Shankaracharya went to house of Mandan Mishra to debate with him, but he found the door locked so he took alternate way and went in
Don't act smart with Shankaracharya, you will get roasted...
This is a very interesting story from ShankarDigvijaya where Mandan Mishra tries to insult Shankaracharya but gets insulted in return.
Shankaracharya went to house of Mandan Mishra to debate with him, but he found the door locked so he took alternate way and went in
On seeing Shankaracharya
Mandan(angrily)- From where did you come, you bald fellow?
Shankar - I am bald till neck.
(He said कुतो मुण्ड्य Shankar took meaning as, 'How far are you shaven?' so he replied till neck. )
Shankar - Then what did the way reply?
(Mandan ment "I asked about your way" (From where did you come?) Shankar twisted meaning as 'I asked your way' so he said "What did the way reply?")
Shankar - But you asked it, it must be talking about your mother not mine.
Shankar - No Alcohol is white not yellow
(He said अहो पीता किं सुरा? Here पीता has two meanings, drunk and yellow, Shankar twisted the meaning as yellow and said no it was white not yellow.)
Shankar - Yes I know the colour but you know the taste.
Shankar - True, just like his father, your child born from you is a poisoned meat eater.
2 "Poisoned meat eater was born from me"
Shankar twisted the meaning and took second meaning.)
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The insertion PRRA together with 7 sequentially preceding residues & succeeding R685 (conserved in β-CoVs) form a motif, Y674QTQTNSPRRAR685, homologous to those of neurotoxins from Ophiophagus (cobra) and Bungarus genera, as well as neurotoxin-like regions from three RABV strains
(20) (Fig. 2D). We further noticed that the same segment bears close similarity to the HIV-1 glycoprotein gp120 SAg motif F164 to V174.
https://t.co/EwwJOSa8RK
In (B), the segment S680PPRAR685 including the PRRA insert and highly conserved cleavage site *R685* is shown in van der Waals representation (black labels) and nearby CDR residues of the TCRVβ domain are labeled in blue/white
https://t.co/BsY8BAIzDa
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https://t.co/BsY8BAIzDa
Y674 - QTQTNSPRRA - R685
Similar to neurotoxins from Ophiophagus (cobra) & Bungarus genera & neurotoxin-like regions from three RABV strains
T678 - NSPRRA- R685
Superantigenic core, consistently aligned against bacterial or viral SAgs
Further Examination of the Motif near PRRA Reveals Close Structural Similarity to the SEB Superantigen as well as Sequence Similarities to Neurotoxins and a Viral SAg.
The insertion PRRA together with 7 sequentially preceding residues & succeeding R685 (conserved in β-CoVs) form a motif, Y674QTQTNSPRRAR685, homologous to those of neurotoxins from Ophiophagus (cobra) and Bungarus genera, as well as neurotoxin-like regions from three RABV strains
(20) (Fig. 2D). We further noticed that the same segment bears close similarity to the HIV-1 glycoprotein gp120 SAg motif F164 to V174.
https://t.co/EwwJOSa8RK
In (B), the segment S680PPRAR685 including the PRRA insert and highly conserved cleavage site *R685* is shown in van der Waals representation (black labels) and nearby CDR residues of the TCRVβ domain are labeled in blue/white
https://t.co/BsY8BAIzDa
Sequence Identity %
https://t.co/BsY8BAIzDa
Y674 - QTQTNSPRRA - R685
Similar to neurotoxins from Ophiophagus (cobra) & Bungarus genera & neurotoxin-like regions from three RABV strains
T678 - NSPRRA- R685
Superantigenic core, consistently aligned against bacterial or viral SAgs
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