THREAD: Women and "Unexplained" Diseases
It's interesting that even a condition as common as #Migraine is still not well understood.
Significant overlap with many other conditions mostly impacting women that are also "not well understood" is present.
https://t.co/EhrnxfItsm https://t.co/R7QUKrZvhR
cc: @jenbrea @ahandvanish @AthenaAkrami @Dr2NisreenAlwan @MBVanElzakker
https://t.co/ITrLBkc3uE
If you work on #longCOVID and say \u201cI\u2019m not an #MECFS expert, I don\u2019t know anything about it, it\u2019s not my job to know about ME or \u2019fatigue\u2019\u201d then you really, REALLY need to learn about ME. This is what MANY infections can do, not just SARS2. pic.twitter.com/zke0MqwrEd
— Jennifer Brea\U0001f992 (@jenbrea) January 14, 2021
Example stats ME/CFS:
https://t.co/GKQqqtWTI7
In ME/CFS is about 80/20 female/male. Before puberty, gender ratio is 50/50. Many anecdotal reports of trans people who take hormones: F to M improve, M to F experience worsening symptoms. Female preponderance is found in both sporadic cases and historically, in outbreaks.
— Jennifer Brea\U0001f992 (@jenbrea) January 12, 2021
Majority of patients with PNES are women, outnumbering men by a ratio of 3:1. Female sex preponderance occurs after puberty & usually before the age of 55
Lack of data does not equal lack of EXISTENCE of a problem, it equals lack of UNDERSTANDING of the problem.
And this problem is immense.
https://t.co/TnF2j4dKs3
Like this tweet if:
— Dr. Jessica Taylor (@DrJessTaylor) January 13, 2021
- You are a woman
- You have ever been ignored, gaslit, accused of exaggerating or told its all in your head by a doctor when you sought help for a medical problem
I just wanna see something.
My optimistic hope is that the enormous amounts of funding for #COVID19 open doors to understanding pathophysiology of previously neglected diseases particularly in women.
But our scientific ignorance should not be wielded to blame & further abuse patients.
Our lack of understanding is not their failure but ours.
https://t.co/LwN8qc0Q4a
Well, it would be so much easier if we didn\u2019t continuously \u201ccarve diagnoses out of the psychosomatic wastebasket\u201d as Maya Dusenbury so eloquently wrote in her book Doing Harm. So I will continue to rant about it. Wont make the medical profession happy, but time to face reality... pic.twitter.com/iFJudV9BLX
— GinaMcGalliard \U0001f9dc\U0001f3fb\u200d\u2640\ufe0f\U0001f315\U0001f339 (@GinaMcGalliard) January 12, 2021
There are more specific, more scientific, and less offensive terminology we can use for women's bodies.
@VirusesImmunity @angie_rasmussen @DocElovitz
To read more of my Threads, please check out: https://t.co/UMdZvE2tDj
More from Health
Why can cefepime cause neurological toxicity?
And why is renal failure the main risk factor for this complication?
The answer requires us to learn about cefepime's structure and why it unexpectedly binds to a certain CNS receptor.
#MedTwitter #Tweetorial
2/
Let's establish a few facts about cefepime:
🔺4th generation cephalosporin antibiotic
🔺Excretion = exclusively in the urine (mostly as unchanged drug)
🔺Readily crosses the blood-brain barrier (so it easily accesses the brain)
https://t.co/rjYG1BfGPR
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The first report of cefepime neurotoxicity was in 1999.
A patient w/ renal failure received high doses of cefepime and then developed encephalopathy, tremors, myoclonic jerks, and tonic-clonic seizures.
✅All symptoms resolved after hemodialysis.
https://t.co/u7JLVitQpp
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Cefepime neurotoxicity is surprisingly common, occurring in up to 15% of treated critically ill patients (w/ symptoms varying from encephalopathy to seizures).
💡The main risk factors = renal failure and lack of dose adjustment for renal function.
https://t.co/nxbnzSq8AR
5/
What about cefepime induces neurotoxicity?
One clue is that it's not the only antibiotic that causes neurotoxicity, particularly seizures.
This actually is a class effect w/ other beta-lactam antibiotics (including penicillins and carbapenems).
https://t.co/Lf4BhON9IY