Keep dwelling on this:
Further Examination of the Motif near PRRA Reveals Close Structural Similarity to the SEB Superantigen as well as Sequence Similarities to Neurotoxins and a Viral SAg.

The insertion PRRA together with 7 sequentially preceding residues & succeeding R685 (conserved in β-CoVs) form a motif, Y674QTQTNSPRRAR685, homologous to those of neurotoxins from Ophiophagus (cobra) and Bungarus genera, as well as neurotoxin-like regions from three RABV strains
(20) (Fig. 2D). We further noticed that the same segment bears close similarity to the HIV-1 glycoprotein gp120 SAg motif F164 to V174.
In (B), the segment S680PPRAR685 including the PRRA insert and highly conserved cleavage site *R685* is shown in van der Waals representation (black labels) and nearby CDR residues of the TCRVβ domain are labeled in blue/white
Sequence Identity %
Y674 - QTQTNSPRRA - R685
Similar to neurotoxins from Ophiophagus (cobra) & Bungarus genera & neurotoxin-like regions from three RABV strains
T678 - NSPRRA- R685
Superantigenic core, consistently aligned against bacterial or viral SAgs
Reference 21:
A nicotinic hypothesis for Covid-19
Above all, fantastic news for chain smokers! (if true)
Keep on Puffing, Ignore the Guys in White Coats!
Anyway, this is where Cheng et al (2020) got the neurotoxin motifs from
Superantigenic character of insert unique to SARS-CoV-2
Reference 22 (from preprint) reveals more...
Bracci L., Ballas S. K., Spreafico A., Neri P., Molecular mimicry between the rabies virus glycoprotein and human immunodeficiency virus-1 GP120: cross-reacting antibodies induced by rabies vaccination.
Something important here but I can't connect the dots
(apart from being good news for smokers...)
Maybe someone else can unravel the implications?
@Parsifaler @w_mccairn @Rossana38510044
The Rubber Policeman..
"For binding experiments, cells were harvested mechanically with a rubber policeman & centrifuged"
Binding of HIV-1 gp120 to the nicotinic receptor (1992)
Referenced in Bracci et al (1997)
earliest reference to this would be in 1990 by same authors (Bracci et al)
Sequence homology between HIV gp120, rabies virus glycoprotein, and snake venom neurotoxins - Is the nicotinic acetylcholine receptor an HIV receptor?
HIV GP120 /Snake Venom/Rabies GP Neurotoxin loop confirmed
(Sönnerborg & Johansson, 1993)
The neurotoxin-like sequence of human immunodeficiency virus GP120: A comparison of sequence data from patients with and without neurological symptoms
Some loose references I don't have time to explore now:
1. Molecular mimicry of HIV gp120 (2005)
2. McCoy cell line as a possible model containing CD4+ receptors for the study of HIV-1 replication
Some loose references I don't have time to explore now:
3. Snake envenomation
4. Modified venom and venom components as anti-retroviral agents (PATENT)
Loose references I don't have time to explore now:
5. Recombinant Newcastle disease virus (NDV) strain rL-RVG expressing the rabies virus glycoprotein
6. Structure, Function, and Antigenicity of the SARS-CoV-2 Spike Glycoprotein
One way that SARS-COV-2 gets in your brain
Role of HIV gp120 in crossing blood brain barrier
Interactions of SARS-CoV-2 with the Blood–Brain Barrier
HIV-1 protein gp120 crosses the blood-brain barrier role of adsorptive endocytosis
Jack Sim's Final Thesis before something happened to him down at the Cardiff Docks...
Final Thesis Jack Sim
In-vitro Characterisation of Targeting Ligands for
Enhanced Delivery Across the Blood-Brain Barrier
A potential interaction between the SARS-CoV-2 spike protein and nicotinic acetylcholine receptors
Binding Confirmed Again
Simulations support the interaction of the SARS-CoV-2 spike protein with nicotinic acetylcholine receptors and suggest subtype specificity
Above paper also here:
Simulations support the interaction of the SARS-CoV-2 spike protein with nicotinic acetylcholine receptors
Media Review:
1. SAg-like motif on SARS-CoV-2 spike distinguished by its high sequence- & structural-similarity to a segment of SEB.
2. SARS-CoV-2 spike may act as a superantigen to trigger the development of MIS-C as well as cytokine storm in adult COVID-19 patients
SAg and SEB gonna get you!
COVID-19–associated multisystem inflammatory syndrome in children (MIS-C): A novel disease that mimics toxic shock syndrome—the superantigen hypothesis
Can COVID-19 pandemic boost the epidemic of neurodegenerative diseases?
SEB confirmed again
Smoking Break
1. What is Happening with Smokers and COVID-19?
2. Cytokine Release Syndrome (CRS) and Nicotine in COVID-19 Patients
3. Involvement of nicotine receptors in COVID-19
Back to the SEB Mystery - @w_mccairn @Parsifaler
Who put the Benzedrine in Mrs Murphy's Ovaltine?
Who put SAg & SEB in SARS COV-2's Spike Protein?
A monoclonal antibody against staphylococcal enterotoxin B superantigen inhibits SARS-CoV-2 entry
Nasty, very Nasty!
But a solution is proposed...
A monoclonal antibody against staphylococcal enterotoxin B superantigen inhibits SARS-CoV-2 entry in vitro
A nice summary of the issue of mimicry between HIV-1 gp120, Rabies Glycoprotein, Snake Neurotoxin, as well as the role of Nicotinic Receptors, hence smoking as prophylaxis:

Molecular mimicry between rabies virus glycoprotein & HIV-1 GP120
This concept has even evolved into a vaccine
A Novel Vaccine Employing Non-Replicating Rabies Virus Expressing Chimeric SARS-CoV-2 Spike Protein Domains: Functional Inhibition of Viral/Nicotinic Acetylcholine Receptor Complexes
Superantigens and Long Covid?
Persistent SARS-2 infections contribute to long COVID-19
For the Curious:
Dampened Bat Immune System Interferon Response?
Let's finish with a question:
Why COVID-19 Transmission Is More Efficient and Aggressive Than Viral Transmission in Previous Coronavirus Epidemics?
Good Luck with finding the answers!
Serial passage is likely a factor in this issue, as @Harvard2H pointed out:
References 145, 146 & 147 for the curious:
Host resistance influences patterns of experimental viral adaptation

More from Billy Bostickson 🏴👁&👁 🆓

Zhengli Shi and Deyin Guo in 2015
Coronavirus nsp10/nsp16 Methyltransferase Can Be Targeted by nsp10-Derived Peptide In Vitro and In Vivo To Increase or Decrease Replication and Pathogenesis

Deyin Guo 2016:
Molecular mechanisms of coronavirus RNA capping and methylation

Deyin Guo 2012
Short peptides derived from the interaction domain of SARS coronavirus nonstructural protein nsp10 can suppress the 2′-O-methyltransferase activity of nsp10/nsp16 complex

Deyin Guo 2013
Structure-function Analysis of SARS Coronavirus RNA Cap Guanine-N7 Methyltransferase.

Deyin Guo 2016
Identification and Characterization of a Ribose 2’-O-Methyltransferase Encoded by the Ronivirus Branch of Nidovirales
Emergent Bio-Kramer-BARDA-HHS-Kadlec-Fauci
U.S. Bet Big on Covid Vaccine Manufacturer Even as Problems Mounted
“Viral cross-contamination confirmed in the control cells for JANSSEN GMP Lot #8.”

an examination by The @nytimes of manufacturing practices at the Baltimore facility found serious problems, including a corporate culture that often ignored or deflected missteps and a government sponsor, BARDA, that acted more as a partner than a policeman."

More from All

Master Thread of all my threads!

Hello!! 👋

• I have curated some of the best tweets from the best traders we know of.

• Making one master thread and will keep posting all my threads under this.

• Go through this for super learning/value totally free of cost! 😃



Got these scanners from the following accounts:

1. @Pathik_Trader
2. @sanjufunda
3. @sanstocktrader
4. @SouravSenguptaI
5. @Rishikesh_ADX

3. 12 TRADING SETUPS which experts are using.

These setups I found from the following 4 accounts:

1. @Pathik_Trader
2. @sourabhsiso19
3. @ITRADE191

4. Curated tweets on HOW TO SELL STRADDLES.

Everything covered in this thread.
1. Management
2. How to initiate
3. When to exit straddles
4. Examples
5. Videos on

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