BC HEALTH
Saved by @Mollyycolllinss

Controversial 3D. Probably none of you knows about Leber congenital amaurosis type 10, congenital blindness that affects 3 out of 100,000 children, condemning them to blindness for life. The only possible treatment is through gene therapy. 1/n

 Thanks to Crispr-CAS9 technology we MODIFY the defective gene inside the patient eye ( they directly inject the treatment into the eye). Before CRISPR the treatment was based on Adenovirus carrying the correct form of the gene 2/n
https://t.co/RbqZKkUIjx
In both cases, we MODIFY the patient DNA and that's the only way (today) to treat this disease. LCA10 is not the only genetic disease affecting kids unfortunately the list is long and the variety of diseases is terrifying. 3/n
https://t.co/iO2jqcIxU0
Now think about a parent with a kid with a genetic disease, he/she would try and do anything to save him/her. ANYTHING and they would take some RISKS, gene therapy was a risk at the beginning, and any new experimental treatment shares a percentage of risk. 4/n
Now we come to #COVID19 and #vaccines. The new RNA vaccines are a HUGE scientific breakthrough, that may open new amazing therapeutic paths. And like ANY other human activity share a risk. 4/n

https://t.co/mG9lQoNCXI
FDA and EMA already cleared that risk to a very small percentage, probably lower than a normal drug. But there is a risk, and why should we take that risk? Because on the other hand, we have Covid19. A disease that killed 2 million people. 5/n
Covid19 can severely damage our body and it can cause long term damages (#LongCovid). 6/n

https://t.co/gnczyUWw9i
People against the RNA vaccine (or vaccine in general) don't want to take a small risk ( FDA and EMA agree that is reasonably low) because they don't see the risk/reward ratio and you why? because they are SELFISH. 7/n
https://t.co/nYLR1Sq2BW
Covid19 has a relatively low lethality that's why people are not scared, that's why people complain about social distancing, lockdown and wearing a mask because they are not directly affected. If it doesn't touch me, why should I be worried? that's so sad and miserable. 8/n
We need lockdown, social distancing, mask and vaccines to PROTECT the weak, the elderly, the immunocompromised. And why we do that? because we are human beings and we are better than wild animals.
So take a small risk to protect the others and stop complaining. 9/n
And maybe spend some times speaking with families hit by covid, speak to a person who has lost a parent, maybe you will realize that you are not the only one. We are one species and we help each other.
#WearADamnMask #vaccinoCovid 10/10
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THIS IS A CATCHY & ATTENTION-GRABBING TITLE

Today, the Province will likely announce what zone of the reopening framework we'll shift into as of Tuesday. Whatever is announced, though, doesn't change what we need to do. Why?

Kindly read these 14 tweets & we'll tell you. (1/14)

Fun fact: COVID-19 does not follow us on Twitter. COVID doesn't know, or particularly care, if we're in the Red or Orange zone.

The behaviours of the virus do not depend on the current ‘zone’ of public health restrictions. And, to be perfectly candid, neither should ours. (2/14)

Once upon a time we used to say #WeAreInThisTogether in our messaging. Here's the thing: we are, but we aren't. Not everyone is experiencing this pandemic the same.

Nurses, doctors, paramedics & healthcare workers have experienced things much differently than most of us. (3/14)

Some people have been home & isolated for months, while others haven't been able to stop working.

Business owners & hospitality workers have been on a rollercoaster of openings & closures.

Students, parents, teachers & school staff have had to adapt to going from online (4/14)

to in-person learning (and back again) numerous times.
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This is a limited point about availability of efficacy data for vaccines under development in the context of the approval for CovidShield and Covaxin in India.

There have been many so-called experts on the idiotbox opining about apparent availability of P III data which 1/n

2/n apparently the SEC had access to based on which it "supposedly" approved Covaxin. Another argument that is prevalent is other regulators (US FDA and MHRA) also approved vaccines based on P II data alone. Let me give you a few facts so that you can make your own decision.

3/n The protocols for both mRNA vaccines are publicly available. You can check. Both protocols *define* when the interim analysis will be done. This is not subjective. They clearly define how many infections need to be documented before the Data Safety Monitoring Board meets.

4/n Find the protocols for the bridging study for CovidShield and Covaxin and look for a similar milestone.

Here is one set of efficacy data post the interim analysis of a mRNA vaccine.

Source: https://t.co/BAPnP3PxEb


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ICYMI, public health officials fear community transmission of B.1.1.7 (the "UK variant") is underway in Ontario.

I'll dissect each piece of worrying news from this story.

1. Simcoe Muskoka has so far reported 3 positive tests in individuals *with no known links* to the massive B.1.1.7 outbreak at Roberta Place LTC.

Two of those are linked to separate outbreaks of their own (a different LTC and a mental health hospital). Testing underway.

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42 household contacts of ppl linked to the outbreak are also COVID+. Public health unit is worried about keeping cases (which are all likely B.1.1.7) from rippling further into the community.

3. A case in Kingston area who tested positive for COVID "several weeks ago" was just discovered to be B.1.1.7. That person travelled to Simcoe Muskoka, but had not travelled internationally, according to the local health unit.

4. Overall, Public Health Ontario counts 47 B.1.1.7 cases as of yesterday -- these are only the ones confirmed thru full genome sequencing. Preliminary screening tests not included (yesterday's 99 in Simcoe Muskoka, for example).

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"Public health" isn't just about vaccinations, clinics and urgent care: it's a holistic discipline that encompasses all the contributors to health outcomes, which include things like housing, employment, transportation, pollution and more.

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A new working paper from @nberpubs estimates the number of US covid deaths that could have been prevented with a coherent, effective eviction moratorium and a ban on utility cutoffs:

The paper, written by a multidisciplinary group of Duke researchers from medicine and economics, found that housing precarity (a risk of losing your home) drove risky behavior that increased the spread of the disease and the resulting deaths.

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For example, it forced people to double-up on lodgings, making social distancing impossible, to say nothing of self-isolating after an exposure. It also drove people to tolerate high-risk workplace conditions, including illegal conditions.

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The authors used regression techniques to control for confounding variables, and used like-for-like counties with different utility and eviction policies to estimate the effect that these had on infection rates.

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A relationship begins to get stiff when excessive patterns begin to form.

Too many patterns leads to a boring, predictable, logical lifestyle.

Get the emotions involved.

Do something spontaneous out of the blue moon & flip the script.

'What's wrong with the patterns?'

Nothing is wrong with patterns.

However, there is a problem when all you have are patterns.

It's boring.

'Can you explain why?'

Sure 👇

The thing with relationships is that it's meant to be an emotional experience.

It's very difficult to logically explain love, right?

'Right.'

Well this is where you want to steer the ship the right way.

1. Too emotional is bad.

2. Too logical is bad.

Let me break it down.

1. Too emotional

If a relationship is completely ruled by emotions, then it's too volatile.

You will never reach productivity if you are aimlessly only following each others emotions.

This lifestyle tarnishes any structure for the couple.

'So why do people do it?'

Because it's fun.

You may ruled by this stage in the honeymoon phase.

Normal.

You'll be so spontaneous that it almost becomes a lifestyle.

But it's hard to level up your life when you're too spontaneous.

Avoid.
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Remembering the Bengali scientist Dr Subhash Mukhopadhyay- the Pioneer of IVF in India, the creator of India's first and world's second child using IVF on his birth anniversary. The Father of IVF in India who was rewarded with suicide was born on 16.01.1931in Hazaribagh.
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Dr. Subhash was the son of a doctor and studied at the National Medical College in Kolkata after completing his schooling. Fascinated by innovations in gynaecological surgery from his early days as a medical student, he completed his PhD in reproductive physiology +


from the University of Calcutta before going to the Edinburgh University in UK for a PhD in reproductive endocrinology. On his return to India in 1978, he started researching ovulation and spermatogenesis. Soon after, he teamed up with Sunit Mukherji, a cryobiologist +


and Saroj Kanti Bhattacharya, a gynaecologist, to work on a method of in-vitro fertilization for a patient (Bela Agarwal) with damaged fallopian tubes. +


Mukhopadhyay with a double PhDstarted work on IVF techniques in the mid 60s and created history by becoming the first physician in India and second in the world after British physicians Robert Edwards and Patrick Steptoe) to perform the In-vitro fertilisation. +
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ANCIENT BHARAT WAS CALLED VISHWAGURU, AND IT REALLY DESERVED IT.

India had a well developed education system centuries before the westerners arrived and called us uncivilized. Education was always given a great importance in Indian civilisation since times immemorial.


Ancient India had the Gurukulas and Ashramas as the epicentres of the knowledge and enlightenment. Bigger Gurukulas served as the centres of higher education called universities. Besides these universities, temples also emerged as the major learning centres.

Studying the Holy Scriptures, character building, personality development, responsibilities towards self,family and society,discipline and preservation of the ancient culture and heritage were the key embodiments of education.

This kind of education system made ancient India, a centre of knowledge all over the world. Many foreign students came to India for education and India was called the 'Vishwaguru'.
Takshshila and Nalanda were the two prominent universities of ancient India.


But were these only Universities of ancient India?The answer is 'No'.Let's learn about these gems of our education system that flourished across ancient India & be proud.

NALANDA UNIVERSITY
This was the oldest university of ancient India.Situated in Nalanda distt. of Bihar...
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Noah Smith
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Krugman is, of course, right about this. BUT, note that universities can do a lot to revitalize declining and rural regions.


See this thing that @lymanstoneky wrote:

And see this thing that I wrote:

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Sculpture of Bhagwan Shiva as the destroyer of the Asura Andhaka - Cave 29,Ellora caves

Asura Andhaka hangs on to a trishula held by 6-armed Shiva.

Once Parvathi & Shiva were relaxing in the pleasant gardens of Mount Mandhara.


Bhagwan Shiva sat down there to enjoy the happiness.Parvati closed the eyes of Shiva playfully & darkness covered the whole universe.Parvati was perplexed & her palms were wet with perspiration.A few drops of her sweat mixed with sweat from Shiva’s body& fell to the ground.

From this sweat,a fierce creature was born,it started to roar.Child was born blind as Shiva's eyes were closed so was named as Andaka.Andha means darkness&also ignorance.Around the same time Asura Hiranyaksha was performing rigorous tapas Shiva for a boon of powerful son.

Bhagwan Shiva was pleased by tapas of Hiranyaksha & blessed him with darshan.Hiranyaksha asked for a powerful son,Shiva told him that he cannot have his own son,but can adopt a blind child who would become very powerful later.Shiva gave child Andaka to Hiranyaksha.

Hiranyaksha returned to his kingdom with Andaka.Later after the vadh of Hiranyaksha, Andaka is said to have lived with his cousins.He was ridiculed,so dejected Andaka went to forest.He did severe tapas for over many years towards Brahma Dev. Brahma dev appeared before him.
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