Here is a tweetorial from our latest publication in @Annals_Oncology about longitudinal tracking of esophageal adenocarcinoma. #OesophagealCancer #EsophagealCancer https://t.co/QWvrzBXmK7 1/8
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Sarcomeres in cardiac myocytes (heart muscle cells) are mechanically coupled to focal adhesions through dorsal stress fiber-like structures. #cardiotwitter #CellBiology
1/13
A thread based on Figure 1
A mature adult cardiac myocyte is packed with sarcomeres, whose contractile forces are coupled to the extracellular environment. With sarcomeres so close to the plasma membrane, how can we study the nature of this coupling?
2/13
Short answer: find a model system where the sarcomeres are not so close to what the cardiac myocyte is attached to. Enter, iPS cell-derived cardiac myocytes. These are “immature” in culture as they resemble fetal or neonatal cardiac myocytes.
3/13
Our previous work on iPS cardiac myocytes reported that sarcomere containing myofibrils assembled on the top surface of the myocyte.
https://t.co/xIBCu3hG1W
4/13
The sarcomeres seemed to be connected to focal adhesions on the bottom of the cell by thin actin bundles that resembled the dorsal stress fibers (DSF) commonly found in non-muscle cells. This movie steps through a Z stack of a myocyte starting at the bottom of the cell.
5/13
1/13
A thread based on Figure 1
A mature adult cardiac myocyte is packed with sarcomeres, whose contractile forces are coupled to the extracellular environment. With sarcomeres so close to the plasma membrane, how can we study the nature of this coupling?
2/13
Short answer: find a model system where the sarcomeres are not so close to what the cardiac myocyte is attached to. Enter, iPS cell-derived cardiac myocytes. These are “immature” in culture as they resemble fetal or neonatal cardiac myocytes.
3/13
Our previous work on iPS cardiac myocytes reported that sarcomere containing myofibrils assembled on the top surface of the myocyte.
https://t.co/xIBCu3hG1W
4/13
The sarcomeres seemed to be connected to focal adhesions on the bottom of the cell by thin actin bundles that resembled the dorsal stress fibers (DSF) commonly found in non-muscle cells. This movie steps through a Z stack of a myocyte starting at the bottom of the cell.
5/13
This is the $1mln question still without an answer: why were these workers cleaning bat guano from that abandoned mine?
Surprisingly we simply don't know.
China would have all interest in clarifying that point if for instance they were prospecting or selling guano. It did not.
What we know is that EcoHealth + WIV were sampling bat sites in the vicinity at the exact time of the workers being in that mine.
#DRASTIC wrote about this and about other oddities in the official story:
Maybe it's just one of these coincidences.
Then it gets interesting: about a year after the miners death, Olival & Epstein from EcoHealth Alliance co-authored a paper about the coronavirus risk infection from bat guano collection.
No mention of the
That paper oddly used some old bat samples collected by DARPA in 2006/7 at the famous Thai bat cave.
It never mentioned that the Thai monks have been doing this every Sunday for many many years without infection.
But most interestingly it never mentioned the Mojiang mine accident, even if the perfect timing and recycling of old DARPA bat samples seem to point to a likely knowledge of it.
Anyway, the idea was to ask for more money, as you correctly
Surprisingly we simply don't know.
China would have all interest in clarifying that point if for instance they were prospecting or selling guano. It did not.
The miners were tasked with removing bat feces. AFAIK it hasn't been established why they were doing this. Given that EcoHealth was collecting bat fecal samples in the same province around the same time, is it possible these miners were actually collecting guano for EcoHealth?
— The Great Gumbino (@gumby4christ) February 15, 2021
What we know is that EcoHealth + WIV were sampling bat sites in the vicinity at the exact time of the workers being in that mine.
#DRASTIC wrote about this and about other oddities in the official story:
Maybe it's just one of these coincidences.
Then it gets interesting: about a year after the miners death, Olival & Epstein from EcoHealth Alliance co-authored a paper about the coronavirus risk infection from bat guano collection.
No mention of the
That paper oddly used some old bat samples collected by DARPA in 2006/7 at the famous Thai bat cave.
It never mentioned that the Thai monks have been doing this every Sunday for many many years without infection.
But most interestingly it never mentioned the Mojiang mine accident, even if the perfect timing and recycling of old DARPA bat samples seem to point to a likely knowledge of it.
Anyway, the idea was to ask for more money, as you correctly
