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Postcard From Luxembourg: normality is restored prior to vaccination.
I’ve repeatedly said that “test, test, test” is madness, if the tests are unregulated. Why?
‘Because pandemic’, NO PCR mass testing has a declared operational false positive rate.

So we don’t know the oFPR of PCR mass testing in U.K. This is conducted in a small number of private labs, set up at pace in summer, anticipating a ‘2nd wave’ (itself a dubious prediction from the Imperial team who’ve been wrong every time before). You’d assume these “Lighthouse
...Labs are surely regulated, inspected, accredited etc. They’re doing the most impactful medical diagnostic testing which has ever happened in history. But no. None of these are true. ‘Because pandemic’. Now, I don’t know the oFPR either. But we’re paying for it. It is NOT ZERO.
However, the authorities take every positive result as a “confirmed case” (though there’s nothing confirmed). There is no open protocol you can examine & debate. None of the results are available for understanding, thinking & interpretation. Wouldn’t it be important to learn...
...how the distribution of cycle threshold for positives varies through a run of tens of thousands of samples? Or through time? Or across geography? There is no routine evaluation of the characteristics of the test, even though we know the oFPR of complex systems is subject to...
...variability due to multiple intrinsic factors that have nothing to do with the PCR part of the chain of custody of the sample.
With very high numbers of tests per day, even low oFPR can make a major contribution to the apparent number of “cases”. It’s not correct to assume...
...that a value for oFPR obtained previously & elsewhere with a test conducted by others under completely different circumstances applies here. It’s easy, cheap & fast to measure it. That it’s never done tells me that the normal rules of good scientific practise have been put...
...to one side.
It’s worth stepping back & asking “if mass testing is untrustworthy & unregulated, why are we doing ever more of it?”
It’s a good question.
Why we ever started down this road is another. Recall what humans have done for millennia when trying to assess if a...
...person represents a potential respiratory illness threat? We look closely at one another, looking for symptoms that warn us “this person could make us ill”. In the absence of such symptoms, no special precautions are needed. But in 2020, for the first time in history, we...
...were told we could have respiratory disease without symptoms & that we could infect others despite having no symptoms. This so-called “asymptomatic transmission” actually isn’t important. The whole story was concocted from flimsy evidence: 6 individual ‘case reports’ & no...
...more than 7 individuals! In the entire world! This is ‘evidence’? When the most famous example turned out to be fraudulent yet the case report wasn’t withdrawn? (a person was said to have infected many others, yet had no symptom. It turned out they did have symptoms & had...
...taken medicines as best they could to suppress their symptoms so they could continue their work).
Armed now with the novel concept of “asymptomatic transmission” & funded mightily by the taxpayer, private labs went full steam ahead on mass testing. Remember, we’ve no idea...
...what the oFPR is. It matters hugely. Most people don’t appreciate that the importance of a FPR cannot be assessed just by knowing it. If I was to suggest it was, for example, 2%, you might think that means, approximately, that 98% of the results are OK. But it doesn’t mean...
...that at all, and it’s probably a weakness in the definitions. Because what we really want to know is “what is the false diagnosis rate? How often is a positive result incorrect?” and the oFPR does not tell you that, not on its own. We also need to know the prevalence of the...
...thing we’re trying to measure. And it’s rather chicken & egg, if we use the sample measuring instrument to do that! Imagine the prevalence was also 2%. Now with an oFPR of 2%, the number of ‘cases’ is right only half the time. Even this doesn’t sound too bad, does it?
There’s still a raging pandemic on, right? Well, hold on. What if the oFPR is a little higher? What if the real prevalence is a little lower? It really doesn’t take very much, once the oFPR is bigger than the prevalence for the false diagnosis rate to skyrocket.
Bluntly, I...
...that particular Euro cent has dropped with decision makers in Luxembourg & they’ve tapered the mass testing. That is all it takes, if an undeclared oFPR & prevalence part company enough, then mass testing becomes the illness, not the virus. You can & should still “test, test..
...test”. But focus efforts only on those with symptoms. Never test blindly in the general population. Blazing away with a mass testing system where it’s literally impossible to take a guess at the false diagnosis rate is highly irresponsible. Even the scientists in those labs...
...know this, because is “diagnostic testing for beginners”. It’s not controversial. It’s not ‘denialism’. I want to know true prevalence as much as anyone. I’m telling you as an experienced lab scientist that you cannot guess at FDR based on the information available. But it’s..
...not zero. It has a value & it will vary, so you also need to know its range. We don’t know that, either. Not only is the FDR not zero & is unknown, but it’s entirely possible that it’s high. Certainly possible that it’s high enough to change how you’d see the whole situation.
So today’s plea (again) is to demand from those running the labs & to anyone in authority: do these simple, low cost & quick experiments. If you won’t, it’s not possible to ascribe good motives to what you’re doing & profiting hugely from. Maybe there’s someone working in one...
...of those labs who has uncertainties about what they’re part of & the impact of untrustworthy data on society? If this is you, please do something.
Everyone else, please know that until proper validation is done on the PCR mass testing system, the daily number of “cases”...
...that you’re being told about & even the number of those dying a “Covid death” are both completely meaningless. They might be correct, though I very much doubt it. There’s extraordinarily clear evidence emerging of large scale misattribution of covid19 deaths in the public...
...record. Hold on: if that’s true (& it it is) doesn’t it mean that the false diagnosis rate could be very high? Doesn’t it mean that it MUST be high? Why, yes & yes. It means exactly that.
Once that penny drops, you surely appreciate what it means? That none of the data can...
...be trusted. Even officialdom cannot know you what extent the official record fairly reflects or hugely deviates from the reality.
If I’m right - and I believe I am by all logical means - then as the daily numbers aren’t reliable, they’re no longer measuring properly a...
...natural phenomenon but something to do with the characteristics of the testing system. And if that’s true...what is happening won’t fade away naturally, not even if the vaccines do what is hoped.
So be more Luxembourgish today. Think whether you’re content with our testing.

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@DesmondSwayne Sir Desmond is right. SAGE makes mathematical predictions based on flawed models.
I chose to stick my neck out almost 4mo ago here:
https://t.co/b0rT5Lq9HI
I experienced much anxiety doing this, aware that, if I was badly wrong here, I would be destroyed as a contributor.

That said, I thought the immunology so clear that I made three, specific & testable predictions which should apply if I was right.
Please examine them, on the right, under the pie chart:


In particular, I predicted that the epidemic would not reignite in London. Obviously, we have many “cases” but I urge people to disregard these & instead to look at excess deaths, on the principle that a severe (occasionally lethal) respiratory virus would show itself this way.

Here is a chart showing the trend of deaths in London alone over recent years. A prominent peak of deaths is evident as the virus swept through in spring. Also visible the August heatwave. But there are no excess deaths now.
I submit this is a striking example of herd immunity.


I’m still waiting for SAGE or indeed anyone to provide an alternative explanation for the sharp nature of the spring excess deaths peak which doesn’t involve herd immunity or otherwise removing from the pool those vulnerable to lethal outcomes (same result). Given this sharp...
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@scottorandojin What if the false diagnosis rate was 90%?
Don’t misunderstand me. I’m a thorough believer in the existence of this virus.

To exemplify: the NHS is under severe winter pressure. Many staff are unavailable, largely due to forced isolation from testing. Also, I’m told the adaptations to the conditions make normal work almost impossible. Trying to keep apart patients in different categories must be...

...incredibly stressful. I doubt I could ever have coped. Add to this the real stream of sick people & it’s a complete nightmare. My sympathies won’t be accepted but I offer them anyway. As to “the deaths”, do you mean the reported count of “covid19 deaths”? Everyone is doing...

...their very best. But as to that count: it’s nothing to do with clinical judgement. A covid19 death is a death from any cause within 28d of a positive test. So once a person is labelled by a positive test, if they then die, they’re a covid19 death. Back to my substantive...

...question: how reliable is that labelling? It’s not a clinical diagnosis. We’re not used to this idea. Never before in medical history has someone had a disease (let alone cause of death) been defined by the result of a single year alone. Yet that’s where we are. I think that..
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Yardley Yeadon
@MichaelYeadon3
https://t.co/xvP6tVlIaE
Quite a surprise. Ferguson isn’t qualified to comment on such things. He lacks understanding of basic biological concepts, partly explaining why his predictions are often so extreme.


That said, I’ll take him as an ally. It’s clear we’re already at herd immunity. How can I be sure? London had a huge peak of excess deaths in spring. The timing of peak deaths showed clearly that the pandemic was self-limiting. Recall much debate about whether the interval...

...between lockdown & peak deaths was long enough for lockdown to have been the cause of reducing deaths? The answer was “no”. But it was close & I can understand people thinking “well, it’s close, so perhaps it was lockdown that did it?”, thereby establishing a foundational...

...myth favoured by those who genuinely believe lockdown saves lives (it clearly doesn’t).
I’ll get to London & here immunity. But those wavering about the evidence about lockdown in spring really will benefit from cogitating on this graph.


In blue are the 30 trusts with the earliest date of peak deaths in spring. In red, the 30 with the latest peak deaths. For me, this is proof that national lockdown, which began Mar 23, played no role whatsoever in turning the pandemic. You’ll see some areas had peak daily...
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Yardley Yeadon
Yardley Yeadon
@MichaelYeadon3
In a number of Sunday papers:
Scientific advisers said it was “hard to see” when the restrictions would end as new variants continued to emerge, delivering a potentially devastating blow to the travel industry. The prime minister said that after progress with vaccinations...

...”what we don’t want to see is all that work undone by the arrival of a new variant that is vaccine-busting”.
The idea is planted in people’s mind that this virus is mutating in such a way as to evade prior immunity. This is completely unfounded, certainly as regards immunity..

...gained naturally, after repelling the virus (which well around 99.9% of the population do, fewer, obviously in the very elderly & already ill, more in those younger & well). It’s important to appreciate that upon infection, the human immune system cuts up an infectious...

...agent into short pieces. Each of these short pieces of protein are presented to other cells in the immune system, like an identity parade. Our cells have a truly astonishing range of abilities to recognise different protein structures, and there will be some which recognise...

...each of the pieces of the invader. The cells which recognise a piece are instructed to multiply selectively so that, after a few days to a couple of weeks, our bodies contain large numbers of virus piece specific cells. These have a range of functions. Some make antibodies...
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Yardley Yeadon
Yardley Yeadon
@MichaelYeadon3
I urge all followers who have read my criticisms of PCR mass testing in U.K. to carefully read Mr Fordham’s carefully worded letter. Note that the innovation minister in the Lords, Lord Bethel, already admitted that the PCR system doesn’t have the equivalent of an MOT. https://t.co/zXzeDMKCBb


Without this information it’s impossible to interpret any result. If the oFPR is 4%, for example, and if the true prevalence is 0.3% (it’s probably less), then for every 10,000 tests, 400 positives would be false & 30 positives would be genuine. So 93% of positives are false.

As Mr Fordham points out, almost all policies pivot on PCR mass testing. Hancock previously admitted on talkRADIO to Julia Hartley-Brewer in late summer that the FPR was “just under 1%”. That was a flat lie (possibly inadvertent but he’s never corrected the record). The reason...

...we are sure Hancock told a lie is that they have never known the FPR. Those including Hancock who believe that the oFPR can be estimated by inspection of the lowest positivity ever recorded, while logical, is completely wrong. Changes in personnel, throughout, testing...

...architecture & the like can radically alter the oFPR. Since Hancock’s remark in late summer, PCR mass testing has moved into the Lighthouse Labs & this creates a new & urgent need to continually assess oFPR. I’ve good reason to believe it’s now VERY much higher now that the...
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My little Jacob Wohl story: August 2016, we're sitting around the trading turrets at my office on a bored to tears slow day. Our receptionist said someone was here for his 2pm appointment. None of us had an appointment on schedule. Who is it? we ask? Some guy named Jacob Wohl 1/

Jacob Wohl, for those out of loop, gained quite a bit of notoriety for becoming the youngest guy to ever get himself barred for life from the financial industry. Now he's waiting in our lobby to pitch something. We're a large merchant bank. 2/

Send him in, we said. In walks young Jacob asking to be seeded with $25mm to start a new hedge fund in exchange for an ownership stake in it. Oh, & he needs an office. And a Bloomberg station. And needs to borrow staff until he can hire some guys. And he needs a leased car... 3/

And he needs an answer today. Right now. Because there's a competing offer from Izzy Englander's firm Millenium (we know those guys well). We fight the urge to literally start laughing, but do ask him...hey, you the same guy who got banned by regulators? He didn't even flinch 4/

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Spent a quaint half hour in a cafe listening to a guy yell at his dad after his dad said that the women Trump molested wanted it: "Dad, that's like saying the Jews who died in the Holocaust were asking for it!" ENJOY YOUR TERRIBLE FAMILIES THIS WEEK!

"Mom, has a man ever touched you without your consent?"
"Of course."
"Did you report it?"
"No."
"Dad, your WIFE has been through this!"

Dad was unmoved and told the guy to stop arguing with him.

At this point we learned the boy child has allergies.

I forgot to remark upon the presence of the very cute grandson, who was very small and gave not one shit about the yelling. I believe a sister or aunt was present and feeling very stressed. I wanted to hand her a Xanax or seven.

It was really hard to not jump in and say, "Sounds like you guys are going to have a fun meal tomorrow!" so they could unite in hatred against me, the outsider, and stop squabbling. Instead I exchanged glances with a nearby fellow lady patron, who also emotionally ate a cookie.

Anyway, I want to thank the random family for yelling about rape and the Holocaust in an Israeli cafe in the US of A today because it reminded me that while this country isn't the greatest, it is inevitably my stupid favorite and I am never, ever bored.
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Joanna Cherry:"Alex Salmond secured a concession that nothing in Scotland Act would preclude the people of Scotland from subsequently choosing an independent future. This is recorded in Hansard during second reading of Referendums (Scotland & Wales) Bill, May 21, 1997."

Donald Dewar said: “I should be the last to challenge the sovereignty of the people, or deny them the right to opt for any solution to the constitutional question they wished. For example, if they want to go for independence, I see no reason why they should not do so." JC

"In same debate Alex Salmond went on to emphasise that “… the Claim of Right referred to sovereign right of the Scottish people to determine a form of Govt best suited to their needs. It did not suggest sovereignty resides with English Members of Parliament." Joanna Cherry

Joanna Cherry: "Donald Dewar articulated the democratic norm later enshrined in the Edinburgh Agreement. His concession laid the foundation for the 2014 referendum in recognising the rights of Scots to choose whether to remain part of our voluntary union with England."

"I am wholly in agreement with view that we must find a legal & constitutional way to demonstrate that public opinion in Scotland has changed since 2014 referendum, in order for our independence to be internationally recognised & therefore meaningful." Joanna Cherry
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Myles McNulty
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@avacta's AVA6000 approved by MHRA. Superb news. First dosing 'around mid-year'; first data to come within 3-4 months after that.

A summary thread on the significance of AVA6000 - and #AVCT's pre CISION platform as a whole - to both the oncology industry and to AVCT itself. 1/10

In very basic terms, #AVCT's pre CISION chemotherapies are essentially reformulated versions of existing, approved chemotherapies that have been used on cancer patients for many years - decades, even.

The pre CISION tech is simply an attempt to improve the safety profile... 2/10

...of the chemo.

Most therapeutics going through clinical trials look for an improvement of at least 20% over the existing industry-standard drug. A 50% increase in efficacy would usually be considered an astonishing result.

In pre-clinical mouse models for #AVCT's AVA6000 3/10

...18 times more pro-doxorubicin was found in the tumour than in the heart. Compare that to the 1:1 ratio of the standard doxorubicin.

What this means is that the pre CISION tech could be used to enable the giving of doses to patients that are multiple times more potent... 4/10

...than standard chemotherapy drugs - either in the form of greater number of cycles of chemo, or in the potency of the individual dose.

For example, in #AVCT's pre-clinical trials, pro-dox (AVA6000) doses were 6x more potent than the standard dox doses.

The results? The...5/10
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Thread

"Main jab mar jaun to meri alag se pehchan likh dena,mere lahu se meri peshani pr Hindustan likh dena(After I die,write my identity differently,with blood,write India on my forehead)”- msg on wall in Brijpuri. It's faded.

A year on,we revisit where #DelhiRiots broke out.


Feb 2020 Vs Feb 2021
While the hustle and bustle of the area has returned in severely hit Shiv Vihar, some cracks in the walls, a black smoke patch on the door, a few burnt utensils and a pile of photographs remind the victims of the days and nights they lived in “terror”.


Khushnaz’s daughter Alfiza was six days old on February 25 when the riots broke out near her house. She recalled pressing her palm against the infant’s mouth to prevent her voice from being heard as she cried.


Shawra Begum’s single-storey residence near Medina Masjid has still not been repaired. Looking at the broken and burnt taps of her washroom, Shawra said, “That time reminds me of death.”


Sitting inside his house near Auliya Masjid, Nizamuddin had tears in his eyes thinking about the time. Over 5,000 men were walking and running amok on the streets destroying everything and everyone, he said.
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