Hard agree. And if this is useful, let me share something that often gets omitted (not by @kakape).
Variants always emerge, & are not good or bad, but expected. The challenge is figuring out which variants are bad, and that can't be done with sequence alone.
Feels like the next thing we're going to need is a ranking system for how concerning "variants of concern\u201d actually are.
— Kai Kupferschmidt (@kakape) January 15, 2021
A lot of constellations of mutations are concerning, but people are lumping together variants with vastly different levels of evidence that we need to worry.
-More viral shedding (infected people produce more virus)
-Increased interval of viral shedding (people are contagious for longer)
-Increased viral fitness (virus can replicate better in infected people)
-Better receptor binding (virus can infect cells more easily)
-Increased environmental stability (virus can remain infectious in the environment for longer)
-Increased ability to evade host defenses (virus can escape innate cellular defenses against infection and thus replicate better)
Could be one, some, or all of the above
-Render masks or other physical barriers useless
-Make the virus transmissible by a totally different route of infection
-Turn the virus into the infectious equivalent of a smart cruise missile
-Defy the laws of conservation of mass and energy
More from Science
https://t.co/a6yrWK5dqg
https://t.co/Xe5xFdtDfO
https://t.co/e3RBxj0ly3
https://t.co/cJlCMqyP2v
https://t.co/5n5TK67iKB

https://t.co/Xe5xFdtDfO

https://t.co/e3RBxj0ly3
1. Monkey Outrage!
— Billy Bostickson \U0001f3f4\U0001f441&\U0001f441 \U0001f193 (@BillyBostickson) August 17, 2020
The worst treatment was kept for the monkeys. The macaques breed of monkeys are small, relatively light primates, which are often used for animal experiments at LPT. \u2018They are kept in cramped conditions in small cages. https://t.co/6D0yisjd9B
https://t.co/cJlCMqyP2v
11. Max Planck Monkey Photos (2) pic.twitter.com/0yE9D6iswp
— Billy Bostickson \U0001f3f4\U0001f441&\U0001f441 \U0001f193 (@BillyBostickson) August 17, 2020
https://t.co/5n5TK67iKB

"NO LONGER BEST IN THE WORLD"
UNEP's new Human Development Index includes a new (separate) index: Planetary pressures-adjusted HDI (PHDI). News in Norway is that its position drops from #1 to #16 because of this, while Ireland rises from #2 to #1.
Why?
https://t.co/aVraIEzRfh
Check out Norway's 'Domestic Material Consumption'. Fossil fuels are no different here to Ireland's. What's different is this huge 'non-metallic minerals' category.
(Note also the jump in 1998, suggesting data problems.)
https://t.co/5QvzONbqmN
In Norway's case, it looks like the apparent consumption equation (production+imports-exports) for non-metal minerals is dominated by production: extraction of material in Norway.
https://t.co/5QvzONbqmN
And here we see that this production of non-metallic minerals is sand, gravel and crushed rock for construction. So it's about Norway's geology.
https://t.co/y6rqWmFVWc
Norway drops 15 places on the PHDI list not because of its CO₂ emissions (fairly high at 41st highest in the world per capita), but because of its geology, because it shifts a lot of rock whenever it builds anything.
UNEP's new Human Development Index includes a new (separate) index: Planetary pressures-adjusted HDI (PHDI). News in Norway is that its position drops from #1 to #16 because of this, while Ireland rises from #2 to #1.
Why?
https://t.co/aVraIEzRfh

Check out Norway's 'Domestic Material Consumption'. Fossil fuels are no different here to Ireland's. What's different is this huge 'non-metallic minerals' category.
(Note also the jump in 1998, suggesting data problems.)
https://t.co/5QvzONbqmN

In Norway's case, it looks like the apparent consumption equation (production+imports-exports) for non-metal minerals is dominated by production: extraction of material in Norway.
https://t.co/5QvzONbqmN

And here we see that this production of non-metallic minerals is sand, gravel and crushed rock for construction. So it's about Norway's geology.
https://t.co/y6rqWmFVWc

Norway drops 15 places on the PHDI list not because of its CO₂ emissions (fairly high at 41st highest in the world per capita), but because of its geology, because it shifts a lot of rock whenever it builds anything.
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I'm still happy that I launched a paid app bcs it involved extra work:
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📈 ~12000 vistis
☑️ 109 transactions
💰 353€ profit (285 after tax)
I have spent 1.5 months on this app. You can make more $ in 2 days.
🤷♂️

I'm still happy that I launched a paid app bcs it involved extra work:
- backend for processing payments (+ permissions, webhooks, etc)
- integration with payment processor
- UI for license activation in Electron
- machine activation limit
- autoupdates
- mailgun emails
etc.
These things seemed super scary at first. I always thought it was way too much work and something would break. But I'm glad I persisted. So far the only problem I have is that mailgun is not delivering the license keys to certain domains like https://t.co/6Bqn0FUYXo etc. 👌
omg I just realized that me . com is an Apple domain, of course something wouldn't work with these dicks