It's a very different perspective when we realize that our bodies consist of an entire ecology of bacteria and viruses that are also passed to our ancestors. Mammals rear their young and as a consequence transfer the microbiome and virome to their offspring.

My attempt to map the research *doctrines* of various groups working on Artificial General Intelligence.

Although one might see names of individuals here as well as organizations, take it just as identification of the organization behind the person and a very narrow slice of their overall research portfolio.

Here is a @swardley map that captures the relationship of doctrine with other individual and organizational processes.

We can capture a party's doctrine by either an explicitly stated agenda or an aggregation of the kind of approach that is pursued. A doctrine is an invariant property of the overall behavior of a party.

In this map one can see the conflict between different parties (compare @garymarcus with the deep learning folks).

Chess may be a good analogy for explaining the difference between a descriptive model of reality and a generative model of reality.

A descriptive model of chess will describe the rules (i.e. initial setup, allowed moves, points per piece, objectives). This tells you how a chessboard might evolve and also narrows the combinations of realistic chess positions.

In contrast, a generative model involves the actual gameplay between competing players that follow the rules. It generates new styles and patterns. It establishes new strategies and tactics. It generates new openings, middle gameplay, and end game tactics.

A generative model is an evolutionary model that leads to emergent behavior. As a consequence, a master of chess is able to recall the layout of chess positions in a real game in an instant, yet is unable to remember pieces placed in random positions.

That is because causality is present in the movements of pieces in a chessboard. An intuitive system like the human mind is able to capture that causality as a means to understanding and recall.

A children's book written in 1954 inspired by Wiener's Cybernetics that explains some common day analog systems:

Analog computation originally meant the construction of a simulation of another system by means of a mechanical or electrical system that represented the same dynamics as the physical system. That is an analog of what's being simulated.

Nobert Wiener generalized this idea in Cybernetics to describe control systems that through negative feedback promoted stability.

W.Ross Ashby argued that negative feedback was insufficient for maintaining the stability (homeostasis) of complex system. Ashby proposed the Law of Requisite Variety.

These machines that 'seem to think' are examples of what was known as analog computation. Cybernetics, control theory, biology are examples of analog computation. But what does this mean other than being the opposite of discrete/digital computation?

Ankle joint is undertrained in a single joint means in both the frontal plane & in dorsiflexion 2 prevent lateral ankle sprains and shin splints. Single joint exercises allows you to evaluate the joint actions ROM & strength to understand injury risk & where development is needed

AJ Abduction (Cutting)

1. I pull the foot in2 dorsiflexion 2 stabilize the joint

2. I pull against the increasing tension of the band in2 abduction w/o losing dorsiflexion & also w/o externally rotating the thigh.

3. On the negative resist the bands pull eccentrically.

AJ Adduction (Cutting)

1. I pull the foot into dorsiflexion and I pull the foot into adduction against the tension of the band w/o medial rotation of the thigh.

2. I resist the negative movement of the band pulling the ankle into abduction eccentrically.

1/23 We haven't had a lot to celebrate during this pandemic. But achieving the milestone of offering vaccine to the over 70s, health and care workers and the most clinically vulnerable just before target date is a huge cause for celebration, given the scale of the achievement.

2/23 When Margaret Keenan got her first jab in Coventry on December 8th last year, who’d have thought that, by Valentine’s Day, we’d have vaccinated over fourteen million people across the UK in just ten short weeks? Amazing, extraordinary and truly, really, world class!

3/23 I’ve been struck by how much joy and relief has been brought to those doing the vaccinations and those receiving them. A GP told me yesterday that nothing had given him greater pleasure in his long career. And that the patient's relief was sometimes overwhelming.

4/23 It's vital to recognise the extraordinary contribution of the staff and volunteers who have made this happen. One of my close family had their jab yesterday and was in awe of the volunteer standing outside in the freezing cold for a four hour shift meeting and greeting.

5/23 What I wanted to share in this thread was the slightly untold story of some of the extraordinary challenges the NHS has had to overcome to deliver this target. Requiring superhuman effort from NHS leaders and staff, way beyond the call of duty. Five challenges set out below.

The #RELAx trial has been published today in @JAMA. It was coordinated by Anna Algera. This thread is to explain the rationale, what we did, the findings and the meaning.
The rationale of #RELAx is based on the following

First, there is NO adequate evidence on the level of PEEP in non-ARDS patients. Most of the studies are old, conducted in post-surgical patients (short-term ventilation), and were not powered to detect differences in patient-centered

Second, despite the absence of evidence, the levels of PEEP used in non-ARDS patients increased over years, from 5 to 7/8 cmH2O, probably as a reflection of studies and practice in ARDS

Third, one IPDM showed that higher levels of PEEP could benefit more severe ARDS patients. However, opposite trends (higher mortality and longer ventilation) were found in mild ARDS with higher PEEP (despite not powered to be statistically

Fourth, most of the weaning protocols include PEEP ≤ 5 cmH2O as a criterion for readiness to wean. Theoretically, a standardized liberal strategy of higher PEEP could delay weaning in some

🧵 on Importance of correct indication of colonoscopic surveillance studies (English 🇺🇸🇬🇧)
@KM_Pawlak @KMonkemuller @drkeithsiau @JacquelineChuMD @PerelmansPearls @stevenbollipo @SWexner @DrBloodandGuts @ebtapper @DCharabaty @RashidLui @AdvaniRashmiMD @AtoosaRabiee @DrMohdZein

@GI_Guy @RodriguezParra_ @DrHarryThomas @TennysonMD @AustinChiangMD @KralJan @thomaskroner @alinkmd #GITwitter

1/ The implementation of screening and surveillance programs can reduce the incidence and mortality of

2 / But for these to be effective and to guarantee protection against CCR, they must meet a series of conditions. One of them is the correct indication for endoscopic studies for both screening and surveillance.

3 / According to a recent meta-analysis, the minority of patients who undergo colonoscopies have a correct indication, with less than 50% adherence to the surveillance intervals proposed by scientific

Folks, we need to talk about this Vitamin D trial. I have no stake in this game - take Vitamin D if you want but this pre-print is super sus.

The paper is presented as a randomized trial of vitamin D supplementation in hospitalized patients with COVID. Interesting and important question! And the results appear dramatic:

If true, this would be one of (if not THE most) effective treatments for COVID. But there are problems...

The first clue something is up is that the randomized groups aren't the same size:

It took me a while to figure out why this was, then I saw in the text that INDIVIDUALS were not randomized, WARDS in the hospital were.