BC COVID19
Saved by @AntonTweets

⚠️TWO DIFFERENT #COVID19 PANDEMICS—Many think with cases dropping that pandemic is nearly over. But truth is, there are now 2 different #SARSCoV2 pandemics diverging—old strain is waning, while the more contagious #B117 strain is dominating. We will be soon slammed very hard. 🧵

 2) Here is what is really going to happen... most countries are having a gentle case decline with R(e) currently around 0.9. But this is deceiving. The #B117 is still relatively rare so far, so the R is being influenced mostly by the old common variant. But not for long...
3) Here is what is going to happen... currently R is ~0.9 in many places, but with the more infectious #B117, the R will jump 50% approximately. And it is inevitable (all CDC and Danish models say this) that B117 will take over as the reigning dominant variant soon...
4) and when that happens, what worked before to keep the pandemic contained at R of 0.9 will no longer work. Here is the model for Alberta, 🇨🇦 by @GosiaGasperoPhD. The B117 dotted red line will soon dominate and drive a new surge in latter half of March and April.
5) And Denmark 🇩🇰 CDC has found the same thing. I GQR works now for keeping R around 0.9 or even 0.8, will absolutely not work anymore once #B117 variant takes over. Forget about it. We will be hit hard. But there is a way—if we suppress R to 0.7 or less.
https://t.co/gOq0put4H5
6) The solution to defeating the #B117 is to chase a #ZeroCovid approach and slam the R even lower to below 0.7.... but optimally 0.6 or less. So that even when the #B117 arises, it will keep R under 1 (0.6*1.5=0.9). And by keeping R at 0.6 now—we will have buffer room for B117.
7) And again Denmark 🇩🇰 CDC agrees with that assessment. Their model for R of 0.8 shows it is insufficient to defeat #B117. But its model for R 0.7 shows it can be enough.
https://t.co/gOq0put4H5
8) The problem is that of the declining states, only 1 state is under R 0.7... which is Wyoming (figure below sorted from lowest to highest R). Every other state’s R is over 0.7. Thus while they would yield decreases now—they won’t once #B117 takes over.
https://t.co/EWqtBZpsuh
9) Meanwhile, the replacement thing is happening in England. #B117 is dominating while old common #SARSCoV2 is all but nearly gone. Total cases dropping only because of tight UK lockdown. But can UK sustain & not let up on gas pedal before politics caves to reopen too soon?
10) Here is another @GosiaGasperoPhD model of the same thing. Keeping the R at 0.8 level is not enough to stop the spread once #B117 takes over.
11) Denmark 🇩🇰 CDC @SSI_dk has been warning about this for over a month. The world hasn’t been listening. Aggressive mitigation for keeping R under 0.7 now is the only way. https://t.co/XfZOC7UXXB
12) Let’s slam this home. suppose we have 1000 cases/day now... with an R=0.86 we could reduce it to 500/day in 2 weeks.

➡️But w/ added contagiousness of B117 variant that has ~60% higher R, in 2 weeks, 3000 new cases/day instead.

➡️6x difference in 2 wks

HT @GosiaGasperoPhD
13) The problem is that to get R low enough, what used to work won’t work anymore. When we previously could afford to open schools, it may be that when B117 becomes dominant, we might lose that buffer to keep R<0.7. https://t.co/yVld1eSrQS
14) Denmark CDC is becoming more right — contagious #B117 variant is continuing to solidify itself as 12.1% of sequenced #SARSCoV2 samples. 70% increase per week!

2.4%

4.0%

7.4%

12.1%
15) Denmark officials, despite their lockdown induced case drop, are really panicking. Seriously— read the WaPo article or this thread 🧵 below. They express that without the 100% sequencing, they would have been lulled into complacency. https://t.co/gMiJdcc6MC
16) “Without this variant, we would be in really good shape,” said Camilla Holten Moller, co-leader of the @SSI_dk group modeling the spread of the virus.

“If you just look at the reproduction number, you just wouldn’t see that it was in growth underneath at all,”
17) The good news so far is that all the vaccines tested so far perform decently against the main #B117 variants, but maybe less so against the 🇿🇦 #B1352 and 🇧🇷#P1 variants. Pfizer, Moderna, etc mostly good for B117. See thread 🧵 below to catch up. https://t.co/x30ufKmTW8
18) So here comes the “but”... there is a new subtype of #B117 emerging... a mutated sublineage of regular main #B117 that had acquired the troublesome E484K mutation. This is the bad mutation that 🇿🇦 CDC & other studies helps B1351 evade antibodies. https://t.co/3Ktkb9Iv8n
19) So what do we know about the #B117+E484K combo sublineage? Not much except this preprint study showing it is might be more resistant to antibody neutralization (more antibodies needed in lab study to neutralize the pseudovirus) than the common strain and the regular B117.
20) This #B117+E484K isn’t for sure resistant to vaccine. We don’t know yet. And we don’t know if it will still be more contagious like the main B117 is, but we should assume it is—& take precautions that it might be the double combo of more contagious & maybe antibody resistant.
21) could #B117+E484K be a fluke? Maybe. But it emerged recently in UK twice—independently arising in Wales, and arising in England. Just like in 🇧🇷 and 🇿🇦—so 4 times means convergent evolution is real. And convergent evolution is usually always greater survival fitness.
22) The other way to win is with mass vaccination like in Israel 🇮🇱 that has already vaccinated 50 shot per 100 people in the elderly. Hence now look how fast the cases, hospitalizations are diverging for those age 60+ vs 59 or under. That is the effect of **mass** vaccinations.
23) Actually, Israel 🇮🇱 has now reached 60 vaccination shots per 100 people: 4x UK 🇬🇧 and 6x the 🇺🇸. Rest of EU is much much lower.
24) Another alarming datapoint: 10% of the village of Corzano 🇮🇹 has the #B117 variant—10% of all residents!!! https://t.co/edbN2KYihV
25) Moreover, of the 10% of the infected 🇮🇹 village with #B117 UK variant, 60% of cases are kids from kindergarten and primary school, while other 40% are their parents. Schools in the village have closed now. https://t.co/xdiZqKOLVc
26) BOTTOMLINE: unless we can mass vaccinate quickly like Israel (which is still not 1/3 of the way done), we must continue to mitigate with *premium* masks preferably and with airborne virus precautions to ventilate.

💡No virus = No mutation.

#ZeroCovid #COVID19 #COVIDzero
27) here is where you can find the R(e) or R(t) in your US state. https://t.co/EWqtBZpsuh
28) Please switch to premium masks if you can. KN95, KF94, FFP2, etc.... the new variant is just too contagious not to take extra precautions. https://t.co/5pDv4nloRi
29) If you’re skeptical, you don’t have to take my word alone. Read this article in Science magazine by @kakape, he essentially outlines the same thing as I have with the ominous pandemic future of #B117. I trust my colleagues at Denmark 🇩🇰 @SSI_dk a lot. https://t.co/5i0oMxNrh1
30) Also why aren’t we aware of that much #B117 in other countries besides Denmark and UK? Well because most countries sequence almost nothing (panel B is a log scale - so the drop off is much much worse as you go down), and also very slow in sequencing even when they do.
31) Based on the limited #SARSCoV2 genomic sequencing that we do have... here is how different mutations are growing in each country so far (data slightly older by 1.5 weeks). Pink is the N501 mutation (seen in a few, but #B117 is the main variant with it)
https://t.co/Dz6NYYEdaX
32) Is #B117 a VARIANT or new STRAIN? People are now use them interchangeably. Let’s end the confusion. Experts say a variant is crowned a new strain when:

📌Becomes dominant (B117 🇬🇧)

📌More transmissible (B117), deadlier, or modifies immunity. #COVID19
https://t.co/nBnmm6gdV4

More from Eric Feigl-Ding

Eric Feigl-Ding
Eric Feigl-Ding
@DrEricDing
NEW—CDC was truly suffocated by Trump WH at every turn. Kyle McGowan, a former chief of staff at CDC, and his deputy, Amanda Campbell, witnessed WH dismissal of science, WH’s slow suffocation of CDC’s voice, meddling in messages & siphoning of CDC budget.
https://t.co/HeuNbUggiw


2) ““Everyone wants to describe the day that the light switch flipped—It didn’t happen that way—more of like a hand grasping something, and it slowly closes, closes, closes, closes until you realize that, middle of the summer, it has a complete grasp on everything at the CDC”

3) “Mr. McGowan and Ms. Campbell, both 34, say they tried to protect their colleagues against political meddling from WH and HHS but was largely stifled by the Trump administration.

4) “The White House insisted on reviewing — and often softening — the C.D.C.’s closely guarded coronavirus guidance documents, the most prominent public expression of its latest research and scientific consensus on the spread of the virus.”

5) “The documents were vetted not only by the White House’s coronavirus task force but by what felt to the agency’s employees like an endless loop of political appointees across Washington.
Mr. McGowan recalled a White House fixated on the economic implications of public health.
HEALTH
Eric Feigl-Ding
Eric Feigl-Ding
@DrEricDing
JUST ONE PERSON—UK 🇬🇧 scientists think one immunocompromised person who cleared virus slowly & only partially wiped out an infection, leaving behind genetically-hardier viruses that rebound & learn how to survive better. That’s likely how #B117 started. 🧵 https://t.co/bMMjM8Hiuz


2) The leading hypothesis is that the new variant evolved within just one person, chronically infected with the virus for so long it was able to evolve into a new, more infectious form.

same thing happened in Boston in another immunocompromised person that was sick for 155 days.

3) What happened in Boston with one 45 year old man who was highly infectious for 155 days straight before he died... is exactly what scientists think happened in Kent, England that gave rise to #B117.


4) Doctors were shocked to find virus has evolved many different forms inside of this one immunocompromised man. 20 new mutations in one virus, akin to the #B117. This is possibly how #B1351 in South Africa 🇿🇦 and #P1 in Brazil 🇧🇷 also evolved.


5) “On its own, the appearance of a new variant in genomic databases doesn’t tell us much. “That’s just one genome amongst thousands every week. It wouldn’t necessarily stick out,” says Oliver Pybus, a professor of evolution and infectious disease at Oxford.
SCIENCE
Advertisement
Eric Feigl-Ding
Eric Feigl-Ding
@DrEricDing
JUST IN — "Camp Auschwitz" insurrectionist of the Capitol siege was just arrested this morning in Newport News, VIrginia.

2) this guy was just arrested.


3) We cannot have a repeat of the fascism from WW2. This is @Schwarzenegger’s speech was so powerful.


4) My wife @andreafeigl1’s 🇦🇹 great grandfather secretly fought Hilter’s Nazi regime & smuggled many Jews to safety as an aircraft engineer. He was thrown into a concentration camp, and escaped.

She knows a few things about Nazi history—Jan 6th was downright fascist. Read 👇


5) So this cover is from a semi-tabloid magazine in Germany, according to @andreafeigl1. But even so, how did such a magazine still get it so damn right?! Maybe Germany 🇩🇪 has seen this kinda fascism before...
LEGAL
Eric Feigl-Ding
Eric Feigl-Ding
@DrEricDing
ATROCIOUS big pharma price gouging of insulin:

This crying mother can’t afford the $1000 for her son’s insulin.

📌yet, it only costs pharma $5 to produce.

📌Insulin was invented 100 years ago by Fred Banting—who donated patent for $1 to make it free for all.

Let that sink in.


2) Insulin is one of the most disgusting cases of price gouging ever.

America has long taken a free market approach to pharmaceuticals.
Drug companies haggle separately over drug prices with a variety of private insurers across the

3) “Meanwhile, Medicare, the government health program for those over age 65 — it’s also the nation’s largest buyer of drugs—is barred from negotiating drug prices. That gives pharma more leverage, and it leads to the kind of price surges of EpiPens, opioid antidotes, & insulin.”

4) In 2018:
Johnson & Johnson CEO made $30M
Pfizer CEO made $28M
Merck CEO made $18M
Eli Lilly CEO made $16M
Gilead CEO made $16M

Meanwhile:

📌Americans spent $535B on Rx drugs

📌1/4 of diabetics rationed insulin to survive

📌500K Americans went bankrupt from medical bills.

5) What’s the right price patients should pay for medications? ZERO dollars, because no copay ==> more patients get their medicine ==> saves lives and saves money. Copays decrease adherence, and copays hurt patients who actually need them.
FINANCE
Eric Feigl-Ding
Eric Feigl-Ding
@DrEricDing
Stupid—Oregon church has huge 74+ person #COVID19 outbreak after dozens of maskless churchgoers stood onstage singing & clapping inside a packed indoor venue for Easter Sunday service. The Peoples Church, is vowing to do continue church service on Sunday.

2) Now, the Oregon Health Authority says that at least 74 people associated with the church have tested positive for the coronavirus — one of the state’s largest workplace outbreaks.

3) “In a statement, the church’s leaders attributed the outbreak to a recent rise in covid-19 cases in Marion County, Ore.

Murray said the church, which has held in-person services throughout the pandemic, intends to continue with in-person ceremonies on Sunday.

4) Who saw this coming? Countless scientists. If only airborne-denialists didn’t muzzle the airborne aerosols science.
ALL

You May Also Like

Amit Schandillia
Amit Schandillia
@Schandillia
[THREAD: HISTORY OF THE HINDU TEMPLE]
1/102
Four hours south of Aswan in Lower Nubia, right by the Nile, is a region dotted with temple complexes built more than 3,000 years ago. Some like the temples of Amada, Derr, and Beit el-Wali go as far back as 1500 BC.


2/102
A little further south, not far from the border with Sudan, is another complex dedicated to Ramses II, Hathor, and Nefertari in the village of Ipsambul, better known locally as Abu Sunbul and internationally as Abu Simbel. These go back to the 13th century BC.


3/102
Djeser-Djeseru, also known as the mortuary temple of Hatshepsut in Upper Egypt also dates to 1400 BC. Over 500 years older is the nearby Mentuhotep II, also a mortuary temple. Both were dedicated to the cult of Amun Ra, besides their respective pharaohs.


4/102
Far older is the Ġgantija complex of Malta. Going as far back as 3600 BC, this one comprises of two temples entirely made of stone and enclosed in a stone wall. From the figures therein, it's understood to be a site of some kind of a fertility cult worship.


5/102
Dating from the same period are the limestone megaliths of Ħaġar Qim and Mnajdra, both said to have once hosted ritualistic sacrifices as part of the same fertility cult worship as found in the Ġgantija complex. Malta has some of the oldest temple complexes in Europe.
RELIGION
Vibhor Varshney
Vibhor Varshney
@nakulvibhor
On the occasion of youtube 20k and Twitter 70k members

A small tribute/gift to members

Screeners

technical screeners - intraday and positional both

before proceeding - i have helped you , can i ask you so that it can help someone else too

thank you

positional one

run - find #stock - draw chart - find levels

1- Stocks closing daily 2% up from 5 days
https://t.co/gTZrYY3Nht

2- Weekly breakout
https://t.co/1f4ahEolYB

3- Breakouts in short term
https://t.co/BI4h0CdgO2

4- Bullish from last 5

intraday screeners

5- 15 minute Stock Breakouts
https://t.co/9eAo82iuNv

6- Intraday Buying seen in the past 15 minutes
https://t.co/XqAJKhLB5G

7- Stocks trading near day's high on 5 min chart with volume BO intraday
https://t.co/flHmm6QXmo

Thank you
SCREENERS , ALL , NAKULSMIX
Advertisement
Respectable Lawyer
Respectable Lawyer
@RespectableLaw
There's been a lot of talk about the missionary killed by the natives of North Sentinel Island. They're probably so aggressive because of this weirdo, Maurice Vidal Portman. So here's a big thread about this creep and some facts from my decade-long obsession with the island.


The Sentinelese are often described as “uncontacted,” but this not strictly true. They had a very significant contact in 1880 with Commander Portman.

Portman, the black sheep third son of some minor noble, was assigned by the English Royal Navy to administer and pacify the Andaman Islands, a job he pursued from 1880-1900 with the full measure of his own perversity.


Portman was erotically obsessed with the Andamanese, and he indulged his passion for photography by kidnapping members of various tribes and posing them in mock-Greek homoerotic compositions.


During his 20 years in a sexualized heart of darkness, Portman measured and cataloged every inch of his prisoner’s bodies, with an obsessive focus on genitals.
SOCIETY
Erik Torenberg
Erik Torenberg
@eriktorenberg
1/ Some initial thoughts on personal moats:

Like company moats, your personal moat should be a competitive advantage that is not only durable—it should also compound over time.

Characteristics of a personal moat below:


2/ Like a company moat, you want to build career capital while you sleep.

As Andrew Chen noted:


3/ You don’t want to build a competitive advantage that is fleeting or that will get commoditized

Things that might get commoditized over time (some longer than


4/ Before the arrival of recorded music, what used to be scarce was the actual music itself — required an in-person artist.

After recorded music, the music itself became abundant and what became scarce was curation, distribution, and self space.

5/ Similarly, in careers, what used to be (more) scarce were things like ideas, money, and exclusive relationships.

In the internet economy, what has become scarce are things like specific knowledge, rare & valuable skills, and great reputations.
LIFE
Billy Bostickson \U0001f3f4\U0001f441&\U0001f441 \U0001f193
Billy Bostickson 🏴👁&👁 ...
@BillyBostickson
Tip from the Monkey
Pangolins, September 2019 and PLA are the key to this mystery
Stay Tuned!


1. Yang


2. A jacobin capuchin dangling a flagellin pangolin on a javelin while playing a mandolin and strangling a mannequin on a paladin's palanquin, said Saladin
More to come tomorrow!


3. Yigang Tong
https://t.co/CYtqYorhzH
Archived: https://t.co/ncz5ruwE2W


4. YT Interview
Some bats & pangolins carry viruses related with SARS-CoV-2, found in SE Asia and in Yunnan, & the pangolins carrying SARS-CoV-2 related viruses were smuggled from SE Asia, so there is a possibility that SARS-CoV-2 were coming from
ALL