Did we get dietary saturated fats all wrong? The #HADLmodel provides a new understanding and an opportunity to get it right. THREAD👇👇👇
@simondankel @kariannesve

Let Uncle Ralph educate you
Synthetic Viral Genomics:
Risks and Benefits for Science and Society

"Alternatively, “No See’m” sites can be used to insert foreign genes into viral, eukaryotic, or microbial genome or vector, simultaneously removing all evidence of the restriction sites that were used in the recombinant DNA manipulation"

By orientating the restriction sites as “No See’m”, the sites are removed during reassembly, leaving only the desired mutation in the final DNA product.

The dual properties of strand specificity & a variable end overhang that can be tailored to match any sequence allow for Esp3I sites to be engineered as “universal connectors” that can be joined with any other four nucleotide restriction site overhangs (e.g. EcoRI, PstX1, BamH1)

Seamless assembly (also called No See’m Sites (85)) cascades have been used to assemble full length cDNAs of the coronaviruses mouse hepatitis virus, transmissible gastroenteritis virus, infectious bronchitis virus and SARS-CoV (Refs: 85,86,87)

What is carbon capture? And how does it work?

While carbon capture is regularly discussed in the media, no one really ever explains what it is.

Below is a quick thread discussing the technology behind traditional carbon capture 👇

Carbon capture is broadly the "capture" of CO2 emissions from a power plant or other type of industrial facility.

Technology is connected to the "tailpipes" of these facilities and is used to remove CO2 from the plant exhaust.

Once the CO2 is removed from the plant exhaust, it is typically pressurized and sent under ground for permanent storage.

This step is called "sequestration" and is why experts often talks about "carbon capture and sequestration" or "CCS".

So how do you "capture" the CO2 molecules from exhaust?

Currently, one of the most economic forms of carbon capture is called "amine-based" capture.

An "amine" is a special liquid chemical which selectively grabs on to CO2 molecules.

To get the amine to grab on to the CO2, the amine is put into the top of a large column, while the exhaust is put into the bottom of the column.

The exhaust bubbles up through the column, and the amine drips down.

The liquid amine and gas exhaust mix in the column.

Azar just released a delusional, alternative history of Covid testing in the US. I’m mad because our testing failures allowed this outbreak to blow-up. We can’t fix our system if we ignore where it is broken. I suspect @PublicHealth agrees.

My fact-check on remarks @HHSGov 🧵

“It is indisputable that the United States has built the most extensive testing system and strategy of any major country,” says Azar.

False. Several countries have had percent positivity ~1% whereas US has never been below 5% and is >10% today. Refs KCDC & USA @JohnsHopkins

"The federal government got out of the way of test development in safe and sensible ways,” says Azar.

False. In Feb, CDC & FDA blocked labs from testing as the disease spread exponentially. I broke this story👇🏼& wrote more like it as the year wore on.

Azar defends questions about why the CDC refused an early German test vetted & distributed by WHO, by saying it was ‘unapproved’ & beneath us.

False. Top US researchers in my stories vetted several tests as early as Feb,& found that the one recommended by WHO was ideal.

Azar refuses to concede that other countries handled Covid better. He attributes Koreas success to less travel, invasiveness & private sector.

False. Korea's gov't marshaled the private sector & tracing success was largely from hiring tons of tracers.

Wonder why your Ph.D./Master's application is being rejected?

Here are some insider reasons (from a committee member) that result in such "Love Letters" 👇

- A Short Thread

1) First, you should know that sometimes, an independent reviewer is required (especially in the US) to review applications even after PIs must have selected their candidates. So, even if any bias slips through the PI, the independent reviewer will pick it up.

2) Having said this, there are three major issues that application reviewers/committees often find with your application. These three components make your applications almost challenging to assess.

3) NUMBER ONE - Incomplete Applications

This occurs when you do not upload the requested documents needed to evaluate your file. Think of a candidate that did not send a GRE score when the institution clearly requires it for admission.

4) NUMBER TWO - Error laden Essays

This is particularly interesting because based on reports from this resource person, it is not particularly about how little your experience is but how you communicate it error-free or at least extensively minimized. This gives headache!