world per capita), but because of its geology, because it shifts a lot of rock whenever it builds anything.
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Shrey Srivastava
Shrey Srivastava
@BlogShrey
#DDDD $LBPS $LOAC

A thread on the potential near term catalysts behind why I have increased my position in 4d Pharma @4dpharmaplc (LON: #DDDD):


1) NASDAQ listing. This is the most obvious.

The idea behind this is that the huge pool of capital and institutional interest in the NASDAQ will enable a higher per-share valuation for #DDDD than was achievable in the UK.

Comparators to @4dpharmaplc #DDDD (market capitalisation £150m) on the NASDAQ and their market capitalisation:

Seres Therapeutics: $2.33bn = £1.72bn (has had a successful phase 3 C. difficile trial); from my previous research (below) the chance of #DDDD achieving this at least once is at least


Kaleido Biosciences: $347m = £256m. 4 products under consideration, compared to #DDDD's potential 16. When you view @4dpharmaplc's 1000+ patents and AI-driven MicroRx platform (not to mention their end-to-end manufacturing capability), 4d's undervaluation is clear.
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Benedikt Kuhnhaeuser
Benedikt Kuhnhaeuser
@BenKuhnhaeuser
The calamoid palms 🌴 have over 500 species spread across the world, but their higher-level relationships were a bit of a mystery. Until now.

Out today in #MolecularPhylogeneticsAndEvolution:

A robust phylogenomic framework for the calamoid palms https://t.co/JiCbSUlheH

1/10


First some background info, so that you know what we are talking about:

Calamoid palms look a bit like snakes 🐍 (don't they!?!), because their fruits are covered in overlapping scales. And with their often fierce spines, they are equally fearsome. 😱

2/10


They are classified into 17 genera, 10 subtribes and 3 tribes. They have an amazing variety of growth forms, from stemless to climbing to tree habit. 🌱🌴

3/10


But as I said, their relationships have been a bit of a mystery. Here's the varying relationships previous studies found over the last 20 years.

4/10


We tackled this mystery with a phylogenomic approach: we sampled almost a thousand genes (a hundred times more than previous studies!) of 75 species representing all calamoid tribes, subtribes and genera.

The resulting data matrix is pretty massive...

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Black Hole Group
Black Hole Group
@BlackHolesUSP
Today, we are bringing other exciting results involving black holes and AI. We released a new paper:

"Black Hole Weather Forecasting with Deep Learning: A Pilot Study"

Work by Roberta Duarte (@import_robs), Rodrigo Nemmen (@nemmen) and João Paulo Navarro (from @NVIDIABrasil).

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They trained the model (U-Net) with frames from numerical solutions of the hydrodynamical equations.

Numerical simulations are time-consuming. A simple simulation can take as long as 7 days to finish. If we go with more complex simulations, this time may increase.

We want to investigate if deep learning can be a new method to simulate accurately in less time!


In the paper, they discussed two examples:

1- The model simulating only one system after learning only from this system
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The result is that the model can simulate up to 8e4 gravitational time accurately with a speed-up of 30000x faster!
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Thomas A. Fine \U0001f1fa\U0001f1f8
Thomas A. Fine 🇺🇸...
@thomasafine
Let's talk about Avi Loeb and his theory about alien

First, I should disclose that I work at the fame research facility as Dr. Loeb, though I work in a different department and to my recollection we've never met.

He's a scientist; I'm in computer support.

With that out of the way...
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Michael King \U0001f1fa\U0001f1f8
Michael King 🇺🇸...
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Ever notice how the top niches are centered around health, wealth, and relationships?

There's a deep-rooted psychological (and biological) reason why.

And today, I'm gonna to explain all of it so you can start profiting off of this knowledge 💰💰

*Now, this thread is going to be long and in depth. Make sure to favorite the top tweet now so you can come back to it later.

So. Down to the very core of every living being (humans, dolphins, bacteria, aliens), there are only two drivers:
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2. To reproduce

Right off the bat, we know that sex is a primary driver to human behavior.

This would also mean that each gender has its own insecurities regarding sex.

Men have a subconscious fear that their woman will leave them for someone more successful

Women have a fear that their man will leave them for someone younger & better-looking

We can conclude that men are attracted to looks, and women are attracted to status.

This is human nature down to its very core.

Crazy, blue-haired feminists will try to argue and say otherwise.

But, 50 years of feminism DOES NOT OVERRIDE millions of years of evolutionary biology.

Here's a quick visualization exercise so you can see how true all this is...
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TRUMP: "I've decided to eat babies."

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Judge Kavanaugh, found drunk in a Capitol Hill closet: "I LIKE BEER. OKAY? I LIKE BEER AND I LIKE BABIES AND THAT'S NOT SO WRONG. THAT'S RIGHT. I LIKE BABIES DIPPED IN BEER. I JUST DIP EM. IN THE BEER. THE BABIES. THE BABIES I EAT. OKAY? THAT'S AMERICA."

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Trump: *eats tons of babies at a rally*

*literal tons of babies*
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Jaya_Upadhyaya
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SRI BANASHANKARI AMMAN, BANGALORE
#bharatmandir

Located in Southern Bangalore, this is one of the most popular places of worship in Bangalore City.
Devoted to Devi Banashankari, this shrine is visited specially during Rahukala which is believed to be an unfavorable time.


Somanna Shetty, a great devotee of Devi, brought this murti from Badami’s Banshankari Amma Kshetram.
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However, upon their insistence, he conducted the puja. When he returned with prasadam, the ladies vanished. This made the people believe that they were none other than the Devi herself. Since then, the people perform poojas here during the Rahukaal.
@GunduHuDuGa


People use lemons as a diya. Lemons are cut from the centre and their pulps are removed, for pouring oil in them.
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1/ Here’s a list of conversational frameworks I’ve picked up that have been helpful.

Please add your own.

2/ The Magic Question: "What would need to be true for you


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“Gun to the head—what would you decide now?”

“Fast forward 6 months after your sabbatical--how would you decide: what criteria is most important to you?”

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“Putting aside a list of pros/cons, what’s the *one* reason you’re doing this?” “Why is that the most important reason?”

“What’s end-game here?”

“What does success look like in a world where you pick that path?”

5/ When listening, after empathizing, and wanting to help them make their own decisions without imposing your world view:

“What would the best version of yourself do”?
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@mikedicenzo
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