BC SCIENCE
Saved by @jacobhtml

I think I've permanently confused KiCAD
it's reminding me that I need to connect this capacitor to Nothing

 attach this end to ground, this end to +5v, and this end to THE VOID
I accidentally made all the capacitors gigantic and they won't fit anymore

halp
gonna design an ISA card using some of these

it's gonna be tricky to fit in the case
that's from this video:
https://t.co/FyMofzOFEX
those kicad motherfuckers
they have an ISA footprint but it doesn't show up when you search for "ISA" because they called it BUS_AT despite it being clearly called "ISA" since THE LATE 80s
and even worse, it's actually the AT bus

The full AT bus, the 16bit extension to the 8bit PC/XT bus!
but surely they included the PC/XT bus as well, since it's just a minor variation of the AT bus, right? You'd just need to make the same design but slightly smaller?
1. no, because
2. fuck you
gotta do it myself like some kind of caveman
ok, finally I can update the ratsnest and fix my board and OH GOD WHAT HAPPENED
apparently I have now fixed the issue of connecting to the void at the expense of every single item on the board deciding to roll scatter dice
I thought I'd quickly google "what size are ISA mounting bracket holes?" and it quickly led me to JOGGLE TABS by GOMPF BRACKETS and I think I wandered into the part of the internet that's generated by markov chains
FUCKING SHIP IT
hang on I'm doing an update of all my symbols & footprints & 3d models.
this will fix and/or cause all my problems
does all software have to constantly gaslight me?
look at this.
it's the wrong 3D library, as that's just the footprint not the socket. I don't even know if here's a socket, so I'd like to look.
See the 3D model path? it's in Package_LCC.3dshapes
so I hit BROWSE and scroll to package_...

there's no LCC
there's no LCC and yet it apparently is working?
even though it doesn't exist?
HOW? WHY?
(my guess is that either it's being cached and doesn't exist anymore (or has been moved), or it's aliased from somewhere else, or autogenerated from the footprint, or any number of things)
but the end user experience is that it makes you think you're going fucking insane
amusingly if I google for "PLCC-68_THT-Socket.wrl" there's two results:
1. the source for kicad which points at this non-existent file
2. @TubeTimeUS's PlaidBib project which points at "Housings_LCC.3dshapes/PLCC-68_THT-Socket.wrl", which is a slightly different path!
which also doesn't exist.
so I'm guessing the answer is that there is no WRL file for this part and this is just a placeholder for in case anyone ever makes one, and it's instead just getting autogenerated from the footprint
computers are one of those fun subjects where the more you learn about them, the more you hate them
oh no

updating the libraries brought back the void
https://t.co/Sunhq9SZuH
FINE
YOU WANT ME TO CONNECT TO THE VOID?
I'LL DO IT. BUT I'LL DO IT RIGHT.
THERE.
We've got out power connectors.
5 volts
ground
and the fucking VOID
pins 11, 10, 9, and 7?

connect them to the void.
mmm, tasty.
https://t.co/6pHY6xZkCZ
fun fact: I couldn't remember how I'd phrased that one and searching "the void" didn't find it, so I had to google "the void drinks machine" and it found a couple reddit posts that screenshotted the tweet and cropped off my name, so I then could search for "diet coke" and find it
less fun fact: that shitpost is probably the most popular thing I ever ever done, and it's all because of people reposting the screenshot without credit!
I seriously only opened up this PCB editor so I could do a shitpost followup to something I said last night and now it's 2 hours later and I'm mostly done setting up a 4-drive floppy controller
why
people like to complain about ADHD keeping you from getting anything done, or only letting you concentrate on "pointless" things like games and TV shows, and that's definitely a big part of it
but the other side is that sometimes you CAN CONCENTRATE and you can do it VERY WELL and FOR A LONG TIME but you have zero ability to control what you're concentrating on
I wanted to wake up and make a quick joke on twitter and then go get some coffee and start the day and NOPE
TWO HOURS LATER I'M DESIGNING A FLOPPY DISK CONTROLLER
JLCPCB here I come
OK I know that one won't work. There's too many overlapping parts.

I fixed it now. This'll work.
I did this one manually but I have seriously considered writing a plugin for kicad that goes through every part and picks a random orientation out of 360 degrees and applies it
and by "manually" I mean I clicked each part and adjusted the properties.
Obviously I let a computer generate the randomness, I'm not a barbarian.
this may be a tad hard to route, though
I'm pretty sure if I pointed an autorouter at this my computer would collapse into a black hole
especially since I have all these pads I need to connect to THE VOID
done routing the ground.
I decided not to use a ground plane fill. it's too easy.
I'm just gonna do point-to-point traces for all the ground points
I may need more than 2 layers
hey what if I just give every major component their own layer?
kicad only supports up to 32 layers, but that should be enough

More from foone

foone
foone
@Foone
love to see a youtube video that references a script that's linked in the comments and it's an obfuscated link to a one-click hoster.

THAT'S DEFINITELY STILL GONNA WORK IN FOUR YEARS

it does still work, but that's because it's only been 2 years.

also, wow, this is horrible.

the script is to generate random kanji/han characters and insert them into minecraft books.
but the video references there being two hotkeys to generate two distinct books, which seemed odd. so I thought I'd check.

it turns out by "random" they mean "pre-randomized and is hardcoded into the 45 kilobyte autohotkey scripot"


I mean, I get it. I don't want to write AutoHotKey scripts either. it's a horrible, horrible language.

BUT STILL
CULTURE
foone
foone
@Foone
An interesting set of games that I've been vaguely interested in since I was a kid, after seeing one at a friend's house and never being able to find it again, was the BATTLES IN A DISTANT DESERT/BATTLES ON DISTANT PLANETS series.


These are turn-based wargames for windows 3.x, sharing the same engine.
Battles in a Distant Desert is from 1992, and is based on the first Iraq war (Desert Storm)


and Battles on Distant Planets is from 1991, and takes place in SPACE!
I'm pretty sure this is the one I played as a kid.


They've got 3 options to play with:
* Player vs. Player
* Player vs. Computer
* Computer vs. Computer

So it's a 0-2 player game!


They also did a DOS strategy game called "STARDATE 2140.2: GALACTIC CONQUEST" in 1990, but it seems to be lost.
All the games share an experimental AI system based on neural networks.
FUN
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foone
foone
@Foone
Keybort

This one is a MicroWeb Touch-1 XT/AT. Kinda.


See if you look up that keyboard you find the Deskthority page on it, showing this.
It's clearly pretty similar, but there are some differences.


Also that one uses a PC/XT/AT DIN5 connector, and this one uses some kind of RJ connector.


This one isn't in the greatest of shape, but considering I got it from the Chuck Colby estate sale, it's surprising it isn't completely water-damaged.


It's got some minor rust damage inside, where the metal clips rubbed off on the PCB.
TECH
foone
foone
@Foone
maybe it's just leftover urges from being a toddler putting round pegs in square holes but every time I see a video card like this on ebay I want to buy it and also some RAM chips to fill it with


when I win the lottery I'm gonna buy all of these and a bunch of RAM chips, put them together, and then relist them right back onto ebay


I have a dream that one day all the super VGA cards on ebay will have full ram expansion sockets


that's a nice VLB video card you have there
be a real shame if someone were to UPGRADE ITS RAM


huh, I don't think I've ever seen RAM in that package
QFP DRAMs?
TECH
foone
foone
@Foone
gonna get in line for the vaccine because I've heard all these urban legends about tracking microchips

and I think I might be able to root it and install Doom

supposedly bill gates is involved, right?
so it's probably like a miniaturized 386 running ROM-DOS.

the doctor walks in, looks down at my charts, and sighs.
"well, the bad news is that you've got the virus. I'm sorry..."
"and the good news?"
"well..."
*at doom's gate starts faintly playing from my

it took them four tries to figure out that I had the virus, because every time they did a nasal sample, the diagnosis machine kept glitching and playing a youtube video

I laugh in the hospital bed while they're like "ma'am sir ma'am sir, please, this is serious: we can't treat you. Our ventilator keeps trying to reboot in to Windows 3.1 and play skifree. we're quarantining you here so you don't spread this DIGITAL VIRUS to other patients"
SOCIETY

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Billy Bostickson \U0001f3f4\U0001f441&\U0001f441 \U0001f193
Billy Bostickson 🏴👁&👁 ...
@BillyBostickson
Let Uncle Ralph educate you
Synthetic Viral Genomics:
Risks and Benefits for Science and Society

"Alternatively, “No See’m” sites can be used to insert foreign genes into viral, eukaryotic, or microbial genome or vector, simultaneously removing all evidence of the restriction sites that were used in the recombinant DNA manipulation"

By orientating the restriction sites as “No See’m”, the sites are removed during reassembly, leaving only the desired mutation in the final DNA product.

The dual properties of strand specificity & a variable end overhang that can be tailored to match any sequence allow for Esp3I sites to be engineered as “universal connectors” that can be joined with any other four nucleotide restriction site overhangs (e.g. EcoRI, PstX1, BamH1)

Seamless assembly (also called No See’m Sites (85)) cascades have been used to assemble full length cDNAs of the coronaviruses mouse hepatitis virus, transmissible gastroenteritis virus, infectious bronchitis virus and SARS-CoV (Refs: 85,86,87)
SCIENCE , ALL
Lior Pachter
Lior Pachter
@lpachter
"The new answer to a 77-year-old problem"

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Smit Patel
Smit Patel
@snazzysmit
Super excited to share my very first lead-author paper in @ScienceAdvances

Supported by @HIRN_CC @NIDDKgov @UFBME @UFWertheim @ufdiabetes @UMCoEDean
Lead by @Cherie_Stabler & @ashu83

link: https://t.co/FbqVWQ0n5p

This is a thread 👇

Highlights:
⚪️A Lab-on-a-Chip platform for organoids w/ wide capabilities: long-term culture | controlled & dynamic perifusion | in situ spatio-temporal imaging | serial cell assessment | ease of sample retrieval


⚪️Continuous fluidic flow increased local oxygen supply to islets in hydrogels & reduced cellular hypoxia
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⚪️Glucolipotoxicity study showed a treatment window as small as 2.5 hours can elevate cell death

What are organoids? – A miniaturized version of an organ that imitate an aspect of human interface. They are commonly developed from stem cells in a lab. Human body also produces organoids naturally particularly within the pancreas.
SCIENCE
Dr Mark D. Scherz
Dr Mark D. Scherz
@MarkScherz
It's another stunning Malagasy #dartfrog/#poisonfrog for today's #FrogOfTheDay, #42 Mantella cowani Boulenger, 1882! A highly threatened, actively conserved and managed frog from the highlands of central #Madagascar
#MadagascarFrogs
📸D.Edmonds/CalPhotos


This thread will cover only a tiny fraction of the work on Mantella cowanii because, being so charismatic and threatened, it has received quite a bit of attention.
#MadagascarFrogs

We start at the very beginning: the first specimens, two females, were collected by Reverend Deans Cowan in East Betsileo, Madagascar, and sent to London, where George Albert Boulenger described the species in 1882.
#MadagascarFrogs


Boulenger placed the species in his new genus, Mantella, along with ebenaui, betsileo, and madagascariensis. He recognised that the other Malagasy poison frogs were distinct from the Dendrobates of the Americas, although he did keep them in the Dendrobatidae.
#MadagascarFrogs

As more specimens were collected, it became clear that the species was highly variable. In 1978, Jean Guibé wrote with interest about this variability, describing a new subspecies, M. cowani nigricans—today a full species. #MadagascarFrogs
https://t.co/dwaHMbrYbj
SCIENCE
Dr. Angela Rasmussen
Dr. Angela Rasmussen
@angie_rasmussen
Hard agree. And if this is useful, let me share something that often gets omitted (not by @kakape).

Variants always emerge, & are not good or bad, but expected. The challenge is figuring out which variants are bad, and that can't be done with sequence alone.


You can't just look at a sequence and say, "Aha! A mutation in spike. This must be more transmissible or can evade antibody neutralization." Sure, we can use computational models to try and predict the functional consequence of a given mutation, but models are often wrong.

The virus acquires mutations randomly every time it replicates. Many mutations don't change the virus at all. Others may change it in a way that have no consequences for human transmission or disease. But you can't tell just looking at sequence alone.

In order to determine the functional impact of a mutation, you need to actually do experiments. You can look at some effects in cell culture, but to address questions relating to transmission or disease, you have to use animal models.

The reason people were concerned initially about B.1.1.7 is because of epidemiological evidence showing that it rapidly became dominant in one area. More rapidly that could be explained unless it had some kind of advantage that allowed it to outcompete other circulating variants.
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🧵EMA + VWAP STRATEGY

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Here's the strategy that I utilize on nearly 80% of my trades.

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What are Exponential Moving Averages?

EMA's are a type of moving average that places a greater weight on more recent data points.

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EMA's adjust with respect to chart time frame.

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STORY OF PURANAS AND SUB PURANA (उप पुराण).

We have already gone through the series on importance & characteristics of all the eighteen Purans. We also know that originally there were hundred crore shlokas but were divided by Vyas in each Kalp and was compiled as eighteen Purans


for the common people to understand it properly and now their total is about four lakhs.

In Brahm Puran, Brahma preached this to Marichi. So this Puran of ten thousand shlokas is called Brahm Puran.

In Padma Puran, the base of the story is the appearance of Brahma on a lotus(Padm) from Vishnu' s navel.This has fifty five thousand shlokas.

Vishnu Puran is primarily based in Varah kalp. This book is on Vishnu and this book has twenty three thousand shlokas.

Vaayu Puran is written in Shwet Kalp and has twenty four thousand shlokas. Here Vayudev preaches about Dharma.

In Bhagwat Puran, which is written with the base of Gayatri mantra describes Dharma extensively. It has 18000 shlokas. It also mentions the story of Vritrasur.

In Narad Puran, which has twenty five thousand shlokas, is a sermon on Dharma by Narad based in Brihad Kalp.

Markandeya Puran has nine thousand shlokas and here it is through the birds that Dharma is described.
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James Felton
@JimMFelton
Butt plugs were originally sold as a miracle cure for headaches, acne, and insanity

Thread, article here and h/t: @qikipedia :
https://t.co/Ts84xnmWKJ


For a long time, medicine was pre-occupied with the question "can this be solved by putting something in the butt?"

Take, for example, tobacco smoke enemas, in which 18th Century physicians saw drowning victims and attempted to de-deadify them by blowing tobacco smoke up their rectums with a pipe.


Despite having no medical benefit whatsoever, the practice was popular, and enema kits lined the Thames like lifebelts, ready to be used as one final humiliation for somebody who was crap at swimming.

This practice ended sometime after 1800 when it became apparent that it didn't really work, given how the anus famously isn't really connected to the lungs, but doctors weren't quite finished with having a poke around in the old anus to see what happens just yet.
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Pieter Levels ✨
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Joe Rogan's podcast is now is listened to 1.5+ billion times per year at around $50-100M/year revenue.

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