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Do you know?
The Battle of Hydaspes (326 BC) was one of the world's most fiercest battles ever fought.
The Battle of Hydaspes was fought between Alexander the Great of Macedonia and the great King Porus of Paurava.
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King Porus ruled the territory lying in between the rivers of Jhelum and Chenab. It was important for Alexander to defeat Porus in order to continue with his conquest.
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Alexander set up his camp near a town on the right bank of the river.
Alexander split his army into parts in order to confuse Porus.His General Craterus led a small force against Porus on the order of Alexander.
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As soon as Porus learned about Alexander’s advance across river, he launched attack.Porus arranged his cavalry on the flanks. His infantry took the central position while the war elephants took the front.
![](https://pbs.twimg.com/media/FHSmx8rVQAAo9h9.jpg)
![](https://pbs.twimg.com/media/FHSm6O_VQAEgMFL.jpg)
The Macedonian forces then confronted the Indian infantry. Alexander and his cavalry launched an attack on the right. But they could not find a gap to execute the attack.
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At the end of one of the world’s fiercest battles, Alexander lost 1,000 of his 41,000 men.
The valorous King Porus lost the Battle of Hydaspes. Yet he was the greatest opponent that Alexander ever faced.
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Although victorious, it was also the most costly battle fought by the Macedonians.
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Starts the night before.
9 evening habits that make all the difference:
1. Write down tomorrow's 3:3:3 plan
• 3 hours on your most important project
• 3 shorter tasks
• 3 maintenance activities
Defining a "productive day" is crucial.
Or else you'll never be at peace (even with excellent output).
Learn more
2. End the workday with a shutdown ritual
Create a short shutdown ritual (hat-tip to Cal Newport). Close your laptop, plug in the charger, spend 2 minutes tidying your desk. Then say, "shutdown."
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Delicious tacos, presentation you crushed, a moment of inner peace. Write it down.
Gratitude programs a mindset of abundance.
4. Lay out clothes
Get exercise clothes ready for tomorrow. Upon waking up, jump rope for 2 mins. It will activate your mind + body.
Starts the night before.
9 evening habits that make all the difference:
1. Write down tomorrow's 3:3:3 plan
• 3 hours on your most important project
• 3 shorter tasks
• 3 maintenance activities
Defining a "productive day" is crucial.
Or else you'll never be at peace (even with excellent output).
Learn more
How to be 5x more productive.
— Ben Meer (@SystemSunday) August 1, 2022
A best-selling author\u2019s 3-3-3 Method:
2. End the workday with a shutdown ritual
Create a short shutdown ritual (hat-tip to Cal Newport). Close your laptop, plug in the charger, spend 2 minutes tidying your desk. Then say, "shutdown."
Separating your life and work is key.
3. Journal 1 beautiful life moment
Delicious tacos, presentation you crushed, a moment of inner peace. Write it down.
Gratitude programs a mindset of abundance.
4. Lay out clothes
Get exercise clothes ready for tomorrow. Upon waking up, jump rope for 2 mins. It will activate your mind + body.
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Keep dwelling on this:
Further Examination of the Motif near PRRA Reveals Close Structural Similarity to the SEB Superantigen as well as Sequence Similarities to Neurotoxins and a Viral SAg.
The insertion PRRA together with 7 sequentially preceding residues & succeeding R685 (conserved in β-CoVs) form a motif, Y674QTQTNSPRRAR685, homologous to those of neurotoxins from Ophiophagus (cobra) and Bungarus genera, as well as neurotoxin-like regions from three RABV strains
(20) (Fig. 2D). We further noticed that the same segment bears close similarity to the HIV-1 glycoprotein gp120 SAg motif F164 to V174.
https://t.co/EwwJOSa8RK
In (B), the segment S680PPRAR685 including the PRRA insert and highly conserved cleavage site *R685* is shown in van der Waals representation (black labels) and nearby CDR residues of the TCRVβ domain are labeled in blue/white
https://t.co/BsY8BAIzDa
Sequence Identity %
https://t.co/BsY8BAIzDa
Y674 - QTQTNSPRRA - R685
Similar to neurotoxins from Ophiophagus (cobra) & Bungarus genera & neurotoxin-like regions from three RABV strains
T678 - NSPRRA- R685
Superantigenic core, consistently aligned against bacterial or viral SAgs
Further Examination of the Motif near PRRA Reveals Close Structural Similarity to the SEB Superantigen as well as Sequence Similarities to Neurotoxins and a Viral SAg.
The insertion PRRA together with 7 sequentially preceding residues & succeeding R685 (conserved in β-CoVs) form a motif, Y674QTQTNSPRRAR685, homologous to those of neurotoxins from Ophiophagus (cobra) and Bungarus genera, as well as neurotoxin-like regions from three RABV strains
(20) (Fig. 2D). We further noticed that the same segment bears close similarity to the HIV-1 glycoprotein gp120 SAg motif F164 to V174.
https://t.co/EwwJOSa8RK
![](https://pbs.twimg.com/media/Ew0HvalUYAYijlY.png)
In (B), the segment S680PPRAR685 including the PRRA insert and highly conserved cleavage site *R685* is shown in van der Waals representation (black labels) and nearby CDR residues of the TCRVβ domain are labeled in blue/white
https://t.co/BsY8BAIzDa
![](https://pbs.twimg.com/media/Ew0MGQlVoAYB2ZO.png)
Sequence Identity %
https://t.co/BsY8BAIzDa
Y674 - QTQTNSPRRA - R685
Similar to neurotoxins from Ophiophagus (cobra) & Bungarus genera & neurotoxin-like regions from three RABV strains
T678 - NSPRRA- R685
Superantigenic core, consistently aligned against bacterial or viral SAgs
![](https://pbs.twimg.com/media/Ew0MumbUcAMRHTO.jpg)