BC HEALTH
Saved by @Mollyycolllinss

I think @SamAdlerBell in his quest to be the contrarian on Fauci gets several things wrong here. 1/

 First, the failure last year actually was driven by the White House, the #Trump inner circle. Watch what's happening now, the US' scientific and public health infrastructure is creaking back to life. 2/
I think Sam underestimates the decimation of many of our health agencies over the past four years and the establishment of ideological control over them during the pandemic. 3/
I also am puzzled why Tony gets the blame for not speaking up, etc. Robert Redfield, Brett Giroir, Deb Birx, Jerome Adams, Alex Azar all could have done the same. 4/
Several of these people Bob Redfield, Brett Giroir, Alex Azar were led by craven ambition, Jerome Adams by cowardice, but I do think Deb Birx and Tony tried as institutionalists, insiders to make a difference. 5/
I wrote to them privately and spoke publicly about the need to do more, but Sam misunderstands how long-time civil servants operate. The entire CDC staff could have resigned in protest, other agencies could have had everyone fall on their swords in protest as well. 6/
This isn't to excuse their behavior. It's just to say expecting people who have devoted their careers to places like CDC or NIH to resign in protest, speak out and get fired, is unrealistic. 7/
Lots can be said about the institutional failures--outside of Trump's influence--that happened last year. The testing debacle, the failure to real screen for new compounds against SARSCOV2 instead of just putting everything in the vaccine basket...8/
We were slow on masks. Yes. I agree. But there were also shortages of supplies even for healthcare settings in March. Remember the bandanas and panty-shields being worn by some on the wards, recycling N-95s? There was some worry about run on PPE by general public. 9/
Not an excuse, but context. The statement on herd immunity that Tony made. Dumb. Yeah. I get it. 10/
And Trump's obsession with loyalty twisted some of them to the breaking point. Redfield collapsed almost reflexively at the beginning. Birx thought she could control the situation. Tony though he could thread the needle, keep silent mostly, try to squeeze in some facts. 11/
No one came out of last year looking good and even if Fauci got accolades from some, those in public health saw what was happening. Shit was flying everywhere, everyone got soiled. 12/
But the biggest problem about @SamAdlerBell piece is not that it's slightly obsessive on Fauci (and I won't even start on the ACT UP sections, since I was there for many of these events), but gets the politics wrong in a big way. How so? 13/
At the end of the article Sam suggests that Tony should have resigned to lead the resistance. I mean, please. And then a bureaucrat arose to lead us. Really? The director of NIAID was going to be at the barricades? 14/
The big political question was NOT where was Dr. Fauci last year, but where were WE? Why didn't those not in government service rise up when the stakes were so much lower for resistance for us? Why didn't all the major non-governmental institutions mobilize on the pandemic? 15/
Many of us in public health were writing furiously about the failures of what was happening, as were others, but no one was doing the mobilization work to tip the scales from op-eds to direct action. 16/
Yes, those in government service do have to answer for their silence last year, but so do we. I am not holding up Fauci as a hero, but flipping him into the anti-hero of the story doesn't work either. 17/
I just posted a report from Brazil, about how Bolsanaro's policies drove the pandemic in Brazil. A fish rots from the head down. Trump and his circle hold the vast majority of blame for 2020 and our predicament today. It's just true. 18/
Bolsanaro's health ministers resigned and he just got other ones. This was also Trump's MO for 4 years, anyone who left, got replaced with people increasingly more loyal. The late arrival of Scott Atlas is a case in point here. 19/
So as a political history this piece fails. That's my main point. I've said terrible things about Fauci in the past in the press during the height of the AIDS epidemic, trashed Obama on global health/HIV in the 2000s. "Heroes" shouldn't be immune from criticism. 20/
Would it have been great if one by one federal scientists got to the mic and denounced Trump in 2020? Yeah, sure. And I want to be 35 again. Not gonna happen. 21/
The most startling thing to me and which no one has written about yet is why the rest of us were frozen like deer-in-the-headlights? 400,000 dead and "the resistance" to it all from outside the Administration was mostly in strongly worded op-eds. 22/
The press played the both sides game early on--kept saying "experts disagree" when Trump's policies were patently insane. This is the @NYTimes political desk's lingering shame, which they will never admit. 23/
Members of Congress sat on their hands. Mayors, governors just tried to keep their own cities and states from going under, but many aided and abetted the President. 24/
But political advocacy organizations, non-governmental actors could have mobilized. We did for the Women's March, after the Parkland shootings, for the March for Science. Yeah. big in-person events were a no-no, still are, but big not-in-person-events didn't happen either. 25/
In the aftermath of all of this, this is what's worry. Tony will retire soon. Take him off the playing field. Now what? We have to rebuild public health, not because of its failures last year, but because it was in shambles before 2020. 26/
We made our beds long before Trump. No national healthcare, a weak social safety net, a desperately under-funded and under-resourced public health infrastructure coast to coast under Republicans and Democrats. 27/
If Tony had spoken out all these structural issues would remain and frankly, it's the structures that outlast us, pave the way for crises out years into the future. 28/
And what are we going to do about that? end/

More from Gregg Gonsalves

Gregg Gonsalves
Gregg Gonsalves
@gregggonsalves
Here @playbookplus goes again: ‘HOW MUCH IS BIPARTISANSHIP WORTH?’ I don't know @politico, how many more months would you like the pandemic to drag on for? How many more dead? How many more people, businesses ruined economically? I'm sorry but this is garbage framing in a crisis.

Oh but this is what powerful people are talking about in DC! Might that point itself be examined with more seriousness than taking this BS at face value? Don't you understand, we just reflect back what people are saying? We are mirrors on the world, we offer no commentary.

If "very serious people" are talking about what "nice number" would be $1.3T, 1.2T and not what we need to get out of this mess, might it be worth saying, perhaps, this conversation w/o reference to epidemiologic or economic reality is just a failure of leadership, governance?
ECONOMY
Gregg Gonsalves
Gregg Gonsalves
@gregggonsalves
One thing I will never understand. In 2020, we let ~340,000 Americans die, sometimes in the thousands per day. And we watched. There were no protests, no daily banner headlines befitting a national tragedy on this scale. It's as if we watched 9/11 in a loop for 300+ days. 1/

It was the non-chalance of all of it, the sangfroid. Yes, of course, there were stories in the media, some great ones, but we were shoving bodies into makeshift morgues in America in 2020, and it all became background noise. 2/

And no one rose up. Punctuated outrage from some. But no one on the streets in any substantial numbers asking for, demanding answers, action. 3/

If it weren't for the #BlackLivesMatter protests you'd think most of America was already dead. 4/

You don't have to ask what would I have done if I was present at one of history's great tragedies where people made choices to let barbarism flourish. We've done it now. 5/
SOCIETY
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Gregg Gonsalves
Gregg Gonsalves
@gregggonsalves
OK. I may get slaughtered here, but there is a kind of pundit who doesn't know what he doesn't know. I'm not talking about ordinary people on @Twitter who shoot the shit on a variety of topics, but people with millions of followers, readers. 1/

These are usually men, who will assume expertise because they've always been told they were the smartest in the room, were given a platform because of who they are, and feel no sense of humility when they decide to ramble off and take down others. 2/

Here I am talking about @NateSilver538 @mattyglesias and @DouthatNYT who have decided they are the arbiters of truth in science and public health. 3/

It started with the #ACIP recommendations on the next phase of #COVID19 vaccination (which as far as I know is still pending). All three of them are suggesting that #ACIP doesn't know what it's doing because there are discussions happening about how to manage trade-offs. 3/

All three believe age-based allocation is the only way to triage vaccine delivery and they've been scornful of the deliberation of #ACIP for talking about things like equity, essential workers, etc. 4/
TWITTER
Gregg Gonsalves
Gregg Gonsalves
@gregggonsalves
Eight years ago, Spencer Cox died of #AIDS. He had access to #antiretroviral therapy, but in his own struggles with #depression and substance use, he stopped taking them. 1/

Spencer left college, dropped out like me in the 80s, and we both found ourselves in @actupny where we joined the Treatment and Data Committee, doing battle with drug companies, the @US_FDA, the @NIH on a quest to save ourselves and our friends from near-certain death. 2/

Now everyone knows what those dark days before the advent of antiretroviral therapy were like. Waves upon waves of dying friends. A government who couldn't care less for the sick and dying. 3/

All this has happened before, and all this will happen again. AIDS. #COVID19. The next pandemic. The fire next time. 4/

And it changes you. Seeing so much death so young. Seeing those in power turn away from the catastrophe, even joke about it (find, listen to the tape of Larry Speakes in Oval Office w Reagan laughing about AIDS). 5/
HEALTH
Gregg Gonsalves
Gregg Gonsalves
@gregggonsalves
And this pathetic move by @JDVance1 isn't what is so odious about him. He's just a phony, all ambition, no real interest in public service. He made a big show out of moving back to #Ohio to start a group to work on the #opioid epidemic. 1/


I work on the opioids, on research on the epidemic, its relationship with HIV/HCV, overdose. I work with data from Ohio, so care deeply about what is going on there. I was excited. Until I started digging. There's no there there. 2/

More here. 3/

You can even read their IRS-990-N filing. Sure looks like @JDVance1 tried real hard on combatting the opioid epidemic in his state. Um. Not. 4/

Now he's moved on to venture capital. Money is more interesting than the suffering of the people of #Ohio I guess. 5/
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More from Health

Tony Breu
Tony Breu
@tony_breu
1/16
Why do B12 and folate deficiencies lead to HUGE red blood cells?

And, if the issue is DNA synthesis, why are red blood cells (which don't have DNA) the key cell line affected?

For answers, we'll have to go back a few billion years.


2/
RNA came first. Then, ~3-4 billion years ago, DNA emerged.

Among their differences:
🔹RNA contains uracil
🔹DNA contains thymine

But why does DNA contains thymine (T) instead of uracil (U)?

https://t.co/XlxT6cLLXg


3/
🔑Cytosine (C) can undergo spontaneous deamination to uracil (U).

In the RNA world, this meant that U could appear intensionally or unintentionally. This is clearly problematic. How can you repair RNA when you can't tell if something is an error?

https://t.co/bIZGviHBUc


4/
DNA's use of T instead of U means that spontaneous C → U deamination can be corrected without worry that an intentional U is being removed.

DNA requires greater stability than RNA so the transition to a thymine-based structure was beneficial.

https://t.co/bIZGviHBUc


5/
Let's return to megaloblastic anemia secondary to B12 or folate deficiency.

When either is severely deficient deoxythymidine monophosphate (dTMP*) production is hindered. With less dTMP, DNA synthesis is abnormal.

[*Note: thymine is the base in dTMP]

https://t.co/AnDUtKkbZh
HEALTH , PATHOPHYSIO
Dinesh S. Thakur
Dinesh S. Thakur
@d_s_thakur
This is a limited point about availability of efficacy data for vaccines under development in the context of the approval for CovidShield and Covaxin in India.

There have been many so-called experts on the idiotbox opining about apparent availability of P III data which 1/n

2/n apparently the SEC had access to based on which it "supposedly" approved Covaxin. Another argument that is prevalent is other regulators (US FDA and MHRA) also approved vaccines based on P II data alone. Let me give you a few facts so that you can make your own decision.

3/n The protocols for both mRNA vaccines are publicly available. You can check. Both protocols *define* when the interim analysis will be done. This is not subjective. They clearly define how many infections need to be documented before the Data Safety Monitoring Board meets.

4/n Find the protocols for the bridging study for CovidShield and Covaxin and look for a similar milestone.

Here is one set of efficacy data post the interim analysis of a mRNA vaccine.

Source: https://t.co/BAPnP3PxEb


5/n This data was analyzed post the interim analysis where the blind was broken by the DSMB. Now ask yourself this question:
How does the SEC, or the sponsor of these studies, or the experts who are offering their opinion liberally on the idiotbox know what the efficacy is
HEALTH
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oatc
@_oatc_
@73inlancs @janethooton_ @ErinInTheMorn @fifi_EY 1/ The 🏴󠁧󠁢󠁥󠁮󠁧󠁿 government decided pediatric gender care in England would be a monopoly contract (a Labour minister, in 2008), despite all other NHS patients officially being entitled to a choice of providers, & second opinions on diagnoses & treatment, & gave it to GIDS, which has…

@janethooton_ @ErinInTheMorn @fifi_EY 2/…always advocated that trans minors & their families must have no alternative source of care, & subsequent Tory ministers have personally put their signature on renewals of it, and even personally rejected proposals for improvement that have been put forward by NHS England…

@janethooton_ @ErinInTheMorn @fifi_EY 3/…as a result of wider & public consultation. They & their civil servants listen only to GIDS on trans minors - it was GIDS advised against <18s being allowed #GenderRecognition in 2004, & since, on the basis that no one under 18 can be certain of their gender identity, just…

@janethooton_ @ErinInTheMorn @fifi_EY 4/…as many other staff at their trust wrote⬇️ to the press in 2002 (when the first instigator of this case, psychoanalyst Susan Evans was on staff too) that no trans people should be allowed that recognition but needed

@janethooton_ @ErinInTheMorn @fifi_EY 5/…to "cure" us instead. Yet GIDS proved incapable of defending its super-conservative protocol in court - no doubt because GIDS has always expected challenges to be from patients seeking care more like that elsewhere, arrogantly ignoring that services in countries where the…
HEALTH
Patrick Strudwick
Patrick Strudwick
@PatrickStrud
I’m deeply saddened to learn that Dr Joseph Sonnabend, one of the most important figures in the history of AIDS, died yesterday. I spent time with him in 2018 for one of the last interviews he ever gave. Let me tell you about this man and what he did:

Sonnabend was one of the first doctors to raise the alarm. In 1979, while running a sexual health clinic in Greenwich Village, he wrote to the NY Health Dept to warn them of the symptoms he was seeing: low white blood cell counts, enlarged lymph nodes. He didn’t get a reply. 2/

So he kept speaking out. When a patient of his developed a very rare cancer – Kaposi’s Sarcoma – he linked up with a dermatologist at NYU who said that over a dozen gay men had it. Sonnabend knew there was something very wrong. He started working at the lab at NYU — for free. 3/

It was soon after this in 1981 that the New York Times famously reported “Rare Cancer Found In 41 Homosexuals”. The next decade would kill most of Sonnabend’s patients and friends — and all of his lovers. What Sonnabend did was to fight for every single of them. 4/

Want to know who was the first to publish advice to wear a condom? That was Sonnabend. In 1983 he co-authored the first safe sex leaflet to fight AIDS: “How To Have Sex In An Epidemic”. 5/
HEALTH
Shiven Taneja
Shiven Taneja
@ShivenTaneja
I have created a step-by-step guide to building a #CorsiRosenthalBox. Thank you @JimRosenthal4 & @CorsIAQ for approving it. Displaying it in waiting rooms, offices, schools, and libraries will help more people stay safe this season. Please DM me if you need a PDF or another size.


Also, thank you to @LadyScorcher and @amandalhu!
HEALTH

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Roger Grosse
Roger Grosse
@RogerGrosse
Important paper from Google on large batch optimization. They do impressively careful experiments measuring # iterations needed to achieve target validation error at various batch sizes. The main "surprise" is the lack of surprises. [thread]

https://t.co/7QIx5CFdfJ


The paper is a good example of lots of elements of good experimental design. They validate their metric by showing lots of variants give consistent results. They tune hyperparamters separately for each condition, check that optimum isn't at the endpoints, and measure sensitivity.

They have separate experiments where the hold fixed # iterations and # epochs, which (as they explain) measure very different things. They avoid confounds, such as batch norm's artificial dependence between batch size and regularization strength.

When the experiments are done carefully enough, the results are remarkably consistent between different datasets and architectures. Qualitatively, MNIST behaves just like ImageNet.

Importantly, they don't find any evidence for a "sharp/flat optima" effect whereby better optimization leads to worse final results. They have a good discussion of experimental artifacts/confounds in past papers where such effects were reported.
MACHINE LEARNING
\u0936\u094d\u0930\u0940\u092e\u093e\u0932\u0940 \u0939\u093f\u0924\u0947\u0936 \u0905\u0935\u0938\u094d\u0925\u0940
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@HiteshAwasthi89
Varahi Amman, Madurai, Tamilnadu

Vaarahi is one of the Saivite Shakti deities with the group of goddesses known as SAPTAMATAS.
They are: Brahmi, Maheshwari, Kaumari, Vaishnavi, Vaarahi, Mahendri and Chamundi. 1/n


They are the Shakti (female) equivalents of their male counterparts. Vaarahi is the Shakti of Bhairavar who is one of the Amsam of Bhairavar.Created from the boar avatara of Vishnu, Vaarahi is often associated with Goddess Kamala (one of the Mahavidyas). 2/n


She is also called Dandini (Lady Commander of the forces of the Mother-Goddess, symbolizing the might of SriVidya). As Vaarahi ("hog-faced" or "the great consumer") she destroys evil forces that obstructs the devotees' progress, paralyses the enemies 3/n


and led the devotees ultimately to SriVidyas. She is also called Panchami). With Kurukalla, she is accorded the parental status to Sri-Chakra (Lalita Tripura-Sundari). While Kurukalla represents the full moon, Vaarahi represents the new-moon. 4/4

Jai Maa Varahi 🙏


Tag for 📷 credit
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Vigilant AFA
Vigilant AFA
@AfaVigilant
One fascist to watch in 2021 is Joseph Charles "Oakman" Golinske of SE MI. He's been a Proud Boy for a couple years, but took a break recently from the group and promotes himself through the "Oak Nation" channel on Telegram.


Most people may be familiar with him as the tall guy in the Proud Boys bridge shot, from their August 17, 2019 attack on Portland, which featured an American Guard bus trying (and failing) to bludgeon antifascists with hammers.


He was also with his g/f at the time (Dominique Tota, left of Tarrio), and that's definitely a twitter account folks will want to block/report because he posts on it.


He's been plenty active at the pro-Covid/anti-mask/ReOpen protests in Lansing MI, seen here with Jerry Wayne and an effigy of Gretchen Whitmer, who his militia friends tried to kidnap and publicly execute.


Outside of the Proud Boys, his solo "career" with Oak Nation features the same misogyny, classism and gateway to far-right domestic terrorism the Proud Boys themselves feature. Here's him peddling oxychlorinque and bragging about harassing service workers.
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Karol296
Karol296
@Karol296
Wracając do sedna dzisiejszego zamieszania z artykułem autosportu / motorsportu. Kubica mówi w nim, że podejmie swoją decyzję w ciągu kilku dni. Rozważa opcję z Williamsem lub posadę kierowcy symulatora w Ferrari. Więc za kilka dni dowiemy się co go czeka za rok. #F1PL

Autosport / motorsport zmienił nagłówek swoje tekstu, bo pierwotnie sugerował on że Kubica jest numerem jeden na liście Williamsa na tytuł mówiący tylko tym, że nadal jest na liście kandydatów. Zrobili to po interwencji zespołu. Same wypowiedzi Kubicy z wywiadu się nie zmieniły.

Trudno powiedzieć czy autor się pośpieszył i wyciągnął inne wnioski niż powinien, a może wie coś więcej, ale nie mógł tego otwarcie napisać. Słowa Kubicy brzmią jednak jednoznacznie: decyzję podejmie w ciągu kilku dni.
SPORT
Anshul Pandey
Anshul Pandey
@Anshulspiritual
RISHI ASHTAVAKRA(DEVAL)

Those who are well versed in our ancient scriptures must definitely have come across the name of Ashtavakra Muni. Who was he and what is the story behind his body getting crooked from all sides.

Muni Asit was the son of Pracheta Rishi.


He was childless and this caused a lot of worry to him. But an Akashvani assured him that he should go to Shivji to get all his
worries nullified.

So he along with his wife go to Shivji and after paying him obeisance start singing Shivji's praises.

He describes Shiv as the one who is beyond any other thing, whose glory has no words to describe. After this the couple stands with folded hands in front of Rudradev. The strotras sung in praise of Shiv possess magical qualities even today.

Shiv gets satisfied by them soon and is ready to grant a boon.

Shiva told him that, he very well knew what the Muni desired. He then gives him the "Sansaar Vijay' mantra and asks him to keep reciting it. The Isht devi would come at an appropriate time and fulfill his wish.

Asit Muni kept reciting this mantra for hundred years. The Devi appeared and granted him the boon of a son as a Shivansh. A son was born and was named as Deval. He grew upto be a great scholar well versed and a handsome young man. Asit Muni got him married to Ratnamalavati.
RELIGION