Read this small thread to know why #GabbaTest win is so special. ๐
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I don't think people understand the vital difference between a well-rehearsed (and physical) team vs a collection of individuals with no real understanding - new players, makeshift centre-backs, other players out of position. Make do an mend when missing a ton of quality = v.hard
Add fatigue,with less option to rotate, and big effort in 3 away games in previous 9 days. Team lacks height and heft without VvD, Matip, Fabinho, Gomez. Team lacks pace and goals without Jota, Manรฉ. Lacks pace at back without VvD and Gomez. No senior keeper undermines confidence
Team has been disrupted constantly this ssn. Rarely below 6 injuries, often = 10. Thiago a real bonus after months out, but the proper team is not around him. Even Gini looked knackered yesterday. 5th/6th-choice strikers and centre-backs will always be a big drop from 1st choices
Last night was a bit grim, and Brighton were excellent. But it was a strong XI for them, in terms of usual players and in terms of physicality. LFC full of skilful slower little guys right now - lacking the skilful bodyguards and pace. Kabak should help, but he's young and new
You can read Mentality Monsters or Perched for how much I talk about the unity of a team, the practiced understanding from years of intense training together, knowing each others runs and movements. Right now it's a team of semi-strangers and stand-ins.
Definitely agree BUT, we should still be beating Burnley and Brighton at home.
— PaulShilly \U0001f339\U0001f339 (@shillcock_paul) February 4, 2021
For me, that is in part, a tactical problem.
Add fatigue,with less option to rotate, and big effort in 3 away games in previous 9 days. Team lacks height and heft without VvD, Matip, Fabinho, Gomez. Team lacks pace and goals without Jota, Manรฉ. Lacks pace at back without VvD and Gomez. No senior keeper undermines confidence
Team has been disrupted constantly this ssn. Rarely below 6 injuries, often = 10. Thiago a real bonus after months out, but the proper team is not around him. Even Gini looked knackered yesterday. 5th/6th-choice strikers and centre-backs will always be a big drop from 1st choices
Last night was a bit grim, and Brighton were excellent. But it was a strong XI for them, in terms of usual players and in terms of physicality. LFC full of skilful slower little guys right now - lacking the skilful bodyguards and pace. Kabak should help, but he's young and new
You can read Mentality Monsters or Perched for how much I talk about the unity of a team, the practiced understanding from years of intense training together, knowing each others runs and movements. Right now it's a team of semi-strangers and stand-ins.
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Keep dwelling on this:
Further Examination of the Motif near PRRA Reveals Close Structural Similarity to the SEB Superantigen as well as Sequence Similarities to Neurotoxins and a Viral SAg.
The insertion PRRA together with 7 sequentially preceding residues & succeeding R685 (conserved in ฮฒ-CoVs) form a motif, Y674QTQTNSPRRAR685, homologous to those of neurotoxins from Ophiophagus (cobra) and Bungarus genera, as well as neurotoxin-like regions from three RABV strains
(20) (Fig. 2D). We further noticed that the same segment bears close similarity to the HIV-1 glycoprotein gp120 SAg motif F164 to V174.
https://t.co/EwwJOSa8RK
In (B), the segment S680PPRAR685 including the PRRA insert and highly conserved cleavage site *R685* is shown in van der Waals representation (black labels) and nearby CDR residues of the TCRVฮฒ domain are labeled in blue/white
https://t.co/BsY8BAIzDa
Sequence Identity %
https://t.co/BsY8BAIzDa
Y674 - QTQTNSPRRA - R685
Similar to neurotoxins from Ophiophagus (cobra) & Bungarus genera & neurotoxin-like regions from three RABV strains
T678 - NSPRRA- R685
Superantigenic core, consistently aligned against bacterial or viral SAgs
Further Examination of the Motif near PRRA Reveals Close Structural Similarity to the SEB Superantigen as well as Sequence Similarities to Neurotoxins and a Viral SAg.
The insertion PRRA together with 7 sequentially preceding residues & succeeding R685 (conserved in ฮฒ-CoVs) form a motif, Y674QTQTNSPRRAR685, homologous to those of neurotoxins from Ophiophagus (cobra) and Bungarus genera, as well as neurotoxin-like regions from three RABV strains
(20) (Fig. 2D). We further noticed that the same segment bears close similarity to the HIV-1 glycoprotein gp120 SAg motif F164 to V174.
https://t.co/EwwJOSa8RK
In (B), the segment S680PPRAR685 including the PRRA insert and highly conserved cleavage site *R685* is shown in van der Waals representation (black labels) and nearby CDR residues of the TCRVฮฒ domain are labeled in blue/white
https://t.co/BsY8BAIzDa
Sequence Identity %
https://t.co/BsY8BAIzDa
Y674 - QTQTNSPRRA - R685
Similar to neurotoxins from Ophiophagus (cobra) & Bungarus genera & neurotoxin-like regions from three RABV strains
T678 - NSPRRA- R685
Superantigenic core, consistently aligned against bacterial or viral SAgs
A brief analysis and comparison of the CSS for Twitter's PWA vs Twitter's legacy desktop website. The difference is dramatic and I'll touch on some reasons why.
Legacy site *downloads* ~630 KB CSS per theme and writing direction.
6,769 rules
9,252 selectors
16.7k declarations
3,370 unique declarations
44 media queries
36 unique colors
50 unique background colors
46 unique font sizes
39 unique z-indices
https://t.co/qyl4Bt1i5x
PWA *incrementally generates* ~30 KB CSS that handles all themes and writing directions.
735 rules
740 selectors
757 declarations
730 unique declarations
0 media queries
11 unique colors
32 unique background colors
15 unique font sizes
7 unique z-indices
https://t.co/w7oNG5KUkJ
The legacy site's CSS is what happens when hundreds of people directly write CSS over many years. Specificity wars, redundancy, a house of cards that can't be fixed. The result is extremely inefficient and error-prone styling that punishes users and developers.
The PWA's CSS is generated on-demand by a JS framework that manages styles and outputs "atomic CSS". The framework can enforce strict constraints and perform optimisations, which is why the CSS is so much smaller and safer. Style conflicts and unbounded CSS growth are avoided.
Legacy site *downloads* ~630 KB CSS per theme and writing direction.
6,769 rules
9,252 selectors
16.7k declarations
3,370 unique declarations
44 media queries
36 unique colors
50 unique background colors
46 unique font sizes
39 unique z-indices
https://t.co/qyl4Bt1i5x
PWA *incrementally generates* ~30 KB CSS that handles all themes and writing directions.
735 rules
740 selectors
757 declarations
730 unique declarations
0 media queries
11 unique colors
32 unique background colors
15 unique font sizes
7 unique z-indices
https://t.co/w7oNG5KUkJ
The legacy site's CSS is what happens when hundreds of people directly write CSS over many years. Specificity wars, redundancy, a house of cards that can't be fixed. The result is extremely inefficient and error-prone styling that punishes users and developers.
The PWA's CSS is generated on-demand by a JS framework that manages styles and outputs "atomic CSS". The framework can enforce strict constraints and perform optimisations, which is why the CSS is so much smaller and safer. Style conflicts and unbounded CSS growth are avoided.
