https://t.co/LjpdlHa0C7 is getting a good face-lift.
Samples now have variant tables with annotation on their impact to the gene.
There is also an IGV integration. You need IGV installed locally but the Start|Jump links will open up you BAM file in IGV.

1/ Thread: "A Silicon Valley Ponzi Scheme"

Thanks to @chamath for laying this out in Social Capital's 2018 annual letter.

I've always appreciated his outspokenness.

2/ The hardest thing for most startups today is the path to market: first finding product-market fit & a way to reach customers, then building a ruthless machine to acquire, monetize & retain them.

3/ Because of this, when the VC industry invests capital into fast growing startups today, the plurality (if not majority) of invested capital will go into user acquisition and ad spending, for better or worse— usually worse.

4/ Todays massive venture-backed advertising, sales, and user acquisition playbook has morphed into one that champions growth at any cost.

This is creating a big bill that will soon come due...

5/ Ad impressions and click-throughs are bid up to outrageous prices by startups flush with venture money, and prospective users demand more and more subsidized products to gain their initial attention.

So, today, for the first time in 25 (!) years of Apple, I downgraded. From the 2016 MacBook Pro to my 2013, which I had kept in a drawer...

It was pretty simple to do—Apple Time Machine backups let me do it with one click.

That first tweet captures, in two pictures, how badly Apple has “lost the plot” (to quote @wylieprof). On the right is the Apple MagSafe adapter, from 2013. On the left, what I had “upgraded” to.

Thanks, Apple! I really was nostalgic for worrying about yanking my computer off the table.

Oh and I really appreciated not knowing if my computer was charging. What was great was the little whoop sound you used, so that the speaker before me could be informed I was charging my laptop.

We're kicking off the Privacy Tech session at #enigma2021 with Mitch Negus speaking about "NO DATA, NO PROBLEM—GIVING NUCLEAR INSPECTORS BETTER TOOLS WITHOUT REVEALING STATE

A nuclear catastrophe hasn't occurred... yet. So we need to stay vigilant. Nuclear inspectors go in according to treaties to check what's going on and check compliance with treaty rules.

But as sophisticated analytics become more common, states will only want to share the minimum amount of information necessary under the treaty.

But perhaps we can use MPC -- secure multi-party computation

Yao's garbled circuits were first demonstrated on the millionaire's problem -- figuring out who's richer without revealing actual amounts.

Used for other things like cryptocurrency these days.

Can we use this for nuclear inspection?

MPC can be used to compute anything computed by a computer [but it's expensive!]

🙋🏾‍♀️ In 2011, I was hired into my first junior role in tech @Groupon

👩🏾‍💻 By 2020, I was headhunted into a VP role in a global tech company @Brandwatch

🤖 I achieved this progression in less than a decade, without ANY coding skills

🔮 How did I do it?

*a thread*

🤓 I established a track record of results.

💪🏾 No magic formula can replace hard work: do your job well & hit all the targets you are set.

😬 When you're struggling, ask for help so you can stay on track to get results, or collaboratively adjust targets.

🎨 I stayed creative.

🧙🏿‍♀️ When challenges arose I was bold enough to try new solutions. Not everything worked, but constantly trying produced valuable innovations.

🧠 I was proactive in finding new, better ways to get the job done.

🤩 I was a self-promoter. I recorded my achievements & ensured they were mentioned in any performance / compensation reviews.

😎 I put myself forward for any opportunities to gain recognition e.g. speaking opportunities or awards.

👀I actively worked on gaining visibility.

🙂 I was myself. Some say you need to be ruthless to succeed. I don't buy it. I'm a nice person so I'm nice at work, too.

❤️ I didn't fake it. I always acted on my values, and spoke up when something didn't feel right. I showed integrity.

🤗 I was a team player. To everyone.