BC FOR LATER READ
Saved by @Mollyycolllinss

The S:N501 build is now updated with data from 25th Jan.

Remember, you can always check on any country by just typing that country name in the 'Filter' box on the left menu!

1/18

https://t.co/FTjvV7T7wL

 In the 501Y.V1 (B.1.1.7) variant, here are a few of the non-UK countries with new sequences in this variant, including Denmark, Italy, Spain, France, Portugal, Norway, Germany, the USA, South Kora, & Switzerland, & the UAE, Austria, & Czech Republic for the 1st time

2/18
Denmark has 52 new samples (some yellow), showing both separate introductions and further spread of existing local clusters.

3/18
Spain has 62 new sequences (orange & yellow). Many of these are separate introductions, and a few new sequences form distinct clusters. Some new sequences also cluster closely with older sequences (green).

4/18
France has 72 new sequences (orange & yellow). These show both separate introductions and clustering with older sequences.

5/18
Portugal has 30 new sequences (orange), most of which are separate introductions, but some do connect with previous sequences.

Norway has 10 new sequences (yellow). Most of these seem to be separate introductions.

6/18
There are 10 new sequences from South Korea (yellow). These are separate introductions, but some of the new seqs cluster, which could indicate local transmission or a common exposure source.

7/18
Germany has 9 new sequences (orange & yellow), which indicate separate introductions.

8/18
The USA has 123 new sequences (orange & yellow). Many of these do cluster with older sequences and seem to indicate ongoing local transmission.

9/18
Switzerland has 30 new sequences (yellow & orange), many of which indicate separate introductions.

10/18
India has 3 new sequences (yellow). These connect to older sequences, which may indicate local transmission or a common exposure source.

11/18
United Arab Emirates has 21 sequences for the first time. Many show independent introductions, but some form a large cluster that is likely local transmission.

12/18
The Czech Republic has 10 sequences for the 1st time and Austria has 41 sequences for the 1st time.

All the Czech & many of the Austrian seqs fall in 1 cluster each, likely indicating local transmission. These clusters are near each other & connected to Slovakian seqs.

13/18
In 501Y.V2, there are new sequences from Germany, Denmark, Spain, the United Arab Emirates, and Belgium.

14/18
Germany has 4 new sequences (yellow & orange). Some indicate a new introduction, others link to an older sequence.

15/18
United Arab Emirates has 5 sequences for the first time, showing multiple introductions.

16/18
Belgium has 6 sequences for the first time, showing multiple introductions.

Denmark and Spain also have sequences for the first time.

17/18
As always, the country plot table is now updated - as usual, be careful interpreting, as sequencing is often still biased toward "S-drop-out" & S:N501 samples, meaning frequencies are not representative.

18/18

https://t.co/c7wlQOLRiq

More from Dr Emma Hodcroft

Dr Emma Hodcroft
Dr Emma Hodcroft
@firefoxx66
Happy Tuesday! The latest focal S:N501 build is now updated with sequences from 11 Jan.
There are 101 new sequences in the 501Y.V1 (B.1.1.7 #b117) & 501Y.V2 variants.

Additionally, I'll include some updates on S:E484K in this thread.

1/20

https://t.co/dXx6nk6Llz


There are 97 new non-UK sequences in 501Y.V1, including the first sequences in the cluster from Slovakia, Mexico, & Belgium, plus additional sequences from the Netherlands, Denmark, Australia, Spain, Ireland, & Sweden.

2/20


Slovakia has 10 sequences that fall in 501Y.V1 for the first time. These are closely linked, & likely indicate a single introduction and ongoing transmission (remember: vertical distance is not meaningful on the same branch - position of the 2 English samples is arbitrary).

3/20


Belgium has 5 sequences in 501Y.V1 for the 1st time, indicating 3 separate intros. 3 seqs cluster together (zoomed, divergence), indicating a single introduction. The connection to Netherlands might indicate transmission, or 2 transmissions from same diversity in the UK.

4/20


Mexico also has a sequence that falls into 501Y.V1 for the first time.

5/20
FOR LATER READ
Dr Emma Hodcroft
Dr Emma Hodcroft
@firefoxx66
To add to the excitement of your Saturday evening, the focal S:N501 build is now updated with data from 8th Jan, including 48 new seqs in 501Y.V1 (B.1.1.7 #b117) & 501Y.V2.

1/12

https://t.co/AbdhO1rqpw


There are 46 new non-UK sequences in 501Y.V1, from the Netherlands, Italy, Israel, Ireland, Norway, Sweden, the USA, and Luxembourg.
And 2 new non-South African sequences in 501Y.V2, from Australia for the first time.

2/12


In 501Y.V1:

Ireland has 4 new sequences (orange). 2 sit separately but are identical, indicating an additional introduction. 2 link to a previous sequence (green), 1 mutation away each. This could indicate location transmission, unsampled diversity, or a common exposure.

3/12


The Netherlands has 10 new seqs (orange). Many sit apart on the tree, indicating additional introductions. 3 cluster together separated by a few mutations. 2 are identical to an older seq. 1 falls in a cluster of older seqs. Some of these could indicate local transmission.

4/12


Israel has 22 new sequences (orange). 1 links to an older sequence, but is separated by 3 mutations, so may be separate introductions. Another is identical to an older sequence. But most new sequences cluster together (blue), clearly indicating local transmission.

5/12
FOR LATER READ
Advertisement
Dr Emma Hodcroft
Dr Emma Hodcroft
@firefoxx66
The latest S:N501 focal build is now up, with data from 28th Dec:

We can see new sequences from Italy, Israel, Spain, France, & Ireland in the SE England variant (501Y.V1) & Switzerland in the South African variant (501Y.V2).

1/8

https://t.co/PEU7dhptO6


In 501Y.V1 (SE England variant), we can see 1 new sequence from France & Spain, each. The French sample has a travel history to the UK.

3 new sequences are from Israel (marked 1 & 2). Zooming in on '2' (divergence view) shows they are identical, indicating 1 introduction.

2/8


There are 7 new sequences from Ireland, found roughly in 5 places on the tree (4 are singletons, 3 cluster together - 2nd 'group' from the top).

These indicate at least 5 introductions, but we need to zoom in on the 3 that cluster to see more clearly.

3/8


Zooming in to the 3 that cluster together (divergence view), shows it can be difficult to distinguish introductions sometimes, especially as we expect strong travel links between the UK & Ireland, & may only be sampling the total diversity present in Ireland.

4/8


14 new sequences from Italy are scattered across the tree - some alone & some clustering.

Zooming in on a few clusters shows some seem to be linked, while others are harder to determine.
4 seem to be clearly linked as 1 introduction.

5/8
WORLD
Dr Emma Hodcroft
Dr Emma Hodcroft
@firefoxx66
The focal S:N501 build is now updated with data from 13 Jan!

There are a total of 247 non-UK & non-South African sequences in 501Y.V1 (B.1.1.7 #b117) & 501Y.V2.

I'll do an additional thread later on, covering S:E484 & the 'Ohio variants'.

1/18

https://t.co/3bdttjKVl4


There are 244 new sequences in 501Y.V1 (B.1.1.7) from Australia, Belgium, Denmark, Germany, India, Israel, Italy, Netherlands, New Zealand, Norway, Portugal, Singapore, Spain & USA, as well sequences as from Ecuador and Greece for the first time.

2/18


Greece has 3 new sequences in 501Y.V1 for the first time. They indicate 2 separate introductions.

Ecuador has 2 sequences for the first time. They also indicate 2 separate introductions.

3/18


The USA has 61 new sequences (orange), from Florida, Minnesota, California, Pennsylvania, & New York.

A few of these represent separate introductions. Others form distinct clusters that may indicate ongoing local transmission.

4/18


Israel has 35 new sequences (orange). Some of these show separate introductions, but many link with older sequences, indicating ongoing local transmission.

5/18
SOCIETY
Dr Emma Hodcroft
Dr Emma Hodcroft
@firefoxx66
Lots of tweets about this today!
Let's see what we can see in the focal S:E484 build!

Phylogenetics (what I do - making 'family trees' from virus genetics) can be very informative to see how different variants are spreading, and how cases

There are two variants circulating predominantly in Brazil:
- 20B/S.484K seems to be older & more widespread. It has (among others) a mutation at position 484
- 20J/501Y.V3 is smaller & detected recently. It has mutations at 501 *and* 484.

2/10

https://t.co/Cw5u2kuATa


The variant predominantly in the UK (501Y.V1 / B.1.1.7) and the variant predominantly in South Africa (501Y.V2) also both have 501. 501Y.V2 *also* has the 484K mutation.

Why are there concerns about these mutations? You can read more at https://t.co/wVE7ubYBoy!

3/10


The view below is from an analysis focusing on sequences with a mutation at 484. It shows all the samples in the 2 variants (20B/S.484K & 20J/501Y.V3) & how they're related. More closely related = closer together (very, very roughly).

4/10


We can colour these samples by region to see where they're from. As we expect - most are in Brazil! A few are in Argentina (also red).

5/10

https://t.co/Cw5u2kuATa
SOCIETY

More from For later read

YogiQBKrakenElect
YogiQBKrakenElect
@YogiQ16
OMG ya'll, I have major decode! Stick with me this is going to be good!
@martingeddes shared this pic earlier showing that according to the Lunar Calendar today is actually 11.3!
@PepeNewsNow
@VeteransAlways_
@ValiantThor12
@VincentCrypt46
@DanScavino
FOR LATER READ , ALL
NotTheMacAnon
NotTheMacAnon
@NotTheMacAnon1
2020 marks the start of the quantum dot revolution.

Completely ignoring the fact that "photocatalytic generation of reactive oxygen species (ROS) from quantum dots (QDs) has been widely reported."

Results: It was found that whereas singlet oxygen (1O2) was not produced by photoexcited QDs, superoxide anion(O2− )and hydroxyl radicals(OH) were generated by QDs, especially in the presence of a physiological concentration of electron donating agent including NADH.

Using cell metabolic activity assays and various probes of ROS generation, the formation of ROS in cellular environments was demonstrated.

Conclusion: Illumination of QD-treated cells and bacteria with light did affect viability. The above results, together with those of assays in the presence of various scavengers of specific ROS, indicate that the formation of ROS by QDs mainly proceeded via electron transfer.
FOR LATER READ
Advertisement
Jason_Q
Jason_Q
@JasonQ38367909
Ok. Here we are. Again. Doom@and gloom. Ya know.....POTUS never says anything without there being something coded within it. Including his short speech last night.

Anyone catch the color of the tie?
It was a baby blue tie with hints of pink. You know. Nursery colors

Because what was it all about? The CHILDREN.

So first off. When we look at numbers of missing children in the 90’s during the Clinton Child Catching and Cooking Machine and THEN compare that with the #’s of that pesky “V” from Chiiiina” ...

There were over 900k kids missing EACH YEAR during their Reign of terror... was there ANY alert or warning about an increase yearly of child snatching?

Nope.

So when you create something in a lab and blame it on “bat soup” in a market... with a survival rate of 99.4%..

Any alarm or warning?

Oh just a “Pan”demic level 6 ( it’s so amusing that these sick pricks use the half man / half goat god Pan along with demic with a level of 6 to stress the pure evil in this)

I to o is 6 spaces
C to n is 11 spaces.

Demic to demon is 17 letter shifts

Wouldn’t it just surprise you that the finishing of #17 left us with 17 spaces left...🤔💫💫
FOR LATER READ
FRSC, NIGERIA
FRSC, NIGERIA
@FRSCNigeria
VALENTINE DAY CELEBRATION: FRSC CAUTIONS MOTORISTS AGAINST EXCESSIVE SPEED, DRUNK DRIVING AND RECKLESSNESS ON THE ROAD.

Owing to the need to ensure a safe and crash free celebration during the 2021 Valentine Day celebration, the Federal Road Safety Corps has warned the teaming community of celebrants and other road users, to desist from indulging in drunk driving, avoid excessive speed,

and resist the temptation to drive recklessly so as to mitigate all incidences of road traffic crashes during the celebration.

The Corps Public Education Officer, @BisiKazeem who made this public, said that the Corps Marshal, Dr Boboye Oyeyemi has directed Commanding Officers across board to double their efforts by ensuring massive deployment of Officers and Men for enhanced visibility,

adequate traffic control, and maximum enforcement of all COVID-19 protocols amongst motorists.
FOR LATER READ
J. Davila-Ashcraft
J. Davila-Ashcraft
@revjackashcraft
Thread: One of the things demons and fallen spirit beings want to do is replicate their torment in your marriage and family. Part of that strategy is to encourage us to treat each other with the same savagery they treat each other, since they have no capacity for love or...

compassion, even for their fellow fallen spirit beings. Even when a demon helps another demon it is only in self interest, never loyalty or love. This is what they hope to do in your family and marriage. Marriage is the foundation of culture. If you can destroy marriage, you can

destroy culture. If they can destroy the relationship between husband and wife, they can destroy the spiritual formation of the children. Demons are keenly aware of the social structure put in place by God and where to launch their attacks against it.

Marriage is properly defined as a solemn contract in which a man and a woman confer bodily rights, among other things, for the sake of procreation. This is strictly a formal theological definition of marriage. Marriage is solemn because it is formalized in public, and witnessed..

by a minister of the church. It is a contract because there is a conferral of bodily and other rights. Now some might ask, isn't marriage a covenant? Yes and no, depending on how you define the word. If we define a covenant as a solemn contract, then yes. In any valid contract,..
FOR LATER READ

You May Also Like

WORLD OF SANATAN DHARMA
WORLD OF SANATAN DHARM...
@world_sanatan
WHY BABUR NEVER TRIED TO ATTACK SRI KRISHNADEVARAYA ?

A🧵u must read

It is very well known that Babur considered Krishna Dev Raya as the strongest ruler of the entire subcontinent, and Vijayanagar empire the strongest during that time in India.

1/10


The Vijayanagar empire reached its peak during 1509-1529 around the reign of Krishna Dev Raya.

Vijayanagar’s famed elephant brigade 👇

2/10


At his command there were over 50000 elite troops with a regiment of Portuguese gunners and 3200 cavalry with 600 elephants.

3/10

Along with that more than four hundred thousand ( four lakh) peasant levies and irregular military made this empire one of the largest in all of South Asia.

A typical Vijayanagar levie soldier 👇

4/10


During Baburs invasion, Krishna Dev Raya ruled supreme in all of deccan.

In fact, in an all our brawl, Krisha Dev Raya will beat Babur fair and square.

Babur could muster at max 50000 troops with 50 canons.

While Krishna Dev Raya had these numbers in Hampi alone

5/10
ALL
Jonathan Ware
Jonathan Ware
@ReassessHistory
Rhino Barges

One of the dullest, coolest, more bizarre and fascinating pieces of kit used in Normandy.

Which NO ONE REALLY CARES ABOUT.

BUT I DO AND YOU SHOULD TOO.
/1

#WW2 #SWW #History


Planning for Overlord and Neptune had a serious snag, how to get troops from LSTs onto the beach as simply ramming them onto the beaches and dropping the ramp was known to damage the exceptionally vulnerable LSTs and felt to be unsustainable in the mid to long term. /2


LSTs were essential in sustaining Overlord's progress and were a subject of major headaches in the planning phase, and a real subject of friction when it came to launching additional amphibious operations such as Dragoon.

A single LSTs loss represented a capability nick. /3


So, logic dictated, we don't really want these remarkable but rare and highly valuable vessels constantly doing beach landings, we want something to act as a medium between ship to shore, and in came the (mostly) American designed Rhino. /4


I fucking love Rhinos.

Seriously.

Graceful lines of pure industrial pedigree.

Modular.

LOOK AT IT. /5
HISTORY
Advertisement
Noah Smith
Noah Smith
@Noahpinion
1/Politics thread time.

To me, the most important aspect of the 2018 midterms wasn't even about partisan control, but about democracy and voting rights. That's the real battle.

2/The good news: It's now an issue that everyone's talking about, and that everyone cares about.

3/More good news: Florida's proposition to give felons voting rights won. But it didn't just win - it won with substantial support from Republican voters.

That suggests there is still SOME grassroots support for democracy that transcends

4/Yet more good news: Michigan made it easier to vote. Again, by plebiscite, showing broad support for voting rights as an

5/OK, now the bad news.

We seem to have accepted electoral dysfunction in Florida as a permanent thing. The 2000 election has never really
POLITICS
Tom Hirst
Tom Hirst
@tom_hirst
How to create a freelancing website that makes money.

Everything I've learned.

A thread.

As a freelancer,

Your website is everything.

First, prioritise its existence.

Second, prioritise its improvement.

The technology you use is irrelevant.

- WordPress
- Notion
- Carrd
- Wix

It doesn't matter which you choose,

What matters is you have a website.

Pick a platform that you're comfortable with.

If you can:

- Capture leads
- Add content easily
- Have a clear design

You're good.

If your website doesn't get leads,

It's not working.

Don't rest on a website that doesn't work for you.

Improve it until it does.
STARTUPS
Reshu Nath
Reshu Nath
@ReshuNath
'Tera mera rishta kya, hindu, hindu,hindutva' is a clear take on 'tera mera rishta kya,la ilaha illallah'. As much as Hindutva hates the monotheistic religions especially Islam, there's a strange wistfulness and subliminal need at display now, to BE that they hate. 1


Charlie Hebdo doesn’t come up as a cautionary tale now but rather 'why cant we be like that'?
Growing up, Hanuman was an adorable deity for us, who swallowed the sun, or who couldn’t figure out what was Sanjeevani booti so he picked up a whole mountain and came back with it. 2

Or he was loyal, admirable and when he cleaved his chest, you saw both Ram and Sita. Now we have a lot of “Angry Hanuman” stickers. Why is a cute childlike God angry? We don’t know. It's a convenient blank space where to paint all the angst of Hindu Khatre mein hain narrative. 3


The other strange thing that has started happening is pictures of Ram appearing sans Sita. “Jai Siya Ram” has become “Jai Shri Ram”. Some people disingenuously explain it as being the same thing - because Shri is a name of Lakshmi. Not really. Siya is an apbhransh of Sita. 4


Shri is a prefix of respect in this case. Hinduism is being militarised. A woman/Sita has no place in it. Even the militaristic Goddess that is Durga has no place in this conception of neo-Hindu divinity, as evidenced by Dilip Mandal wondering where Durga came from. 5
RELIGION