BC SCIENCE
Saved by @Alex1Powell

The halal polemics has begun … yet again!
Race and religious bigots will spin to trigger tension
Important to stick to the back of basics of Shari’ah (Islamic jurisprudence) & Research ethics
The relationship between Shari’ah and Fiqh is represented by a tree and its parts.

 The roots rep the Shari’ah & its primary sources of legislation-Qur’an &Traditions of the Prophet (Sunnah)
The trunk and branches rep the tools & methodologies (Usul al- Fiqh/foundations of Fiqh & Maqasid/Objectives) used by scholars to derive the fruits (fatwas/rulings)
For e.g. The primary sources constitute the raw ingredients of a medicine
The methodology & tools are how pharmacists process the raw ingredients into a medicine
The resulting medicine is dispensed by doctors.
The meds may be out of date or cause adverse effects.
It warrants an alternative prescription.
The relevance of a fatwa would dep on its quality, the societal context & its ability to effectively achieve Maqasid Shari’ah-bringing benefit (maslahah) or removing harm (mafsada).
The 2nd Maqasid Shari’ah aka Priorities of Islamic Law is the preservation of life
Global-70 Million cases & 1.6 million deaths
M’sia-78K cases & 396 deaths
A #COVID19 vaccine is one of the solutions to end the pandemic apart from masking, distancing and hygiene
A maxim in Islamic law is that in social/human affairs (muamalat) the default rule is “everything is permissible unless proven otherwise”
In the absence of clear textual evidence to the contrary everything is permissible
Permissibility (Halal) does not require textual evidence
Silence in the text means permissible or an opportunity for ijtihad
To say any intervention is not allowed (Haram) requires textual evidence
The burden of proof that a medicine/vaccine/custom (mu’amalat) is impermissible falls on those who repudiate it, not on those who affirm it
Nevertheless, in borderline cases, the law prefers to err on the side of leniency, compassion and mercy.
The issue of the use of impure animal products in medicine was forwarded by the WHO office in 2001 to IOMS (Islamic Organisation of Medical Sciences) based in Kuwait.
It was attended by > 100 Muslim religious scholars and medical experts.
The seminar stated:
Transformation (istihalah) is the conversion of a substance into another which is different in characteristics.
It changes substances that are judicially impure or are found in an impure environment into pure substances
It changes substances that are judicially impure or are found in an impure environment into pure substances
It changes substances that are prohibited into lawful and permitted substances
e.g. Gelatine formed as a result of the transformation of the bones, skin & tendons of a judicially impure animal is pure and it is judicially permissible to eat.
e.g. Gelatine in medicines, capsules, vaccines etc
In vaccines gelatine is used as a stabilizer to preserve it’s potency.
Gelatine is hydrolysed (transformed) into a mixture of amino acids which is not specie specific.
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Santa Fe Institute
Santa Fe Institute
@sfiscience
"You don't see radio changing gradually and suddenly become radar. #Darwin's theory doesn't work for #technology, and we have to make a new observation."

- W Brian Arthur at SFI today

#evolution #innovation #invention


"Novel technologies are constructed from existing technologies. These offer themselves as components for the construction of further technologies."

- W Brian Arthur at SFI today

#evolution #innovation #invention #technology #engineering #design


Unlike the two-parent #inheritance typical to (but not ubiquitous among) #complex organisms, #technology inherits features from n parents - a "vast ancestral #network" more like horizontal gene transfer networks in #bacteria.

W Brian Arthur on sumulating #invention on a chip:


Does #Archaeology support the Theory of the #AdjacentPossible - that #innovation is combinatorial, persistent, cumulative?

In short, yes. SFI's Tim Kohler on the #Paleolithic data of #technology #evolution & the #prehistory of the infamous "hockeystick" curve:

😉 @SAPIENS_org


#Economist Roger Koppl of @SyracuseU presents a model for the #AdjacentPossible at SFI.

Output = "a combinatorial explosion" or #singularity, albeit one that arguably occurred millions of years ago, or in the distant future (since the model doesn't specify t = 0):
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Eric Feigl-Ding
Eric Feigl-Ding
@DrEricDing
JUST ONE PERSON—UK 🇬🇧 scientists think one immunocompromised person who cleared virus slowly & only partially wiped out an infection, leaving behind genetically-hardier viruses that rebound & learn how to survive better. That’s likely how #B117 started. 🧵 https://t.co/bMMjM8Hiuz


2) The leading hypothesis is that the new variant evolved within just one person, chronically infected with the virus for so long it was able to evolve into a new, more infectious form.

same thing happened in Boston in another immunocompromised person that was sick for 155 days.

3) What happened in Boston with one 45 year old man who was highly infectious for 155 days straight before he died... is exactly what scientists think happened in Kent, England that gave rise to #B117.


4) Doctors were shocked to find virus has evolved many different forms inside of this one immunocompromised man. 20 new mutations in one virus, akin to the #B117. This is possibly how #B1351 in South Africa 🇿🇦 and #P1 in Brazil 🇧🇷 also evolved.


5) “On its own, the appearance of a new variant in genomic databases doesn’t tell us much. “That’s just one genome amongst thousands every week. It wouldn’t necessarily stick out,” says Oliver Pybus, a professor of evolution and infectious disease at Oxford.
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Michael Lin, PhD-MD
Michael Lin, PhD-MD
@michaelzlin
Fellow academics, when are we going to start fixing our urgent structural problems that strain family bonds and present ongoing barriers to diversifying our educational and scientific leadership? You wonder, what the heck is this guy talking about?
1/n

We’re all very familiar what I am talking about, actually: the impossibility for most academics in the life sciences to do their jobs in a reaonable amount of time, due to more and more demands on writing grants, and to a lesser degree, papers.
2/n

As of yesterday I hadn’t intended to write about this subject, but was wondering as I finished a Saturday of straight work, what happened to all my time? Why has WFH not reduced my pile of tasks to do? Instead why is my to-do list growing bigger and bigger?
3/n

I decided to figure out how much time our jobs actually require. I estimated per year (m=month, w=week, d=day, h=hour):
Teaching: 20h/w x 20w = 400h
Meetings of all sorts: 10h/w x 48w= 480h
Replying to email: 2h/d x 365d = 730h
Attending and giving talks: 2h/w x 50w = 100h
4/n

Papers: If each person needs 2 papers during a 5y stint, and you run a 7.5-person lab, then you need 7.5 papers per 2.5y = 3 papers/y. Throw in a review and it’s 4 papers. If you need 15d at 8h/d per paper, that’s 480h writing papers.
5/n
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foone
foone
@Foone
I think I've permanently confused KiCAD
it's reminding me that I need to connect this capacitor to Nothing


attach this end to ground, this end to +5v, and this end to THE VOID

I accidentally made all the capacitors gigantic and they won't fit anymore

halp


gonna design an ISA card using some of these

it's gonna be tricky to fit in the case


that's from this
SCIENCE
Jimmy Bernot PhD \U0001f990\U0001fab1\U0001f3f3\ufe0f\u200d\U0001f308
Jimmy Bernot PhD 🦐🪱🏳️‍...
@JimmyBernot
Heres the story of how I volunteered to be infected with 50 parasitic worms (hookworm) for a year as part of a research study. Check out this thread & follow me for more #parasite & marine biology content [t]
#ScienceTwitter
imgs: https://t.co/hH5YsfS0ay https://t.co/kVurE6BbTS


1st some background on the parasites I got. Hookworms are blood-feeding nematodes that live in the intestine of mammals including cats, dogs & humans. ~500 million people are infected with hookworm, mostly in tropical and subtropical areas including the southern USA

Infection with many worms (100+) can cause anemia, which is most problematic in kids, pregnant women, and the elderly. This clinical study was launched to try to develop a vaccine against hookworms to prevent infection

People become infected when baby worms living in the soil penetrate their skin. Baby worms hatch from eggs that infected people poop out. Where plumbing is scarce, poor waste disposal is a common source of heavy infections (100s to 1,000s of worms)

I volunteered to be vaccinated with an experimental hookworm vaccine (I was also paid). After vaccination, the vaccine (or placebo idk) was tested by infecting me with 50 hookworms (Necator americanus) that penetrated my skin from a patch of gauze I wore on my wrist for 1 hour
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Sometimes it is because just one tiny fact will upset a whole worldview that has grown as comfortable as an overstuffed chair. (Settling into such worldviews is a lot like settling into chairs like that because the longer you're there and the deeper you sink...

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Important paper from Google on large batch optimization. They do impressively careful experiments measuring # iterations needed to achieve target validation error at various batch sizes. The main "surprise" is the lack of surprises. [thread]

https://t.co/7QIx5CFdfJ


The paper is a good example of lots of elements of good experimental design. They validate their metric by showing lots of variants give consistent results. They tune hyperparamters separately for each condition, check that optimum isn't at the endpoints, and measure sensitivity.

They have separate experiments where the hold fixed # iterations and # epochs, which (as they explain) measure very different things. They avoid confounds, such as batch norm's artificial dependence between batch size and regularization strength.

When the experiments are done carefully enough, the results are remarkably consistent between different datasets and architectures. Qualitatively, MNIST behaves just like ImageNet.

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foone
foone
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The backlight is fucked so I'm shining a flashlight on it.
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What The Trans!?
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