BC HEALTH
Saved by @Alex1Powell

NEW—CDC was truly suffocated by Trump WH at every turn. Kyle McGowan, a former chief of staff at CDC, and his deputy, Amanda Campbell, witnessed WH dismissal of science, WH’s slow suffocation of CDC’s voice, meddling in messages & siphoning of CDC budget.
https://t.co/HeuNbUggiw

 2) ““Everyone wants to describe the day that the light switch flipped—It didn’t happen that way—more of like a hand grasping something, and it slowly closes, closes, closes, closes until you realize that, middle of the summer, it has a complete grasp on everything at the CDC”
3) “Mr. McGowan and Ms. Campbell, both 34, say they tried to protect their colleagues against political meddling from WH and HHS but was largely stifled by the Trump administration.
4) “The White House insisted on reviewing — and often softening — the C.D.C.’s closely guarded coronavirus guidance documents, the most prominent public expression of its latest research and scientific consensus on the spread of the virus.”
5) “The documents were vetted not only by the White House’s coronavirus task force but by what felt to the agency’s employees like an endless loop of political appointees across Washington.
Mr. McGowan recalled a White House fixated on the economic implications of public health.
6) “He and Dr. Robert R. Redfield, the C.D.C. director, negotiated w/ Russell T. Vought, the White House budget director, over social distancing guidelines for restaurants, as Mr. Vought argued that specific spacing recommendations would be too onerous for businesses to enforce”
7) ““It is not the C.D.C.’s role to determine the economic viability of a guidance document,” Mr. McGowan said.
They compromised anyway, recommending social distancing without a reference to the typical six-foot measurement.
8) “Over the summer, political appointees at the health department repeatedly asked C.D.C. officials to revise, delay and even scuttle drafts of @CDCMMWR they thought could be viewed, by implication, as criticism of President Trump.”
9) ““It wasn’t until something was in the M.M.W.R. that was in contradiction to what message the White House and H.H.S. were trying to put forward that they became scrutinized,” Ms. Campbell said.

“What’s not legitimate is to overrule science,” he said.
10) “Often, Mr. McGowan and Ms. Campbell mediated between Dr. Redfield and agency scientists when the WH’s requests and dictates would arrive: edits from Mr. Vought & Kellyanne Conway on choirs and communion in faith communities, or suggestions from Ivanka Trump, on schools.
11) “Every time that science clashed w/ messaging, messaging won”. Episodes of meddling sometimes turned absurd. In the spring, CDC published an app that allowed Americans to screen themselves for symptoms. But WH built its own, then demanded CDC wipe its app off its website”!
12) “Top CDC officials devised workarounds. Instead of posting new guidance for schools and election officials in the spring, they published “updates” to previous guidance that skipped formal review from Washington. That prompted officials in Dc to insist on reviewing updates.”
13) “especially unnerved last winter when officials in Washington told the C.D.C. that regular telephone briefings with another senior scientist, Dr. Nancy Messonnier, were no longer needed because Mr. Trump had his own daily briefings.”

(Sidebar: Dr Messonier is my hero)
14) “Dr. Messonnier angered the White House in late February when she issued a public warning that the virus was about to change Americans’ lives.
15) “There’s not a single thing that she said that didn’t come true,” Mr. McGowan said. “Is it more important to have her telling the world and the American public what to be prepared for, or is it just to say, ‘All is well?’”

“They need to be allowed to lead.”
16) BOTTOMLINE: CDC being censored and muzzled is one of the greatest travesties of this pandemic. And its tarnish reputation one of the worst stains of Trump WH.

➡️ all this is incredible painful to me cuz of what I also went thru in Jan trying to warn:
https://t.co/I5G7PL6boG

More from Eric Feigl-Ding

Eric Feigl-Ding
Eric Feigl-Ding
@DrEricDing
📍DOUBLE REINFECTIONS—wow, both PM Justin Trudeau and Biden’s HHS Secretary Becerra got *reinfected* with #COVID19–from same conference—➡️when did Becerra last get infected? May 18th 2022—not even a full month ago! Trudeau in Jan 2022. I worry it’s reinfections due to #BA5/#BA4.


2) #BA5 and #BA4 are worrisome. They are surging and they have high reinfection potential. Your past BA1/BA2 doesn’t substantially protect you from #Ba5/4


3) Excess deaths—the new #BA4 & #BA5 variants of the coronavirus are currently the **fastest growing** strains in the US & UK. ➡️They are exponentially replacing all other past strains. Learn from South Africa’s early warning signs and their excess deaths. #CovidIsNotOver #COVID


4) Is it a Paxlovid rebound for Becerra, as some are asking? Unclear—Paxlovid rebound usually only happens at day 10-14 that we know of and have data. The FDA says it’s 1-2% rebound but I counted 12% from this Pfizer graph submitted to FDA.


5) and yes, #ba5 / #BA4 are very problematic. they are 2x more resistant than even BA2 for neutralizing the virus compared to those who had breakthrough reinfections from older Omicron.
CATEGORY PDFMAKERAPP GRAB THIS READWISEIO SAVE READWISEIO SAVE THREAD THREADER COMPILE SUMMARIZE
Eric Feigl-Ding
Eric Feigl-Ding
@DrEricDing
Wow. 1 in 3 hospitalized with #COVID19 gets readmitted to the hospital within a few months after discharge. ~48,000 UK patients.

Great animated lecture on #LongCovid by @Dr2NisreenAlwan, animated by @VickiGSP using info from UK @IndependentSage experts.


2) Furthermore, 1 in 8 of those who were discharged subsequently die. And many suffer long term ailments like heart disease, liver, kidney, diabetes, and more. This doesn’t even include less clinical critical cognitive effects. #LongCovid is real.


3) How common is #LongCovid overall? UK estimates 1 in 5 at 5 weeks and 1 in 10 have symptoms have even 12 weeks after initial #COVID19 diagnosis.

Lecture again by @Dr2NisreenAlwan


4) Let these numbers sink in... 1 in 10 at 12 weeks still have symptoms!


5) Here is the original study of the above lecture from few weeks ago. We need to prepare our healthcare system long term for the impact of millions with #LongCovid. This is gonna be larger than Gulf War Syndrome or long term health of 9/11 first responders.
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Eric Feigl-Ding
Eric Feigl-Ding
@DrEricDing
JUST ONE PERSON—UK 🇬🇧 scientists think one immunocompromised person who cleared virus slowly & only partially wiped out an infection, leaving behind genetically-hardier viruses that rebound & learn how to survive better. That’s likely how #B117 started. 🧵 https://t.co/bMMjM8Hiuz


2) The leading hypothesis is that the new variant evolved within just one person, chronically infected with the virus for so long it was able to evolve into a new, more infectious form.

same thing happened in Boston in another immunocompromised person that was sick for 155 days.

3) What happened in Boston with one 45 year old man who was highly infectious for 155 days straight before he died... is exactly what scientists think happened in Kent, England that gave rise to #B117.


4) Doctors were shocked to find virus has evolved many different forms inside of this one immunocompromised man. 20 new mutations in one virus, akin to the #B117. This is possibly how #B1351 in South Africa 🇿🇦 and #P1 in Brazil 🇧🇷 also evolved.


5) “On its own, the appearance of a new variant in genomic databases doesn’t tell us much. “That’s just one genome amongst thousands every week. It wouldn’t necessarily stick out,” says Oliver Pybus, a professor of evolution and infectious disease at Oxford.
SCIENCE
Eric Feigl-Ding
Eric Feigl-Ding
@DrEricDing
Breaking—UK scientists just reported a case-control study that the mutated UK 🇬🇧B.1.1.7 variant is not associated w/ more severe #COVID19— “found no significant differences in hospital admissions and case fatality at 28 days, & occurrence of reinfections”, says @mvankerkhove

2) That said, the new UK mutated strain is a more transmissible (contagious) variant. Keep transmissibility and illness severity separate. They are two different things. Don’t get them confused.

3) The new UK variant severity study is included in today’s WHO report, to be released soon this afternoon according to WHO sources. Waiting for it to drop. I’ll keep folks posted on the details.

4) Update: here is UK Technical report on #SARSCoV2 variant of concern (B.1.1.7) in 🇬🇧 with prelim findings from their case-control study of no increased severity for the new variant that I reported yesterday.

5) Also keep in a mind that a virus that spreads faster (more contagious) yields much worse total outcomes than a virus that is just merely more severe.

All things equal, a new mutated variant that is more contagious & no more severe is worse. And that is what we now have.
COVID
Eric Feigl-Ding
Eric Feigl-Ding
@DrEricDing
JUST IN — "Camp Auschwitz" insurrectionist of the Capitol siege was just arrested this morning in Newport News, VIrginia.

2) this guy was just arrested.


3) We cannot have a repeat of the fascism from WW2. This is @Schwarzenegger’s speech was so powerful.


4) My wife @andreafeigl1’s 🇦🇹 great grandfather secretly fought Hilter’s Nazi regime & smuggled many Jews to safety as an aircraft engineer. He was thrown into a concentration camp, and escaped.

She knows a few things about Nazi history—Jan 6th was downright fascist. Read 👇


5) So this cover is from a semi-tabloid magazine in Germany, according to @andreafeigl1. But even so, how did such a magazine still get it so damn right?! Maybe Germany 🇩🇪 has seen this kinda fascism before...
LEGAL

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Tony Breu
Tony Breu
@tony_breu
1/16
Why do B12 and folate deficiencies lead to HUGE red blood cells?

And, if the issue is DNA synthesis, why are red blood cells (which don't have DNA) the key cell line affected?

For answers, we'll have to go back a few billion years.


2/
RNA came first. Then, ~3-4 billion years ago, DNA emerged.

Among their differences:
🔹RNA contains uracil
🔹DNA contains thymine

But why does DNA contains thymine (T) instead of uracil (U)?

https://t.co/XlxT6cLLXg


3/
🔑Cytosine (C) can undergo spontaneous deamination to uracil (U).

In the RNA world, this meant that U could appear intensionally or unintentionally. This is clearly problematic. How can you repair RNA when you can't tell if something is an error?

https://t.co/bIZGviHBUc


4/
DNA's use of T instead of U means that spontaneous C → U deamination can be corrected without worry that an intentional U is being removed.

DNA requires greater stability than RNA so the transition to a thymine-based structure was beneficial.

https://t.co/bIZGviHBUc


5/
Let's return to megaloblastic anemia secondary to B12 or folate deficiency.

When either is severely deficient deoxythymidine monophosphate (dTMP*) production is hindered. With less dTMP, DNA synthesis is abnormal.

[*Note: thymine is the base in dTMP]

https://t.co/AnDUtKkbZh
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Aureliano Stingi
Aureliano Stingi
@AurelianoStingi
Controversial 3D. Probably none of you knows about Leber congenital amaurosis type 10, congenital blindness that affects 3 out of 100,000 children, condemning them to blindness for life. The only possible treatment is through gene therapy. 1/n


Thanks to Crispr-CAS9 technology we MODIFY the defective gene inside the patient eye ( they directly inject the treatment into the eye). Before CRISPR the treatment was based on Adenovirus carrying the correct form of the gene

In both cases, we MODIFY the patient DNA and that's the only way (today) to treat this disease. LCA10 is not the only genetic disease affecting kids unfortunately the list is long and the variety of diseases is terrifying.

Now think about a parent with a kid with a genetic disease, he/she would try and do anything to save him/her. ANYTHING and they would take some RISKS, gene therapy was a risk at the beginning, and any new experimental treatment shares a percentage of risk. 4/n

Now we come to #COVID19 and #vaccines. The new RNA vaccines are a HUGE scientific breakthrough, that may open new amazing therapeutic paths. And like ANY other human activity share a risk.
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Adam Wagner
Adam Wagner
@AdamWagner1
🚨New lockdown regulations just published, in force tomorrow

The Health Protection (Coronavirus, Restrictions) (No. 3) and (All Tiers) (England) (Amendment) Regulations 2021

https://t.co/L5jwlTDaIE

(Thread)


These are not a new set of regulations: they are amendments an old set of regulations

Which we thought were gone! But they are back

Welcome back No.3 regulations

A quick thing before we continue!

I have been analysing these laws for free for 9 months now - if you want to say thanks and have a few £ to spare please give to my @LawCentres fundraiser

They give free legal advice to people who need it

They also amend the All Tiers regulations

Oh god it's all amendments by paragraph references

Basically all of England now in Tier 4 and Tier 4 is amended but not by a huge amount

This really is a terrible way to make laws on the fly - who can possibly understand it?!


So, to explain, you need 2 documents open if you want to understand what is going on:

All Tiers regulations (Tiers 1-4, 2 December as amended) https://t.co/IraPQ112ak

And amendments https://t.co/L5jwlTDaIE

No sensible way of doing except by track changes, on it now, back soon
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Rebecca Fitzgerald Lab
Rebecca Fitzgerald Lab
@RFitzgerald_lab
Here is a tweetorial from our latest publication in @Annals_Oncology about longitudinal tracking of esophageal adenocarcinoma. #OesophagealCancer #EsophagealCancer https://t.co/QWvrzBXmK7 1/8

We sequenced 245 plasma samples from 97 patients with oesophageal adenocarcinoma using a 77 gene pan-cancer ctDNA panel. 2/8


Variants derived from previously characterised driver oesophageal adenocarcinoma genes had a significantly higher VAF than variants from other genes, indicating selection. 3/8


Peripheral blood cell samples were also sequenced for 78/97 patients. CHIP mutations were identified in 23% of cases, longitudinal tracking of CHIP variants suggested these variants were dynamic over time. 4/8


We found patients that were ctDNA positive post-surgery had a significantly poorer survival than ctDNA negative patients, and the elimination of CHIP variants improved the positive predictive value. 5/8
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\U0001f1ee\U0001f1ea & \U0001f1ec\U0001f1e7 COVID \U0001f9f5 \U0001f9f5 \U0001f9f5
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@ThreadsIrish
1. “Dr Tomas Ryan : Sociopath Or Psychopath : Or Both ?”

Answer = Both. Shortest Thread Ever. Only joking. Let’s jump in and try to see what makes Dr Tomas Ryan tick 🧵 1/21


2. Dr Tomas Ryan is a Neuroscientist at Trinity College Dublin. He has appeared on Claire Byrne Live, Prime Time & The Tonight Show in addition to radio appearances. He calls himself a Scholar on his Twitter bio.


3. He is part of the Zero Covid Cult Crew (ZCCC) out of that hallowed institute of learning, Trinity College Dublin. Other contemporaries of his in the merry little band are Luke O Neill, Kingston Mills & Aoife McLysaght.


4. Kingston Mills & Aoife McLysaght are staunch proponents of the Zero Covid strategy. Mills is an agenda contributor to the World Economic Forum and recently wrote an article for them entitled "Is reaching zero Covid-19

5. Did I forget to mention that TCD got funding from the Bill & Melinda Gates foundation for Vaccine development to the tune of $230,000. Tomas was also sponsored by Wellcome Trust Sanger Institute to complete his Phd in Cambridge. Let's just say he has connections to Big Pharma
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Today is Jayanti of Ahilyabai Holkar

She was a widow who became Malwa's greatest queen. Defended our country & personally led armies into battle.Never plundered anyone. Developed Malwa into a prosperous kingdom. Rebuilt temples destroyed by Mughals. Built Dharmashalas at Tirthas


Unfortunately, her memory has been blemished by inaccurate representations in modern popular media.

The serial "Punyashlok Ahilyabai" depicts her as ultra secularist feminazi icon who questions Hindu rituals & Pandits while patronising Sufis.

This is far from historical truth!


Ahilyabai was born on May 31 1725 to Patil Mankoji Shinde.

She was from Dhangar clan(classified as OBC today). While Dhangars were traditionally into herding, they took up arms & held several military /civil roles in various eras of history(especially during Maratha resurgence)


In 1737, when she was 12, Ahilyabai Holkar was married to Khanderao , son of Subedar Malhar Rao Holkar.

By the time she was married, fortunes of Holkar family had already waxed.

Malhar Rao was a Subedar of territory comprising 30 Parganas yielding a revenue of at least 7 Lakh


In 1741, when Ahilyabai was newly married, her father -in-law Malhar Rao Built Indore palace & ordered the kanungo to populate the settlement with a promise of protection to traders.

This began rise of Indore from its background as modest trading town Indrapuri to a great city
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Story of Thumba Poo and Shiva

Thumba poo is a tiny white flower which grows in all areas. These flowers are used for treatment for sinus. Small children who have polyps in Nose are told to crush tumbha leaves and apply in nose part.
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Mahadeva. Thumba flowers were not taken for Shiva Pooja. Saddened to this Thumba prayed sincerely and Mahadeva appeared before her.
She was surprised that Shiva had appeared before her. Instead of saying that she wants to under his feet always, she said
@SriramKannan77


She said that her feet should be on his head. Shiva accepted her prayers. It is because of this Thumba flower is placed in the head of Shiva Linga.
Shambo Mahadeva
Om Namah Sivaye
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