Reason for high repeatability for songs is due to connection with old memories !

Clinical Trial Process | A Thread🧵

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We have discussed the drug discovery process in a previous 🧵. In this 🧵 we will attempt to shed some light on the clinical trials process to enhance our understanding of the drug discovery process

Topics Covered :
1. What are clinical trials
2. Why are they conducted
3. Phase 0 Trials
4. Phase 1 Trials
5. Types of studies in Phase 1
6. Phase 2 Trials
7. Phase 3 Trials
8. Filing of NDA
9. Phase 4 Trials
10. Success rates

1. What are clinical trials ?
A type of research study that tests how well new medical approaches work in people. These studies test new methods of screening, prevention, diagnosis, or treatment of a disease. Before doing a clinical trial, investigators conduct preclinical

research using human cell cultures or animal models. For example, they might test whether a new medication is toxic to a small sample of human cells in a laboratory.

2. Why are they conducted ?
Clinical trials are conducted to evaluate if a drug is safe for consumption by

human beings and if it is actually effective in curing or preventing a medical condition or disease. Keep in mind, this will be the first time that the drug will be tested on human beings.

3. Phase 0 trials
Phase 0 trials are also known as human micro-dosing study.

#MTAR Technologies - Leader in Niche Precision Engineering 🛩️🛩️

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CMP - ₹ 1803

1. Company Overview

MTAR Technologies is a leader in the precision engineering industry. They serve clients in the Defence, Space, Nuclear and Clean Energy industries. The company is engaged in the manufacture of

mission-critical precision assemblies and components with close tolerance levels of 5-10 microns.

2. Business Segments

The company operates in 4 segments: Nuclear, Defence, Space and Clean Energy.

Nuclear: In the Nuclear Segment, the company is partnered with Nuclear

Power Corporation of India Limited (NPCIL) which controls all operational, under construction and planned reactors in the country given India does not allow private participation. They manufacture products which are highly critical to the functioning of nuclear reactors.

They have 14 kinds of products with a wide range of applications.

Defence: In this segment, the company has undertaken complex assemblies for the DRDO, such as the base shroud assembly for Agni missiles and the assembly of Secondary Injection Thrust Vector Control (SITVC)

#Neogen Chemicals - Niche Bromine & Lithium Manufacturer ?

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CMP - ₹1596

1. Introduction

Neogen chemicals ltd. was founded in 1991 by technocrat Harish Kanani.The company has expertise in bromine and lithium chemistries.
The products manufactured are served for pharmaceuticals, agrochemicals, engineering industries,

speciality chemicals companies in India, Europe, Usa, and Japan.
Increasing the revenue contribution from Custom Synthesis and Contract Manufacturing segments.

2. Promoters
IIT graduate and technocrat promoter Mr Haridas Kanani had set up India's first bromine plant in 1968, but it failed as the plant was hit by floods caused by Morbi dam. Lack of knowledge in business kept him away from insuring the plants.

Later years he worked as an engineering consultant for manufacturers to set up the bromine plants for others.
In 1989 the technocrat decided to set up Neogen chemicals Pvt. Ltd. and started the manufacturing of bromine compounds.

#IGX (Indian Gas Exchange) Revenue Calculation

Watch this video to understand #IEX(Indian Energy Exchange) Business model
Link : https://t.co/rqll7Ct9Cn

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Boxerman
----------
(Sung to the tune of Wellerman)

[A Musical Thread]

🎵
There once was a plan for an AFV
The name of the plan was the MIV
There’s more to the tail than you may know
Brew that bivvie boys, brew
🎵

(Hurr! 💪)

🎶
Soon may the Boxerman come
To bring us armour and tea and gun
One day, when the fightin’ is done
We’ll take our wheels and go
🎶

🎵
They must deploy two kay from shore
Fit two to a Herc or maybe more
We envied all that Soviet Cav
And soon was born MRAV
🎵

"Music, Sense and Nonsense: Collected Essays and Lectures", por Alfred Brendel.

Capítulo: “Conversations - On Schnabel and Interpretation with Konrad

En esta conversación de 1979, Alfred Brendel y Konrad Wolff, autor de “The Teaching of Artur Schnabel. A Guide to Interpretation”, discuten sobre ciertos puntos en los que Brendel no coincide con Schnabel.

Para Wolff, Brendel es el primer pianista desde Schnabel que ha gozado de plena autoridad en la interpretación de Mozart, Beethoven y Schubert. Además, en su opinión, su enfoque tiene mucho en común con el de Schnabel en los detalles de fraseo, tempo y dinámicas.

Sin embargo, hay varias opiniones en las que Brendel difiere de Schnabel. Para Brendel, las frases son como curvas que no necesariamente se miden por compases: “Very often for me the art of phrasing consists in forgetting about bars, ignoring bars and seeing large units”.

Por su parte, de acuerdo a Wolff, Schnabel veía las frases en función de la respiración y del énfasis al principio o al final: “he wanted to know how far he was to play before there was a breath (…), a phrase begins and then goes from there, or else it ends and goes to there”.

One of all time favourite motivational song & I listen to it almost daily😊

Underrated song but a true nasterpiece with amazing lyrics & music👌🏻

https://t.co/Omhz4gyJqI

Let me know if you had heard this song before & how did you find it!

#music #inspiring

"Music, Sense and Nonsense: Collected Essays and Lectures", por Alfred Brendel.

Capítulo: “Conversations - Bach and the Piano with Terry

En 1976 Terry Snow entrevistó a Alfred Brendel sobre sus puntos de vista acerca de la obra de Bach para teclado, la cual hasta ese entonces Brendel había evitado ejecutar en sus conciertos.

Brendel cambió de opinión en esa época. Al haber sido alumno de Edwin Fischer, quien transmitía la música de Bach de una manera única y con poderosa autoridad, le tomó tiempo considerar que estaba listo para abordar a Bach en sus propios

En un principio, Brendel no se sentía muy convencido por las ejecuciones “históricas”. Sin embargo, para él la obra de Bach es menos dependiente de los instrumentos contemporáneos que la de Monteverdi, Domenico Scarlatti, Purcell, Rameau y Couperin.

Entre las ventajas de interpretar las obras para teclado de Bach en piano, Brendel considera el hecho de que este es más adecuado para las salas de concierto modernas. Además, para Brendel dichas obras están llenas de posibilidades