It's a very different perspective when we realize that our bodies consist of an entire ecology of bacteria and viruses that are also passed to our ancestors. Mammals rear their young and as a consequence transfer the microbiome and virome to their offspring.

Interesting to realize that the living things that lay the foundation of the biosphere are extremely robust as compared to the humans that are destroying the biosphere.

Seed can remain dry and dormant for ages only to reborn when provided the proper nutrients. In contrast, most animals require a continual living vessel to reconstruct itself from its DNA.

Evolution appears to constantly perform tradeoffs between robust organisms and organisms that are adaptable. Co-evolution makes possible the development of complex species as a consequence of robust organisms.

We exist as a consequence of the multitude of less complex individuals that make up our biosphere. We are in fact symbionts that are in constant cooperation with our microbiome. Absent our individual ecologies leads to death.

We are inseparable from our microbiome, we are inseparable from our societies, and we are inseparable from our biosphere. The biggest lie we are told is that as individuals, we are independent of our world.

AGI Significance Paradox: As progress accelerates towards AGI, the number of people who realize the significance of each new breakthrough decreases.

Why is it that you can boil a frog in water without it jumping out if you gradually increase the temperature?

The problem for the frog is that it does not have the internal models to realize that there is a change in the water temperature. A cold-blooded creature like the frog has its temperature regulated by the external environment.

To recognize change, an agent must have an internal model of reality that is able to recognize this change. Unfortunately, a majority of the population do not have good models of human general intelligence.

In fact, even the simplistic dual-process model of system 1 and system 2 is not very well known.

Genes are to Evolution, Memes are to Culture, Dicenes are to General Intelligences.

Open-ended generative processes like evolution and human culture have a thing that is replicated and propagated by the process. For evolution, these are known as genes. For culture, these are known as memes.

It became obvious to me that there isn't an equivalent for individual brains. Is there something that is equivalent to this in general intelligent systems or biological brains?

I have come up with a term that describes these. The word I've invented is 'dicene'. This word is inspired by C.S. Peirce's dicent sign or dicisign. It is the combination then of dicent and gene, and thus dicene.

But why dicene over so many other possibilities like schemes, themes, intuitions, patterns, schemas, embeddings, attention, habits, explanations, ideas, meanings, representations, concepts, analogies, and lekta?

The Nature versus Nurture is a debate about scientific doctrine. It is a debate about the correct way of explanation for cognition.

The Representation versus Non-Representation shares the same debate. It is also about the correct way of explanation for cognition.

It is also the difference between thinking in nouns versus thinking in verbs. Nature and Representation have deep roots in Western thinking. It is a functionalist and reductionist way of thinking that meets its limits when analyzing complex adaptive systems.

It is perhaps due to this Western bias that concepts from the study of complex systems have had little traction in modern society. It is of course, more than a Western bias, but a human bias to seek out simple causal explanations of this world.

But the world is complex and messy. Spiral dynamics which is an evolutionary model of individuals and society explains how models of the world shape ourselves and our civilization.

We wake up each day with the same attention budget as everyone else. This is the one thing all humans equally share.

Spending that attention budget by doing this is what gives meaning to our lives.

It's is only through doing that we learn. It is only through learning that we find meaning.

Yet many of us waste attention budget exclusively on consumption. Seeking the random dopamine hits that tickle our curiosity. Yet we seek only the convenient things to do.

Activities that are convenient, that takes little effort don't consume a lot of attention. But enough of these small distractions will. But unfortunately, there's little learning taking place.

@73inlancs @janethooton_ @ErinInTheMorn @fifi_EY 1/ The 🏴󠁧󠁢󠁥󠁮󠁧󠁿 government decided pediatric gender care in England would be a monopoly contract (a Labour minister, in 2008), despite all other NHS patients officially being entitled to a choice of providers, & second opinions on diagnoses & treatment, & gave it to GIDS, which has…

@janethooton_ @ErinInTheMorn @fifi_EY 2/…always advocated that trans minors & their families must have no alternative source of care, & subsequent Tory ministers have personally put their signature on renewals of it, and even personally rejected proposals for improvement that have been put forward by NHS England…

@janethooton_ @ErinInTheMorn @fifi_EY 3/…as a result of wider & public consultation. They & their civil servants listen only to GIDS on trans minors - it was GIDS advised against <18s being allowed #GenderRecognition in 2004, & since, on the basis that no one under 18 can be certain of their gender identity, just…

@janethooton_ @ErinInTheMorn @fifi_EY 4/…as many other staff at their trust wrote⬇️ to the press in 2002 (when the first instigator of this case, psychoanalyst Susan Evans was on staff too) that no trans people should be allowed that recognition but needed

@janethooton_ @ErinInTheMorn @fifi_EY 5/…to "cure" us instead. Yet GIDS proved incapable of defending its super-conservative protocol in court - no doubt because GIDS has always expected challenges to be from patients seeking care more like that elsewhere, arrogantly ignoring that services in countries where the…

ADHD, a thread (1)
If you have #ADHD & are struggling please know you’re not alone. This week on @Overview, we're talking about living w/ ADHD & Anxiety during the pandemic & many the stigmas & misconceptions that making things worse.

I was diagnosed w/ ADHD when I was 7. And in so many ways it’s been a blessing. I love my energy, the hyper-focus, the calm I feel in chaos, the ability to & feel emotions so intensely. It’s allowed me to to see the world differently be in a constant state of wonder.(2)

But realizing all that has been a long, difficult journey so figured I’d share some of my own struggles as well as the resources from @HowtoADHD because Jessica's channel has been a game-changer for me.(3)

First off, #ADHD Attention Deficit Hyperactivity Disorder is a dumb description. It implies a deficit in attention & always hyper people. ADHD is a spectrum, & what we all have in common isn’t that we can’t pay attention. It’s that we have trouble controlling our attention.(4)

There are amazing analogies out there, like trying to watch 6 TV’s at once when someone else controls the remote. Or like driving a race car on city streets and spinning out whenever you try to turn.

it seems to me that not many know that navalny is an avowed nationalist & racist and not just a blonde guy who likes to gently kiss his blonde wife before going to jail and watches “rick & morty”. so here’s a little thread and some of it is pretty personal.

here is navalny’s 2007 video. “a tooth without a root is called “dead”. a nationalist is someone who doesn’t want the russian root to be removed from the word “russia”. we have the right to be russian in russia, and we will defend it.”

i downloaded it to make sure it won’t disappear but it is still shared by navalny’s official youtube channel. btw, in this video, navalny is introduced in the caption as a “certified nationalist”.

here is another video navalny is not keen to share anymore, in which he compares muslims to cockroaches and flies and recommends shooting them with guns if swatters and shoes

here is a 2011 interview with navalny where he explains why he goes to the so-called “russian march”, a yearly nationalist gathering, and why he thinks it’s ok to collaborate with

Here is a tweetorial from our latest publication in @Annals_Oncology about longitudinal tracking of esophageal adenocarcinoma. #OesophagealCancer #EsophagealCancer https://t.co/QWvrzBXmK7 1/8

We sequenced 245 plasma samples from 97 patients with oesophageal adenocarcinoma using a 77 gene pan-cancer ctDNA panel. 2/8

Variants derived from previously characterised driver oesophageal adenocarcinoma genes had a significantly higher VAF than variants from other genes, indicating selection. 3/8

Peripheral blood cell samples were also sequenced for 78/97 patients. CHIP mutations were identified in 23% of cases, longitudinal tracking of CHIP variants suggested these variants were dynamic over time. 4/8

We found patients that were ctDNA positive post-surgery had a significantly poorer survival than ctDNA negative patients, and the elimination of CHIP variants improved the positive predictive value. 5/8