1/13
On the night of Thursday, May 28th, I was standing in front of a burning liquor store at the corner of E. Lake St. & Minnehaha Ave in Minneapolis. 3 days had passed since the killing of George Floyd by police. #velshi

1/10
Three days ago, we saw the putrid runoff of what’s been stoked, distilled & fomented by Trump since the beginning of his term. The riot in service of an attempted coup wasn’t spontaneous. It was planned & encouraged by the President of the United States of America. #velshi

2/10
The halls of our Capitol have only twice seen such insurrection - the last being August 24, 1814 when the British invaded Washington DC, set fire to the White House and breached the U.S. Capitol building before setting it ablaze. #velshi

3/10
The U.S. Senate was unable to meet in the historic Old Senate Chamber for nearly 5 years after that. On Wednesday, Senators returned after just five hours. But what a chaotic five hours it was. #velshi

4/10
Members of Congress were in the building because federal law dictates that the sealed certificates of each state's Electoral votes - which were cast on 12/14 - be transported to the Congressional chamber to be counted. There they were stored in the three wooden boxes.#velshi

5/10
Staffers took those boxes with them as they were ushered out of the House chamber. There are duplicates and, had the rioters taken the boxes and burned them, we’d still be able to account for all of the votes and get this done. #velshi

1/11
This week, over half the Republican Congress signed on to a Texas lawsuit asking the Supreme Court to invalidate millions of votes in 4 battleground states, despite having ZERO evidence of voter fraud. This is shocking but, sadly, not the least bit surprising. #velshi

2/11
Last night, the Supreme Court—including all 3 of Donald Trump’s appointees—rejected Texas’ case to overturn the election results. But one wonders whether it would have been more useful for the court to have heard it and then decided against it. #velshi

3/11
Trump’s tactics may not have worked in the ACTUAL courts, but a poll out this week indicated that 77% of Republicans believe there was fraud in this election. While most of that misinformation comes from Donald Trump himself—he’s the spark—the fuel is all around us. #velshi

4/11
Months ago, I warned that congressional candidates who hold dangerous fringe views could potentially get elected. They did, and I thought that was going to be our biggest problem moving forward: candidates whipping up conspiracies on the campaign trail. #velshi

5/11
I failed at the time to recognize that the dangers are far greater. Since Nov 3, elected members of the GOP and their constituents have pushed actual lies in favor of overturning the election and the will of the people who voted Biden in and Trump out. #velshi

1/13
President Biden signed an executive order phasing out the federal govt's use of privatized prisons. It instructs the Justice dept. NOT to renew contracts with privately-operated prisons; a policy that was first implemented under Obama, then reversed in 2017 by Trump. #velshi

2/13
Private prisons are a stupid, amoral idea. So how did we end up with them in the first place? For starters, the U.S. is the most prolific incarcerator on the planet. That is a fact & it is not new. #velshi

3/13
2018 figures show the U.S. ranks number one when it comes to the total number of incarcerated people. It has roughly 300,000 more people that have been sentenced to prison than China does... which has literally one billion more in population. #velshi

4/13
What about prisoners as a percentage of the population? America for the win, again, with the highest rate of incarceration in the world, a great deal higher than the next country on the list, El Salvador. #velshi

5/13
Our prison system became so overwhelmed, partly due to misguided federal initiatives like The War on Drugs in the 80s and the 1994 Crime Bill, that it was forced to outsource help. #velshi

1/15
By now you have undoubtedly seen the craziness going on in the stock market, with a selection of stocks surging hundreds if not thousands of percent in a matter of days or even hours, along with a whole bunch of financial jargon. So what exactly is going on? #velshi

2/15
One major term you have heard is "shorting" - which is just placing a bet that a stock will go down in price. #velshi

3/15
An investor can make money on this type of gamble by borrowing shares from a broker, w/o initially paying for them, selling them immediately & then later buying the shares at a lower price & returning them to the broker, keeping the difference in price as profit. #velshi

4/15
For example, an investor borrows 1 share of stock XYZ at $200 & sells it. The investor now has $200 at an initial cost of $0. However, the investor stills owes the broker that 1 share. #velshi

5/15
The gamble is that the price of the stock XYZ will go down - let's say to $100 a share. The investor can then buy the 1 share that it owes the broker at that lower $100 price. #velshi

1/11
On Thursday the Biden administration, along with congressional Democrats, unveiled a new immigration bill creating a path of 8 years to citizenship for the estimated 11 million undocumented immigrants already in the country. #velshi

2/11
The bill also provides an expedited path for DREAMERS - the undocumented immigrants brought to the U.S. as children by their parents. #velshi

3/11
The bill’s approval has a tough road ahead given razor thin Democratic majorities in both houses, but while there’s little bipartisan support for immigration reform in Washington, DC, there’s broad support for what it aims to do among Americans. #velshi

4/11
A new Vox and Data for Progress poll found a majority of likely voters and an overwhelming proportion of Democrats “strongly” or “somewhat” support offering a path to citizenship for undocumented immigrants. #velshi

5/11
When asked specifically about DREAMERS, support was even greater with 72% of all likely voters & 87% of Democrats in favor. This poll is consistent with a PEW survey from last year. 72% of Americans couldn't agree that today is Saturday, so it’s is a big deal. #velshi

A thread on how absurd the UK is on transgender issues and how the UK got so transphobic

In 2015 Parliament held an inquiry looking into the state of Transgender equality. Trans people of all stripes outlined many different problems across many, many different areas.

As a result Parliament created a list of recommendations including legal recognition for non binary people, gender recognition act reform, allowing 16 year olds to change their legal gender and reform of NHS gender identity services.

The government under Theresa May ignored everything that was recommended except for Gender recognition act reform. This act came into law in 2003 and gave trans men and women (but not non-binary people) the ability to legally change their gender on their birth certificates.

The process at that time to change your birth certificate under the GRA was to make an application to a panel of cisgender people who would decide if you were sufficiently trans based on your payslips, photo ID and bank statements. You would not get the option to speak to them.

(Also this process cost £140 which is just a tax on being trans)

My little Jacob Wohl story: August 2016, we're sitting around the trading turrets at my office on a bored to tears slow day. Our receptionist said someone was here for his 2pm appointment. None of us had an appointment on schedule. Who is it? we ask? Some guy named Jacob Wohl 1/

Jacob Wohl, for those out of loop, gained quite a bit of notoriety for becoming the youngest guy to ever get himself barred for life from the financial industry. Now he's waiting in our lobby to pitch something. We're a large merchant bank. 2/

Send him in, we said. In walks young Jacob asking to be seeded with $25mm to start a new hedge fund in exchange for an ownership stake in it. Oh, & he needs an office. And a Bloomberg station. And needs to borrow staff until he can hire some guys. And he needs a leased car... 3/

And he needs an answer today. Right now. Because there's a competing offer from Izzy Englander's firm Millenium (we know those guys well). We fight the urge to literally start laughing, but do ask him...hey, you the same guy who got banned by regulators? He didn't even flinch 4/

He went on about that being untrue & handed over a letter he said was from his lawyer who had confirmed he was not barred, had been vindicated but it 'just wasn't in the system yet at the SEC, CFTC'...whatever that means. 5/

@avacta's AVA6000 approved by MHRA. Superb news. First dosing 'around mid-year'; first data to come within 3-4 months after that.

A summary thread on the significance of AVA6000 - and #AVCT's pre CISION platform as a whole - to both the oncology industry and to AVCT itself. 1/10

In very basic terms, #AVCT's pre CISION chemotherapies are essentially reformulated versions of existing, approved chemotherapies that have been used on cancer patients for many years - decades, even.

The pre CISION tech is simply an attempt to improve the safety profile... 2/10

...of the chemo.

Most therapeutics going through clinical trials look for an improvement of at least 20% over the existing industry-standard drug. A 50% increase in efficacy would usually be considered an astonishing result.

In pre-clinical mouse models for #AVCT's AVA6000 3/10

...18 times more pro-doxorubicin was found in the tumour than in the heart. Compare that to the 1:1 ratio of the standard doxorubicin.

What this means is that the pre CISION tech could be used to enable the giving of doses to patients that are multiple times more potent... 4/10

...than standard chemotherapy drugs - either in the form of greater number of cycles of chemo, or in the potency of the individual dose.

For example, in #AVCT's pre-clinical trials, pro-dox (AVA6000) doses were 6x more potent than the standard dox doses.

The results? The...5/10

For those of us suffering & dying in Texas, the sociopathy of @GOP that leads to an astonishing lack of concern about our lives by evil folk like @GregAbbott_TX @GovernorPerry @TuckerCarlson @DanCrenshawTX et al who blatantly lie about what’s happening...1

...just to score political points - and protect the profits of energy companies - is almost incomprehensible. These are people who would claim Social Security caused 9/11 if it was convenient. What caused this catastrophe is vast vast majority from gas, then coal/nuclear...2

...then wind. The ONLY source of power that is delivering more than expected in budgeting is wind. But that’s not convenient to say for the oil/gas/coal industry, so the @GregAbbott_TX @GovernorPerry @DanCrenshawTX stand atop our dead bodies lying to protect the companies...2

...shockingly, the ONLY people in a position of state/national strength are the executives with the company that manages electricity in the state, @ERCOT_ISO. But they can’t tell the whole truth, because that would entail revealing how much stupidity was done here for profit...3

...of industry by Texas @GOP. If gas/nuke/nuclear/wind had been winterized - as they are everywhere else in the country - this would have largely been prevented. But it would have cost companies money, and that would cut into profits. If the gas lines has been buried deeper...3