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The problem with meta-analysis like this is that it obfuscates the most important issue of treatment, which is timing.

 This meta-analysis of controlled trials only looks at hospitalized patients. How long were the patients ill for before being hospitalized? One week? Two? Three? Too late for zinc ionophores (HCQ) (+ZINC? No zinc no point..) to work. Severe illness becomes bacterial in nature.
Was azythromycin administered when the bacterial infections were also too advanced? I have seen Azythromycin work with my very own eyes but that's not to say that if administered too late it may not save the patient. How many patients were given AZT & ventilated? It's all timing.
All the meta-analysis is telling us is if you leave it too late you may have missed the early window for antiviral zinc treatment (Zn+HCQ) & that if you are given AZT when you are ventilated or very severe it may too late for it to save you & corticosteroids may be last resort.
And of course antibiotics need also probiotics, or they may harm the bacterial flora which is part of the immune response. Difficult to tell from a meta-analysis how this problem was managed.
Anyway, good news on the corticosteroids as the now accepted last line of treatment.
However, if you treat with corticosteroids too early you may run into problems:
"Corticosteroid treatment was associated with delayed viral clearance in four studies and one study that recruited 120 patients with critical illness found no difference between corticosteroid and control groups." https://t.co/pekXcIBUQP
But it may still reduce mortality if it is used as the last line of treatment (after other treatments not instead of):
"all-cause mortality was lower among patients who received corticosteroids compared with those who received usual care or placebo (summary odds ratio, 0.66)" https://t.co/5sdHOl6yJ1

More from Robin Monotti

Robin Monotti
Robin Monotti
@robinmonotti
I have now re-examined this document:


It clearly does indicate both the risks of bacterial infection & to prescribe broad spectrum antibiotics as part of treatment:
"Collect blood cultures for bacteria that cause pneumonia and sepsis, ideally before antimicrobial therapy. DO NOT
delay antimicrobial therapy"

"6. Management of severe COVID-19: treatment of co-infections
Give empiric antimicrobials [broad spectrum antibiotics] to treat all likely pathogens causing SARI and sepsis as soon as possible, within 1 hour
of initial assessment for patients with sepsis."

"Empiric antibiotic treatment should be based on the clinical diagnosis (community-acquired
pneumonia, health care-associated pneumonia [if infection was acquired in health care setting] or sepsis), local epidemiology &
susceptibility data, and national treatment guidelines"

"When there is ongoing local circulation of seasonal influenza, empiric therapy with a neuraminidase inhibitor [anti-viral influenza drugs] should
be considered for the treatment for patients with influenza or at risk for severe disease."
HEALTH
Robin Monotti FRSA
Robin Monotti FRSA
@robinmonotti
I have studied the pandemic response of many countries. One of them got a key element right, which resulted in very few deaths: Japan. Their response was to keep people OUT of hospitals. A policy of early home treatment works best, hospitals only for severe cases & NO INTUBATIONS

JAPAN: "No restrictions were placed on residents’ movements, and businesses from restaurants to hairdressers stayed open. No high-tech apps that tracked people’s movements were deployed." RESULT: Among the lowest deaths in the

Saving the NHS simply means providing early treatment kits in pharmacies & avoiding hospitals for Covid19 patients. For Covid19 infections during a pandemic, hospitals are the problem, not the solution.

I have read accounts of people with high fever literally turned away from hospitals, yet being told by phone what treatment protocol to follow. That was the best pandemic response by far, NOT lockdowns.

JAPAN had some of the lowest Covid19 mortality in the world:
-NO LOCKDOWN
-NO TEST AND TRACE
-NO BUSINESS CLOSURES
-NO HOSPITAL FOR NON CRITICAL CASES
-HOME TREATMENT
-HEALTHY DIET
-LOW OBESITY
CATEGORY C19
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Robin Monotti MA FRSA \u2b50
Robin Monotti MA FRSA ...
@robinmonotti
They are now saying my tweets are misleading. It's another lie. They are the ones who are misleading, and I will now prove it in this thread. They are lying about the safety of the vaccines:

"Why was vaccination with the COVID-19 vaccine AstraZeneca suspended?" Paul-Erlich Federal Institute for Vaccines & Biomedicines,

"A specific form of severe cerebral venous thrombosis associated with platelet deficiency (thrombocytopenia) and bleeding has been identified in seven cases (as of 15 March 2021) in temporal association with vaccination with COVID-19 Vaccine AstraZeneca."

"1. It is a very serious disease that is also difficult to treat. Of the seven affected individuals, three individuals had died."

"2. The affected individuals had ages ranging from about 20 to 50 years."
CATEGORY C19
Robin Monotti
Robin Monotti
@robinmonotti
Can any MP ask the government why early treatment kits to stop viral replication & infection are not made available cheaply & prescription free in pharmacies as they are in India? Is it lives we want to save or is it Big Pharma profits? Because the two are mutually exclusive.


There could even be competing kits, & the decision which to take could be left to doctors & patients, as happens with most medicines. The problem is that there is not one of these kits available cheaply & prescription free anywhere in the West.

Doxycycline, Ivermectin, Azithromycin, Hydroxychloroquine, Zinc, Vitamin D, Vitamin C, omega-3s, all approved as safe drugs decades ago. This is clearly not an issue of safety. It should be left to a doctor's experience & judgement whether they are effective or not, not academia.

A GP could simply state on his website: of all the kits I recommend Kit Z, then Kit Y etc. No need to wait hours for consultations, as soon as the symptoms are clear the self administered treatment begins, and thousands of lives are saved, as well as hospitals remain underwhelmed

There is no need to go to ER or ICU if people can buy early treatment kits from pharmacies. There is no need for any hospital to be overwhelmed. This problem could be resolved in days. There is simply no political will to save lives as it means to go against Big Pharma profits.
HEALTH
Robin Monotti Graziadei
Robin Monotti Graziade...
@robinmonotti
"PCR is just a process..it does not tell you that you are sick."

Kary Mullis Inventor of the PCR test & Nobel Prize in
PCR

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Jenn Dolari
Jenn Dolari
@dolari
At the risk of crapping on Star Trek: The Motion Picture before it's 40th anniversary, I really think I've figured out why that movie is kind of plodding.

Don't get me wrong, I love the movie. It's my favorite cause it's the closest the movies have gotten to Pulp SciFi.

But it really is slow, lacks character moments and just goes on and on. Robert Wise's Director's Cut does fix things in the case of speeding the movie up, but it's still lacking in a lot of action or character moments.

Ever since I got my hands on the first draft of the movie written by Harold Livingston back when it was a two hour TV pilot, I tried to figure out where everything went wrong.

The pilot is actually really good, has a lot of action, a few nice nice character moments and really moves. The only real flaw is the ending, where V'Ger learns humans created it and it literally just turns and leaves.

How did it go so wrong?

I think it was the "Writer's War" between Harold Livingston and Gene Roddenberry.

I got several other drafts of the movie, including the second draft by Gene Roddenberry. Roddenberry's second draft actually added in a lot more character moments.
MOVIE
Charlotte Clymer \U0001f3f3\ufe0f\u200d\U0001f308
Charlotte Clymer 🏳️‍🌈...
@cmclymer
Okay, finally watching #HappiestSeason... I shall tweet my thoughts with no spoilers. 🥰

Fun little reindeer kink scene. 😂

I literally thought: "this has gotta be Ohio or PA", and looked it up and sure enough...

Kristen Stewart pet-sitting for others during the holidays on an annual basis hits waaaay too close to home.

The "marriage as an institution" dialogue is a bit meh. Not the point itself, but I feel like I've listened to this exchange a million times.
MOVIE
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Su Lin
Su Lin
@SuLinSommelier
I've been watching the Netflix chess show and it reminded me of the time I beat Garry Kasparov. A thread 👇 1/

So it was back in the old USSR (I gave that title to my old friend Bruce for his songs) in the late 80s. As usual, there were 24 games. On the opening day I sat across the table from Garry and tried to out psych him with my famous penetrating stare 2/

I was shocked by his audacious first move: Queen's pawn to Q4! Outrageous! Especially since he was playing black... I left immediately and spent the rest of the day in my hotel, consoling myself with some delicious Cos D'Estournel Grand Cru 1988. 3/

By day two I had drunk so much high quality wine that I was barely able to focus on the board and was seeing double. However, with two sets of chess pieces at my mental disposal, I was able to access hitherto unknown forms of play. 4/

I began with the "Triple Bishop Castle", and followed with "The pawn Tsunami". For those who are eager to learn, the latter move is when all eight of your pawns reach the opponents side of the board and are simultaneously converted to Queens. 5/
MOVIE
Eric Spiegelman
Eric Spiegelman
@ericspiegelman
The AT&T Warner Brothers HBO Max Thing is Suuuuuper Interesting: A Thread

Background: AT&T announced that all Warner blockbusters for 2021 will get day and date release on HBO Max, even (apparently) if theaters open up again. This includes Wonder Woman 1984, the Dune reboot, and the fourth Matrix.

What happened next was basically a rebellion, led by big directors, big actors, the big agencies and the big unions. The reason, of course, is the AT&T decision might cost them all big money.

A massive chunk of big talent compensation is dependent on box office receipts. Gross points and box office bonuses are part of the compensation package for big actors and big directors. It's a big part of their deals.

What happens when there's no box office? Take a wild guess. These are tentpole releases. High risk, high reward. The actors, directors and agents are going to take a big hit relative to their expectations.
MOVIE
Sarah 12 Days of Xmas
Sarah 12 Days of Xmas
@scribblingfox
Is anyone else having a cocktail and watching the director's cut of ALIENS, the best action movie ever made, tonight?

BUILDING BETTER WORLDS

The Shining came out in 1980, so given that the audience already knows what's going to happen to all these poor colonists, the kid riding around on the Weyland-Yutani bigwheel tricycle has gotta be a reference to little Danny Torrance.

Fun fact: The original ALIEN broke me of my childhood ambitions to be a starship captain, because when 2/3ds of the crew is dead and someone needs to hunt a malevolent acid-blooded alien through the spaceship with a flamethrower? That's you, motherfucker.

SPACE MARINES!!!!!
MOVIE

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Billy Bostickson \U0001f3f4\U0001f441&\U0001f441 \U0001f193
Billy Bostickson 🏴👁&👁 ...
@BillyBostickson
Keep dwelling on this:
Further Examination of the Motif near PRRA Reveals Close Structural Similarity to the SEB Superantigen as well as Sequence Similarities to Neurotoxins and a Viral SAg.

The insertion PRRA together with 7 sequentially preceding residues & succeeding R685 (conserved in β-CoVs) form a motif, Y674QTQTNSPRRAR685, homologous to those of neurotoxins from Ophiophagus (cobra) and Bungarus genera, as well as neurotoxin-like regions from three RABV strains

(20) (Fig. 2D). We further noticed that the same segment bears close similarity to the HIV-1 glycoprotein gp120 SAg motif F164 to V174.
https://t.co/EwwJOSa8RK


In (B), the segment S680PPRAR685 including the PRRA insert and highly conserved cleavage site *R685* is shown in van der Waals representation (black labels) and nearby CDR residues of the TCRVβ domain are labeled in blue/white
https://t.co/BsY8BAIzDa


Sequence Identity %
https://t.co/BsY8BAIzDa
Y674 - QTQTNSPRRA - R685
Similar to neurotoxins from Ophiophagus (cobra) & Bungarus genera & neurotoxin-like regions from three RABV strains
T678 - NSPRRA- R685
Superantigenic core, consistently aligned against bacterial or viral SAgs
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Formula 1
Formula 1
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After 17 years and more than 300 races, it could be @alo_oficial's last F1 race on Sunday 😭 He's given us a lot over the years... including some superb GIFs!

Here we have a rare example of a GIF you can actually hear. TOMA. 💪


The Spanish Samurai


Never give up. 💪 #GraciasFernando


Winning is everything. #GraciasFernando
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हठयोगी...
@hathyogi31
#3/thread on Angkor wat

Christianity and islam may be the largest religion of today’s world but Sanatan dharm has the largest religious monument in the world in the form of Angkor wat. It is situated in combodia and spread across over 400 acres / 1.6 km².


It was listed as a UNESCO World Heritage Site in 1992, which encouraged an international effort to save the complex.
It was originally built as a Hindu temple dedicated to the god Vishnu. In Khmer, the Cambodian language, Angkor means "city" and Wat means "temple grounds".


So Angkor Wat means "Temple City". Its original name was Vrah Vishnuloka or Parama Vishnuloka, meaning the sacred dwelling of Vishnu in Sanskrit.
But, it gradually turned into a Buddhist temple towards the end of the 12th century & is still used for worship today.


Angkor Wat was initially designed and constructed in the first half of the 12th century, during the reign of Suryavarman II, as the king’s state temple and capital city. It was built without the aid of any machinery, as there was no machinery available at that time.


Evidence for these dates comes in part from inscriptions, which are vague, but also from the architectural design and artistic style of the temple and its associated sculptures.

Another aspect is that the five central towers of Angkor Wat symbolize the peaks of Mount Meru,
HISTORY
Guillaume Chaslot
Guillaume Chaslot
@gchaslot
The YouTube algorithm that I helped build in 2011 still recommends the flat earth theory by the *hundreds of millions*. This investigation by @RawStory shows some of the real-life consequences of this badly designed AI.


This spring at SxSW, @SusanWojcicki promised "Wikipedia snippets" on debated videos. But they didn't put them on flat earth videos, and instead @YouTube is promoting merchandising such as "NASA lies - Never Trust a Snake". 2/


A few example of flat earth videos that were promoted by YouTube #today:
https://t.co/TumQiX2tlj 3/

https://t.co/uAORIJ5BYX 4/

https://t.co/yOGZ0pLfHG 5/
TECH , FLAT EARTH
Peggy Klaver #FBR \U0001f30a\u270a\U0001f3fb\u270a\U0001f3fd\u270a\U0001f3ff\u270a\U0001f3fc
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@Pegerella
The man who invented autocorrect should burn in hello.

It was meant to put a smile on your face. Please stop sending me instructions on how to turn my autocorrect off. 😳🤔

Texted my friends to ask if I could take their kids with me to Satan... still have not heard back from them. I meant Santa...

Thanks for all the love, I appreciate a follow. 💗
FUN