Extremely triggered by these well wishers advising Muslim women to not post pictures online, take care to hide addresses etc. what if somebody clicks u while walking on the road? What makes u think you can hide your address? Why can’t somebody click photos of you while you are +

There's been a lot of talk about the missionary killed by the natives of North Sentinel Island. They're probably so aggressive because of this weirdo, Maurice Vidal Portman. So here's a big thread about this creep and some facts from my decade-long obsession with the island.

The Sentinelese are often described as “uncontacted,” but this not strictly true. They had a very significant contact in 1880 with Commander Portman.

Portman, the black sheep third son of some minor noble, was assigned by the English Royal Navy to administer and pacify the Andaman Islands, a job he pursued from 1880-1900 with the full measure of his own perversity.

Portman was erotically obsessed with the Andamanese, and he indulged his passion for photography by kidnapping members of various tribes and posing them in mock-Greek homoerotic compositions.

During his 20 years in a sexualized heart of darkness, Portman measured and cataloged every inch of his prisoner’s bodies, with an obsessive focus on genitals.

#2020yearinreview
My coverage and commentary of San Francisco homelessness in the past year.

To make it more interesting, I'm interspersing quotes throughout this thread ⬇️

‘The letters or cards that I had… they could never be replaced. It just meant more to me than a zillion dollars.’ -- Derrick, who lost his tent, ID and letters from his mother to sweeps by

'We’re essentially under arrest. On an equally interesting note, I haven’t had any medical examination since my arrival — a bit strange considering what I’m here for.' -- Ken, shelter client who was tested positive for

'The shelter in place has given us permission to be out here, otherwise it was just cat and mouse' -- Toro, whose tent camp in Castro District was temporarily reprieved from police

'It’s scary coming here, especially for people using on the street and with mental health issues, there’s a lot of paranoia. I didn’t know if I was being taken to a black site.' -- Joshua Owens, on his initial trepidation about entering a SIP hotel

@avacta's AVA6000 approved by MHRA. Superb news. First dosing 'around mid-year'; first data to come within 3-4 months after that.

A summary thread on the significance of AVA6000 - and #AVCT's pre CISION platform as a whole - to both the oncology industry and to AVCT itself. 1/10

In very basic terms, #AVCT's pre CISION chemotherapies are essentially reformulated versions of existing, approved chemotherapies that have been used on cancer patients for many years - decades, even.

The pre CISION tech is simply an attempt to improve the safety profile... 2/10

...of the chemo.

Most therapeutics going through clinical trials look for an improvement of at least 20% over the existing industry-standard drug. A 50% increase in efficacy would usually be considered an astonishing result.

In pre-clinical mouse models for #AVCT's AVA6000 3/10

...18 times more pro-doxorubicin was found in the tumour than in the heart. Compare that to the 1:1 ratio of the standard doxorubicin.

What this means is that the pre CISION tech could be used to enable the giving of doses to patients that are multiple times more potent... 4/10

...than standard chemotherapy drugs - either in the form of greater number of cycles of chemo, or in the potency of the individual dose.

For example, in #AVCT's pre-clinical trials, pro-dox (AVA6000) doses were 6x more potent than the standard dox doses.

The results? The...5/10

In the 90s I was a host on a talk radio station in LA, the same that aired Rush. I was president of LA NOW, & the liberal wkend host when he visited the station. He was so vilified by my then-crowd, I expected a monster. Instead, I met a remarkable, kind and encouraging man... 1/

He was gregarious & generous when we met. He shook my hand & I was shocked that he was nice & genuinely curious about my radio work and activism. I realized I was going to have a fascinating conversation 2/

There were many events during this time as a radio talk show host that changed me. It was my first job in the medium starting in 1993. My meeting Rush & our conversations made me realize the left had been lying to me about many things... 3/

Rush was not a monster, he wasn’t evil, he did not mean people harm, he wasn’t a bigot, or any of the other smears lobbed against him by my leftist associates. I liked him very much, and while we disagreed on many things (then) he was nothing has he had been painted 4/

In my conversations with him, we talked about the issues and despite the disagreements, he also took time to give me advice about hosting, style, connecting w the audience, etc. He encouraged me and gave me advice that made a huge difference in my career… 5/