First time I bought because I like the management focus on R&D. It had chosen the most difficult therapeutic area in pharma which is CNS and it was investing the cash
2/n
28. Before moving on to DARPA, let's look at DTRA:
— Billy Bostickson \U0001f3f4\U0001f441&\U0001f441 \U0001f193 (@BillyBostickson) July 31, 2020
A must read!
It is astonishing the number of pies they had their dirty little fingers poking into:
Note John Epstein and Kevin Olival from EcoHealth Alliance are key figures in DTRA:https://t.co/O4QwVWrm7m pic.twitter.com/cnNGZ7AApj
24. DTRA Network for Collection of Viruses
— Billy Bostickson \U0001f3f4\U0001f441&\U0001f441 \U0001f193 (@BillyBostickson) January 9, 2021
7. DTRA - Metabiota - One Health - Ecohealth
Bat Research Networks and Viral Surveillance: Gaps and Opportunities in Western Asia pic.twitter.com/SOqSSXF3pa
That is the key question
— Billy Bostickson \U0001f3f4\U0001f441&\U0001f441 \U0001f193 (@BillyBostickson) January 5, 2021
1. DARPA/DTRA use NGOs like Ecohealth or Metabiota to collect new pathogens
2. They are sent to US labs (Mailman, Rocky Mountain, Atlanta CDC, UNC, USAMRIID) for GOF work by Lipkin, Nichols, Rasmussen, Baric, Dension, Munster, etchttps://t.co/wqhHK7uZO6
1. I wonder why Dr. Angela Rasmussen is so so upset & full of almost palpable venom about a Hypothesis and a "What if" question by @nicholsonbaker8 in the @NYMag https://t.co/a6lxtJLpKR
— Billy Bostickson \U0001f3f4\U0001f441&\U0001f441 \U0001f193 (@BillyBostickson) January 5, 2021
Did I hear someone say "DARPA"?
Did I hear someone say "DTRA"?https://t.co/i27mpxJDw2 pic.twitter.com/x4X3QPnTMS
I'm increasingly interested in the idea of "personal moats" in the context of careers.
— Erik Torenberg (@eriktorenberg) November 22, 2018
Moats should be:
- Hard to learn and hard to do (but perhaps easier for you)
- Skills that are rare and valuable
- Legible
- Compounding over time
- Unique to your own talents & interests https://t.co/bB3k1YcH5b
People talk about \u201cpassive income\u201d a lot but not about \u201cpassive social capital\u201d or \u201cpassive networking\u201d or \u201cpassive knowledge gaining\u201d but that\u2019s what you can architect if you have a thing and it grows over time without intensive constant effort to sustain it
— Andrew Chen (@andrewchen) November 22, 2018
Things that look like moats but likely aren\u2019t or may fade:
— Erik Torenberg (@eriktorenberg) November 22, 2018
- Proprietary networks
- Being something other than one of the best at any tournament style-game
- Many "awards"
- Twitter followers or general reach without "respect"
- Anything that depends on information asymmetry https://t.co/abjxesVIh9
1. From Day 1, SARS-COV-2 was very well adapted to humans .....and transgenic hACE2 Mice
— Billy Bostickson \U0001f3f4\U0001f441&\U0001f441 \U0001f193 (@BillyBostickson) January 30, 2021
"we generated a mouse model expressing hACE2 by using CRISPR/Cas9 knockin technology. In comparison with wild-type C57BL/6 mice, both young & aged hACE2 mice sustained high viral loads... pic.twitter.com/j94XtSkscj
1. High Probability of serial passaging in Transgenic Mice expressing hACE2 in genesis of SARS-COV-2!
— Billy Bostickson \U0001f3f4\U0001f441&\U0001f441 \U0001f193 (@BillyBostickson) January 2, 2021
2 papers:
Human\u2013viral molecular mimicryhttps://t.co/irfH0Zgrve
Molecular Mimicryhttps://t.co/yLQoUtfS6s https://t.co/lsCv2iMEQz