How long should trans females be made to reduce their levels of circulating testosterone should prior to competing in the women competition?

Gooren found that during the first 12 months muscle mass (area) was decreased by 9.4% & hemoglobin levels by 14% in 20 transwomen (M2F trans) treated with an estrogen-based regimen that reduced circulating T concentrations from the male range to the female range.
Conversely, in 17 transmen (F2M transgender) treated for the first time with testosterone for 12 months (which increased circulating testosterone levels to a mean of 31 nmol/L), muscle mass increased by 19.2% and hemoglobin by 15%.
https://t.co/MOZtfh5Raf
The muscle mass findings remained stable between 1 and 3 years after initiation of treatment, although fat mass continued to change between 1 & 3 years of T treatment. although with disproportionately greater effect on muscle strength than on muscle mass.
https://t.co/8rMfUi4brV
This study did not report muscle strength, but other studies of T dose-response relationships for muscle mass and strength show consistently positively correlation,

https://t.co/0SqyneBjPZ…

https://t.co/pgyggiNG2u

https://t.co/0SqyneBjPZ…

https://t.co/A5AVkkShDj
Hence, the muscle mass estimates in these prospective treatment initiation studies in trans individuals likely underestimate the muscle strength gains from...
Elevated T levels where the circulating T markedly exceeds female range to be within the male range as occurs in severe hyperandrogenism of DSD females, poorly controlled transwomen (M2F transgender),..
or transmen (F2M transgender). These effects are also the biological basis of the ergogenic efficacy of androgen doping in women.
In both intersex/DSD and trans individuals, the developmental effects of adult male circulating T concentrations will have established the sex difference in muscle, hemoglobin, & bone, some of which is fixed & irreversible (bone size)....
.& some of which is maintained by the male circulating testosterone concentrations (muscle, hemoglobin).
The limited available prospective evidence from initiation of trans cross-sex hormone treatment suggests that the advantageous increases in muscle & hemoglobin due to male circulating T concentrations....
...are induced or reversed during the first 12mths & the androgenic effects may plateau after time.
This time course is much faster than the somatic effects of male puberty, which evolve over years and for some variables (e.g., peak bone mass) are not complete for up to a decade after the start of puberty.
However, the abrupt hormonal changes induced by medical treatment in intersex/DSD or transgender individuals may be telescoped compared with male puberty where circulating testosterone concentrations increase irregularly and incompletely for some years.
Additional data are available from the unique investigative model of men undergoing castration for prostate cancer. Just as androgen sensitivity to testosterone may differ between tissues...
https://t.co/S2yyg9Xq8j
The time course of offset of androgen effects following withdrawal of male testosterone concentrations may also differ between the major androgen-responsive tissues.
For example, circulating hemoglobin shows a progressive fall for 6 months reaching a nadir and plateau at 12 to 16 months in six studies involving 534 men undergoing medical castration for prostate cancer.
https://t.co/Bcg0PuNNu3
Although these studies of older men with prostate cancer must be extrapolated with caution, age, stage of disease, race, & baseline circulating T concentration did not affect the rate or extent of decline in hemoglobin.
https://t.co/Bcg0PuNNu3

https://t.co/2bii5lMZYy
Comparable longitudinal studies of muscle loss, strength, and performance following castration for prostate cancer are well summarized,
https://t.co/olda0NryXA
Showing progressive loss for 24 months (see Fig. 4).
Further clinical studies to define the time course of changes, mainly offset, in testosterone-dependent effects, notably on muscle and hemoglobin, are badly needed to determine the optimal duration for cross-sex hormone effects in sports.

End
@threadreaderapp please unroll

More from Kirsti Miller

There is little understanding within Australian society of the requirement to and legitimacy of adopting special measures.


Government policy does not acknowledge the applicability to Indigenous people of the right to self-determination. In 1997 the cruel Howard government actively rejected self- determination as the basis of Indigenous policy.

Key reports which make recommendations for redressing Indigenous disadvantage, including the Royal Commission into Aboriginal Deaths in Custody, and Bringing them home, .....

the National Inquiry into the Separation of Aboriginal and Torres Strait Islander Children from Their Families, have ’NOT’  been fully implemented.

Many recommendations, particularly those concerning the application of the principle of self-determination, have been actively rejected.

More from Society

A long thread on how an obsessive & violent antisemite & Holocaust denier has been embraced by the international “community of the good.”

Sarah Wilkinson has a history of Holocaust denial & anti-Jewish hatred dating back (in documented examples) to around 2015.


She is a self-proclaimed British activist for “Palestinian rights” but is more accurately a far Left neo-Nazi. Her son shares the same characteristics of violence, racism & Holocaust denial.

I first documented Sarah Wilkinson’s Holocaust denial back in July 2016. I believe I was the 1st person to do so.

Since then she has produced a long trail of written hate and abuse. See here for a good summary.


Wilkinson has recently been publicly celebrated by @XRebellionUK over her latest violent action against a Jewish owned business. Despite many people calling XR’s attention to her history, XR have chosen to remain in alliance with this neo-Nazi.

Former Labour Shadow Chancellor John McDonnell MP is among those who also chose to stand with Wilkinson via a tweet.

But McDonnell is not alone.

Neo-Nazi Sarah Wilkinson is supported and encouraged by thousands of those on the Left who consider themselves “anti-racists”.
The Nashville Operation - A Battle in the War

A thread exploring the Nashville bombing in the context of the 2020 Digital War (via SolarWinds) against the United States perpetrated by our enemies, likely China, Iran and/or Russia.


SolarWinds Hack

A digital "Pearl Harbor" moment for the United States, whoever was responsible had access to the keys to the kingdom for months during 2020, including sensitive military infrastructure. This is war!

SunGard + SolarWinds

SolarWinds software company is owned by same company that owns SunGard, which essentially provides data center services. A secure place to host internet servers with redundant power and "big pipe" data connections.

https://t.co/U3P3SrrkM1


SunGard Data Center

In Nashville, around the corner from their "big pipe" connection, AT&T. Like any data center, highly secure. Only authorized personnel can enter, and even fewer can access the actual server rooms. Backup generators are available in case of power failure.


If the SunGard hardware was being used to "host" critical command and control software related to SolarWinds, the US powers would be very interested in gaining special access keys that are stored on the hard-drives of specific servers.
Hi @officestudents @EHRC @EHRCChair @KishwerFalkner @RJHilsenrath @trussliz @GEOgovuk

The Equality and Diversity section of your job application has 'gender' in what appears to be a list of the protected characteristics under the Equality Act 2010.

However...

1/15


However, 'gender' is not a protected characteristic under the Equality Act 2010 and is not defined in the Act.

https://t.co/qisFhCiV1u

Sex is the protected characteristic under the Act, but that is not on your list.

2/15


You then ask for the 'gender' of the applicant with options:

Male
Female.

3/15


Again, 'gender' is not a protected characteristic under the Equality Act 2010 and is not defined in the Act.

https://t.co/qisFhCiV1u

4/15


Sex is the protected characteristic and the only two possible options for sex are 'Female' and 'Male' as defined in the Act and consistent with biology, but you don't ask for that.

https://t.co/CEJ0gkr6nF

'Gender' is not a synonym for sex.

5/15

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I think a plausible explanation is that whatever Corbyn says or does, his critics will denounce - no matter how much hypocrisy it necessitates.


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He's wrong to prioritise the public over Labour Party
MDZS is laden with buddhist references. As a South Asian person, and history buff, it is so interesting to see how Buddhism, which originated from India, migrated, flourished & changed in the context of China. Here's some research (🙏🏼 @starkjeon for CN insight + citations)

1. LWJ’s sword Bichen ‘is likely an abbreviation for the term 躲避红尘 (duǒ bì hóng chén), which can be translated as such: 躲避: shunning or hiding away from 红尘 (worldly affairs; which is a buddhist teaching.) (
https://t.co/zF65W3roJe) (abbrev. TWX)

2. Sandu (三 毒), Jiang Cheng’s sword, refers to the three poisons (triviṣa) in Buddhism; desire (kāma-taṇhā), delusion (bhava-taṇhā) and hatred (vibhava-taṇhā).

These 3 poisons represent the roots of craving (tanha) and are the cause of Dukkha (suffering, pain) and thus result in rebirth.

Interesting that MXTX used this name for one of the characters who suffers, arguably, the worst of these three emotions.

3. The Qian kun purse “乾坤袋 (qián kūn dài) – can be called “Heaven and Earth” Pouch. In Buddhism, Maitreya (मैत्रेय) owns this to store items. It was believed that there was a mythical space inside the bag that could absorb the world.” (TWX)