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Jimmy Bernot PhD 🦐🪱🏳️‍🌈
@JimmyBernot 3 years, 2 months ago 938 views

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Heres the story of how I volunteered to be infected with 50 parasitic worms (hookworm) for a year as part of a research study. Check out this thread & follow me for more #parasite & marine biology content [t]
#ScienceTwitter
imgs: https://t.co/hH5YsfS0ay https://t.co/kVurE6BbTS

1st some background on the parasites I got. Hookworms are blood-feeding nematodes that live in the intestine of mammals including cats, dogs & humans. ~500 million people are infected with hookworm, mostly in tropical and subtropical areas including the southern USA

Infection with many worms (100+) can cause anemia, which is most problematic in kids, pregnant women, and the elderly. This clinical study was launched to try to develop a vaccine against hookworms to prevent infection

People become infected when baby worms living in the soil penetrate their skin. Baby worms hatch from eggs that infected people poop out. Where plumbing is scarce, poor waste disposal is a common source of heavy infections (100s to 1,000s of worms)

I volunteered to be vaccinated with an experimental hookworm vaccine (I was also paid). After vaccination, the vaccine (or placebo idk) was tested by infecting me with 50 hookworms (Necator americanus) that penetrated my skin from a patch of gauze I wore on my wrist for 1 hour

Within minutes I felt a tingling sensation under the patch. The baby worms were penetrating my skin! The worms sense fatty acids in my skin and release proteolytic enzymes to make it easier to slip between my skin cells and into my blood vessels.

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@IntuitMachine

The Nature versus Nurture is a debate about scientific doctrine. It is a debate about the correct way of explanation for cognition.

The Representation versus Non-Representation shares the same debate. It is also about the correct way of explanation for cognition.

It is also the difference between thinking in nouns versus thinking in verbs. Nature and Representation have deep roots in Western thinking. It is a functionalist and reductionist way of thinking that meets its limits when analyzing complex adaptive systems.

It is perhaps due to this Western bias that concepts from the study of complex systems have had little traction in modern society. It is of course, more than a Western bias, but a human bias to seek out simple causal explanations of this world.

But the world is complex and messy. Spiral dynamics which is an evolutionary model of individuals and society explains how models of the world shape ourselves and our civilization.

Benedikt Kuhnhaeuser
@BenKuhnhaeuser

The calamoid palms 🌴 have over 500 species spread across the world, but their higher-level relationships were a bit of a mystery. Until now.

Out today in #MolecularPhylogeneticsAndEvolution:

A robust phylogenomic framework for the calamoid palms https://t.co/JiCbSUlheH

1/10

First some background info, so that you know what we are talking about:

Calamoid palms look a bit like snakes 🐍 (don't they!?!), because their fruits are covered in overlapping scales. And with their often fierce spines, they are equally fearsome. 😱

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They are classified into 17 genera, 10 subtribes and 3 tribes. They have an amazing variety of growth forms, from stemless to climbing to tree habit. 🌱🌴

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But as I said, their relationships have been a bit of a mystery. Here's the varying relationships previous studies found over the last 20 years.

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We tackled this mystery with a phylogenomic approach: we sampled almost a thousand genes (a hundred times more than previous studies!) of 75 species representing all calamoid tribes, subtribes and genera.

The resulting data matrix is pretty massive...

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Stephen Barlow
@SteB777

1) Science denial is destroying our societies, our civilization. Various vested interests, usually right wing ideologues find various scientific facts and information contrary to their agenda, so through propaganda they are orchestrating the public into denying this science.

2) We are seeing this with regard to the COVID virus, where a range of denial is being promoted, ranging from absolute denial the virus exists, to different levels of denial, such as only some people are vulnerable to the virus, to facilitate business as usual.

3) For a long time, to promote business as usual, vested interests have been promoting the denial of the climate and ecological crisis through propaganda. The aim being to create a large enough body of public denial to prevent action which can change anything.

4) We have seen similar patterns over a long time, such as when tobacco companies promoted denial of the emerging scientific evidence of how harmful and addictive tobacco smoking was. This further denial uses exactly the same methods.

5) Understandably, the public can't be educated about everything and have to rely on experts to inform them of concerns about threats to public safety. Malicious vested interests take advantage of this by using pseudo-experts to misinform the public.

Daoyu
@Daoyu15

https://t.co/hXlo8qgkD0
Look like that they got a classical case of PCR Cross-Contamination.
They had 2 fabricated samples (SRX9714436 and SRX9714921) on the same PCR run. Alongside with Lung07. They did not perform metagenomic sequencing on the “feces” and they did not get

A positive oral or anal swab from anywhere in their sampling. Feces came from anus and if these were positive the anal swabs must also be positive. Clearly it got there after the NA have been extracted and were from the very low-level degraded RNA which were mutagenized from

The Taq. https://t.co/yKXCgiT29w to see SRX9714921 and SRX9714436.
Human+Mouse in the positive SRA, human in both of them. Seeing human+mouse in identical proportions across 3 different sequencers (PRJNA573298, A22, SEX9714436) are pretty straight indication that the originals

Were already contaminated with Human and mouse from the very beginning, and that this contamination is due to dishonesty in the sample handling process which prescribe a spiking of samples in ACE2-HEK293T/A549, VERO E6 and Human lung xenograft mouse.

The “lineages” they claimed to have found aren’t mutational lineages at all—all the mutations they see on these sequences were unique to that specific sequence, and are the result of RNA degradation and from the Taq polymerase errors accumulated from the nested PCR process

James Hay
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Ct values can be used to estimate epidemic dynamics UPDATE! Ct values are expected to change depending on whether the epidemic is growing or declining, and we harness this to estimate the epidemic trajectory. Lots of cool new analyses and methods!

Highlights:
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- Unbiased by changing testing coverage
- Gaussian process (wiggly line) model for incidence tracking using Ct values
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This work is *JOINTLY led* with @LeekShaffer and PI’d by @michaelmina_lab. Thank you also to the ever insightful @mlipsitch and to coauthors @SanjatKanjilal @gabriel_stacey and @nialljlennon. 3/12

Premise: times since infection depend on the epidemic trajectory. Distributions of randomly sampled viral loads proxy times since infection. With calibration, Ct values can estimate growth rate. We focus on qPCR in SARS-CoV-2, but the principle applies to any outbreak. 4/12

Result 1: viral loads are shifted higher (Cts lower) during epidemic growth and lower (Cts higher) during decline when individuals are sampled *based on the onset of symptoms*. We simulated linelist data under symptom-based surveillance and looked at TSI and Cts over time. 5/12

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सा विद्या या विमुक्तये...
@raghav_aanya

कुंडली में 12 भाव होते हैं। कैसे ज्योतिष द्वारा रोग के आंकलन करते समय कुंडली के विभिन्न भावों से गणना करते हैं आज इस पर चर्चा करेंगे।
कुण्डली को कालपुरुष की संज्ञा देकर इसमें शरीर के अंगों को स्थापित कर उनसे रोग, रोगेश, रोग को बढ़ाने घटाने वाले ग्रह

रोग की स्थिति में उत्प्रेरक का कार्य करने वाले ग्रह, आयुर्वेदिक/ऐलोपैथी/होमियोपैथी में से कौन कारगर होगा इसका आँकलन, रक्त विकार, रक्त और आपरेशन की स्थिति, कौन सा आंतरिक या बाहरी अंग प्रभावित होगा इत्यादि गणना करने में कुंडली का प्रयोग किया जाता है।

मेडिकल ज्योतिष में आज के समय में Dr. K. S. Charak का नाम निर्विवाद रूप से प्रथम स्थान रखता है। उनकी लिखी कई पुस्तकें आज इस क्षेत्र में नए ज्योतिषों का मार्गदर्शन कर रही हैं।
प्रथम भाव -
इस भाव से हम व्यक्ति की रोगप्रतिरोधक क्षमता, सिर, मष्तिस्क का विचार करते हैं।

द्वितीय भाव-
दाहिना नेत्र, मुख, वाणी, नाक, गर्दन व गले के ऊपरी भाग का विचार होता है।
तृतीय भाव-
अस्थि, गला,कान, हाथ, कंधे व छाती के आंतरिक अंगों का शुरुआती भाग इत्यादि।

चतुर्थ भाव- छाती व इसके आंतरिक अंग, जातक की मानसिक स्थिति/प्रकृति, स्तन आदि की गणना की जाती है

पंचम भाव-
जातक की बुद्धि व उसकी तीव्रता,पीठ, पसलियां,पेट, हृदय की स्थिति आंकलन में प्रयोग होता है।

षष्ठ भाव-
रोग भाव कहा जाता है। कुंडली मे इसके तत्कालिक भाव स्वामी, कालपुरुष कुंडली के स्वामी, दृष्टि संबंध, रोगेश की स्थिति, रोगेश के नक्षत्र औऱ रोगेश व भाव की डिग्री इत्यादि।

itrade(DJ)
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Here is the detailed information of about strategy,

Entry time : 9.30 - 10
Exit : Upto you

Strategy :
Sell weekly ATM CE & PE at almost equal price
For ex : Sell Nifty 17250 CE at 50 and Nifty 17250 PE at 48 so it will become short straddle

Buy monthly ATM or near ATM CE & PE at matching price (5-10 points diff should be fine) as hedge
For ex : Buy Nifty 17250 CE at 150 and Nifty 17300 PE at 155 so it will become long straddle.

Weekly Short straddle + Monthly Long straddle

Adjustment:

• If you feel slightly bullish/bearish then no adjustment needed
• If Nifty moves 50 up or down and sustain then just simply roll up or down half of qnty and keep rest of the quantity. If market goes up or down further then roll up or down rest.

• If Nifty moves one side or about to breach BEP then add equal amount of lot. This can balance tested side. For ex: If I bought 17300 CE 4 lot as hedge then add 4 lot so you will have only one side risk . Note: Remember to keep SL at cost price (only for additional lot bought)

Capital requirement:
2.2 L for 4 lot
Adjustment requires additional capital upto 1L

Note : High risk high reward strategy, please don’t execute until you fully understand. Kindly do paper trading or backtest.
RR : 1:1
POP : 45-55%

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10 billion transistors in the A12X. 8-core CPU. 7-Core GPU. 35% faster single-core performance. 1000x faster GPU. iPad Pro is Xbox One S class GPU performance in "94% smaller" package, Ternus jokes.

Apple's silicon team is just dropping bombs every event.

live shot of Apple's silicon team

iPad Pro gets USB-C for up to 5K external displays and enables charging out to iPhones. Wild.

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If there is one thing I have learned it is that people love bullshit. They buy bullshit stories from professional bullshit artists, accept bullshit philosophies, purchase bullshit how-to-books, vote for bullshitting politicians.

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But if you actually are interested in facts you begin to notice how little most people care for them. Sometimes it is because they are heard to learn and bullshit is so much more widely and easily available. Sometimes it is because facts make them uncomfortable about themselves.

Sometimes it is because just one tiny fact will upset a whole worldview that has grown as comfortable as an overstuffed chair. (Settling into such worldviews is a lot like settling into chairs like that because the longer you're there and the deeper you sink...

...the harder it is to hoist yourself up and out of your fat-assed intellectual laziness.) But I actually think the reason people have such an appetite for bullshit goes deeper, goes to an aspect of ourselves we just can't accept.

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