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@pjvanerp Ok, see if I can save some time later in the week with this ongoing nonsense: there is a group that claims that the original PCR assay developed by Victor Corman and Christian Drosten and validated by a collaboration of expert labs does not detect a new virus at all.


They argue that this is because the PCR primers also detect SARS

Fortunately, virologists know this ……viruses do indeed have parts in their genetic code that are conserved. That is actually used to classify them, and it can come in handy when designing a test to pick up all variants of a family of viruses.

See an example where this knowledge is used for design of a test that can pick up ALL coronaviruses https://t.co/NCoN3sMR14 . This type of test was also used when this virus first emerged.

So yes, when designing a test, selection of primers is key (as anyone involved in diagnostic virology knows) https://t.co/6p8sKCft7W In the paper, the sequence conservation among a highly selected sublineage of SARS-like viruses was used for primer selection.
THREAD: I was living in @rbkc when I first learnt how to ride a bike, by taking a @TfL cycle confident course.

But despite having the skills to ride, the roads around my home were so dangerous that I could never build up the confidence to ride a bike ~properly~


I lived just across from Olympia, where the red marker is. Every day I would walk up High Street Kensington to get to Holland Park or Gail’s Bakery or even Hyde Park — and I’d wish I was brave enough to cycle the journey.


At first I thought it would be a problem that would be solved as soon as I learnt how to ride a bike. That straight away High Street Kensington would not look so treacherous but instead would look safe and welcoming.

Nope.

Even once I knew how to ride a bike, High Street Ken still terrified me. I could stay upright on a bike, but I was a bit wobbly — especially when nervous (which I was all the time).

Looking at that road, I knew it was the kind of place where any mistake could cost me my life.

All I needed was to build up my confidence. I figured if I could get some cycling practice under my belt, I’d be okay cycling on the road.

So I walked out to Hyde Park and rented a Santander Cycle to get practicing.

But that didn’t go so well either.