More from Dannielle (Dossy) Blumenthal PhD
SolarWinds follow up. Very good tweet explaining what happened.
Basically what this means is that SolarWinds itself was exploited. Someone posted an infected update as legitimate (digitally signed), leading customers to download a bad update.
“Multiple trojanized updates were digitally signed from March - May 2020 and posted to the SolarWinds updates website” https://t.co/8e3bMFWXYu
FireEye then explains that infected organizations were approached and exploited. This is a separate Step 2.
At this point, information is already going to “malicious domains” without extra intervention, after the malware does nothing for “up to two weeks”
Hackers reportedly slipped malware into prior SolarWinds software updates, which gave them access to a "God-mode" for infected networks, including the Treasury and Commerce departments.
— Wes Wilson (@weswilson4) December 14, 2020
The Pentagon is also a SolarWinds customer.https://t.co/Srcoztssol https://t.co/OgMhAjJqPx
Basically what this means is that SolarWinds itself was exploited. Someone posted an infected update as legitimate (digitally signed), leading customers to download a bad update.
“Multiple trojanized updates were digitally signed from March - May 2020 and posted to the SolarWinds updates website” https://t.co/8e3bMFWXYu
FireEye then explains that infected organizations were approached and exploited. This is a separate Step 2.
At this point, information is already going to “malicious domains” without extra intervention, after the malware does nothing for “up to two weeks”
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Keep dwelling on this:
Further Examination of the Motif near PRRA Reveals Close Structural Similarity to the SEB Superantigen as well as Sequence Similarities to Neurotoxins and a Viral SAg.
The insertion PRRA together with 7 sequentially preceding residues & succeeding R685 (conserved in β-CoVs) form a motif, Y674QTQTNSPRRAR685, homologous to those of neurotoxins from Ophiophagus (cobra) and Bungarus genera, as well as neurotoxin-like regions from three RABV strains
(20) (Fig. 2D). We further noticed that the same segment bears close similarity to the HIV-1 glycoprotein gp120 SAg motif F164 to V174.
https://t.co/EwwJOSa8RK
In (B), the segment S680PPRAR685 including the PRRA insert and highly conserved cleavage site *R685* is shown in van der Waals representation (black labels) and nearby CDR residues of the TCRVβ domain are labeled in blue/white
https://t.co/BsY8BAIzDa
Sequence Identity %
https://t.co/BsY8BAIzDa
Y674 - QTQTNSPRRA - R685
Similar to neurotoxins from Ophiophagus (cobra) & Bungarus genera & neurotoxin-like regions from three RABV strains
T678 - NSPRRA- R685
Superantigenic core, consistently aligned against bacterial or viral SAgs
Further Examination of the Motif near PRRA Reveals Close Structural Similarity to the SEB Superantigen as well as Sequence Similarities to Neurotoxins and a Viral SAg.
The insertion PRRA together with 7 sequentially preceding residues & succeeding R685 (conserved in β-CoVs) form a motif, Y674QTQTNSPRRAR685, homologous to those of neurotoxins from Ophiophagus (cobra) and Bungarus genera, as well as neurotoxin-like regions from three RABV strains
(20) (Fig. 2D). We further noticed that the same segment bears close similarity to the HIV-1 glycoprotein gp120 SAg motif F164 to V174.
https://t.co/EwwJOSa8RK
In (B), the segment S680PPRAR685 including the PRRA insert and highly conserved cleavage site *R685* is shown in van der Waals representation (black labels) and nearby CDR residues of the TCRVβ domain are labeled in blue/white
https://t.co/BsY8BAIzDa
Sequence Identity %
https://t.co/BsY8BAIzDa
Y674 - QTQTNSPRRA - R685
Similar to neurotoxins from Ophiophagus (cobra) & Bungarus genera & neurotoxin-like regions from three RABV strains
T678 - NSPRRA- R685
Superantigenic core, consistently aligned against bacterial or viral SAgs