Cliff breakdown.
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1/ One year of destroyed economies, social isolation & deep social splits calls for an anniversary โฌ๏ธthread โฌ๏ธ to celebrate the RT-qPCR manuscript by Christian Drosten (@c_drosten) & Victor Corman (@vmcorman), submitted on 21st Jan 2020 to @Eurosurveillanc. #UnbiasedScience
2/ Before this very publication, virologists were neither treated like superstars, nor were they considered icons or half-gods. In 2009, Drosten almost succeeded in installing the false premise virology could supersede holistic medical sciences as discussed in this thread.
3/ Drosten is a virologist. He neither has any background in epidemiology, nor has he ever worked in the civil service. He also doesnโt have a background in public health. Yet he and his colleagues affect our daily lives to the level of whom to meet up or how to flush the toilet.
4/ Before January 2020, Drosten and Corman were common virologists at Charitรฉ Berlin, whenever they were not involved in economic implications (https://t.co/UTDwG8U7Du). Other than that, they looked at coronaviruses in dromedary calves in the Middle East or Africa. ๐ #cute
5/ Finally in Jan 2020, the published paper laid the theoretical grounds for the current pandemic, the RT-qPCR mass testing-religion, for which he was awarded his second German Federal Cross of Merit (he received the first one in 2005 for developing the SARS-CoV PCR test).
2/ Before this very publication, virologists were neither treated like superstars, nor were they considered icons or half-gods. In 2009, Drosten almost succeeded in installing the false premise virology could supersede holistic medical sciences as discussed in this thread.
3/ Drosten is a virologist. He neither has any background in epidemiology, nor has he ever worked in the civil service. He also doesnโt have a background in public health. Yet he and his colleagues affect our daily lives to the level of whom to meet up or how to flush the toilet.
4/ Before January 2020, Drosten and Corman were common virologists at Charitรฉ Berlin, whenever they were not involved in economic implications (https://t.co/UTDwG8U7Du). Other than that, they looked at coronaviruses in dromedary calves in the Middle East or Africa. ๐ #cute
5/ Finally in Jan 2020, the published paper laid the theoretical grounds for the current pandemic, the RT-qPCR mass testing-religion, for which he was awarded his second German Federal Cross of Merit (he received the first one in 2005 for developing the SARS-CoV PCR test).
I've seen many news articles cite that "the UK variant could be the dominant strain by March". This is emphasized by @CDCDirector.
While this will likely to be the case, this should not be an automatic cause for concern. Cases could still remain contained.
Here's how: ๐งต
One of @CDCgov's own models has tracked the true decline in cases quite accurately thus far.
Their projection shows that the B.1.1.7 variant will become the dominant variant in March. But interestingly... there's no fourth wave. Cases simply level out:
https://t.co/tDce0MwO61
Just because a variant becomes the dominant strain does not automatically mean we will see a repeat of Fall 2020.
Let's look at UK and South Africa, where cases have been falling for the past month, in unison with the US (albeit with tougher restrictions):
Furthermore, the claim that the "variant is doubling every 10 days" is false. It's the *proportion of the variant* that is doubling every 10 days.
If overall prevalence drops during the studied time period, the true doubling time of the variant is actually much longer 10 days.
Simple example:
Day 0: 10 variant / 100 cases -> 10% variant
Day 10: 15 variant / 75 cases -> 20% variant
Day 20: 20 variant / 50 cases -> 40% variant
1) Proportion of variant doubles every 10 days
2) Doubling time of variant is actually 20 days
3) Total cases still drop by 50%
While this will likely to be the case, this should not be an automatic cause for concern. Cases could still remain contained.
Here's how: ๐งต
One of @CDCgov's own models has tracked the true decline in cases quite accurately thus far.
Their projection shows that the B.1.1.7 variant will become the dominant variant in March. But interestingly... there's no fourth wave. Cases simply level out:
https://t.co/tDce0MwO61
Just because a variant becomes the dominant strain does not automatically mean we will see a repeat of Fall 2020.
Let's look at UK and South Africa, where cases have been falling for the past month, in unison with the US (albeit with tougher restrictions):
Furthermore, the claim that the "variant is doubling every 10 days" is false. It's the *proportion of the variant* that is doubling every 10 days.
If overall prevalence drops during the studied time period, the true doubling time of the variant is actually much longer 10 days.
Simple example:
Day 0: 10 variant / 100 cases -> 10% variant
Day 10: 15 variant / 75 cases -> 20% variant
Day 20: 20 variant / 50 cases -> 40% variant
1) Proportion of variant doubles every 10 days
2) Doubling time of variant is actually 20 days
3) Total cases still drop by 50%
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Keep dwelling on this:
Further Examination of the Motif near PRRA Reveals Close Structural Similarity to the SEB Superantigen as well as Sequence Similarities to Neurotoxins and a Viral SAg.
The insertion PRRA together with 7 sequentially preceding residues & succeeding R685 (conserved in ฮฒ-CoVs) form a motif, Y674QTQTNSPRRAR685, homologous to those of neurotoxins from Ophiophagus (cobra) and Bungarus genera, as well as neurotoxin-like regions from three RABV strains
(20) (Fig. 2D). We further noticed that the same segment bears close similarity to the HIV-1 glycoprotein gp120 SAg motif F164 to V174.
https://t.co/EwwJOSa8RK
In (B), the segment S680PPRAR685 including the PRRA insert and highly conserved cleavage site *R685* is shown in van der Waals representation (black labels) and nearby CDR residues of the TCRVฮฒ domain are labeled in blue/white
https://t.co/BsY8BAIzDa
Sequence Identity %
https://t.co/BsY8BAIzDa
Y674 - QTQTNSPRRA - R685
Similar to neurotoxins from Ophiophagus (cobra) & Bungarus genera & neurotoxin-like regions from three RABV strains
T678 - NSPRRA- R685
Superantigenic core, consistently aligned against bacterial or viral SAgs
Further Examination of the Motif near PRRA Reveals Close Structural Similarity to the SEB Superantigen as well as Sequence Similarities to Neurotoxins and a Viral SAg.
The insertion PRRA together with 7 sequentially preceding residues & succeeding R685 (conserved in ฮฒ-CoVs) form a motif, Y674QTQTNSPRRAR685, homologous to those of neurotoxins from Ophiophagus (cobra) and Bungarus genera, as well as neurotoxin-like regions from three RABV strains
(20) (Fig. 2D). We further noticed that the same segment bears close similarity to the HIV-1 glycoprotein gp120 SAg motif F164 to V174.
https://t.co/EwwJOSa8RK
In (B), the segment S680PPRAR685 including the PRRA insert and highly conserved cleavage site *R685* is shown in van der Waals representation (black labels) and nearby CDR residues of the TCRVฮฒ domain are labeled in blue/white
https://t.co/BsY8BAIzDa
Sequence Identity %
https://t.co/BsY8BAIzDa
Y674 - QTQTNSPRRA - R685
Similar to neurotoxins from Ophiophagus (cobra) & Bungarus genera & neurotoxin-like regions from three RABV strains
T678 - NSPRRA- R685
Superantigenic core, consistently aligned against bacterial or viral SAgs
