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It's another stunning Malagasy #dartfrog/#poisonfrog for today's #FrogOfTheDay, #42 Mantella cowani Boulenger, 1882! A highly threatened, actively conserved and managed frog from the highlands of central #Madagascar
#MadagascarFrogs
📸D.Edmonds/CalPhotos

 This thread will cover only a tiny fraction of the work on Mantella cowanii because, being so charismatic and threatened, it has received quite a bit of attention.
#MadagascarFrogs
We start at the very beginning: the first specimens, two females, were collected by Reverend Deans Cowan in East Betsileo, Madagascar, and sent to London, where George Albert Boulenger described the species in 1882.
#MadagascarFrogs
Boulenger placed the species in his new genus, Mantella, along with ebenaui, betsileo, and madagascariensis. He recognised that the other Malagasy poison frogs were distinct from the Dendrobates of the Americas, although he did keep them in the Dendrobatidae.
#MadagascarFrogs
As more specimens were collected, it became clear that the species was highly variable. In 1978, Jean Guibé wrote with interest about this variability, describing a new subspecies, M. cowani nigricans—today a full species. #MadagascarFrogs
https://t.co/dwaHMbrYbj
Although Guibé was wrong about the affinities of those two species, it is true that there is astounding variability of colour in this (and other) Mantella species, and that they evidently hybridise with other species.
#MadagascarFrogs
📸B.Freiermuth/CalPhotos
Little was known about Mantella cowanii in the wild until the 1990s. By 1999, when Miguel Vences et al. published a revision of Mantella, it was known from a few different locations, but populations between it and M. baroni posed challenges to identification.
#MadagascarFrogs
These frogs occur in bizarre habitat in central Madagascar, often with wet, exposed rocks interspersed with low bushes.
📸Mantella cowanii Action Plan, 2021–2025 (on which more below)
The first (?) DNA-based phylogeny came out in 2002, confirming close affinity with M. baroni and M. nigricans, and showing that Malagasy poison frogs may have Müllerian mimicry generating repeated colour pattern evolution. https://t.co/4qqzbiiAev
#MadagascarFrogs
The hybridisation of M. cowanii with M. baroni received a lot of interest, in part because the species are generally morphologically and ecologically distinct.
https://t.co/VMFGZ7tP0Y
https://t.co/9uFZ7KBRzZ
International interest has always been strong in the beautiful #Mantella #frogs, so M. cowanii were targeted for the pet trade. Between 1988 and 2003, some 12,877 individuals were reportedly exported from Madagascar.
https://t.co/gJXip5xMTv
#MadagascarFrogs
In 2005, @CITES imposed a zero quota on M. cowanii, effectively banning export. For a species known from only a few locations in threatened habitat, and low fecundity (Tessa et al., see link), harvesting at these rates was unsustainable.
#MadagascarFrogs
https://t.co/SAON3F2VqF
Until 2014, Mantella cowanii was listed as Critically Endangered, but it was then downgraded to Endangered. Apparently the population declines seen until 2003 were halted by the cessation of trade. https://t.co/2rS29qFNQT
#MadagascarFrogs
Nevertheless, Mantella cowanii is heavily threatened. Representatives of @ASG_IUCN @Voakajy @amphibiansorg @chesterzoo and other organisations are actively involved in its conservation. A new action plan for 2021–2025 was just released.
#MadagascarFrogs
https://t.co/ozm89CMSSR
As I understand it, captive populations of Mantella cowanii are being maintained. So, if extirpated, it might be possible to reintroduce this frog, as long as habitat remains available. So there is hope for the 'harlequin' mantella!
#MadagascarFrogs

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https://t.co/xvP6tVlIaE
Quite a surprise. Ferguson isn’t qualified to comment on such things. He lacks understanding of basic biological concepts, partly explaining why his predictions are often so extreme.


That said, I’ll take him as an ally. It’s clear we’re already at herd immunity. How can I be sure? London had a huge peak of excess deaths in spring. The timing of peak deaths showed clearly that the pandemic was self-limiting. Recall much debate about whether the interval...

...between lockdown & peak deaths was long enough for lockdown to have been the cause of reducing deaths? The answer was “no”. But it was close & I can understand people thinking “well, it’s close, so perhaps it was lockdown that did it?”, thereby establishing a foundational...

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Corey Lynn 🙏🇺🇸...
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3) It reminded me of taking off in an airplane a bit. I felt like I was in a vacuum. It went on and off for a couple of days. I’ve picked up on frequencies and high pitched sounds (not audible to most) for 30 years, and today my right ear began to ring for longer than usual.

4) This is nothing unusual for me, with exception of the duration. This happens often with me. No, it’s not tinnitus. Only this time, when I spoke, there was reverb creating a high pitch in my ear from my voice. This lasted for about 30 minutes. It did not hurt, just annoying.

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Asbj\xf8rn St\xf8ylen
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@strain_rate
1/ #LBBB generates often a classical pattern on #EchoFirst. The pattern is very distinctive in Tissue Doppler of the septum.


The classical pattern arises from the time lapse of the activation and relaxation of the two walls, creating a pattern of interaction due to a sequence temporal imbalances of the tension between the two walls.


2/ As the septum is activated first, it contracts (shortening - septal flash) without activation of the lateral wall, which stretches. This generates slower pressure build up than a normal IVC, which then is prolonged.


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Amy Maxmen, PhD
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@amymaxmen
Azar just released a delusional, alternative history of Covid testing in the US. I’m mad because our testing failures allowed this outbreak to blow-up. We can’t fix our system if we ignore where it is broken. I suspect @PublicHealth agrees.

My fact-check on remarks @HHSGov 🧵

“It is indisputable that the United States has built the most extensive testing system and strategy of any major country,” says Azar.

False. Several countries have had percent positivity ~1% whereas US has never been below 5% and is >10% today. Refs KCDC & USA @JohnsHopkins


"The federal government got out of the way of test development in safe and sensible ways,” says Azar.

False. In Feb, CDC & FDA blocked labs from testing as the disease spread exponentially. I broke this story👇🏼& wrote more like it as the year wore on.

Azar defends questions about why the CDC refused an early German test vetted & distributed by WHO, by saying it was ‘unapproved’ & beneath us.

False. Top US researchers in my stories vetted several tests as early as Feb,& found that the one recommended by WHO was ideal.


Azar refuses to concede that other countries handled Covid better. He attributes Koreas success to less travel, invasiveness & private sector.

False. Korea's gov't marshaled the private sector & tracing success was largely from hiring tons of tracers.
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Daoyu
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https://t.co/hXlo8qgkD0
Look like that they got a classical case of PCR Cross-Contamination.
They had 2 fabricated samples (SRX9714436 and SRX9714921) on the same PCR run. Alongside with Lung07. They did not perform metagenomic sequencing on the “feces” and they did not get


A positive oral or anal swab from anywhere in their sampling. Feces came from anus and if these were positive the anal swabs must also be positive. Clearly it got there after the NA have been extracted and were from the very low-level degraded RNA which were mutagenized from

The Taq. https://t.co/yKXCgiT29w to see SRX9714921 and SRX9714436.
Human+Mouse in the positive SRA, human in both of them. Seeing human+mouse in identical proportions across 3 different sequencers (PRJNA573298, A22, SEX9714436) are pretty straight indication that the originals

Were already contaminated with Human and mouse from the very beginning, and that this contamination is due to dishonesty in the sample handling process which prescribe a spiking of samples in ACE2-HEK293T/A549, VERO E6 and Human lung xenograft mouse.

The “lineages” they claimed to have found aren’t mutational lineages at all—all the mutations they see on these sequences were unique to that specific sequence, and are the result of RNA degradation and from the Taq polymerase errors accumulated from the nested PCR process
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BANASHANKARI AMMA, NEAR BADAMI (KAR)
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